Affinity Data by PubMed id=25855505

PubMed code 25855505

Found 12 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Putative heat shock protein HSP 90-alpha A4 (Homo sapiens (Human))	BDBM166675 (3-(5-chloro-2,4-dihydroxyphenyl)-5,6-dihydro-4H-be...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
University of Milano					Assay Description The fluorescence polarization (FP) assay was performed as described in the reference (Bioorg Med Chem. 2010. 18:6031-6043).				Chem Biol Drug Des 86: 1030-5 (2015) Article DOI: 10.1111/cbdd.12570 BindingDB Entry DOI: 10.7270/Q22806CD
University of Milano					More data for this Ligand-Target Pair
Putative heat shock protein HSP 90-alpha A4 (Homo sapiens (Human))	BDBM166670 (17-AAG) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Milano					Assay Description The fluorescence polarization (FP) assay was performed as described in the reference (Bioorg Med Chem. 2010. 18:6031-6043).				Chem Biol Drug Des 86: 1030-5 (2015) Article DOI: 10.1111/cbdd.12570 BindingDB Entry DOI: 10.7270/Q22806CD
University of Milano					More data for this Ligand-Target Pair
Putative heat shock protein HSP 90-alpha A4 (Homo sapiens (Human))	BDBM166672 (3-(5-chloro-2,4-dihydroxyphenyl)-5,6-dihydroisoxaz...) Show SMILES Oc1cc(O)c(cc1Cl)-c1noc2c1CCNC2=O Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Milano					Assay Description The fluorescence polarization (FP) assay was performed as described in the reference (Bioorg Med Chem. 2010. 18:6031-6043).				Chem Biol Drug Des 86: 1030-5 (2015) Article DOI: 10.1111/cbdd.12570 BindingDB Entry DOI: 10.7270/Q22806CD
University of Milano					More data for this Ligand-Target Pair
Putative heat shock protein HSP 90-alpha A4 (Homo sapiens (Human))	BDBM166673 (3-(5-chloro-2,4-dihydroxyphenyl)-5,6-dihydrobenzo[...) Show SMILES Oc1cc(O)c(cc1Cl)-c1noc2c1CCCC2=O Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Milano					Assay Description The fluorescence polarization (FP) assay was performed as described in the reference (Bioorg Med Chem. 2010. 18:6031-6043).				Chem Biol Drug Des 86: 1030-5 (2015) Article DOI: 10.1111/cbdd.12570 BindingDB Entry DOI: 10.7270/Q22806CD
University of Milano					More data for this Ligand-Target Pair
Putative heat shock protein HSP 90-alpha A4 (Homo sapiens (Human))	BDBM166676 (3-(5-chloro-2,4-dihydroxyphenyl)-5,6-dihydro-4H-be...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Milano					Assay Description The fluorescence polarization (FP) assay was performed as described in the reference (Bioorg Med Chem. 2010. 18:6031-6043).				Chem Biol Drug Des 86: 1030-5 (2015) Article DOI: 10.1111/cbdd.12570 BindingDB Entry DOI: 10.7270/Q22806CD
University of Milano					More data for this Ligand-Target Pair
Putative heat shock protein HSP 90-alpha A4 (Homo sapiens (Human))	BDBM166671 (3-(5-chloro-2,4-dihydroxyphenyl)-5,6-dihydro-6-met...) Show SMILES CN1CCc2c(noc2C1=O)-c1cc(Cl)c(O)cc1O Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Milano					Assay Description The fluorescence polarization (FP) assay was performed as described in the reference (Bioorg Med Chem. 2010. 18:6031-6043).				Chem Biol Drug Des 86: 1030-5 (2015) Article DOI: 10.1111/cbdd.12570 BindingDB Entry DOI: 10.7270/Q22806CD
University of Milano					More data for this Ligand-Target Pair
Putative heat shock protein HSP 90-alpha A4 (Homo sapiens (Human))	BDBM166674 (3-(5-chloro-2,4-dihydroxyphenyl)-4,5,6,7-tetrahydr...) Show SMILES OC1CCCc2c1onc2-c1cc(Cl)c(O)cc1O Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Milano					Assay Description The fluorescence polarization (FP) assay was performed as described in the reference (Bioorg Med Chem. 2010. 18:6031-6043).				Chem Biol Drug Des 86: 1030-5 (2015) Article DOI: 10.1111/cbdd.12570 BindingDB Entry DOI: 10.7270/Q22806CD
University of Milano					More data for this Ligand-Target Pair
Putative heat shock protein HSP 90-alpha A4 (Homo sapiens (Human))	BDBM166681 (4-(7-Hydroxy-4,5,6,7-tetrahydro-benzo[d]isoxazol-3...) Show SMILES NC(=O)c1ccc(cc1)-c1noc2C(O)CCCc12 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Milano					Assay Description The fluorescence polarization (FP) assay was performed as described in the reference (Bioorg Med Chem. 2010. 18:6031-6043).				Chem Biol Drug Des 86: 1030-5 (2015) Article DOI: 10.1111/cbdd.12570 BindingDB Entry DOI: 10.7270/Q22806CD
University of Milano					More data for this Ligand-Target Pair
Putative heat shock protein HSP 90-alpha A4 (Homo sapiens (Human))	BDBM166679 (4-(7-(2-Morpholin-4-yl-ethoxyimino)-4,5,6,7-tetrah...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Milano					Assay Description The fluorescence polarization (FP) assay was performed as described in the reference (Bioorg Med Chem. 2010. 18:6031-6043).				Chem Biol Drug Des 86: 1030-5 (2015) Article DOI: 10.1111/cbdd.12570 BindingDB Entry DOI: 10.7270/Q22806CD
University of Milano					More data for this Ligand-Target Pair
Putative heat shock protein HSP 90-alpha A4 (Homo sapiens (Human))	BDBM166678 (4-(7-Hydroxyimino-4,5,6,7-tetrahydro-benzo[d]isoxa...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Milano					Assay Description The fluorescence polarization (FP) assay was performed as described in the reference (Bioorg Med Chem. 2010. 18:6031-6043).				Chem Biol Drug Des 86: 1030-5 (2015) Article DOI: 10.1111/cbdd.12570 BindingDB Entry DOI: 10.7270/Q22806CD
University of Milano					More data for this Ligand-Target Pair
Putative heat shock protein HSP 90-alpha A4 (Homo sapiens (Human))	BDBM166677 (4-(7-Oxo-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-yl)-...) Show SMILES NC(=O)c1ccc(cc1)-c1noc2c1CCCC2=O Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Milano					Assay Description The fluorescence polarization (FP) assay was performed as described in the reference (Bioorg Med Chem. 2010. 18:6031-6043).				Chem Biol Drug Des 86: 1030-5 (2015) Article DOI: 10.1111/cbdd.12570 BindingDB Entry DOI: 10.7270/Q22806CD
University of Milano					More data for this Ligand-Target Pair
Putative heat shock protein HSP 90-alpha A4 (Homo sapiens (Human))	BDBM166680 (4-(7-(2-Aminoethoxyimino)-4,5,6,7-tetrahydrobenzo[...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Milano					Assay Description The fluorescence polarization (FP) assay was performed as described in the reference (Bioorg Med Chem. 2010. 18:6031-6043).				Chem Biol Drug Des 86: 1030-5 (2015) Article DOI: 10.1111/cbdd.12570 BindingDB Entry DOI: 10.7270/Q22806CD
University of Milano					More data for this Ligand-Target Pair

* indicates data uncertainty>20%