Found 8 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50498791
(CHEMBL3623716)Show SMILES OC(=O)[C@H](CS)NC(=O)CCN1c2ccccc2Sc2ccccc12 |r| Show InChI InChI=1S/C18H18N2O3S2/c21-17(19-12(11-24)18(22)23)9-10-20-13-5-1-3-7-15(13)25-16-8-4-2-6-14(16)20/h1-8,12,24H,9-11H2,(H,19,21)(H,22,23)/t12-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human FTase using FPP/dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis |
Bioorg Med Chem Lett 25: 4447-52 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.008
BindingDB Entry DOI: 10.7270/Q2XS5ZDS |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50498787
(CHEMBL3623718)Show SMILES CSCC[C@H](NC(=O)CCN1c2ccccc2Sc2ccccc12)C(O)=O |r| Show InChI InChI=1S/C20H22N2O3S2/c1-26-13-11-14(20(24)25)21-19(23)10-12-22-15-6-2-4-8-17(15)27-18-9-5-3-7-16(18)22/h2-9,14H,10-13H2,1H3,(H,21,23)(H,24,25)/t14-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.17E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human FTase using FPP/dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis |
Bioorg Med Chem Lett 25: 4447-52 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.008
BindingDB Entry DOI: 10.7270/Q2XS5ZDS |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50498792
(CHEMBL3623720)Show SMILES OC[C@H](NC(=O)CCN1c2ccccc2Sc2ccccc12)C(O)=O |r| Show InChI InChI=1S/C18H18N2O4S/c21-11-12(18(23)24)19-17(22)9-10-20-13-5-1-3-7-15(13)25-16-8-4-2-6-14(16)20/h1-8,12,21H,9-11H2,(H,19,22)(H,23,24)/t12-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human FTase using FPP/dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis |
Bioorg Med Chem Lett 25: 4447-52 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.008
BindingDB Entry DOI: 10.7270/Q2XS5ZDS |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50498786
(CHEMBL3623723)Show SMILES CSCC[C@H](NC(=O)CCN1c2ccccc2Sc2ccc(Cl)cc12)C(O)=O |r| Show InChI InChI=1S/C20H21ClN2O3S2/c1-27-11-9-14(20(25)26)22-19(24)8-10-23-15-4-2-3-5-17(15)28-18-7-6-13(21)12-16(18)23/h2-7,12,14H,8-11H2,1H3,(H,22,24)(H,25,26)/t14-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.89E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human FTase using FPP/dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis |
Bioorg Med Chem Lett 25: 4447-52 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.008
BindingDB Entry DOI: 10.7270/Q2XS5ZDS |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50498785
(CHEMBL3623734)Show InChI InChI=1S/C17H17NO2S/c19-17(20-11-12-21)9-10-18-15-7-3-1-5-13(15)14-6-2-4-8-16(14)18/h1-8,21H,9-12H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description
Inhibition of human FTase |
Bioorg Med Chem Lett 25: 4447-52 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.008
BindingDB Entry DOI: 10.7270/Q2XS5ZDS |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50498788
(CHEMBL3623717)Show SMILES CSCC[C@H](NC(=O)CCn1c2ccccc2c2ccccc12)C(O)=O |r| Show InChI InChI=1S/C20H22N2O3S/c1-26-13-11-16(20(24)25)21-19(23)10-12-22-17-8-4-2-6-14(17)15-7-3-5-9-18(15)22/h2-9,16H,10-13H2,1H3,(H,21,23)(H,24,25)/t16-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.02E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human FTase using FPP/dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis |
Bioorg Med Chem Lett 25: 4447-52 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.008
BindingDB Entry DOI: 10.7270/Q2XS5ZDS |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50498790
(CHEMBL3623722)Show SMILES CC(C)[C@H](NC(=O)CCN1c2ccccc2Sc2ccccc12)C(O)=O |r| Show InChI InChI=1S/C20H22N2O3S/c1-13(2)19(20(24)25)21-18(23)11-12-22-14-7-3-5-9-16(14)26-17-10-6-4-8-15(17)22/h3-10,13,19H,11-12H2,1-2H3,(H,21,23)(H,24,25)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.47E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human FTase using FPP/dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis |
Bioorg Med Chem Lett 25: 4447-52 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.008
BindingDB Entry DOI: 10.7270/Q2XS5ZDS |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50498789
(CHEMBL3623715)Show SMILES OC(=O)[C@H](CS)NC(=O)CCn1c2ccccc2c2ccccc12 |r| Show InChI InChI=1S/C18H18N2O3S/c21-17(19-14(11-24)18(22)23)9-10-20-15-7-3-1-5-12(15)13-6-2-4-8-16(13)20/h1-8,14,24H,9-11H2,(H,19,21)(H,22,23)/t14-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.54E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human FTase using FPP/dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis |
Bioorg Med Chem Lett 25: 4447-52 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.008
BindingDB Entry DOI: 10.7270/Q2XS5ZDS |
More data for this
Ligand-Target Pair | |
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