Found 29 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Procathepsin L
(Homo sapiens (Human)) | BDBM50128821
(CHEMBL3629203)Show SMILES NC(=S)N\N=C(/c1cc(Br)cc(c1)C(=O)c1ccccc1F)c1ccccc1F Show InChI InChI=1S/C21H14BrF2N3OS/c22-14-10-12(9-13(11-14)20(28)16-6-2-4-8-18(16)24)19(26-27-21(25)29)15-5-1-3-7-17(15)23/h1-11H,(H3,25,27,29)/b26-19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured every 15 sec for 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM50128809
(CHEMBL3629191)Show SMILES NC(=S)N\N=C(/c1ccccc1)c1cccc(c1)C(=O)c1ccccc1 Show InChI InChI=1S/C21H17N3OS/c22-21(26)24-23-19(15-8-3-1-4-9-15)17-12-7-13-18(14-17)20(25)16-10-5-2-6-11-16/h1-14H,(H3,22,24,26)/b23-19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured every 15 sec for 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM50128812
(CHEMBL3629194)Show SMILES NC(=S)N\N=C(/c1ccc(F)cc1)c1cccc(c1)C(=O)c1ccc(F)cc1 Show InChI InChI=1S/C21H15F2N3OS/c22-17-8-4-13(5-9-17)19(25-26-21(24)28)15-2-1-3-16(12-15)20(27)14-6-10-18(23)11-7-14/h1-12H,(H3,24,26,28)/b25-19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured every 15 sec for 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM50128811
(CHEMBL3629193)Show SMILES NC(=S)N\N=C(/c1ccccc1)c1cccc(c1)C(O)c1ccccc1 Show InChI InChI=1S/C21H19N3OS/c22-21(26)24-23-19(15-8-3-1-4-9-15)17-12-7-13-18(14-17)20(25)16-10-5-2-6-11-16/h1-14,20,25H,(H3,22,24,26)/b23-19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured every 15 sec for 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM50128810
(CHEMBL3629192)Show SMILES NC(=S)N\N=C(/c1ccccc1)c1cc(cc(c1)C(=O)c1ccccc1)C(=O)c1ccccc1 Show InChI InChI=1S/C28H21N3O2S/c29-28(34)31-30-25(19-10-4-1-5-11-19)22-16-23(26(32)20-12-6-2-7-13-20)18-24(17-22)27(33)21-14-8-3-9-15-21/h1-18H,(H3,29,31,34)/b30-25+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured every 15 sec for 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM50128820
(CHEMBL3629202)Show SMILES NC(=S)N\N=C(/c1cccc(O)c1)c1cc(Br)cc(c1)C(=O)c1cccc(O)c1 Show InChI InChI=1S/C21H16BrN3O3S/c22-16-8-14(7-15(9-16)20(28)13-4-2-6-18(27)11-13)19(24-25-21(23)29)12-3-1-5-17(26)10-12/h1-11,26-27H,(H3,23,25,29)/b24-19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured every 15 sec for 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM50128816
(CHEMBL3629198)Show SMILES NC(=S)N\N=C(/c1ccc(O)cc1)c1cccc(c1)C(=O)c1ccc(O)cc1 Show InChI InChI=1S/C21H17N3O3S/c22-21(28)24-23-19(13-4-8-17(25)9-5-13)15-2-1-3-16(12-15)20(27)14-6-10-18(26)11-7-14/h1-12,25-26H,(H3,22,24,28)/b23-19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 341 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured every 15 sec for 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM50128818
(CHEMBL3629200)Show SMILES Cc1cccc(c1)C(=O)c1cccc(c1)C(=N\NC(N)=S)\c1cccc(C)c1 Show InChI InChI=1S/C23H21N3OS/c1-15-6-3-8-17(12-15)21(25-26-23(24)28)18-9-5-11-20(14-18)22(27)19-10-4-7-16(2)13-19/h3-14H,1-2H3,(H3,24,26,28)/b25-21+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 654 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured every 15 sec for 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM50128813
(CHEMBL3629195)Show SMILES NC(=S)N\N=C(/c1ccc(Br)cc1)c1cccc(c1)C(=O)c1ccc(Br)cc1 Show InChI InChI=1S/C21H15Br2N3OS/c22-17-8-4-13(5-9-17)19(25-26-21(24)28)15-2-1-3-16(12-15)20(27)14-6-10-18(23)11-7-14/h1-12H,(H3,24,26,28)/b25-19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.52E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured every 15 sec for 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM50128815
(CHEMBL3629197)Show SMILES COc1ccc(cc1)C(=O)c1cccc(c1)C(=N\NC(N)=S)\c1ccc(OC)cc1 Show InChI InChI=1S/C23H21N3O3S/c1-28-19-10-6-15(7-11-19)21(25-26-23(24)30)17-4-3-5-18(14-17)22(27)16-8-12-20(29-2)13-9-16/h3-14H,1-2H3,(H3,24,26,30)/b25-21+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured every 15 sec for 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM50128822
(CHEMBL3629204)Show SMILES NC(=S)N\N=C(/c1cccc(Br)c1)c1cc(Br)cc(c1)C(=O)c1cccc(Br)c1 Show InChI InChI=1S/C21H14Br3N3OS/c22-16-5-1-3-12(8-16)19(26-27-21(25)29)14-7-15(11-18(24)10-14)20(28)13-4-2-6-17(23)9-13/h1-11H,(H3,25,27,29)/b26-19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin B using Z-RR-AMC as substrate after 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM50128817
(CHEMBL3629199)Show SMILES CC(C)Oc1ccc(cc1)C(=O)c1cccc(c1)C(=N\NC(N)=S)\c1ccc(OC(C)C)cc1 Show InChI InChI=1S/C27H29N3O3S/c1-17(2)32-23-12-8-19(9-13-23)25(29-30-27(28)34)21-6-5-7-22(16-21)26(31)20-10-14-24(15-11-20)33-18(3)4/h5-18H,1-4H3,(H3,28,30,34)/b29-25+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured every 15 sec for 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM50128816
(CHEMBL3629198)Show SMILES NC(=S)N\N=C(/c1ccc(O)cc1)c1cccc(c1)C(=O)c1ccc(O)cc1 Show InChI InChI=1S/C21H17N3O3S/c22-21(28)24-23-19(13-4-8-17(25)9-5-13)15-2-1-3-16(12-15)20(27)14-6-10-18(26)11-7-14/h1-12,25-26H,(H3,22,24,28)/b23-19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin B using Z-RR-AMC as substrate after 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM50128813
(CHEMBL3629195)Show SMILES NC(=S)N\N=C(/c1ccc(Br)cc1)c1cccc(c1)C(=O)c1ccc(Br)cc1 Show InChI InChI=1S/C21H15Br2N3OS/c22-17-8-4-13(5-9-17)19(25-26-21(24)28)15-2-1-3-16(12-15)20(27)14-6-10-18(23)11-7-14/h1-12H,(H3,24,26,28)/b25-19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin B using Z-RR-AMC as substrate after 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM50128815
(CHEMBL3629197)Show SMILES COc1ccc(cc1)C(=O)c1cccc(c1)C(=N\NC(N)=S)\c1ccc(OC)cc1 Show InChI InChI=1S/C23H21N3O3S/c1-28-19-10-6-15(7-11-19)21(25-26-23(24)30)17-4-3-5-18(14-17)22(27)16-8-12-20(29-2)13-9-16/h3-14H,1-2H3,(H3,24,26,30)/b25-21+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin B using Z-RR-AMC as substrate after 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM50128820
(CHEMBL3629202)Show SMILES NC(=S)N\N=C(/c1cccc(O)c1)c1cc(Br)cc(c1)C(=O)c1cccc(O)c1 Show InChI InChI=1S/C21H16BrN3O3S/c22-16-8-14(7-15(9-16)20(28)13-4-2-6-18(27)11-13)19(24-25-21(23)29)12-3-1-5-17(26)10-12/h1-11,26-27H,(H3,23,25,29)/b24-19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin B using Z-RR-AMC as substrate after 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM50128821
(CHEMBL3629203)Show SMILES NC(=S)N\N=C(/c1cc(Br)cc(c1)C(=O)c1ccccc1F)c1ccccc1F Show InChI InChI=1S/C21H14BrF2N3OS/c22-14-10-12(9-13(11-14)20(28)16-6-2-4-8-18(16)24)19(26-27-21(25)29)15-5-1-3-7-17(15)23/h1-11H,(H3,25,27,29)/b26-19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin B using Z-RR-AMC as substrate after 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM50128814
(CHEMBL3629196)Show SMILES NC(=S)N\N=C(/c1ccc(Br)cc1)c1cccc(c1)C(=N\NC(N)=S)\c1ccc(Br)cc1 Show InChI InChI=1S/C22H18Br2N6S2/c23-17-8-4-13(5-9-17)19(27-29-21(25)31)15-2-1-3-16(12-15)20(28-30-22(26)32)14-6-10-18(24)11-7-14/h1-12H,(H3,25,29,31)(H3,26,30,32)/b27-19+,28-20+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin B using Z-RR-AMC as substrate after 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM50128819
(CHEMBL3629201)Show SMILES NC(=S)N\N=C(/c1cccc(Br)c1)c1cc(O)cc(c1)C(=O)c1cccc(Br)c1 Show InChI InChI=1S/C21H15Br2N3O2S/c22-16-5-1-3-12(8-16)19(25-26-21(24)29)14-7-15(11-18(27)10-14)20(28)13-4-2-6-17(23)9-13/h1-11,27H,(H3,24,26,29)/b25-19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin B using Z-RR-AMC as substrate after 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM50128812
(CHEMBL3629194)Show SMILES NC(=S)N\N=C(/c1ccc(F)cc1)c1cccc(c1)C(=O)c1ccc(F)cc1 Show InChI InChI=1S/C21H15F2N3OS/c22-17-8-4-13(5-9-17)19(25-26-21(24)28)15-2-1-3-16(12-15)20(27)14-6-10-18(23)11-7-14/h1-12H,(H3,24,26,28)/b25-19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin B using Z-RR-AMC as substrate after 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM50128811
(CHEMBL3629193)Show SMILES NC(=S)N\N=C(/c1ccccc1)c1cccc(c1)C(O)c1ccccc1 Show InChI InChI=1S/C21H19N3OS/c22-21(26)24-23-19(15-8-3-1-4-9-15)17-12-7-13-18(14-17)20(25)16-10-5-2-6-11-16/h1-14,20,25H,(H3,22,24,26)/b23-19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin B using Z-RR-AMC as substrate after 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM50128814
(CHEMBL3629196)Show SMILES NC(=S)N\N=C(/c1ccc(Br)cc1)c1cccc(c1)C(=N\NC(N)=S)\c1ccc(Br)cc1 Show InChI InChI=1S/C22H18Br2N6S2/c23-17-8-4-13(5-9-17)19(27-29-21(25)31)15-2-1-3-16(12-15)20(28-30-22(26)32)14-6-10-18(24)11-7-14/h1-12H,(H3,25,29,31)(H3,26,30,32)/b27-19+,28-20+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured every 15 sec for 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM50128818
(CHEMBL3629200)Show SMILES Cc1cccc(c1)C(=O)c1cccc(c1)C(=N\NC(N)=S)\c1cccc(C)c1 Show InChI InChI=1S/C23H21N3OS/c1-15-6-3-8-17(12-15)21(25-26-23(24)28)18-9-5-11-20(14-18)22(27)19-10-4-7-16(2)13-19/h3-14H,1-2H3,(H3,24,26,28)/b25-21+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin B using Z-RR-AMC as substrate after 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM50128817
(CHEMBL3629199)Show SMILES CC(C)Oc1ccc(cc1)C(=O)c1cccc(c1)C(=N\NC(N)=S)\c1ccc(OC(C)C)cc1 Show InChI InChI=1S/C27H29N3O3S/c1-17(2)32-23-12-8-19(9-13-23)25(29-30-27(28)34)21-6-5-7-22(16-21)26(31)20-10-14-24(15-11-20)33-18(3)4/h5-18H,1-4H3,(H3,28,30,34)/b29-25+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin B using Z-RR-AMC as substrate after 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM50128809
(CHEMBL3629191)Show SMILES NC(=S)N\N=C(/c1ccccc1)c1cccc(c1)C(=O)c1ccccc1 Show InChI InChI=1S/C21H17N3OS/c22-21(26)24-23-19(15-8-3-1-4-9-15)17-12-7-13-18(14-17)20(25)16-10-5-2-6-11-16/h1-14H,(H3,22,24,26)/b23-19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin B using Z-RR-AMC as substrate after 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM50128819
(CHEMBL3629201)Show SMILES NC(=S)N\N=C(/c1cccc(Br)c1)c1cc(O)cc(c1)C(=O)c1cccc(Br)c1 Show InChI InChI=1S/C21H15Br2N3O2S/c22-16-5-1-3-12(8-16)19(25-26-21(24)29)14-7-15(11-18(27)10-14)20(28)13-4-2-6-17(23)9-13/h1-11,27H,(H3,24,26,29)/b25-19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured every 15 sec for 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM50128810
(CHEMBL3629192)Show SMILES NC(=S)N\N=C(/c1ccccc1)c1cc(cc(c1)C(=O)c1ccccc1)C(=O)c1ccccc1 Show InChI InChI=1S/C28H21N3O2S/c29-28(34)31-30-25(19-10-4-1-5-11-19)22-16-23(26(32)20-12-6-2-7-13-20)18-24(17-22)27(33)21-14-8-3-9-15-21/h1-18H,(H3,29,31,34)/b30-25+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin B using Z-RR-AMC as substrate after 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM50128823
(CHEBI:27750 | E1504 | Ethyl acetate)Show InChI InChI=1S/C4H8O2/c1-3-6-4(2)5/h3H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
KEGG
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured every 15 sec for 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM50128822
(CHEMBL3629204)Show SMILES NC(=S)N\N=C(/c1cccc(Br)c1)c1cc(Br)cc(c1)C(=O)c1cccc(Br)c1 Show InChI InChI=1S/C21H14Br3N3OS/c22-16-5-1-3-12(8-16)19(26-27-21(25)29)14-7-15(11-18(24)10-14)20(28)13-4-2-6-17(23)9-13/h1-11H,(H3,25,27,29)/b26-19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.03E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University
Curated by ChEMBL
| Assay Description
Inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured every 15 sec for 5 mins by fluorescence assay |
Bioorg Med Chem 23: 6974-92 (2015)
Article DOI: 10.1016/j.bmc.2015.09.036
BindingDB Entry DOI: 10.7270/Q2T43VX1 |
More data for this
Ligand-Target Pair | |
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