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PubMed code 26343830

Compile data set for download or QSAR
Found 15 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50123929
PNG
(CHEMBL3621760)
Show SMILES O[C@@H](CCCCCCCC(=O)c1c(O)cc(O)c(C(CCc2ccccc2)c2ccc(O)cc2O)c1O)c1ccccc1 |r|
Show InChI InChI=1S/C36H40O7/c37-26-19-21-27(31(40)22-26)28(20-18-24-12-6-4-7-13-24)34-32(41)23-33(42)35(36(34)43)30(39)17-11-3-1-2-10-16-29(38)25-14-8-5-9-15-25/h4-9,12-15,19,21-23,28-29,37-38,40-43H,1-3,10-11,16-18,20H2/t28?,29-/m0/s1
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 3.80E+5n/an/an/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Non-competitive inhibition of rat intestinal Sucrase using sucrose as substrate assessed as glucose release after 40 mins by Lineweaver-Burk plot ana...

Bioorg Med Chem Lett 25: 4529-33 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.069
BindingDB Entry DOI: 10.7270/Q2WD42C3
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Rattus norvegicus)		BDBM50123930
PNG
(CHEMBL3621759)
Show SMILES O[C@@H](CCCCCCCC(=O)c1c(O)cc(O)cc1O)c1ccccc1 |r|
Show InChI InChI=1S/C21H26O5/c22-16-13-19(25)21(20(26)14-16)18(24)12-8-3-1-2-7-11-17(23)15-9-5-4-6-10-15/h4-6,9-10,13-14,17,22-23,25-26H,1-3,7-8,11-12H2/t17-/m0/s1
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 4.80E+5n/an/an/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Non-competitive inhibition of rat intestinal Maltase using maltose as substrate assessed as glucose release after 10 mins by Lineweaver-Burk plot ana...

Bioorg Med Chem Lett 25: 4529-33 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.069
BindingDB Entry DOI: 10.7270/Q2WD42C3
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Rattus norvegicus)		BDBM50123929
PNG
(CHEMBL3621760)
Show SMILES O[C@@H](CCCCCCCC(=O)c1c(O)cc(O)c(C(CCc2ccccc2)c2ccc(O)cc2O)c1O)c1ccccc1 |r|
Show InChI InChI=1S/C36H40O7/c37-26-19-21-27(31(40)22-26)28(20-18-24-12-6-4-7-13-24)34-32(41)23-33(42)35(36(34)43)30(39)17-11-3-1-2-10-16-29(38)25-14-8-5-9-15-25/h4-9,12-15,19,21-23,28-29,37-38,40-43H,1-3,10-11,16-18,20H2/t28?,29-/m0/s1
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 5.30E+5n/an/an/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Non-competitive inhibition of rat intestinal Maltase using maltose as substrate assessed as glucose release after 10 mins by Lineweaver-Burk plot ana...

Bioorg Med Chem Lett 25: 4529-33 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.069
BindingDB Entry DOI: 10.7270/Q2WD42C3
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50123930
PNG
(CHEMBL3621759)
Show SMILES O[C@@H](CCCCCCCC(=O)c1c(O)cc(O)cc1O)c1ccccc1 |r|
Show InChI InChI=1S/C21H26O5/c22-16-13-19(25)21(20(26)14-16)18(24)12-8-3-1-2-7-11-17(23)15-9-5-4-6-10-15/h4-6,9-10,13-14,17,22-23,25-26H,1-3,7-8,11-12H2/t17-/m0/s1
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 5.40E+5n/an/an/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Non-competitive inhibition of rat intestinal Sucrase using sucrose as substrate assessed as glucose release after 40 mins by Lineweaver-Burk plot ana...

Bioorg Med Chem Lett 25: 4529-33 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.069
BindingDB Entry DOI: 10.7270/Q2WD42C3
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50123930
PNG
(CHEMBL3621759)
Show SMILES O[C@@H](CCCCCCCC(=O)c1c(O)cc(O)cc1O)c1ccccc1 |r|
Show InChI InChI=1S/C21H26O5/c22-16-13-19(25)21(20(26)14-16)18(24)12-8-3-1-2-7-11-17(23)15-9-5-4-6-10-15/h4-6,9-10,13-14,17,22-23,25-26H,1-3,7-8,11-12H2/t17-/m0/s1
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 1.09E+6n/an/an/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Competitive inhibition of rat intestinal Sucrase using sucrose as substrate assessed as glucose release after 40 mins by Lineweaver-Burk plot analysi...

Bioorg Med Chem Lett 25: 4529-33 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.069
BindingDB Entry DOI: 10.7270/Q2WD42C3
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Rattus norvegicus)		BDBM50123930
PNG
(CHEMBL3621759)
Show SMILES O[C@@H](CCCCCCCC(=O)c1c(O)cc(O)cc1O)c1ccccc1 |r|
Show InChI InChI=1S/C21H26O5/c22-16-13-19(25)21(20(26)14-16)18(24)12-8-3-1-2-7-11-17(23)15-9-5-4-6-10-15/h4-6,9-10,13-14,17,22-23,25-26H,1-3,7-8,11-12H2/t17-/m0/s1
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 1.64E+6n/an/an/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Competitive inhibition of rat intestinal Maltase using maltose as substrate assessed as glucose release after 10 mins by Lineweaver-Burk plot analysi...

Bioorg Med Chem Lett 25: 4529-33 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.069
BindingDB Entry DOI: 10.7270/Q2WD42C3
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Rattus norvegicus)		BDBM50123929
PNG
(CHEMBL3621760)
Show SMILES O[C@@H](CCCCCCCC(=O)c1c(O)cc(O)c(C(CCc2ccccc2)c2ccc(O)cc2O)c1O)c1ccccc1 |r|
Show InChI InChI=1S/C36H40O7/c37-26-19-21-27(31(40)22-26)28(20-18-24-12-6-4-7-13-24)34-32(41)23-33(42)35(36(34)43)30(39)17-11-3-1-2-10-16-29(38)25-14-8-5-9-15-25/h4-9,12-15,19,21-23,28-29,37-38,40-43H,1-3,10-11,16-18,20H2/t28?,29-/m0/s1
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 1.96E+6n/an/an/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Competitive inhibition of rat intestinal Maltase using maltose as substrate assessed as glucose release after 10 mins by Lineweaver-Burk plot analysi...

Bioorg Med Chem Lett 25: 4529-33 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.069
BindingDB Entry DOI: 10.7270/Q2WD42C3
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50123929
PNG
(CHEMBL3621760)
Show SMILES O[C@@H](CCCCCCCC(=O)c1c(O)cc(O)c(C(CCc2ccccc2)c2ccc(O)cc2O)c1O)c1ccccc1 |r|
Show InChI InChI=1S/C36H40O7/c37-26-19-21-27(31(40)22-26)28(20-18-24-12-6-4-7-13-24)34-32(41)23-33(42)35(36(34)43)30(39)17-11-3-1-2-10-16-29(38)25-14-8-5-9-15-25/h4-9,12-15,19,21-23,28-29,37-38,40-43H,1-3,10-11,16-18,20H2/t28?,29-/m0/s1
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 3.07E+6n/an/an/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Competitive inhibition of rat intestinal Sucrase using sucrose as substrate assessed as glucose release after 40 mins by Lineweaver-Burk plot analysi...

Bioorg Med Chem Lett 25: 4529-33 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.069
BindingDB Entry DOI: 10.7270/Q2WD42C3
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Rattus norvegicus)		BDBM50333465
PNG
((2R,3R,4R,5R,6R)-5-((2R,3R,4R,5S,6R)-5-((2R,3R,4S,...)
Show SMILES C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O |r,t:37|
Show InChI InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1
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n/an/a 2.10E+3n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal Maltase using maltose as substrate assessed as glucose release after 10 mins by glucose oxidase method

Bioorg Med Chem Lett 25: 4529-33 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.069
BindingDB Entry DOI: 10.7270/Q2WD42C3
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50333465
PNG
((2R,3R,4R,5R,6R)-5-((2R,3R,4R,5S,6R)-5-((2R,3R,4S,...)
Show SMILES C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O |r,t:37|
Show InChI InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1
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n/an/a 2.60E+4n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal Sucrase using sucrose as substrate assessed as glucose release after 40 mins by glucose oxidase method

Bioorg Med Chem Lett 25: 4529-33 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.069
BindingDB Entry DOI: 10.7270/Q2WD42C3
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Rattus norvegicus)		BDBM50123929
PNG
(CHEMBL3621760)
Show SMILES O[C@@H](CCCCCCCC(=O)c1c(O)cc(O)c(C(CCc2ccccc2)c2ccc(O)cc2O)c1O)c1ccccc1 |r|
Show InChI InChI=1S/C36H40O7/c37-26-19-21-27(31(40)22-26)28(20-18-24-12-6-4-7-13-24)34-32(41)23-33(42)35(36(34)43)30(39)17-11-3-1-2-10-16-29(38)25-14-8-5-9-15-25/h4-9,12-15,19,21-23,28-29,37-38,40-43H,1-3,10-11,16-18,20H2/t28?,29-/m0/s1
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n/an/a 3.39E+4n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal Maltase using maltose as substrate assessed as glucose release after 10 mins by glucose oxidase method

Bioorg Med Chem Lett 25: 4529-33 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.069
BindingDB Entry DOI: 10.7270/Q2WD42C3
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Rattus norvegicus)		BDBM50123930
PNG
(CHEMBL3621759)
Show SMILES O[C@@H](CCCCCCCC(=O)c1c(O)cc(O)cc1O)c1ccccc1 |r|
Show InChI InChI=1S/C21H26O5/c22-16-13-19(25)21(20(26)14-16)18(24)12-8-3-1-2-7-11-17(23)15-9-5-4-6-10-15/h4-6,9-10,13-14,17,22-23,25-26H,1-3,7-8,11-12H2/t17-/m0/s1
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n/an/a 4.72E+4n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal Maltase using maltose as substrate assessed as glucose release after 10 mins by glucose oxidase method

Bioorg Med Chem Lett 25: 4529-33 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.069
BindingDB Entry DOI: 10.7270/Q2WD42C3
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50123929
PNG
(CHEMBL3621760)
Show SMILES O[C@@H](CCCCCCCC(=O)c1c(O)cc(O)c(C(CCc2ccccc2)c2ccc(O)cc2O)c1O)c1ccccc1 |r|
Show InChI InChI=1S/C36H40O7/c37-26-19-21-27(31(40)22-26)28(20-18-24-12-6-4-7-13-24)34-32(41)23-33(42)35(36(34)43)30(39)17-11-3-1-2-10-16-29(38)25-14-8-5-9-15-25/h4-9,12-15,19,21-23,28-29,37-38,40-43H,1-3,10-11,16-18,20H2/t28?,29-/m0/s1
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n/an/a 4.74E+4n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal Sucrase using sucrose as substrate assessed as glucose release after 40 mins by glucose oxidase method

Bioorg Med Chem Lett 25: 4529-33 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.069
BindingDB Entry DOI: 10.7270/Q2WD42C3
More data for this
Ligand-Target Pair
Sucrase-isomaltase, intestinal


(Rattus norvegicus (Rat))		BDBM50123930
PNG
(CHEMBL3621759)
Show SMILES O[C@@H](CCCCCCCC(=O)c1c(O)cc(O)cc1O)c1ccccc1 |r|
Show InChI InChI=1S/C21H26O5/c22-16-13-19(25)21(20(26)14-16)18(24)12-8-3-1-2-7-11-17(23)15-9-5-4-6-10-15/h4-6,9-10,13-14,17,22-23,25-26H,1-3,7-8,11-12H2/t17-/m0/s1
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n/an/a 9.49E+4n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal Sucrase using sucrose as substrate assessed as glucose release after 40 mins by glucose oxidase method

Bioorg Med Chem Lett 25: 4529-33 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.069
BindingDB Entry DOI: 10.7270/Q2WD42C3
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Rattus norvegicus)		BDBM50123931
PNG
(CHEMBL3621761)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1c(O)cc(O)c2C(=O)C[C@H](Oc12)c1ccccc1 |r|
Show InChI InChI=1S/C21H22O9/c22-8-14-17(26)18(27)19(28)21(30-14)16-11(24)6-10(23)15-12(25)7-13(29-20(15)16)9-4-2-1-3-5-9/h1-6,13-14,17-19,21-24,26-28H,7-8H2/t13-,14+,17+,18-,19+,21-/m0/s1
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n/an/a 1.85E+6n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal Maltase using maltose as substrate assessed as glucose release after 10 mins by glucose oxidase method

Bioorg Med Chem Lett 25: 4529-33 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.069
BindingDB Entry DOI: 10.7270/Q2WD42C3
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%