| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin B |
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| Ligand | BDBM50128813 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1522724 (CHEMBL3629950) |
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| IC50 | >10000±n/a nM |
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| Citation |  Parker, EN; Song, J; Kishore Kumar, GD; Odutola, SO; Chavarria, GE; Charlton-Sevcik, AK; Strecker, TE; Barnes, AL; Sudhan, DR; Wittenborn, TR; Siemann, DW; Horsman, MR; Chaplin, DJ; Trawick, ML; Pinney, KG Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L. Bioorg Med Chem23:6974-92 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin B |
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| Name: | Cathepsin B |
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| Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 37819.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_63102437 |
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| Residue: | 339 |
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| Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
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| BDBM50128813 |
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| n/a |
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| Name | BDBM50128813 |
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| Synonyms: | CHEMBL3629195 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H15Br2N3OS |
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| Mol. Mass. | 517.236 |
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| SMILES | NC(=S)N\N=C(/c1ccc(Br)cc1)c1cccc(c1)C(=O)c1ccc(Br)cc1 |
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| Structure | 
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