Found 30 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127676
(CHEMBL3629325)Show SMILES CCCc1cnc(N)c(CNC(=O)Nc2ccc3[nH]c(=O)oc3c2)n1 Show InChI InChI=1S/C16H18N6O3/c1-2-3-10-7-18-14(17)12(20-10)8-19-15(23)21-9-4-5-11-13(6-9)25-16(24)22-11/h4-7H,2-3,8H2,1H3,(H2,17,18)(H,22,24)(H2,19,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127688
(CHEMBL3629147)Show SMILES CCCc1cnc(N)c(CN\C(Nc2ccc3[nH]c(=O)oc3c2)=N/C#N)n1 Show InChI InChI=1S/C17H18N8O2/c1-2-3-11-7-20-15(19)13(23-11)8-21-16(22-9-18)24-10-4-5-12-14(6-10)27-17(26)25-12/h4-7H,2-3,8H2,1H3,(H2,19,20)(H,25,26)(H2,21,22,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127682
(CHEMBL3629153)Show SMILES Nc1ncc(nc1CN\C(Nc1ccc2[nH]c(=O)oc2c1)=N/C(=O)c1ccc(Cl)cc1)C1CC1 Show InChI InChI=1S/C23H20ClN7O3/c24-14-5-3-13(4-6-14)21(32)31-22(28-15-7-8-16-19(9-15)34-23(33)30-16)27-11-18-20(25)26-10-17(29-18)12-1-2-12/h3-10,12H,1-2,11H2,(H2,25,26)(H,30,33)(H2,27,28,31,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127677
(CHEMBL3629324)Show SMILES Nc1ncc(nc1CNC(=O)Nc1ccc2[nH]c(=O)oc2c1)C1CC1 Show InChI InChI=1S/C16H16N6O3/c17-14-12(21-11(6-18-14)8-1-2-8)7-19-15(23)20-9-3-4-10-13(5-9)25-16(24)22-10/h3-6,8H,1-2,7H2,(H2,17,18)(H,22,24)(H2,19,20,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127683
(CHEMBL3629152)Show SMILES Cc1ccc(cc1)C(=O)\N=C(/NCc1nc(cnc1N)C1CC1)Nc1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C24H23N7O3/c1-13-2-4-15(5-3-13)22(32)31-23(28-16-8-9-17-20(10-16)34-24(33)30-17)27-12-19-21(25)26-11-18(29-19)14-6-7-14/h2-5,8-11,14H,6-7,12H2,1H3,(H2,25,26)(H,30,33)(H2,27,28,31,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127689
(CHEMBL3629146)Show SMILES CC(C)(C)OC(=O)Nc1ccc(N\C(NCc2nc(cnc2N)C2CC2)=N\C#N)cc1 Show InChI InChI=1S/C21H26N8O2/c1-21(2,3)31-20(30)28-15-8-6-14(7-9-15)27-19(26-12-22)25-11-17-18(23)24-10-16(29-17)13-4-5-13/h6-10,13H,4-5,11H2,1-3H3,(H2,23,24)(H,28,30)(H2,25,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127694
(CHEMBL3628991)Show SMILES CO\N=C(/NCc1nc(Cl)cnc1N)Nc1ccc(cc1)N(C(=O)c1ccccc1)c1ccccc1 Show InChI InChI=1S/C26H24ClN7O2/c1-36-33-26(30-16-22-24(28)29-17-23(27)32-22)31-19-12-14-21(15-13-19)34(20-10-6-3-7-11-20)25(35)18-8-4-2-5-9-18/h2-15,17H,16H2,1H3,(H2,28,29)(H2,30,31,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127695
(CHEMBL3628990)Show SMILES CO\N=C(/NCc1nc(Cl)cnc1N)Nc1ccc(NC(=O)OC(C)(C)C)cc1 Show InChI InChI=1S/C18H24ClN7O3/c1-18(2,3)29-17(27)24-12-7-5-11(6-8-12)23-16(26-28-4)22-9-13-15(20)21-10-14(19)25-13/h5-8,10H,9H2,1-4H3,(H2,20,21)(H,24,27)(H2,22,23,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127678
(CHEMBL3629323)Show InChI InChI=1S/C13H11ClN6O3/c14-10-5-16-11(15)8(19-10)4-17-12(21)18-6-1-2-7-9(3-6)23-13(22)20-7/h1-3,5H,4H2,(H2,15,16)(H,20,22)(H2,17,18,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127675
(CHEMBL3629326)Show SMILES CCCc1cnc(N)c(CNC(=O)Nc2ccc(NC(=O)OC(C)(C)C)cc2)n1 Show InChI InChI=1S/C20H28N6O3/c1-5-6-15-11-22-17(21)16(24-15)12-23-18(27)25-13-7-9-14(10-8-13)26-19(28)29-20(2,3)4/h7-11H,5-6,12H2,1-4H3,(H2,21,22)(H,26,28)(H2,23,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127686
(CHEMBL3629148)Show SMILES CCCc1cnc(N)c(CN\C(Nc2ccc(cc2)N(C(=O)c2ccccc2)c2ccccc2)=N/C#N)n1 Show InChI InChI=1S/C29H28N8O/c1-2-9-23-18-32-27(31)26(35-23)19-33-29(34-20-30)36-22-14-16-25(17-15-22)37(24-12-7-4-8-13-24)28(38)21-10-5-3-6-11-21/h3-8,10-18H,2,9,19H2,1H3,(H2,31,32)(H2,33,34,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127684
(CHEMBL3629151)Show SMILES CCOC(=O)\N=C(/NCc1nc(cnc1N)C1CC1)Nc1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C19H21N7O4/c1-2-29-18(27)26-17(23-11-5-6-12-15(7-11)30-19(28)25-12)22-9-14-16(20)21-8-13(24-14)10-3-4-10/h5-8,10H,2-4,9H2,1H3,(H2,20,21)(H,25,28)(H2,22,23,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127671
(CHEMBL3629330)Show SMILES CCCc1cnc(N)c(CNC(=O)Nc2ccc(NC(=O)OCc3ccccc3)cc2)n1 Show InChI InChI=1S/C23H26N6O3/c1-2-6-19-13-25-21(24)20(27-19)14-26-22(30)28-17-9-11-18(12-10-17)29-23(31)32-15-16-7-4-3-5-8-16/h3-5,7-13H,2,6,14-15H2,1H3,(H2,24,25)(H,29,31)(H2,26,28,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127680
(CHEMBL3629155)Show SMILES CCCc1cnc(N)c(CN\C(Nc2ccc3[nH]c(=O)oc3c2)=N/C(=O)c2ccccc2)n1 Show InChI InChI=1S/C23H23N7O3/c1-2-6-16-12-25-20(24)18(27-16)13-26-22(30-21(31)14-7-4-3-5-8-14)28-15-9-10-17-19(11-15)33-23(32)29-17/h3-5,7-12H,2,6,13H2,1H3,(H2,24,25)(H,29,32)(H2,26,28,30,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127681
(CHEMBL3629154)Show SMILES COc1ccc(cc1)C(=O)\N=C(/NCc1nc(cnc1N)C1CC1)Nc1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C24H23N7O4/c1-34-16-7-4-14(5-8-16)22(32)31-23(28-15-6-9-17-20(10-15)35-24(33)30-17)27-12-19-21(25)26-11-18(29-19)13-2-3-13/h4-11,13H,2-3,12H2,1H3,(H2,25,26)(H,30,33)(H2,27,28,31,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127674
(CHEMBL3629327)Show SMILES CCCc1cnc(N)c(CNC(=O)Nc2ccc(OC(=O)OC(C)(C)C)cc2)n1 Show InChI InChI=1S/C20H27N5O4/c1-5-6-14-11-22-17(21)16(24-14)12-23-18(26)25-13-7-9-15(10-8-13)28-19(27)29-20(2,3)4/h7-11H,5-6,12H2,1-4H3,(H2,21,22)(H2,23,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127672
(CHEMBL3629329)Show InChI InChI=1S/C17H22N6O3/c1-3-4-13-9-19-15(18)14(21-13)10-20-16(24)22-11-5-7-12(8-6-11)23-17(25)26-2/h5-9H,3-4,10H2,1-2H3,(H2,18,19)(H,23,25)(H2,20,22,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.18E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127667
(CHEMBL3629334)Show SMILES Nc1ncc(Cl)nc1CNC(=O)Nc1ccc(cc1)N(C(=O)c1ccccc1)c1ccccc1 Show InChI InChI=1S/C25H21ClN6O2/c26-22-16-28-23(27)21(31-22)15-29-25(34)30-18-11-13-20(14-12-18)32(19-9-5-2-6-10-19)24(33)17-7-3-1-4-8-17/h1-14,16H,15H2,(H2,27,28)(H2,29,30,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.45E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127668
(CHEMBL3629333)Show SMILES Nc1ncc(nc1CNC(=O)Nc1ccc(cc1)N(C(=O)c1ccccc1)c1ccccc1)C1CC1 Show InChI InChI=1S/C28H26N6O2/c29-26-25(33-24(17-30-26)19-11-12-19)18-31-28(36)32-21-13-15-23(16-14-21)34(22-9-5-2-6-10-22)27(35)20-7-3-1-4-8-20/h1-10,13-17,19H,11-12,18H2,(H2,29,30)(H2,31,32,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.62E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127673
(CHEMBL3629328)Show SMILES CCCc1cnc(N)c(CNC(=O)Nc2ccc(NC(=O)Nc3ccccc3)cc2)n1 Show InChI InChI=1S/C22H25N7O2/c1-2-6-18-13-24-20(23)19(26-18)14-25-21(30)27-16-9-11-17(12-10-16)29-22(31)28-15-7-4-3-5-8-15/h3-5,7-13H,2,6,14H2,1H3,(H2,23,24)(H2,25,27,30)(H2,28,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127669
(CHEMBL3629332)Show InChI InChI=1S/C15H18ClN5O/c1-2-5-10-8-18-14(17)13(20-10)9-19-15(22)21-12-7-4-3-6-11(12)16/h3-4,6-8H,2,5,9H2,1H3,(H2,17,18)(H2,19,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127670
(CHEMBL3629331)Show SMILES CCCc1cnc(N)c(CNC(=O)Nc2ccc(cc2)N(C(=O)c2ccccc2)c2ccccc2)n1 Show InChI InChI=1S/C28H28N6O2/c1-2-9-22-18-30-26(29)25(32-22)19-31-28(36)33-21-14-16-24(17-15-21)34(23-12-7-4-8-13-23)27(35)20-10-5-3-6-11-20/h3-8,10-18H,2,9,19H2,1H3,(H2,29,30)(H2,31,33,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127698
(CHEMBL3629156)Show SMILES CCCc1cnc(N)c(CN\C(Nc2ccc(cc2)N(C(=O)c2ccccc2)c2ccccc2)=N/C(=O)c2ccc(Cl)cc2)n1 Show InChI InChI=1S/C35H32ClN7O2/c1-2-9-28-22-38-32(37)31(40-28)23-39-35(42-33(44)24-14-16-26(36)17-15-24)41-27-18-20-30(21-19-27)43(29-12-7-4-8-13-29)34(45)25-10-5-3-6-11-25/h3-8,10-22H,2,9,23H2,1H3,(H2,37,38)(H2,39,41,42,44) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127696
(CHEMBL3629157)Show SMILES CC(C)(C)OC(=O)Nc1ccc(N\C(NCc2nc(cnc2N)C2CC2)=N\S(C)(=O)=O)cc1 Show InChI InChI=1S/C21H29N7O4S/c1-21(2,3)32-20(29)26-15-9-7-14(8-10-15)25-19(28-33(4,30)31)24-12-17-18(22)23-11-16(27-17)13-5-6-13/h7-11,13H,5-6,12H2,1-4H3,(H2,22,23)(H,26,29)(H2,24,25,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127693
(CHEMBL3628992)Show InChI InChI=1S/C13H12ClN7/c14-11-7-17-12(16)10(21-11)6-18-13(19-8-15)20-9-4-2-1-3-5-9/h1-5,7H,6H2,(H2,16,17)(H2,18,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127692
(CHEMBL3628993)Show SMILES CC(C)(C)OC(=O)Nc1ccc(N\C(NCc2nc(Cl)cnc2N)=N\C#N)cc1 Show InChI InChI=1S/C18H21ClN8O2/c1-18(2,3)29-17(28)26-12-6-4-11(5-7-12)25-16(24-10-20)23-8-13-15(21)22-9-14(19)27-13/h4-7,9H,8H2,1-3H3,(H2,21,22)(H,26,28)(H2,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127691
(CHEMBL3629145)Show SMILES Cc1cnc(N)c(CN\C(Nc2ccc(NC(=O)OC(C)(C)C)cc2)=N/C#N)n1 Show InChI InChI=1S/C19H24N8O2/c1-12-9-22-16(21)15(25-12)10-23-17(24-11-20)26-13-5-7-14(8-6-13)27-18(28)29-19(2,3)4/h5-9H,10H2,1-4H3,(H2,21,22)(H,27,28)(H2,23,24,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127679
(CHEMBL3629322)Show SMILES CC(C)(C)OC(=O)Nc1ccc(NC(=O)NCc2nc(Cl)cnc2N)cc1 Show InChI InChI=1S/C17H21ClN6O3/c1-17(2,3)27-16(26)23-11-6-4-10(5-7-11)22-15(25)21-8-12-14(19)20-9-13(18)24-12/h4-7,9H,8H2,1-3H3,(H2,19,20)(H,23,26)(H2,21,22,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127685
(CHEMBL3629150)Show SMILES CC(C)(C)OC(=O)Nc1ccc(N\C(NCc2nc(Cl)cnc2N)=N\C(=O)c2ccccc2)cc1 Show InChI InChI=1S/C24H26ClN7O3/c1-24(2,3)35-23(34)30-17-11-9-16(10-12-17)29-22(32-21(33)15-7-5-4-6-8-15)28-13-18-20(26)27-14-19(25)31-18/h4-12,14H,13H2,1-3H3,(H2,26,27)(H,30,34)(H2,28,29,32,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50127699
(CHEMBL3629149)Show SMILES CC(=O)\N=C(/NCc1nc(Cl)cnc1N)Nc1ccc(NC(=O)OC(C)(C)C)cc1 Show InChI InChI=1S/C19H24ClN7O3/c1-11(28)24-17(23-9-14-16(21)22-10-15(20)27-14)25-12-5-7-13(8-6-12)26-18(29)30-19(2,3)4/h5-8,10H,9H2,1-4H3,(H2,21,22)(H,26,29)(H2,23,24,25,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of MK2 (unknown origin) by scintillation proximity assay |
Bioorg Med Chem Lett 25: 5402-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.016
BindingDB Entry DOI: 10.7270/Q28C9Z2S |
More data for this
Ligand-Target Pair | |
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