Compile Data Set for Download or QSAR

Found 389 hits with Last Name = 'pinney' and Initial = 'kg'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Procathepsin L (Homo sapiens (Human))	BDBM50330030 (CHEMBL1269632 | [(3-Bromophenyl)-(3-hydroxyphenyl)...) Show SMILES NC(=S)NN=C(c1cccc(O)c1)c1cccc(Br)c1 |w:4.3| Show InChI InChI=1S/C14H12BrN3OS/c15-11-5-1-3-9(7-11)13(17-18-14(16)20)10-4-2-6-12(19)8-10/h1-8,19H,(H3,16,18,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Covalent/reversible inhibition of human liver cathepsin-L using Z-FR-AMC as substrate preincubated for 5 mins followed by substrate addition measured...				Bioorg Med Chem Lett 27: 1304-1310 (2017) Article DOI: 10.1016/j.bmcl.2016.12.039 BindingDB Entry DOI: 10.7270/Q23B62C1
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50232473 (CHEMBL4087627) Show SMILES NC(=S)N\N=C(/c1cccc(O)c1)c1cc(Br)cc(Br)c1 Show InChI InChI=1S/C14H11Br2N3OS/c15-10-4-9(5-11(16)7-10)13(18-19-14(17)21)8-2-1-3-12(20)6-8/h1-7,20H,(H3,17,19,21)/b18-13+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	8.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Covalent/reversible inhibition of human liver cathepsin-L using Z-FR-AMC as substrate preincubated for 5 mins followed by substrate addition measured...				Bioorg Med Chem Lett 27: 1304-1310 (2017) Article DOI: 10.1016/j.bmcl.2016.12.039 BindingDB Entry DOI: 10.7270/Q23B62C1
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50128821 (CHEMBL3629203) Show SMILES NC(=S)N\N=C(/c1cc(Br)cc(c1)C(=O)c1ccccc1F)c1ccccc1F Show InChI InChI=1S/C21H14BrF2N3OS/c22-14-10-12(9-13(11-14)20(28)16-6-2-4-8-18(16)24)19(26-27-21(25)29)15-5-1-3-7-17(15)23/h1-11H,(H3,25,27,29)/b26-19+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.10	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured every 15 sec for 5 mins by fluorescence assay				Bioorg Med Chem 23: 6974-92 (2015) Article DOI: 10.1016/j.bmc.2015.09.036 BindingDB Entry DOI: 10.7270/Q2T43VX1
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM138145 (US8877967, 11) Show SMILES NC(=S)NN=C(c1cc(Br)cc(c1)C(=O)c1ccccc1F)c1ccccc1F |w:4.3| Show InChI InChI=1S/C21H14BrF2N3OS/c22-14-10-12(9-13(11-14)20(28)16-6-2-4-8-18(16)24)19(26-27-21(25)29)15-5-1-3-7-17(15)23/h1-11H,(H3,25,27,29)/b26-19-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.12	n/a	n/a	n/a	n/a	5.5	n/a
OXiGENE, Inc.; Baylor University US Patent					Assay Description Human liver Cathepsin L (Sigma) was preincubated with test compounds at various concentrations for 5 minutes at 25C. The assay was initiated by addit...				US Patent US8877967 (2014) BindingDB Entry DOI: 10.7270/Q25H7F0C
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50128809 (CHEMBL3629191) Show SMILES NC(=S)N\N=C(/c1ccccc1)c1cccc(c1)C(=O)c1ccccc1 Show InChI InChI=1S/C21H17N3OS/c22-21(26)24-23-19(15-8-3-1-4-9-15)17-12-7-13-18(14-17)20(25)16-10-5-2-6-11-16/h1-14H,(H3,22,24,26)/b23-19+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.90	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured every 15 sec for 5 mins by fluorescence assay				Bioorg Med Chem 23: 6974-92 (2015) Article DOI: 10.1016/j.bmc.2015.09.036 BindingDB Entry DOI: 10.7270/Q2T43VX1
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM138142 (US8877967, 3) Show SMILES CN(N=C(c1ccccc1)c1cccc(c1)C(=O)c1ccccc1)C(N)=S |w:2.1| Show InChI InChI=1S/C22H19N3OS/c1-25(22(23)27)24-20(16-9-4-2-5-10-16)18-13-8-14-19(15-18)21(26)17-11-6-3-7-12-17/h2-15H,1H3,(H2,23,27)/b24-20+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10.5	n/a	n/a	n/a	n/a	5.5	n/a
OXiGENE, Inc.; Baylor University US Patent					Assay Description Human liver Cathepsin L (Sigma) was preincubated with test compounds at various concentrations for 5 minutes at 25C. The assay was initiated by addit...				US Patent US8877967 (2014) BindingDB Entry DOI: 10.7270/Q25H7F0C
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50128812 (CHEMBL3629194) Show SMILES NC(=S)N\N=C(/c1ccc(F)cc1)c1cccc(c1)C(=O)c1ccc(F)cc1 Show InChI InChI=1S/C21H15F2N3OS/c22-17-8-4-13(5-9-17)19(25-26-21(24)28)15-2-1-3-16(12-15)20(27)14-6-10-18(23)11-7-14/h1-12H,(H3,24,26,28)/b25-19+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured every 15 sec for 5 mins by fluorescence assay				Bioorg Med Chem 23: 6974-92 (2015) Article DOI: 10.1016/j.bmc.2015.09.036 BindingDB Entry DOI: 10.7270/Q2T43VX1
					More data for this Ligand-Target Pair
Cruzipain (Trypanosoma cruzi)	BDBM50189273 (1-(7-bromo-3,4-dihydronaphthalen-1(2H)-ylidene)thi...) Show SMILES NC(=S)NN=C1CCCc2ccc(Br)cc12 |w:4.3| Show InChI InChI=1S/C11H12BrN3S/c12-8-5-4-7-2-1-3-10(9(7)6-8)14-15-11(13)16/h4-6H,1-3H2,(H3,13,15,16)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi recombinant cruzain				Bioorg Med Chem Lett 16: 4405-9 (2006) Article DOI: 10.1016/j.bmcl.2006.05.041 BindingDB Entry DOI: 10.7270/Q23R0SHC
					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM138142 (US8877967, 3) Show SMILES CN(N=C(c1ccccc1)c1cccc(c1)C(=O)c1ccccc1)C(N)=S |w:2.1| Show InChI InChI=1S/C22H19N3OS/c1-25(22(23)27)24-20(16-9-4-2-5-10-16)18-13-8-14-19(15-18)21(26)17-11-6-3-7-12-17/h2-15H,1H3,(H2,23,27)/b24-20+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17.4	n/a	n/a	n/a	n/a	3.5	25
OXiGENE, Inc.; Baylor University US Patent					Assay Description Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...				US Patent US8877967 (2014) BindingDB Entry DOI: 10.7270/Q25H7F0C
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM138143 (US8877967, 6) Show SMILES NC(=S)NN=C(c1ccccc1)c1cccc(c1)C(O)c1ccccc1 |w:18.20,4.3| Show InChI InChI=1S/C21H19N3OS/c22-21(26)24-23-19(15-8-3-1-4-9-15)17-12-7-13-18(14-17)20(25)16-10-5-2-6-11-16/h1-14,20,25H,(H3,22,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	23.8	n/a	n/a	n/a	n/a	5.5	n/a
OXiGENE, Inc.; Baylor University US Patent					Assay Description Human liver Cathepsin L (Sigma) was preincubated with test compounds at various concentrations for 5 minutes at 25C. The assay was initiated by addit...				US Patent US8877967 (2014) BindingDB Entry DOI: 10.7270/Q25H7F0C
					More data for this Ligand-Target Pair
Cruzipain (Trypanosoma cruzi)	BDBM50189279 (1-(bis(3-bromophenyl)methylene)thiosemicarbazide |...) Show SMILES [#7]-[#6](=S)-[#7]\[#7]=[#6](\c1cccc(Br)c1)-c1cccc(Br)c1 Show InChI InChI=1S/C14H11Br2N3S/c15-11-5-1-3-9(7-11)13(18-19-14(17)20)10-4-2-6-12(16)8-10/h1-8H,(H3,17,19,20)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi recombinant cruzain				Bioorg Med Chem Lett 16: 4405-9 (2006) Article DOI: 10.1016/j.bmcl.2006.05.041 BindingDB Entry DOI: 10.7270/Q23R0SHC
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50128811 (CHEMBL3629193) Show SMILES NC(=S)N\N=C(/c1ccccc1)c1cccc(c1)C(O)c1ccccc1 Show InChI InChI=1S/C21H19N3OS/c22-21(26)24-23-19(15-8-3-1-4-9-15)17-12-7-13-18(14-17)20(25)16-10-5-2-6-11-16/h1-14,20,25H,(H3,22,24,26)/b23-19+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured every 15 sec for 5 mins by fluorescence assay				Bioorg Med Chem 23: 6974-92 (2015) Article DOI: 10.1016/j.bmc.2015.09.036 BindingDB Entry DOI: 10.7270/Q2T43VX1
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM138146 (US8877967, 13) Show SMILES NC(=S)NN=C(c1ccc(F)cc1)c1cccc(c1)C(=O)c1ccc(F)cc1 |w:4.3| Show InChI InChI=1S/C21H15F2N3OS/c22-17-8-4-13(5-9-17)19(25-26-21(24)28)15-2-1-3-16(12-15)20(27)14-6-10-18(23)11-7-14/h1-12H,(H3,24,26,28)/b25-19-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	24.3	n/a	n/a	n/a	n/a	5.5	n/a
OXiGENE, Inc.; Baylor University US Patent					Assay Description Human liver Cathepsin L (Sigma) was preincubated with test compounds at various concentrations for 5 minutes at 25C. The assay was initiated by addit...				US Patent US8877967 (2014) BindingDB Entry DOI: 10.7270/Q25H7F0C
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM138154 (US8877967, 25) Show SMILES NC(=S)NN=C(c1ccccc1)c1cc(cc(c1)C(=O)c1ccccc1)C(=O)c1ccccc1 |w:4.3| Show InChI InChI=1S/C28H21N3O2S/c29-28(34)31-30-25(19-10-4-1-5-11-19)22-16-23(26(32)20-12-6-2-7-13-20)18-24(17-22)27(33)21-14-8-3-9-15-21/h1-18H,(H3,29,31,34)/b30-25-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	5.5	n/a
OXiGENE, Inc.; Baylor University US Patent					Assay Description Human liver Cathepsin L (Sigma) was preincubated with test compounds at various concentrations for 5 minutes at 25C. The assay was initiated by addit...				US Patent US8877967 (2014) BindingDB Entry DOI: 10.7270/Q25H7F0C
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50306641 (CHEMBL589280 | [(3-Bromophenyl)-(2-fluorophenyl)-k...) Show SMILES NC(=S)NN=C(c1cccc(Br)c1)c1ccccc1F |w:4.3| Show InChI InChI=1S/C14H11BrFN3S/c15-10-5-3-4-9(8-10)13(18-19-14(17)20)11-6-1-2-7-12(11)16/h1-8H,(H3,17,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30.5	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L				Bioorg Med Chem Lett 20: 1415-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.090 BindingDB Entry DOI: 10.7270/Q2NG4QQZ
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50388838 (CHEMBL2062897) Show SMILES NC(=S)NN=C1CCSc2cc(F)c(F)cc12 |w:4.3| Show InChI InChI=1S/C10H9F2N3S2/c11-6-3-5-8(14-15-10(13)16)1-2-17-9(5)4-7(6)12/h3-4H,1-2H2,(H3,13,15,16)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...				ACS Med Chem Lett 3: 450-453 (2012) Article DOI: 10.1021/ml200299g BindingDB Entry DOI: 10.7270/Q2QC04JR
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50306647 (CHEMBL601890 | [(3-Bromophenyl)-(3-trifluoromethyl...) Show SMILES NC(=S)NN=C(c1cccc(Br)c1)c1cccc(c1)C(F)(F)F |w:4.3| Show InChI InChI=1S/C15H11BrF3N3S/c16-12-6-2-4-10(8-12)13(21-22-14(20)23)9-3-1-5-11(7-9)15(17,18)19/h1-8H,(H3,20,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	46.5	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L				Bioorg Med Chem Lett 20: 1415-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.090 BindingDB Entry DOI: 10.7270/Q2NG4QQZ
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50128810 (CHEMBL3629192) Show SMILES NC(=S)N\N=C(/c1ccccc1)c1cc(cc(c1)C(=O)c1ccccc1)C(=O)c1ccccc1 Show InChI InChI=1S/C28H21N3O2S/c29-28(34)31-30-25(19-10-4-1-5-11-19)22-16-23(26(32)20-12-6-2-7-13-20)18-24(17-22)27(33)21-14-8-3-9-15-21/h1-18H,(H3,29,31,34)/b30-25+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured every 15 sec for 5 mins by fluorescence assay				Bioorg Med Chem 23: 6974-92 (2015) Article DOI: 10.1016/j.bmc.2015.09.036 BindingDB Entry DOI: 10.7270/Q2T43VX1
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50306656 (CHEMBL600860 | [(3-Bromophenyl)-(2,4-difluoropheny...) Show SMILES NC(=S)NN=C(c1cccc(Br)c1)c1cc(F)cc(F)c1 |w:4.3| Show InChI InChI=1S/C14H10BrF2N3S/c15-10-3-1-2-8(4-10)13(19-20-14(18)21)9-5-11(16)7-12(17)6-9/h1-7H,(H3,18,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	59.4	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L				Bioorg Med Chem Lett 20: 1415-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.090 BindingDB Entry DOI: 10.7270/Q2NG4QQZ
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50306662 (CHEMBL602934 | [(3-Bromophenyl)-(2,3,4,5-tetrafluo...) Show SMILES NC(=S)NN=C(c1cccc(Br)c1)c1cc(F)c(F)c(F)c1F |w:4.3| Show InChI InChI=1S/C14H8BrF4N3S/c15-7-3-1-2-6(4-7)13(21-22-14(20)23)8-5-9(16)11(18)12(19)10(8)17/h1-5H,(H3,20,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	63.2	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L				Bioorg Med Chem Lett 20: 1415-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.090 BindingDB Entry DOI: 10.7270/Q2NG4QQZ
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50388851 (CHEMBL2062909) Show SMILES NC(=S)NN=C1CCSc2ccc(cc12)[N+]([O-])=O |w:4.3| Show InChI InChI=1S/C10H10N4O2S2/c11-10(17)13-12-8-3-4-18-9-2-1-6(14(15)16)5-7(8)9/h1-2,5H,3-4H2,(H3,11,13,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...				ACS Med Chem Lett 3: 450-453 (2012) Article DOI: 10.1021/ml200299g BindingDB Entry DOI: 10.7270/Q2QC04JR
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50128820 (CHEMBL3629202) Show SMILES NC(=S)N\N=C(/c1cccc(O)c1)c1cc(Br)cc(c1)C(=O)c1cccc(O)c1 Show InChI InChI=1S/C21H16BrN3O3S/c22-16-8-14(7-15(9-16)20(28)13-4-2-6-18(27)11-13)19(24-25-21(23)29)12-3-1-5-17(26)10-12/h1-11,26-27H,(H3,23,25,29)/b24-19+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured every 15 sec for 5 mins by fluorescence assay				Bioorg Med Chem 23: 6974-92 (2015) Article DOI: 10.1016/j.bmc.2015.09.036 BindingDB Entry DOI: 10.7270/Q2T43VX1
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50306649 (CHEMBL602093 | [(3-Bromophenyl)-(4-fluorophenyl)-k...) Show SMILES NC(=S)NN=C(c1ccc(F)cc1)c1cccc(Br)c1 |w:4.3| Show InChI InChI=1S/C14H11BrFN3S/c15-11-3-1-2-10(8-11)13(18-19-14(17)20)9-4-6-12(16)7-5-9/h1-8H,(H3,17,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	79.6	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L				Bioorg Med Chem Lett 20: 1415-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.090 BindingDB Entry DOI: 10.7270/Q2NG4QQZ
					More data for this Ligand-Target Pair
Cruzipain (Trypanosoma cruzi)	BDBM50189280 (1-((3-bromophenyl)(phenyl)methylene)thiosemicarbaz...) Show SMILES NC(=S)NN=C(c1ccccc1)c1cccc(Br)c1 |w:4.3| Show InChI InChI=1S/C14H12BrN3S/c15-12-8-4-7-11(9-12)13(17-18-14(16)19)10-5-2-1-3-6-10/h1-9H,(H3,16,18,19)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi recombinant cruzain				Bioorg Med Chem Lett 16: 4405-9 (2006) Article DOI: 10.1016/j.bmcl.2006.05.041 BindingDB Entry DOI: 10.7270/Q23R0SHC
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50306654 (CHEMBL601644 | [(3-Bromophenyl)-(2,3-difluoropheny...) Show SMILES NC(=S)NN=C(c1cccc(Br)c1)c1cccc(F)c1F |w:4.3| Show InChI InChI=1S/C14H10BrF2N3S/c15-9-4-1-3-8(7-9)13(19-20-14(18)21)10-5-2-6-11(16)12(10)17/h1-7H,(H3,18,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	83.8	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L				Bioorg Med Chem Lett 20: 1415-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.090 BindingDB Entry DOI: 10.7270/Q2NG4QQZ
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50306658 (CHEMBL603084 | [(3-Bromophenyl)-(2,4-ditrifluorome...) Show SMILES NC(=S)NN=C(c1cccc(Br)c1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |w:4.3| Show InChI InChI=1S/C16H10BrF6N3S/c17-12-3-1-2-8(6-12)13(25-26-14(24)27)9-4-10(15(18,19)20)7-11(5-9)16(21,22)23/h1-7H,(H3,24,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	96	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L				Bioorg Med Chem Lett 20: 1415-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.090 BindingDB Entry DOI: 10.7270/Q2NG4QQZ
					More data for this Ligand-Target Pair
Cruzipain (Trypanosoma cruzi)	BDBM50189271 (1-(6-bromo-2,3-dihydrochromen-4-ylidene)thiosemica...) Show SMILES NC(=S)NN=C1CCOc2ccc(Br)cc12 |w:4.3| Show InChI InChI=1S/C10H10BrN3OS/c11-6-1-2-9-7(5-6)8(3-4-15-9)13-14-10(12)16/h1-2,5H,3-4H2,(H3,12,14,16)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi recombinant cruzain				Bioorg Med Chem Lett 16: 4405-9 (2006) Article DOI: 10.1016/j.bmcl.2006.05.041 BindingDB Entry DOI: 10.7270/Q23R0SHC
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50388835 (CHEMBL2062926) Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2ccc(cc12)[N+]([O-])=O |w:4.3| Show InChI InChI=1S/C10H10N4O4S2/c11-10(19)13-12-8-3-4-20(17,18)9-2-1-6(14(15)16)5-7(8)9/h1-2,5H,3-4H2,(H3,11,13,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	112	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...				ACS Med Chem Lett 3: 450-453 (2012) Article DOI: 10.1021/ml200299g BindingDB Entry DOI: 10.7270/Q2QC04JR
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50306660 (CHEMBL603085 | [(3-Bromophenyl)-(3-bromo,4-fluorop...) Show SMILES NC(=S)NN=C(c1cccc(Br)c1)c1ccc(F)c(Br)c1 |w:4.3| Show InChI InChI=1S/C14H10Br2FN3S/c15-10-3-1-2-8(6-10)13(19-20-14(18)21)9-4-5-12(17)11(16)7-9/h1-7H,(H3,18,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	114	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L				Bioorg Med Chem Lett 20: 1415-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.090 BindingDB Entry DOI: 10.7270/Q2NG4QQZ
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50306661 (CHEMBL599998 | [(3-Bromophenyl)-(3,4,5-trifluoroph...) Show SMILES NC(=S)NN=C(c1cccc(Br)c1)c1cc(F)c(F)c(F)c1 |w:4.3| Show InChI InChI=1S/C14H9BrF3N3S/c15-9-3-1-2-7(4-9)13(20-21-14(19)22)8-5-10(16)12(18)11(17)6-8/h1-6H,(H3,19,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	118	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L				Bioorg Med Chem Lett 20: 1415-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.090 BindingDB Entry DOI: 10.7270/Q2NG4QQZ
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50330034 (Bis(3-bromophenyl)(4-hydroxy)thiosemicarbazone | C...) Show SMILES NC(=S)NN=C(c1cccc(Br)c1)c1ccc(O)c(Br)c1 |w:4.3| Show InChI InChI=1S/C14H11Br2N3OS/c15-10-3-1-2-8(6-10)13(18-19-14(17)21)9-4-5-12(20)11(16)7-9/h1-7,20H,(H3,17,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L after 5 mins by microplate reader analysis				Bioorg Med Chem Lett 20: 6610-5 (2010) Article DOI: 10.1016/j.bmcl.2010.09.026 BindingDB Entry DOI: 10.7270/Q2MP53HZ
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50306646 (CHEMBL606452 | [(3-Bromophenyl)-(3-chlorophenyl)-k...) Show SMILES NC(=S)NN=C(c1cccc(Cl)c1)c1cccc(Br)c1 |w:4.3| Show InChI InChI=1S/C14H11BrClN3S/c15-11-5-1-3-9(7-11)13(18-19-14(17)20)10-4-2-6-12(16)8-10/h1-8H,(H3,17,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	131	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L				Bioorg Med Chem Lett 20: 1415-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.090 BindingDB Entry DOI: 10.7270/Q2NG4QQZ
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50330030 (CHEMBL1269632 | [(3-Bromophenyl)-(3-hydroxyphenyl)...) Show SMILES NC(=S)NN=C(c1cccc(O)c1)c1cccc(Br)c1 |w:4.3| Show InChI InChI=1S/C14H12BrN3OS/c15-11-5-1-3-9(7-11)13(17-18-14(16)20)10-4-2-6-12(19)8-10/h1-8,19H,(H3,16,18,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	131	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L after 5 mins by microplate reader analysis				Bioorg Med Chem Lett 20: 6610-5 (2010) Article DOI: 10.1016/j.bmcl.2010.09.026 BindingDB Entry DOI: 10.7270/Q2MP53HZ
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50330031 (CHEMBL1272261 | [(3-Bromophenyl)-(3-acetoxyphenyl)...) Show SMILES CC(=O)Oc1cccc(c1)C(=NNC(N)=S)c1cccc(Br)c1 |w:11.12| Show InChI InChI=1S/C16H14BrN3O2S/c1-10(21)22-14-7-3-5-12(9-14)15(19-20-16(18)23)11-4-2-6-13(17)8-11/h2-9H,1H3,(H3,18,20,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	151	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L after 5 mins by microplate reader analysis				Bioorg Med Chem Lett 20: 6610-5 (2010) Article DOI: 10.1016/j.bmcl.2010.09.026 BindingDB Entry DOI: 10.7270/Q2MP53HZ
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50388837 (CHEMBL2062896) Show SMILES NC(=S)NN=C1CCSc2ccc(Br)cc12 |w:4.3| Show InChI InChI=1S/C10H10BrN3S2/c11-6-1-2-9-7(5-6)8(3-4-16-9)13-14-10(12)15/h1-2,5H,3-4H2,(H3,12,14,15)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	152	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...				ACS Med Chem Lett 3: 450-453 (2012) Article DOI: 10.1021/ml200299g BindingDB Entry DOI: 10.7270/Q2QC04JR
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50491138 (CHEMBL2376019) Show SMILES NC(=S)N\N=C1/CCNc2ccc(Br)cc12 Show InChI InChI=1S/C10H11BrN4S/c11-6-1-2-8-7(5-6)9(3-4-13-8)14-15-10(12)16/h1-2,5,13H,3-4H2,(H3,12,15,16)/b14-9+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	164	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver Cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrate incubated for 5 mins prior to substrate addition measured for ...				Bioorg Med Chem Lett 23: 2801-7 (2013) Article DOI: 10.1016/j.bmcl.2012.12.025 BindingDB Entry DOI: 10.7270/Q2NS0XSX
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50232473 (CHEMBL4087627) Show SMILES NC(=S)N\N=C(/c1cccc(O)c1)c1cc(Br)cc(Br)c1 Show InChI InChI=1S/C14H11Br2N3OS/c15-10-4-9(5-11(16)7-10)13(18-19-14(17)21)8-2-1-3-12(20)6-8/h1-7,20H,(H3,17,19,21)/b18-13+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	202	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin-L using Z-FR-AMC as substrate preincubated for 5 mins followed by substrate addition measured at 15 sec interval ...				Bioorg Med Chem Lett 27: 1304-1310 (2017) Article DOI: 10.1016/j.bmcl.2016.12.039 BindingDB Entry DOI: 10.7270/Q23B62C1
					More data for this Ligand-Target Pair
Cruzipain (Trypanosoma cruzi)	BDBM50189278 (6-bromo-2,3-dihydro-4H-thiochromen-4-one thiosemic...) Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2ccc(Br)cc12 |w:4.3| Show InChI InChI=1S/C10H10BrN3O2S2/c11-6-1-2-9-7(5-6)8(13-14-10(12)17)3-4-18(9,15)16/h1-2,5H,3-4H2,(H3,12,14,17)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi recombinant cruzain				Bioorg Med Chem Lett 16: 4405-9 (2006) Article DOI: 10.1016/j.bmcl.2006.05.041 BindingDB Entry DOI: 10.7270/Q23R0SHC
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50388842 (CHEMBL2062901) Show SMILES Cc1ccc2SCCC(=NNC(N)=S)c2c1 |w:9.9| Show InChI InChI=1S/C11H13N3S2/c1-7-2-3-10-8(6-7)9(4-5-16-10)13-14-11(12)15/h2-3,6H,4-5H2,1H3,(H3,12,14,15)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	214	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...				ACS Med Chem Lett 3: 450-453 (2012) Article DOI: 10.1021/ml200299g BindingDB Entry DOI: 10.7270/Q2QC04JR
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50306648 (CHEMBL602092 | [(3-Bromophenyl)-m-tolyl-ketone]thi...) Show SMILES Cc1cccc(c1)C(=NNC(N)=S)c1cccc(Br)c1 |w:8.9| Show InChI InChI=1S/C15H14BrN3S/c1-10-4-2-5-11(8-10)14(18-19-15(17)20)12-6-3-7-13(16)9-12/h2-9H,1H3,(H3,17,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	224	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L				Bioorg Med Chem Lett 20: 1415-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.090 BindingDB Entry DOI: 10.7270/Q2NG4QQZ
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM87123 (3,4-bis(fluoranyl)-N-[2-[1-(3-fluorophenyl)-4-oxid...) Show SMILES Fc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc(F)c(F)c2)CC1 Show InChI InChI=1S/C22H23F3N4O2/c23-16-2-1-3-17(13-16)29-14-27-21(31)22(29)6-9-28(10-7-22)11-8-26-20(30)15-4-5-18(24)19(25)12-15/h1-5,12-13H,6-11,14H2,(H,26,30)(H,27,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	228	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...				ACS Med Chem Lett 3: 450-453 (2012) Article DOI: 10.1021/ml200299g BindingDB Entry DOI: 10.7270/Q2QC04JR
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50491134 (CHEMBL2376003) Show SMILES NC(=S)N\N=C1/CCN(c2ccc(cc12)[N+]([O-])=O)[N+]([O-])=O Show InChI InChI=1S/C10H10N6O4S/c11-10(21)13-12-8-3-4-14(16(19)20)9-2-1-6(15(17)18)5-7(8)9/h1-2,5H,3-4H2,(H3,11,13,21)/b12-8+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	228	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver Cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrate incubated for 5 mins prior to substrate addition measured for ...				Bioorg Med Chem Lett 23: 2801-7 (2013) Article DOI: 10.1016/j.bmcl.2012.12.025 BindingDB Entry DOI: 10.7270/Q2NS0XSX
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50330036 (Bis(3-bromophenyl)(5-hydroxy)thiosemicarbazone | C...) Show SMILES NC(=S)NN=C(c1cccc(Br)c1)c1cc(O)cc(Br)c1 |w:4.3| Show InChI InChI=1S/C14H11Br2N3OS/c15-10-3-1-2-8(4-10)13(18-19-14(17)21)9-5-11(16)7-12(20)6-9/h1-7,20H,(H3,17,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	232	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L after 5 mins by microplate reader analysis				Bioorg Med Chem Lett 20: 6610-5 (2010) Article DOI: 10.1016/j.bmcl.2010.09.026 BindingDB Entry DOI: 10.7270/Q2MP53HZ
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50306659 (CHEMBL602683 | [(3-Bromophenyl)-(3-bromo,2-fluorop...) Show SMILES NC(=S)NN=C(c1cccc(Br)c1)c1cccc(Br)c1F |w:4.3| Show InChI InChI=1S/C14H10Br2FN3S/c15-9-4-1-3-8(7-9)13(19-20-14(18)21)10-5-2-6-11(16)12(10)17/h1-7H,(H3,18,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	233	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L				Bioorg Med Chem Lett 20: 1415-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.090 BindingDB Entry DOI: 10.7270/Q2NG4QQZ
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50306645 (CHEMBL605998 | [(3-Bromophenyl)-(3-fluorophenyl)-k...) Show SMILES NC(=S)NN=C(c1cccc(F)c1)c1cccc(Br)c1 |w:4.3| Show InChI InChI=1S/C14H11BrFN3S/c15-11-5-1-3-9(7-11)13(18-19-14(17)20)10-4-2-6-12(16)8-10/h1-8H,(H3,17,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L				Bioorg Med Chem Lett 20: 1415-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.090 BindingDB Entry DOI: 10.7270/Q2NG4QQZ
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50388848 (CHEMBL2062907) Show SMILES NC(=S)NN=C1CCSc2ccc(OC(F)(F)F)cc12 |w:4.3| Show InChI InChI=1S/C11H10F3N3OS2/c12-11(13,14)18-6-1-2-9-7(5-6)8(3-4-20-9)16-17-10(15)19/h1-2,5H,3-4H2,(H3,15,17,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	256	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...				ACS Med Chem Lett 3: 450-453 (2012) Article DOI: 10.1021/ml200299g BindingDB Entry DOI: 10.7270/Q2QC04JR
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50388832 (CHEMBL2062923) Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2ccc(cc12)C(F)(F)F |w:4.3| Show InChI InChI=1S/C11H10F3N3O2S2/c12-11(13,14)6-1-2-9-7(5-6)8(16-17-10(15)20)3-4-21(9,18)19/h1-2,5H,3-4H2,(H3,15,17,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...				ACS Med Chem Lett 3: 450-453 (2012) Article DOI: 10.1021/ml200299g BindingDB Entry DOI: 10.7270/Q2QC04JR
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50388847 (CHEMBL2062906) Show SMILES NC(=S)NN=C1CCSc2ccc(cc12)C(F)(F)F |w:4.3| Show InChI InChI=1S/C11H10F3N3S2/c12-11(13,14)6-1-2-9-7(5-6)8(3-4-19-9)16-17-10(15)18/h1-2,5H,3-4H2,(H3,15,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	284	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...				ACS Med Chem Lett 3: 450-453 (2012) Article DOI: 10.1021/ml200299g BindingDB Entry DOI: 10.7270/Q2QC04JR
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50306650 (CHEMBL602094 | [(3-Bromophenyl)-(4-chlorophenyl)-k...) Show SMILES NC(=S)NN=C(c1ccc(Cl)cc1)c1cccc(Br)c1 |w:4.3| Show InChI InChI=1S/C14H11BrClN3S/c15-11-3-1-2-10(8-11)13(18-19-14(17)20)9-4-6-12(16)7-5-9/h1-8H,(H3,17,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	327	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver cathepsin L				Bioorg Med Chem Lett 20: 1415-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.090 BindingDB Entry DOI: 10.7270/Q2NG4QQZ
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50491155 (CHEMBL2376004) Show SMILES NC(=S)N\N=C1/CCNc2c1cc(cc2[N+]([O-])=O)[N+]([O-])=O Show InChI InChI=1S/C10H10N6O4S/c11-10(21)14-13-7-1-2-12-9-6(7)3-5(15(17)18)4-8(9)16(19)20/h3-4,12H,1-2H2,(H3,11,14,21)/b13-7+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	338	n/a	n/a	n/a	n/a	n/a	n/a
Baylor University Curated by ChEMBL					Assay Description Inhibition of human liver Cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrate incubated for 5 mins prior to substrate addition measured for ...				Bioorg Med Chem Lett 23: 2801-7 (2013) Article DOI: 10.1016/j.bmcl.2012.12.025 BindingDB Entry DOI: 10.7270/Q2NS0XSX
					More data for this Ligand-Target Pair

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