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PubMed code 26433449

Compile data set for download or QSAR
Found 29 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucose-dependent insulinotropic receptor


(Mus musculus)		BDBM50128362
PNG
(CHEMBL3629483)
Show SMILES Cc1c(Nc2ccc(cc2F)S(C)(=O)=O)ncnc1OC1CC2COCC(C1)N2C(=O)OC1(C)CC1 |THB:19:20:23.24.25:28|
Show InChI InChI=1S/C24H29FN4O6S/c1-14-21(28-20-5-4-18(10-19(20)25)36(3,31)32)26-13-27-22(14)34-17-8-15-11-33-12-16(9-17)29(15)23(30)35-24(2)6-7-24/h4-5,10,13,15-17H,6-9,11-12H2,1-3H3,(H,26,27,28)
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Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50128508
PNG
(CHEMBL3629482)
Show SMILES CC(C)OC(=O)N1CC2COCC(C1)C2Oc1ncnc(Nc2cccnc2C)c1C |THB:4:6:9.10.11:14|
Show InChI InChI=1S/C22H29N5O4/c1-13(2)30-22(28)27-8-16-10-29-11-17(9-27)19(16)31-21-14(3)20(24-12-25-21)26-18-6-5-7-23-15(18)4/h5-7,12-13,16-17,19H,8-11H2,1-4H3,(H,24,25,26)
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Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)		BDBM50128501
PNG
(CHEMBL3629596)
Show SMILES CC1(CC1)OC(=O)N1CC2COCC(C1)C2Oc1cc(Nc2ccc(cc2Cl)C#N)ncn1 |THB:5:7:10.11.12:15|
Show InChI InChI=1S/C23H24ClN5O4/c1-23(4-5-23)33-22(30)29-9-15-11-31-12-16(10-29)21(15)32-20-7-19(26-13-27-20)28-18-3-2-14(8-25)6-17(18)24/h2-3,6-7,13,15-16,21H,4-5,9-12H2,1H3,(H,26,27,28)
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n/an/an/an/a 254n/an/an/an/a



Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)		BDBM50128503
PNG
(CHEMBL3629597)
Show SMILES COc1c(Nc2ccc(cc2F)C#N)ncnc1OC1C2COCC1CN(C2)C(=O)OC1(C)CC1 |TLB:28:26:21.22.23:19|
Show InChI InChI=1S/C24H26FN5O5/c1-24(5-6-24)35-23(31)30-9-15-11-33-12-16(10-30)19(15)34-22-20(32-2)21(27-13-28-22)29-18-4-3-14(8-26)7-17(18)25/h3-4,7,13,15-16,19H,5-6,9-12H2,1-2H3,(H,27,28,29)
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Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50128361
PNG
(CHEMBL3629481)
Show SMILES Cc1c(Nc2ccc(cc2Cl)C#N)ncnc1OC1C2COCC1CN(C2)C(=O)OC(C)(C)C |TLB:27:25:20.21.22:18|
Show InChI InChI=1S/C24H28ClN5O4/c1-14-21(29-19-6-5-15(8-26)7-18(19)25)27-13-28-22(14)33-20-16-9-30(10-17(20)12-32-11-16)23(31)34-24(2,3)4/h5-7,13,16-17,20H,9-12H2,1-4H3,(H,27,28,29)
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Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50128508
PNG
(CHEMBL3629482)
Show SMILES CC(C)OC(=O)N1CC2COCC(C1)C2Oc1ncnc(Nc2cccnc2C)c1C |THB:4:6:9.10.11:14|
Show InChI InChI=1S/C22H29N5O4/c1-13(2)30-22(28)27-8-16-10-29-11-17(9-27)19(16)31-21-14(3)20(24-12-25-21)26-18-6-5-7-23-15(18)4/h5-7,12-13,16-17,19H,8-11H2,1-4H3,(H,24,25,26)
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Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50128505
PNG
(CHEMBL3629598)
Show SMILES Cc1c(Nc2ccc(cc2Cl)C#N)ncnc1OC1CC2COCC(C1)N2S(=O)(=O)C1CC1 |THB:17:18:21.22.23:26|
Show InChI InChI=1S/C22H24ClN5O4S/c1-13-21(27-20-5-2-14(9-24)6-19(20)23)25-12-26-22(13)32-17-7-15-10-31-11-16(8-17)28(15)33(29,30)18-3-4-18/h2,5-6,12,15-18H,3-4,7-8,10-11H2,1H3,(H,25,26,27)
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Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)		BDBM50128504
PNG
(CHEMBL3629477)
Show SMILES Cc1c(OC2C3COCC2CN(C3)C(=O)OC2(C)CC2)ncnc1Oc1ccc(cc1Cl)C#N |TLB:13:11:6.7.8:4|
Show InChI InChI=1S/C24H25ClN4O5/c1-14-21(32-19-4-3-15(8-26)7-18(19)25)27-13-28-22(14)33-20-16-9-29(10-17(20)12-31-11-16)23(30)34-24(2)5-6-24/h3-4,7,13,16-17,20H,5-6,9-12H2,1-2H3
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Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50128362
PNG
(CHEMBL3629483)
Show SMILES Cc1c(Nc2ccc(cc2F)S(C)(=O)=O)ncnc1OC1CC2COCC(C1)N2C(=O)OC1(C)CC1 |THB:19:20:23.24.25:28|
Show InChI InChI=1S/C24H29FN4O6S/c1-14-21(28-20-5-4-18(10-19(20)25)36(3,31)32)26-13-27-22(14)34-17-8-15-11-33-12-16(9-17)29(15)23(30)35-24(2)6-7-24/h4-5,10,13,15-17H,6-9,11-12H2,1-3H3,(H,26,27,28)
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Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50128503
PNG
(CHEMBL3629597)
Show SMILES COc1c(Nc2ccc(cc2F)C#N)ncnc1OC1C2COCC1CN(C2)C(=O)OC1(C)CC1 |TLB:28:26:21.22.23:19|
Show InChI InChI=1S/C24H26FN5O5/c1-24(5-6-24)35-23(31)30-9-15-11-33-12-16(10-30)19(15)34-22-20(32-2)21(27-13-28-22)29-18-4-3-14(8-26)7-17(18)25/h3-4,7,13,15-16,19H,5-6,9-12H2,1-2H3,(H,27,28,29)
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Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)		BDBM50128361
PNG
(CHEMBL3629481)
Show SMILES Cc1c(Nc2ccc(cc2Cl)C#N)ncnc1OC1C2COCC1CN(C2)C(=O)OC(C)(C)C |TLB:27:25:20.21.22:18|
Show InChI InChI=1S/C24H28ClN5O4/c1-14-21(29-19-6-5-15(8-26)7-18(19)25)27-13-28-22(14)33-20-16-9-30(10-17(20)12-32-11-16)23(31)34-24(2,3)4/h5-7,13,16-17,20H,9-12H2,1-4H3,(H,27,28,29)
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Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50128507
PNG
(CHEMBL3629479)
Show SMILES Cc1c(Nc2ccc(cc2Cl)S(C)(=O)=O)ncnc1OC1CC2COCC(C1)N2C(=O)OC(C)(C)C |THB:19:20:23.24.25:28|
Show InChI InChI=1S/C24H31ClN4O6S/c1-14-21(28-20-7-6-18(10-19(20)25)36(5,31)32)26-13-27-22(14)34-17-8-15-11-33-12-16(9-17)29(15)23(30)35-24(2,3)4/h6-7,10,13,15-17H,8-9,11-12H2,1-5H3,(H,26,27,28)
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Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50128360
PNG
(CHEMBL3629480)
Show SMILES Cc1c(Nc2ccc(cc2Cl)C#N)ncnc1OC1C2COCC1CN(C2)S(=O)(=O)C1CC1 |TLB:27:25:20.21.22:18|
Show InChI InChI=1S/C22H24ClN5O4S/c1-13-21(27-19-5-2-14(7-24)6-18(19)23)25-12-26-22(13)32-20-15-8-28(9-16(20)11-31-10-15)33(29,30)17-3-4-17/h2,5-6,12,15-17,20H,3-4,8-11H2,1H3,(H,25,26,27)
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Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50128360
PNG
(CHEMBL3629480)
Show SMILES Cc1c(Nc2ccc(cc2Cl)C#N)ncnc1OC1C2COCC1CN(C2)S(=O)(=O)C1CC1 |TLB:27:25:20.21.22:18|
Show InChI InChI=1S/C22H24ClN5O4S/c1-13-21(27-19-5-2-14(7-24)6-18(19)23)25-12-26-22(13)32-20-15-8-28(9-16(20)11-31-10-15)33(29,30)17-3-4-17/h2,5-6,12,15-17,20H,3-4,8-11H2,1H3,(H,25,26,27)
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Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50128363
PNG
(CHEMBL3629484)
Show SMILES Cc1c(Nc2ccc(cc2Cl)C#N)ncnc1OC1C2COCC1CN(C2)C(=O)OC1(C)CC1 |TLB:27:25:20.21.22:18|
Show InChI InChI=1S/C24H26ClN5O4/c1-14-21(29-19-4-3-15(8-26)7-18(19)25)27-13-28-22(14)33-20-16-9-30(10-17(20)12-32-11-16)23(31)34-24(2)5-6-24/h3-4,7,13,16-17,20H,5-6,9-12H2,1-2H3,(H,27,28,29)
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Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50128501
PNG
(CHEMBL3629596)
Show SMILES CC1(CC1)OC(=O)N1CC2COCC(C1)C2Oc1cc(Nc2ccc(cc2Cl)C#N)ncn1 |THB:5:7:10.11.12:15|
Show InChI InChI=1S/C23H24ClN5O4/c1-23(4-5-23)33-22(30)29-9-15-11-31-12-16(10-29)21(15)32-20-7-19(26-13-27-20)28-18-3-2-14(8-25)6-17(18)24/h2-3,6-7,13,15-16,21H,4-5,9-12H2,1H3,(H,26,27,28)
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n/an/an/an/a 25n/an/an/an/a



Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)		BDBM50128506
PNG
(CHEMBL3629478)
Show SMILES Cc1c(Nc2ccc(cc2Cl)C#N)ncnc1OC1CC2COCC(C1)N2C(=O)OC(C)(C)C |THB:17:18:21.22.23:26|
Show InChI InChI=1S/C24H28ClN5O4/c1-14-21(29-20-6-5-15(10-26)7-19(20)25)27-13-28-22(14)33-18-8-16-11-32-12-17(9-18)30(16)23(31)34-24(2,3)4/h5-7,13,16-18H,8-9,11-12H2,1-4H3,(H,27,28,29)
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Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)		BDBM50128506
PNG
(CHEMBL3629478)
Show SMILES Cc1c(Nc2ccc(cc2Cl)C#N)ncnc1OC1CC2COCC(C1)N2C(=O)OC(C)(C)C |THB:17:18:21.22.23:26|
Show InChI InChI=1S/C24H28ClN5O4/c1-14-21(29-20-6-5-15(10-26)7-19(20)25)27-13-28-22(14)33-18-8-16-11-32-12-17(9-18)30(16)23(31)34-24(2,3)4/h5-7,13,16-18H,8-9,11-12H2,1-4H3,(H,27,28,29)
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Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50128361
PNG
(CHEMBL3629481)
Show SMILES Cc1c(Nc2ccc(cc2Cl)C#N)ncnc1OC1C2COCC1CN(C2)C(=O)OC(C)(C)C |TLB:27:25:20.21.22:18|
Show InChI InChI=1S/C24H28ClN5O4/c1-14-21(29-19-6-5-15(8-26)7-18(19)25)27-13-28-22(14)33-20-16-9-30(10-17(20)12-32-11-16)23(31)34-24(2,3)4/h5-7,13,16-17,20H,9-12H2,1-4H3,(H,27,28,29)
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n/an/an/an/a 7n/an/an/an/a



Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)		BDBM50128505
PNG
(CHEMBL3629598)
Show SMILES Cc1c(Nc2ccc(cc2Cl)C#N)ncnc1OC1CC2COCC(C1)N2S(=O)(=O)C1CC1 |THB:17:18:21.22.23:26|
Show InChI InChI=1S/C22H24ClN5O4S/c1-13-21(27-20-5-2-14(9-24)6-19(20)23)25-12-26-22(13)32-17-7-15-10-31-11-16(8-17)28(15)33(29,30)18-3-4-18/h2,5-6,12,15-18H,3-4,7-8,10-11H2,1H3,(H,25,26,27)
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n/an/an/an/a 1.60E+3n/an/an/an/a



Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)		BDBM50128360
PNG
(CHEMBL3629480)
Show SMILES Cc1c(Nc2ccc(cc2Cl)C#N)ncnc1OC1C2COCC1CN(C2)S(=O)(=O)C1CC1 |TLB:27:25:20.21.22:18|
Show InChI InChI=1S/C22H24ClN5O4S/c1-13-21(27-19-5-2-14(7-24)6-18(19)23)25-12-26-22(13)32-20-15-8-28(9-16(20)11-31-10-15)33(29,30)17-3-4-17/h2,5-6,12,15-17,20H,3-4,8-11H2,1H3,(H,25,26,27)
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n/an/an/an/a 844n/an/an/an/a



Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)		BDBM50128499
PNG
(CHEMBL3629485)
Show SMILES COc1c(Nc2ccc(cc2Cl)C#N)ncnc1OC1C2COCC1CN(C2)C(=O)OC1(C)CC1 |TLB:28:26:21.22.23:19|
Show InChI InChI=1S/C24H26ClN5O5/c1-24(5-6-24)35-23(31)30-9-15-11-33-12-16(10-30)19(15)34-22-20(32-2)21(27-13-28-22)29-18-4-3-14(8-26)7-17(18)25/h3-4,7,13,15-16,19H,5-6,9-12H2,1-2H3,(H,27,28,29)
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n/an/an/an/a 43n/an/an/an/a



Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50128506
PNG
(CHEMBL3629478)
Show SMILES Cc1c(Nc2ccc(cc2Cl)C#N)ncnc1OC1CC2COCC(C1)N2C(=O)OC(C)(C)C |THB:17:18:21.22.23:26|
Show InChI InChI=1S/C24H28ClN5O4/c1-14-21(29-20-6-5-15(10-26)7-19(20)25)27-13-28-22(14)33-18-8-16-11-32-12-17(9-18)30(16)23(31)34-24(2,3)4/h5-7,13,16-18H,8-9,11-12H2,1-4H3,(H,27,28,29)
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n/an/an/an/a 114n/an/an/an/a



Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)		BDBM50128507
PNG
(CHEMBL3629479)
Show SMILES Cc1c(Nc2ccc(cc2Cl)S(C)(=O)=O)ncnc1OC1CC2COCC(C1)N2C(=O)OC(C)(C)C |THB:19:20:23.24.25:28|
Show InChI InChI=1S/C24H31ClN4O6S/c1-14-21(28-20-7-6-18(10-19(20)25)36(5,31)32)26-13-27-22(14)34-17-8-15-11-33-12-16(9-17)29(15)23(30)35-24(2,3)4/h6-7,10,13,15-17H,8-9,11-12H2,1-5H3,(H,26,27,28)
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n/an/an/an/a 190n/an/an/an/a



Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)		BDBM50128361
PNG
(CHEMBL3629481)
Show SMILES Cc1c(Nc2ccc(cc2Cl)C#N)ncnc1OC1C2COCC1CN(C2)C(=O)OC(C)(C)C |TLB:27:25:20.21.22:18|
Show InChI InChI=1S/C24H28ClN5O4/c1-14-21(29-19-6-5-15(8-26)7-18(19)25)27-13-28-22(14)33-20-16-9-30(10-17(20)12-32-11-16)23(31)34-24(2,3)4/h5-7,13,16-17,20H,9-12H2,1-4H3,(H,27,28,29)
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n/an/an/an/a 28n/an/an/an/a



Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50128499
PNG
(CHEMBL3629485)
Show SMILES COc1c(Nc2ccc(cc2Cl)C#N)ncnc1OC1C2COCC1CN(C2)C(=O)OC1(C)CC1 |TLB:28:26:21.22.23:19|
Show InChI InChI=1S/C24H26ClN5O5/c1-24(5-6-24)35-23(31)30-9-15-11-33-12-16(10-30)19(15)34-22-20(32-2)21(27-13-28-22)29-18-4-3-14(8-26)7-17(18)25/h3-4,7,13,15-16,19H,5-6,9-12H2,1-2H3,(H,27,28,29)
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n/an/an/an/a 7n/an/an/an/a



Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50128504
PNG
(CHEMBL3629477)
Show SMILES Cc1c(OC2C3COCC2CN(C3)C(=O)OC2(C)CC2)ncnc1Oc1ccc(cc1Cl)C#N |TLB:13:11:6.7.8:4|
Show InChI InChI=1S/C24H25ClN4O5/c1-14-21(32-19-4-3-15(8-26)7-18(19)25)27-13-28-22(14)33-20-16-9-29(10-17(20)12-31-11-16)23(30)34-24(2)5-6-24/h3-4,7,13,16-17,20H,5-6,9-12H2,1-2H3
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n/an/an/an/a 16n/an/an/an/a



Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50128506
PNG
(CHEMBL3629478)
Show SMILES Cc1c(Nc2ccc(cc2Cl)C#N)ncnc1OC1CC2COCC(C1)N2C(=O)OC(C)(C)C |THB:17:18:21.22.23:26|
Show InChI InChI=1S/C24H28ClN5O4/c1-14-21(29-20-6-5-15(10-26)7-19(20)25)27-13-28-22(14)33-18-8-16-11-32-12-17(9-18)30(16)23(31)34-24(2,3)4/h5-7,13,16-18H,8-9,11-12H2,1-4H3,(H,27,28,29)
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n/an/an/an/a 114n/an/an/an/a



Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)		BDBM50128363
PNG
(CHEMBL3629484)
Show SMILES Cc1c(Nc2ccc(cc2Cl)C#N)ncnc1OC1C2COCC1CN(C2)C(=O)OC1(C)CC1 |TLB:27:25:20.21.22:18|
Show InChI InChI=1S/C24H26ClN5O4/c1-14-21(29-19-4-3-15(8-26)7-18(19)25)27-13-28-22(14)33-20-16-9-30(10-17(20)12-32-11-16)23(31)34-24(2)5-6-24/h3-4,7,13,16-17,20H,5-6,9-12H2,1-2H3,(H,27,28,29)
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n/an/an/an/a 33n/an/an/an/a



Merck Research Laboratory

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by fluorescence analysis

Bioorg Med Chem Lett 25: 5291-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.047
BindingDB Entry DOI: 10.7270/Q2QC05BG
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%