Affinity Data by PubMed id=26233799

PubMed code 26233799

Found 15 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50114071 (CHEMBL3604009) Show SMILES CNC(C)C(=O)c1ccc2OCCOc2c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	496	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity to DAT in Sprague-Dawley rat brain synaptosomes assessed as induction of [3H]MPP+ release by liquid scintillation counting method				Bioorg Med Chem 23: 5574-9 (2015) Article DOI: 10.1016/j.bmc.2015.07.035 BindingDB Entry DOI: 10.7270/Q2TH8PGT
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50114075 (CHEMBL3603956) Show SMILES CN[C@H](C)Cc1ccc2OCCOc2c1 \|r\| Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.46E+4	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity to DAT in Sprague-Dawley rat brain synaptosomes assessed as induction of [3H]MPP+ release by liquid scintillation counting method				Bioorg Med Chem 23: 5574-9 (2015) Article DOI: 10.1016/j.bmc.2015.07.035 BindingDB Entry DOI: 10.7270/Q2TH8PGT
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM50010588 ((RS)-3,4-(methylenedioxy)methamphetamine \| 1-(1,3-...) Show SMILES CNC(C)Cc1ccc2OCOc2c1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity to human DAT expressed in HEK293 cells assessed as induction of [3H]MPP+ release by liquid scintillation counting method				Bioorg Med Chem 23: 5574-9 (2015) Article DOI: 10.1016/j.bmc.2015.07.035 BindingDB Entry DOI: 10.7270/Q2TH8PGT
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50010588 ((RS)-3,4-(methylenedioxy)methamphetamine \| 1-(1,3-...) Show SMILES CNC(C)Cc1ccc2OCOc2c1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	61	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity to SERT in Sprague-Dawley rat brain synaptosomes assessed as induction of [3H]5-HT release by liquid scintillation counting method				Bioorg Med Chem 23: 5574-9 (2015) Article DOI: 10.1016/j.bmc.2015.07.035 BindingDB Entry DOI: 10.7270/Q2TH8PGT
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50010588 ((RS)-3,4-(methylenedioxy)methamphetamine \| 1-(1,3-...) Show SMILES CNC(C)Cc1ccc2OCOc2c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity to human NET expressed in HEK293 cells assessed as induction of [3H]MPP+ release by liquid scintillation counting method				Bioorg Med Chem 23: 5574-9 (2015) Article DOI: 10.1016/j.bmc.2015.07.035 BindingDB Entry DOI: 10.7270/Q2TH8PGT
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50010588 ((RS)-3,4-(methylenedioxy)methamphetamine \| 1-(1,3-...) Show SMILES CNC(C)Cc1ccc2OCOc2c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	75	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity to DAT in Sprague-Dawley rat brain synaptosomes assessed as induction of [3H]MPP+ release by liquid scintillation counting method				Bioorg Med Chem 23: 5574-9 (2015) Article DOI: 10.1016/j.bmc.2015.07.035 BindingDB Entry DOI: 10.7270/Q2TH8PGT
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50114075 (CHEMBL3603956) Show SMILES CN[C@H](C)Cc1ccc2OCCOc2c1 \|r\| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	573	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity to SERT in Sprague-Dawley rat brain synaptosomes assessed as induction of [3H]5-HT release by liquid scintillation counting method				Bioorg Med Chem 23: 5574-9 (2015) Article DOI: 10.1016/j.bmc.2015.07.035 BindingDB Entry DOI: 10.7270/Q2TH8PGT
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50114071 (CHEMBL3604009) Show SMILES CNC(C)C(=O)c1ccc2OCCOc2c1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	347	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity to SERT in Sprague-Dawley rat brain synaptosomes assessed as induction of [3H]5-HT release by liquid scintillation counting method				Bioorg Med Chem 23: 5574-9 (2015) Article DOI: 10.1016/j.bmc.2015.07.035 BindingDB Entry DOI: 10.7270/Q2TH8PGT
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50114074 (CHEMBL3603955) Show SMILES CN[C@@H](C)Cc1ccc2OCCOc2c1 \|r\| Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	276	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity to DAT in Sprague-Dawley rat brain synaptosomes assessed as induction of [3H]MPP+ release by liquid scintillation counting method				Bioorg Med Chem 23: 5574-9 (2015) Article DOI: 10.1016/j.bmc.2015.07.035 BindingDB Entry DOI: 10.7270/Q2TH8PGT
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50114072 (CHEMBL3603954) Show SMILES CNC(C)Cc1ccc2OCCOc2c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	597	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity to DAT in Sprague-Dawley rat brain synaptosomes assessed as induction of [3H]MPP+ release by liquid scintillation counting method				Bioorg Med Chem 23: 5574-9 (2015) Article DOI: 10.1016/j.bmc.2015.07.035 BindingDB Entry DOI: 10.7270/Q2TH8PGT
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50114072 (CHEMBL3603954) Show SMILES CNC(C)Cc1ccc2OCCOc2c1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	117	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity to SERT in Sprague-Dawley rat brain synaptosomes assessed as induction of [3H]5-HT release by liquid scintillation counting method				Bioorg Med Chem 23: 5574-9 (2015) Article DOI: 10.1016/j.bmc.2015.07.035 BindingDB Entry DOI: 10.7270/Q2TH8PGT
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50114073 (CHEMBL3604010) Show SMILES CNC(C)C(=O)c1ccc2OCOc2c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	133	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity to DAT in Sprague-Dawley rat brain synaptosomes assessed as induction of [3H]MPP+ release by liquid scintillation counting method				Bioorg Med Chem 23: 5574-9 (2015) Article DOI: 10.1016/j.bmc.2015.07.035 BindingDB Entry DOI: 10.7270/Q2TH8PGT
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50010588 ((RS)-3,4-(methylenedioxy)methamphetamine \| 1-(1,3-...) Show SMILES CNC(C)Cc1ccc2OCOc2c1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity to human SERT expressed in HEK293 cells assessed as induction of [3H]5-HT release by liquid scintillation counting method				Bioorg Med Chem 23: 5574-9 (2015) Article DOI: 10.1016/j.bmc.2015.07.035 BindingDB Entry DOI: 10.7270/Q2TH8PGT
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50114074 (CHEMBL3603955) Show SMILES CN[C@@H](C)Cc1ccc2OCCOc2c1 \|r\| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	91	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity to SERT in Sprague-Dawley rat brain synaptosomes assessed as induction of [3H]5-HT release by liquid scintillation counting method				Bioorg Med Chem 23: 5574-9 (2015) Article DOI: 10.1016/j.bmc.2015.07.035 BindingDB Entry DOI: 10.7270/Q2TH8PGT
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50114073 (CHEMBL3604010) Show SMILES CNC(C)C(=O)c1ccc2OCOc2c1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	242	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity to SERT in Sprague-Dawley rat brain synaptosomes assessed as induction of [3H]5-HT release by liquid scintillation counting method				Bioorg Med Chem 23: 5574-9 (2015) Article DOI: 10.1016/j.bmc.2015.07.035 BindingDB Entry DOI: 10.7270/Q2TH8PGT
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%