BindingDB logo
myBDB logout

PubMed code 26003342

Compile data set for download or QSAR
Found 8 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50092478
PNG
(CHEMBL3586177)
Show SMILES Clc1cccc(Nc2ncnc3ccc(NC(=O)[C@@H]4CCCN4C4=NC(=O)\C(S4)=C/c4cccc(Br)n4)cc23)c1 |r,t:24|
Show InChI InChI=1S/C28H21BrClN7O2S/c29-24-8-2-6-18(33-24)14-23-27(39)36-28(40-23)37-11-3-7-22(37)26(38)35-19-9-10-21-20(13-19)25(32-15-31-21)34-17-5-1-4-16(30)12-17/h1-2,4-6,8-10,12-15,22H,3,7,11H2,(H,35,38)(H,31,32,34)/b23-14+/t22-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.10E+3n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of recombinant EGFR (unknown origin) assessed as inhibition of autophosphorylation after 1 hr by DELFIA/Time-resolved fluorometry

Bioorg Med Chem 23: 3221-7 (2015)


Article DOI: 10.1016/j.bmc.2015.04.065
BindingDB Entry DOI: 10.7270/Q2DF6SXQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50092479
PNG
(CHEMBL3586176)
Show SMILES Cc1cccc(\C=C2\SC(=NC2=O)N2CCC[C@H]2C(=O)Nc2ccc3ncnc(Nc4cccc(Cl)c4)c3c2)n1 |r,c:9|
Show InChI InChI=1S/C29H24ClN7O2S/c1-17-5-2-7-20(33-17)15-25-28(39)36-29(40-25)37-12-4-9-24(37)27(38)35-21-10-11-23-22(14-21)26(32-16-31-23)34-19-8-3-6-18(30)13-19/h2-3,5-8,10-11,13-16,24H,4,9,12H2,1H3,(H,35,38)(H,31,32,34)/b25-15+/t24-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.50E+3n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of recombinant EGFR (unknown origin) assessed as inhibition of autophosphorylation after 1 hr by DELFIA/Time-resolved fluorometry

Bioorg Med Chem 23: 3221-7 (2015)


Article DOI: 10.1016/j.bmc.2015.04.065
BindingDB Entry DOI: 10.7270/Q2DF6SXQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50092477
PNG
(CHEMBL3586178)
Show SMILES Clc1cccc(Nc2ncnc3ccc(NC(=O)[C@@H]4CCCN4C4=NC(=O)\C(S4)=C/c4cccnc4Cl)cc23)c1 |r,t:24|
Show InChI InChI=1S/C28H21Cl2N7O2S/c29-17-5-1-6-18(13-17)34-25-20-14-19(8-9-21(20)32-15-33-25)35-26(38)22-7-3-11-37(22)28-36-27(39)23(40-28)12-16-4-2-10-31-24(16)30/h1-2,4-6,8-10,12-15,22H,3,7,11H2,(H,35,38)(H,32,33,34)/b23-12+/t22-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 7.40E+3n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of recombinant EGFR (unknown origin) assessed as inhibition of autophosphorylation after 1 hr by DELFIA/Time-resolved fluorometry

Bioorg Med Chem 23: 3221-7 (2015)


Article DOI: 10.1016/j.bmc.2015.04.065
BindingDB Entry DOI: 10.7270/Q2DF6SXQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50092475
PNG
(CHEMBL3586185)
Show SMILES Clc1ccc(\C=C2\SC(=NC2=O)N2CCC[C@H]2C(=O)Nc2ccc3ncnc(Nc4cccc(Cl)c4)c3c2)cc1 |r,c:8|
Show InChI InChI=1S/C29H22Cl2N6O2S/c30-18-8-6-17(7-9-18)13-25-28(39)36-29(40-25)37-12-2-5-24(37)27(38)35-21-10-11-23-22(15-21)26(33-16-32-23)34-20-4-1-3-19(31)14-20/h1,3-4,6-11,13-16,24H,2,5,12H2,(H,35,38)(H,32,33,34)/b25-13+/t24-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 7.60E+3n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of recombinant EGFR (unknown origin) assessed as inhibition of autophosphorylation after 1 hr by DELFIA/Time-resolved fluorometry

Bioorg Med Chem 23: 3221-7 (2015)


Article DOI: 10.1016/j.bmc.2015.04.065
BindingDB Entry DOI: 10.7270/Q2DF6SXQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50092481
PNG
(CHEMBL3586174)
Show SMILES Clc1cccc(Nc2ncnc3ccc(NC(=O)[C@@H]4CCCN4C4=NC(=O)\C(S4)=C/c4cccs4)cc23)c1 |r,t:24|
Show InChI InChI=1S/C27H21ClN6O2S2/c28-16-4-1-5-17(12-16)31-24-20-13-18(8-9-21(20)29-15-30-24)32-25(35)22-7-2-10-34(22)27-33-26(36)23(38-27)14-19-6-3-11-37-19/h1,3-6,8-9,11-15,22H,2,7,10H2,(H,32,35)(H,29,30,31)/b23-14+/t22-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a 8.10E+3n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of recombinant EGFR (unknown origin) assessed as inhibition of autophosphorylation after 1 hr by DELFIA/Time-resolved fluorometry

Bioorg Med Chem 23: 3221-7 (2015)


Article DOI: 10.1016/j.bmc.2015.04.065
BindingDB Entry DOI: 10.7270/Q2DF6SXQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50092476
PNG
(CHEMBL3586179)
Show SMILES Clc1cccc(Nc2ncnc3ccc(NC(=O)[C@@H]4CCCN4C4=NC(=O)\C(S4)=C/c4cccnc4)cc23)c1 |r,t:24|
Show InChI InChI=1S/C28H22ClN7O2S/c29-18-5-1-6-19(13-18)33-25-21-14-20(8-9-22(21)31-16-32-25)34-26(37)23-7-3-11-36(23)28-35-27(38)24(39-28)12-17-4-2-10-30-15-17/h1-2,4-6,8-10,12-16,23H,3,7,11H2,(H,34,37)(H,31,32,33)/b24-12+/t23-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 9.80E+3n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of recombinant EGFR (unknown origin) assessed as inhibition of autophosphorylation after 1 hr by DELFIA/Time-resolved fluorometry

Bioorg Med Chem 23: 3221-7 (2015)


Article DOI: 10.1016/j.bmc.2015.04.065
BindingDB Entry DOI: 10.7270/Q2DF6SXQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50092474
PNG
(CHEMBL3586189)
Show SMILES Clc1cccc(Nc2ncnc3ccc(NC(=O)[C@@H]4CCCN4C4=NC(=O)\C(S4)=C/c4ccc(cc4)-c4ccccc4)cc23)c1 |r,t:24|
Show InChI InChI=1S/C35H27ClN6O2S/c36-25-8-4-9-26(19-25)39-32-28-20-27(15-16-29(28)37-21-38-32)40-33(43)30-10-5-17-42(30)35-41-34(44)31(45-35)18-22-11-13-24(14-12-22)23-6-2-1-3-7-23/h1-4,6-9,11-16,18-21,30H,5,10,17H2,(H,40,43)(H,37,38,39)/b31-18+/t30-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.32E+4n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of recombinant EGFR (unknown origin) assessed as inhibition of autophosphorylation after 1 hr by DELFIA/Time-resolved fluorometry

Bioorg Med Chem 23: 3221-7 (2015)


Article DOI: 10.1016/j.bmc.2015.04.065
BindingDB Entry DOI: 10.7270/Q2DF6SXQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50092480
PNG
(CHEMBL3586175)
Show SMILES Clc1cccc(Nc2ncnc3ccc(NC(=O)[C@@H]4CCCN4C4=NC(=O)\C(S4)=C/c4ccc(Br)s4)cc23)c1 |r,t:24|
Show InChI InChI=1S/C27H20BrClN6O2S2/c28-23-9-7-18(38-23)13-22-26(37)34-27(39-22)35-10-2-5-21(35)25(36)33-17-6-8-20-19(12-17)24(31-14-30-20)32-16-4-1-3-15(29)11-16/h1,3-4,6-9,11-14,21H,2,5,10H2,(H,33,36)(H,30,31,32)/b22-13+/t21-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.14E+4n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of recombinant EGFR (unknown origin) assessed as inhibition of autophosphorylation after 1 hr by DELFIA/Time-resolved fluorometry

Bioorg Med Chem 23: 3221-7 (2015)


Article DOI: 10.1016/j.bmc.2015.04.065
BindingDB Entry DOI: 10.7270/Q2DF6SXQ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%