Reaction Details |
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Target | Cruzipain |
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Ligand | BDBM50189279 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_381155 (CHEMBL867357) |
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IC50 | 24±n/a nM |
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Citation | Siles, R; Chen, SE; Zhou, M; Pinney, KG; Trawick, ML Design, synthesis, and biochemical evaluation of novel cruzain inhibitors with potential application in the treatment of Chagas' disease. Bioorg Med Chem Lett16:4405-9 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cruzipain |
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Name: | Cruzipain |
Synonyms: | CYSP_TRYCR | Cruzain | Cruzaine | Major cysteine proteinase |
Type: | Protein |
Mol. Mass.: | 49831.41 |
Organism: | Trypanosoma cruzi |
Description: | P25779 |
Residue: | 467 |
Sequence: | MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLS
VFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEV
VGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDK
TDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVEL
PQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYW
IIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSY
FVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVR
SSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
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BDBM50189279 |
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n/a |
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Name | BDBM50189279 |
Synonyms: | 1-(bis(3-bromophenyl)methylene)thiosemicarbazide | CHEMBL384296 |
Type | Small organic molecule |
Emp. Form. | C14H11Br2N3S |
Mol. Mass. | 413.13 |
SMILES | [#7]-[#6](=S)-[#7]\[#7]=[#6](\c1cccc(Br)c1)-c1cccc(Br)c1 |
Structure |
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