Found 20 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human)) | BDBM50498901
(CHEMBL3735517)Show InChI InChI=1S/C16H19NO2/c1-16(2,3)14-8-13-12(9-19-14)10-6-4-5-7-11(10)15(18)17-13/h4-7,14H,8-9H2,1-3H3,(H,17,18) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <60 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TNKS2 (unknown origin) by fluorescence analysis |
ACS Med Chem Lett 6: 1019-24 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00251
BindingDB Entry DOI: 10.7270/Q25B05GZ |
More data for this
Ligand-Target Pair | |
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human)) | BDBM50498903
(CHEMBL3735964)Show SMILES O=C(C1COC1)N1CCC(CC1)C1Cc2[nH]c(=O)c3ccccc3c2CO1 Show InChI InChI=1S/C21H24N2O4/c24-20-16-4-2-1-3-15(16)17-12-27-19(9-18(17)22-20)13-5-7-23(8-6-13)21(25)14-10-26-11-14/h1-4,13-14,19H,5-12H2,(H,22,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <60 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TNKS2 (unknown origin) by fluorescence analysis |
ACS Med Chem Lett 6: 1019-24 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00251
BindingDB Entry DOI: 10.7270/Q25B05GZ |
More data for this
Ligand-Target Pair | |
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human)) | BDBM50498905
(CHEMBL3736012)Show InChI InChI=1S/C17H21NO3/c1-10-5-4-6-11-15(10)12-8-21-14(17(2,3)9-19)7-13(12)18-16(11)20/h4-6,14,19H,7-9H2,1-3H3,(H,18,20) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <60 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TNKS2 (unknown origin) by fluorescence analysis |
ACS Med Chem Lett 6: 1019-24 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00251
BindingDB Entry DOI: 10.7270/Q25B05GZ |
More data for this
Ligand-Target Pair | |
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human)) | BDBM50498904
(CHEMBL3734991)Show InChI InChI=1S/C16H19NO2/c1-9(2)14-7-13-12(8-19-14)15-10(3)5-4-6-11(15)16(18)17-13/h4-6,9,14H,7-8H2,1-3H3,(H,17,18) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | <60 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TNKS2 (unknown origin) by fluorescence analysis |
ACS Med Chem Lett 6: 1019-24 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00251
BindingDB Entry DOI: 10.7270/Q25B05GZ |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human)) | BDBM50498897
(CHEMBL3734971)Show InChI InChI=1S/C16H19NO3/c1-16(2,9-18)14-7-13-12(8-20-14)10-5-3-4-6-11(10)15(19)17-13/h3-6,14,18H,7-9H2,1-2H3,(H,17,19) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | <60 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TNKS2 (unknown origin) by fluorescence analysis |
ACS Med Chem Lett 6: 1019-24 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00251
BindingDB Entry DOI: 10.7270/Q25B05GZ |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human)) | BDBM50498898
(CHEMBL3736494)Show InChI InChI=1S/C15H17NO2/c1-9(2)14-7-13-12(8-18-14)10-5-3-4-6-11(10)15(17)16-13/h3-6,9,14H,7-8H2,1-2H3,(H,16,17) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <60 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TNKS2 (unknown origin) by fluorescence analysis |
ACS Med Chem Lett 6: 1019-24 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00251
BindingDB Entry DOI: 10.7270/Q25B05GZ |
More data for this
Ligand-Target Pair | |
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human)) | BDBM50498900
(CHEMBL3736145)Show SMILES CS(=O)(=O)N1CCC(C1)C1Cc2[nH]c(=O)c3ccccc3c2CO1 Show InChI InChI=1S/C17H20N2O4S/c1-24(21,22)19-7-6-11(9-19)16-8-15-14(10-23-16)12-4-2-3-5-13(12)17(20)18-15/h2-5,11,16H,6-10H2,1H3,(H,18,20) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <60 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TNKS2 (unknown origin) by fluorescence analysis |
ACS Med Chem Lett 6: 1019-24 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00251
BindingDB Entry DOI: 10.7270/Q25B05GZ |
More data for this
Ligand-Target Pair | |
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human)) | BDBM50498899
(CHEMBL3736005)Show InChI InChI=1S/C14H16N2O2/c1-8(2)12-6-11-10(7-18-12)13-9(14(17)16-11)4-3-5-15-13/h3-5,8,12H,6-7H2,1-2H3,(H,16,17) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TNKS2 (unknown origin) by fluorescence analysis |
ACS Med Chem Lett 6: 1019-24 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00251
BindingDB Entry DOI: 10.7270/Q25B05GZ |
More data for this
Ligand-Target Pair | |
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human)) | BDBM50321122
(2-Ethylquinazolin-4(3H)-one | CHEMBL1163173)Show InChI InChI=1S/C14H9ClN2O/c15-10-7-5-9(6-8-10)13-16-12-4-2-1-3-11(12)14(18)17-13/h1-8H,(H,16,17,18) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TNKS1 (unknown origin) by fluorescence analysis |
ACS Med Chem Lett 6: 1019-24 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00251
BindingDB Entry DOI: 10.7270/Q25B05GZ |
More data for this
Ligand-Target Pair | |
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human)) | BDBM50321122
(2-Ethylquinazolin-4(3H)-one | CHEMBL1163173)Show InChI InChI=1S/C14H9ClN2O/c15-10-7-5-9(6-8-10)13-16-12-4-2-1-3-11(12)14(18)17-13/h1-8H,(H,16,17,18) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TNKS2 (unknown origin) by fluorescence analysis |
ACS Med Chem Lett 6: 1019-24 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00251
BindingDB Entry DOI: 10.7270/Q25B05GZ |
More data for this
Ligand-Target Pair | |
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human)) | BDBM50498902
(CHEMBL1527375)Show InChI InChI=1S/C12H14N2O2/c1-7(2)11-4-10-9(6-16-11)3-8(5-13)12(15)14-10/h3,7,11H,4,6H2,1-2H3,(H,14,15) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TNKS1 (unknown origin) by fluorescence analysis |
ACS Med Chem Lett 6: 1019-24 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00251
BindingDB Entry DOI: 10.7270/Q25B05GZ |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human)) | BDBM50498902
(CHEMBL1527375)Show InChI InChI=1S/C12H14N2O2/c1-7(2)11-4-10-9(6-16-11)3-8(5-13)12(15)14-10/h3,7,11H,4,6H2,1-2H3,(H,14,15) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TNKS2 (unknown origin) by fluorescence analysis |
ACS Med Chem Lett 6: 1019-24 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00251
BindingDB Entry DOI: 10.7270/Q25B05GZ |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2
(Homo sapiens (Human)) | BDBM50498904
(CHEMBL3734991)Show InChI InChI=1S/C16H19NO2/c1-9(2)14-7-13-12(8-19-14)15-10(3)5-4-6-11(15)16(18)17-13/h4-6,9,14H,7-8H2,1-3H3,(H,17,18) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Tankyrase in human DLD1 cells assessed as T-cell factor level after 24 hrs by luciferase reporter gene assay |
ACS Med Chem Lett 6: 1019-24 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00251
BindingDB Entry DOI: 10.7270/Q25B05GZ |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2
(Homo sapiens (Human)) | BDBM50498901
(CHEMBL3735517)Show InChI InChI=1S/C16H19NO2/c1-16(2,3)14-8-13-12(9-19-14)10-6-4-5-7-11(10)15(18)17-13/h4-7,14H,8-9H2,1-3H3,(H,17,18) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 127 | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Tankyrase in human DLD1 cells assessed as T-cell factor level after 24 hrs by luciferase reporter gene assay |
ACS Med Chem Lett 6: 1019-24 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00251
BindingDB Entry DOI: 10.7270/Q25B05GZ |
More data for this
Ligand-Target Pair | |
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2
(Homo sapiens (Human)) | BDBM50498898
(CHEMBL3736494)Show InChI InChI=1S/C15H17NO2/c1-9(2)14-7-13-12(8-18-14)10-5-3-4-6-11(10)15(17)16-13/h3-6,9,14H,7-8H2,1-2H3,(H,16,17) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 320 | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Tankyrase in human DLD1 cells assessed as T-cell factor level after 24 hrs by luciferase reporter gene assay |
ACS Med Chem Lett 6: 1019-24 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00251
BindingDB Entry DOI: 10.7270/Q25B05GZ |
More data for this
Ligand-Target Pair | |
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2
(Homo sapiens (Human)) | BDBM50498900
(CHEMBL3736145)Show SMILES CS(=O)(=O)N1CCC(C1)C1Cc2[nH]c(=O)c3ccccc3c2CO1 Show InChI InChI=1S/C17H20N2O4S/c1-24(21,22)19-7-6-11(9-19)16-8-15-14(10-23-16)12-4-2-3-5-13(12)17(20)18-15/h2-5,11,16H,6-10H2,1H3,(H,18,20) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 47 | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Tankyrase in human DLD1 cells assessed as T-cell factor level after 24 hrs by luciferase reporter gene assay |
ACS Med Chem Lett 6: 1019-24 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00251
BindingDB Entry DOI: 10.7270/Q25B05GZ |
More data for this
Ligand-Target Pair | |
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2
(Homo sapiens (Human)) | BDBM50498903
(CHEMBL3735964)Show SMILES O=C(C1COC1)N1CCC(CC1)C1Cc2[nH]c(=O)c3ccccc3c2CO1 Show InChI InChI=1S/C21H24N2O4/c24-20-16-4-2-1-3-15(16)17-12-27-19(9-18(17)22-20)13-5-7-23(8-6-13)21(25)14-10-26-11-14/h1-4,13-14,19H,5-12H2,(H,22,24) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 31 | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Tankyrase in human DLD1 cells assessed as T-cell factor level after 24 hrs by luciferase reporter gene assay |
ACS Med Chem Lett 6: 1019-24 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00251
BindingDB Entry DOI: 10.7270/Q25B05GZ |
More data for this
Ligand-Target Pair | |
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2
(Homo sapiens (Human)) | BDBM50498899
(CHEMBL3736005)Show InChI InChI=1S/C14H16N2O2/c1-8(2)12-6-11-10(7-18-12)13-9(14(17)16-11)4-3-5-15-13/h3-5,8,12H,6-7H2,1-2H3,(H,16,17) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 810 | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Tankyrase in human DLD1 cells assessed as T-cell factor level after 24 hrs by luciferase reporter gene assay |
ACS Med Chem Lett 6: 1019-24 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00251
BindingDB Entry DOI: 10.7270/Q25B05GZ |
More data for this
Ligand-Target Pair | |
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2
(Homo sapiens (Human)) | BDBM50498897
(CHEMBL3734971)Show InChI InChI=1S/C16H19NO3/c1-16(2,9-18)14-7-13-12(8-20-14)10-5-3-4-6-11(10)15(19)17-13/h3-6,14,18H,7-9H2,1-2H3,(H,17,19) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | n/a | n/a | 341 | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Tankyrase in human DLD1 cells assessed as T-cell factor level after 24 hrs by luciferase reporter gene assay |
ACS Med Chem Lett 6: 1019-24 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00251
BindingDB Entry DOI: 10.7270/Q25B05GZ |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2
(Homo sapiens (Human)) | BDBM50498905
(CHEMBL3736012)Show InChI InChI=1S/C17H21NO3/c1-10-5-4-6-11-15(10)12-8-21-14(17(2,3)9-19)7-13(12)18-16(11)20/h4-6,14,19H,7-9H2,1-3H3,(H,18,20) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 7 | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Tankyrase in human DLD1 cells assessed as T-cell factor level after 24 hrs by luciferase reporter gene assay |
ACS Med Chem Lett 6: 1019-24 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00251
BindingDB Entry DOI: 10.7270/Q25B05GZ |
More data for this
Ligand-Target Pair | |
Search and Browse
