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Compile Data Set for Download or QSAR

Found 758 hits with Last Name = 'chen' and Initial = 'se'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50318625
PNG
(CHEMBL1083654 | N-Methyl-(3-phenylsulfonyl)-7,8-di...)
Show SMILES CNc1nn2c3CCCc3cnc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H16N4O2S/c1-17-15-14(23(21,22)12-7-3-2-4-8-12)16-18-10-11-6-5-9-13(11)20(16)19-15/h2-4,7-8,10H,5-6,9H2,1H3,(H,17,19)
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PubMed
 0.0880n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cells

J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50318626
PNG
(CHEMBL1082763 | N-Methyl-(3-phenylsulfonyl)-6,7,8,...)
Show SMILES CNc1nn2c3CCCCc3cnc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H18N4O2S/c1-18-16-15(24(22,23)13-8-3-2-4-9-13)17-19-11-12-7-5-6-10-14(12)21(17)20-16/h2-4,8-9,11H,5-7,10H2,1H3,(H,18,20)
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PubMed
 0.112n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cells

J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50358778
PNG
(CHEMBL1922616)
Show SMILES CNc1nn2c(N)c(Cl)c(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H14ClN5O2S/c1-8-10(15)12(16)20-14(18-8)11(13(17-2)19-20)23(21,22)9-6-4-3-5-7-9/h3-7H,16H2,1-2H3,(H,17,19)
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 0.140n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 5-HT6 receptor expressed in human HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation

J Med Chem 54: 8161-73 (2011)


Article DOI: 10.1021/jm201079g
BindingDB Entry DOI: 10.7270/Q2X067F0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50417934
PNG
(CHEMBL1668590 | US8829009, 1.1(7))
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C15H15ClN4O2S/c1-9-7-10(2)20-15(18-9)13(14(17-3)19-20)23(21,22)12-6-4-5-11(16)8-12/h4-8H,1-3H3,(H,17,19)
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 0.186n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...

Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50340725
PNG
(CHEMBL1668584 | N,5,7-trimethyl-3-(phenylsulfonyl)...)
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O2S/c1-10-9-11(2)19-15(17-10)13(14(16-3)18-19)22(20,21)12-7-5-4-6-8-12/h4-9H,1-3H3,(H,16,18)
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 0.200n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor

Eur J Med Chem 46: 1189-97 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.038
BindingDB Entry DOI: 10.7270/Q2HT2PMN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50318627
PNG
(CHEMBL1083075 | N,5-Dimethyl-3-(phenylsulfonyl)-7,...)
Show SMILES CNc1nn2c3CCCc3c(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H18N4O2S/c1-11-13-9-6-10-14(13)21-17(19-11)15(16(18-2)20-21)24(22,23)12-7-4-3-5-8-12/h3-5,7-8H,6,9-10H2,1-2H3,(H,18,20)
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 0.202n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cells

J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50318633
PNG
(3-benzenesulfonyl-8-piperazin-1-ylquinoline | CHEM...)
Show SMILES O=S(=O)(c1ccccc1)c1cnc2c(cccc2c1)N1CCNCC1
Show InChI InChI=1S/C19H19N3O2S/c23-25(24,16-6-2-1-3-7-16)17-13-15-5-4-8-18(19(15)21-14-17)22-11-9-20-10-12-22/h1-8,13-14,20H,9-12H2
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 0.234n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to 5HT6 receptor

J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50417915
PNG
(CHEMBL1668586 | US8618114, 1.2.3(1))
Show SMILES CNc1nn2c(C)ccnc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H14N4O2S/c1-10-8-9-16-14-12(13(15-2)17-18(10)14)21(19,20)11-6-4-3-5-7-11/h3-9H,1-2H3,(H,15,17)
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 0.240n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...

Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50318624
PNG
(CHEMBL1082762 | N,9-Dimethyl-3-(phenylsulfonyl)-5,...)
Show SMILES CNc1nn2c(C)c3CCCCc3nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H20N4O2S/c1-12-14-10-6-7-11-15(14)20-18-16(17(19-2)21-22(12)18)25(23,24)13-8-4-3-5-9-13/h3-5,8-9H,6-7,10-11H2,1-2H3,(H,19,21)
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 0.256n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cells

J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50340725
PNG
(CHEMBL1668584 | N,5,7-trimethyl-3-(phenylsulfonyl)...)
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O2S/c1-10-9-11(2)19-15(17-10)13(14(16-3)18-19)22(20,21)12-7-5-4-6-8-12/h4-9H,1-3H3,(H,16,18)
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 0.257n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...

Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50318626
PNG
(CHEMBL1082763 | N-Methyl-(3-phenylsulfonyl)-6,7,8,...)
Show SMILES CNc1nn2c3CCCCc3cnc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H18N4O2S/c1-18-16-15(24(22,23)13-8-3-2-4-9-13)17-19-11-12-7-5-6-10-14(12)21(17)20-16/h2-4,8-9,11H,5-7,10H2,1H3,(H,18,20)
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 0.259n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP release

J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50340725
PNG
(CHEMBL1668584 | N,5,7-trimethyl-3-(phenylsulfonyl)...)
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O2S/c1-10-9-11(2)19-15(17-10)13(14(16-3)18-19)22(20,21)12-7-5-4-6-8-12/h4-9H,1-3H3,(H,16,18)
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 0.260n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...

Eur J Med Chem 46: 1189-97 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.038
BindingDB Entry DOI: 10.7270/Q2HT2PMN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50340725
PNG
(CHEMBL1668584 | N,5,7-trimethyl-3-(phenylsulfonyl)...)
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O2S/c1-10-9-11(2)19-15(17-10)13(14(16-3)18-19)22(20,21)12-7-5-4-6-8-12/h4-9H,1-3H3,(H,16,18)
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 0.260n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 5-HT6 receptor expressed in human HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation

J Med Chem 54: 8161-73 (2011)


Article DOI: 10.1021/jm201079g
BindingDB Entry DOI: 10.7270/Q2X067F0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50417916
PNG
(CHEMBL1668564 | US8618114, 1.2.5(1))
Show SMILES CNc1nn2c(C)cc(COC)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H18N4O3S/c1-11-9-12(10-23-3)18-16-14(15(17-2)19-20(11)16)24(21,22)13-7-5-4-6-8-13/h4-9H,10H2,1-3H3,(H,17,19)
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 0.269n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...

Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50417917
PNG
(CHEMBL1668565 | US8618114, 1.2.6(1))
Show SMILES CNc1nn2c(CO)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O3S/c1-10-8-11(9-20)19-15(17-10)13(14(16-2)18-19)23(21,22)12-6-4-3-5-7-12/h3-8,20H,9H2,1-2H3,(H,16,18)
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 0.282n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...

Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))		BDBM17292
PNG
((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Show SMILES [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])c3ccc(O)cc3CC[C@@]21[H]
Show InChI InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
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 0.300n/an/an/an/an/an/an/an/a



University of New Mexico Health Sciences Center

Curated by ChEMBL


Assay Description
Displacement of E2-Alexa633 from GFP-tagged ERalpha expressed in COS7 cells by FACS

Nat Chem Biol 2: 207-12 (2006)


Article DOI: 10.1038/nchembio775
BindingDB Entry DOI: 10.7270/Q2ZK5GV2
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50318625
PNG
(CHEMBL1083654 | N-Methyl-(3-phenylsulfonyl)-7,8-di...)
Show SMILES CNc1nn2c3CCCc3cnc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H16N4O2S/c1-17-15-14(23(21,22)12-7-3-2-4-8-12)16-18-10-11-6-5-9-13(11)20(16)19-15/h2-4,7-8,10H,5-6,9H2,1H3,(H,17,19)
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 0.375n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP release

J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
Estrogen receptor beta


(Homo sapiens (Human))		BDBM17292
PNG
((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Show SMILES [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])c3ccc(O)cc3CC[C@@]21[H]
Show InChI InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
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 0.380n/an/an/an/an/an/an/an/a



University of New Mexico Health Sciences Center

Curated by ChEMBL


Assay Description
Displacement of E2-Alexa633 from GFP-tagged ERbeta expressed in COS7 cells by FACS

Nat Chem Biol 2: 207-12 (2006)


Article DOI: 10.1038/nchembio775
BindingDB Entry DOI: 10.7270/Q2ZK5GV2
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50417920
PNG
(CHEMBL1668592 | US8829009, 1.1(3))
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C15H15FN4O2S/c1-9-8-10(2)20-15(18-9)13(14(17-3)19-20)23(21,22)12-6-4-11(16)5-7-12/h4-8H,1-3H3,(H,17,19)
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 0.398n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...

Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50318627
PNG
(CHEMBL1083075 | N,5-Dimethyl-3-(phenylsulfonyl)-7,...)
Show SMILES CNc1nn2c3CCCc3c(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H18N4O2S/c1-11-13-9-6-10-14(13)21-17(19-11)15(16(18-2)20-21)24(22,23)12-7-4-3-5-8-12/h3-5,7-8H,6,9-10H2,1-2H3,(H,18,20)
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 0.413n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP release

J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50314762
PNG
(5-methyl-2-(methylthio)-3-(phenylsulfonyl)-6,7,8,9...)
Show SMILES CSc1nn2c3CCCCc3c(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H19N3O2S2/c1-12-14-10-6-7-11-15(14)21-17(19-12)16(18(20-21)24-2)25(22,23)13-8-4-3-5-9-13/h3-5,8-9H,6-7,10-11H2,1-2H3
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 0.440n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from 5HT6 receptor in humanHeLa cells after 120 mins

Bioorg Med Chem Lett 20: 2133-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.046
BindingDB Entry DOI: 10.7270/Q2V40VBK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50314759
PNG
(2-(methylthio)-3-(phenylsulfonyl)-7,8-dihydro-6H-c...)
Show SMILES CSc1nn2c3CCCc3cnc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H15N3O2S2/c1-22-16-14(23(20,21)12-7-3-2-4-8-12)15-17-10-11-6-5-9-13(11)19(15)18-16/h2-4,7-8,10H,5-6,9H2,1H3
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 0.458n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from 5HT6 receptor in humanHeLa cells after 120 mins

Bioorg Med Chem Lett 20: 2133-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.046
BindingDB Entry DOI: 10.7270/Q2V40VBK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50417933
PNG
(CHEMBL1668588 | US8618114, 1.2.7(1))
Show SMILES CNc1nn2c(C)cc(CO)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O3S/c1-10-8-11(9-20)17-15-13(14(16-2)18-19(10)15)23(21,22)12-6-4-3-5-7-12/h3-8,20H,9H2,1-2H3,(H,16,18)
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 0.479n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...

Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50318628
PNG
(CHEMBL1083076 | N,5-Dimethyl-3-(phenylsulfonyl)-6,...)
Show SMILES CNc1nn2c3CCCCc3c(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H20N4O2S/c1-12-14-10-6-7-11-15(14)22-18(20-12)16(17(19-2)21-22)25(23,24)13-8-4-3-5-9-13/h3-5,8-9H,6-7,10-11H2,1-2H3,(H,19,21)
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 0.490n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cells

J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50318623
PNG
(CHEMBL1082761 | N-Methyl-3-(phenylsulfonyl)-5,6,7,...)
Show SMILES CNc1nn2cc3CCCCc3nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H18N4O2S/c1-18-16-15(24(22,23)13-8-3-2-4-9-13)17-19-14-10-6-5-7-12(14)11-21(17)20-16/h2-4,8-9,11H,5-7,10H2,1H3,(H,18,20)
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 0.499n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cells

J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50417919
PNG
(CHEMBL1668591 | US8829009, 1.1(5))
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C15H15FN4O2S/c1-9-7-10(2)20-15(18-9)13(14(17-3)19-20)23(21,22)12-6-4-5-11(16)8-12/h4-8H,1-3H3,(H,17,19)
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 0.501n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...

Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50318623
PNG
(CHEMBL1082761 | N-Methyl-3-(phenylsulfonyl)-5,6,7,...)
Show SMILES CNc1nn2cc3CCCCc3nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H18N4O2S/c1-18-16-15(24(22,23)13-8-3-2-4-9-13)17-19-14-10-6-5-7-12(14)11-21(17)20-16/h2-4,8-9,11H,5-7,10H2,1H3,(H,18,20)
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 0.542n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP release

J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50314760
PNG
(2-(methylthio)-3-(phenylsulfonyl)-6,7,8,9-tetrahyd...)
Show SMILES CSc1nn2c3CCCCc3cnc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H17N3O2S2/c1-23-17-15(24(21,22)13-8-3-2-4-9-13)16-18-11-12-7-5-6-10-14(12)20(16)19-17/h2-4,8-9,11H,5-7,10H2,1H3
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 0.549n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from 5HT6 receptor in humanHeLa cells after 120 mins

Bioorg Med Chem Lett 20: 2133-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.046
BindingDB Entry DOI: 10.7270/Q2V40VBK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50417904
PNG
(CHEMBL1668568 | US8618114, 1.1.6(1))
Show SMILES CSc1nn2c(CO)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H15N3O3S2/c1-10-8-11(9-19)18-14(16-10)13(15(17-18)22-2)23(20,21)12-6-4-3-5-7-12/h3-8,19H,9H2,1-2H3
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 0.562n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...

Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50417936
PNG
(CHEMBL1668596 | US8829009, 1.1(9))
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C15H14ClFN4O2S/c1-8-6-9(2)21-15(19-8)13(14(18-3)20-21)24(22,23)10-4-5-12(17)11(16)7-10/h4-7H,1-3H3,(H,18,20)
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 0.603n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...

Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50314763
PNG
(9-methyl-2-(methylthio)-3-(phenylsulfonyl)-5,6,7,8...)
Show SMILES CSc1nn2c(C)c3CCCCc3nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H19N3O2S2/c1-12-14-10-6-7-11-15(14)19-17-16(18(24-2)20-21(12)17)25(22,23)13-8-4-3-5-9-13/h3-5,8-9H,6-7,10-11H2,1-2H3
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 0.680n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from 5HT6 receptor in humanHeLa cells after 120 mins

Bioorg Med Chem Lett 20: 2133-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.046
BindingDB Entry DOI: 10.7270/Q2V40VBK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50417906
PNG
(CHEMBL1668571 | US8552005, 1.1(11))
Show SMILES CSc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C15H14ClN3O2S2/c1-9-7-10(2)19-14(17-9)13(15(18-19)22-3)23(20,21)12-6-4-5-11(16)8-12/h4-8H,1-3H3
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 0.759n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...

Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50358774
PNG
(CHEMBL1642114 | Ro-657674)
Show SMILES CSc1nn2c(N3CCNCC3)c3CCCc3nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H23N5O2S2/c1-28-19-17(29(26,27)14-6-3-2-4-7-14)18-22-16-9-5-8-15(16)20(25(18)23-19)24-12-10-21-11-13-24/h2-4,6-7,21H,5,8-13H2,1H3
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 0.850n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 5-HT6 receptor expressed in human HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation

J Med Chem 54: 8161-73 (2011)


Article DOI: 10.1021/jm201079g
BindingDB Entry DOI: 10.7270/Q2X067F0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50318634
PNG
(CHEMBL1084244 | N-methyl-3-(phenylsulfonyl)-8-(pip...)
Show SMILES O=S(=O)(c1cnn2c(N3CCNCC3)c3CCCc3nc12)c1ccccc1
Show InChI InChI=1S/C19H21N5O2S/c25-27(26,14-5-2-1-3-6-14)17-13-21-24-18(17)22-16-8-4-7-15(16)19(24)23-11-9-20-10-12-23/h1-3,5-6,13,20H,4,7-12H2
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 0.850n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to 5HT6 receptor

J Med Chem 53: 5186-96 (2010)


Article DOI: 10.1021/jm100350r
BindingDB Entry DOI: 10.7270/Q26T0NMP
More data for this
Ligand-Target Pair
Plasmepsin II


(Plasmodium falciparum)		BDBM50001073
PNG
(CHEMBL3236067)
Show SMILES Cc1cc(NC(=O)CCCCN)cc(C)c1OCC(=O)N[C@@H](Cc1ccccc1)[C@H](O)C(=O)N1CSC(C)(C)[C@H]1C(=O)N[C@@H]1[C@H](O)Cc2ccccc12 |r|
Show InChI InChI=1S/C40H51N5O7S/c1-24-18-28(42-32(47)16-10-11-17-41)19-25(2)36(24)52-22-33(48)43-30(20-26-12-6-5-7-13-26)35(49)39(51)45-23-53-40(3,4)37(45)38(50)44-34-29-15-9-8-14-27(29)21-31(34)46/h5-9,12-15,18-19,30-31,34-35,37,46,49H,10-11,16-17,20-23,41H2,1-4H3,(H,42,47)(H,43,48)(H,44,50)/t30-,31+,34-,35-,37+/m0/s1
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 1n/an/an/an/an/an/an/an/a



Kyoto Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin 2

Bioorg Med Chem Lett 24: 1698-701 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.051
BindingDB Entry DOI: 10.7270/Q27S7Q8N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50417907
PNG
(CHEMBL1668572 | US8552005, 1.1(9))
Show SMILES CSc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C15H14FN3O2S2/c1-9-7-10(2)19-14(17-9)13(15(18-19)22-3)23(20,21)12-6-4-5-11(16)8-12/h4-8H,1-3H3
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 1.07n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...

Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
Plasmepsin II


(Plasmodium falciparum)		BDBM50001072
PNG
(CHEMBL3236066)
Show SMILES Cc1cc(NC(=O)CCCN)cc(C)c1OCC(=O)N[C@@H](Cc1ccccc1)[C@H](O)C(=O)N1CSC(C)(C)[C@H]1C(=O)N[C@@H]1[C@H](O)Cc2ccccc12 |r|
Show InChI InChI=1S/C39H49N5O7S/c1-23-17-27(41-31(46)15-10-16-40)18-24(2)35(23)51-21-32(47)42-29(19-25-11-6-5-7-12-25)34(48)38(50)44-22-52-39(3,4)36(44)37(49)43-33-28-14-9-8-13-26(28)20-30(33)45/h5-9,11-14,17-18,29-30,33-34,36,45,48H,10,15-16,19-22,40H2,1-4H3,(H,41,46)(H,42,47)(H,43,49)/t29-,30+,33-,34-,36+/m0/s1
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 1.10n/an/an/an/an/an/an/an/a



Kyoto Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin 2

Bioorg Med Chem Lett 24: 1698-701 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.051
BindingDB Entry DOI: 10.7270/Q27S7Q8N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50417918
PNG
(CHEMBL1668589 | US8618114, 1.2.1(4))
Show SMILES CNc1nn2cccnc2c1S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C13H11ClN4O2S/c1-15-12-11(13-16-6-3-7-18(13)17-12)21(19,20)10-5-2-4-9(14)8-10/h2-8H,1H3,(H,15,17)
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 1.17n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...

Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
Plasmepsin II


(Plasmodium falciparum)		BDBM50001070
PNG
(CHEMBL3236064)
Show SMILES Cc1cc(NC(=O)CN)cc(C)c1OCC(=O)N[C@@H](Cc1ccccc1)[C@H](O)C(=O)N1CSC(C)(C)[C@H]1C(=O)N[C@@H]1[C@H](O)Cc2ccccc12 |r|
Show InChI InChI=1S/C37H45N5O7S/c1-21-14-25(39-29(44)18-38)15-22(2)33(21)49-19-30(45)40-27(16-23-10-6-5-7-11-23)32(46)36(48)42-20-50-37(3,4)34(42)35(47)41-31-26-13-9-8-12-24(26)17-28(31)43/h5-15,27-28,31-32,34,43,46H,16-20,38H2,1-4H3,(H,39,44)(H,40,45)(H,41,47)/t27-,28+,31-,32-,34+/m0/s1
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 1.20n/an/an/an/an/an/an/an/a



Kyoto Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin 2

Bioorg Med Chem Lett 24: 1698-701 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.051
BindingDB Entry DOI: 10.7270/Q27S7Q8N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50340726
PNG
(5,7-dimethyl-2-(methylthio)-3-(phenylsulfonyl)pyra...)
Show SMILES CSc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H15N3O2S2/c1-10-9-11(2)18-14(16-10)13(15(17-18)21-3)22(19,20)12-7-5-4-6-8-12/h4-9H,1-3H3
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 1.20n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...

Eur J Med Chem 46: 1189-97 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.038
BindingDB Entry DOI: 10.7270/Q2HT2PMN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50340726
PNG
(5,7-dimethyl-2-(methylthio)-3-(phenylsulfonyl)pyra...)
Show SMILES CSc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H15N3O2S2/c1-10-9-11(2)18-14(16-10)13(15(17-18)21-3)22(19,20)12-7-5-4-6-8-12/h4-9H,1-3H3
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 1.20n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...

Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50358776
PNG
(CHEMBL1922716)
Show SMILES CNc1cc(ccc1S(=O)(=O)c1cccc(F)c1)N1CCCNCC1
Show InChI InChI=1S/C18H22FN3O2S/c1-20-17-13-15(22-10-3-8-21-9-11-22)6-7-18(17)25(23,24)16-5-2-4-14(19)12-16/h2,4-7,12-13,20-21H,3,8-11H2,1H3
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 1.40n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 5-HT6 receptor expressed in human HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation

J Med Chem 54: 8161-73 (2011)


Article DOI: 10.1021/jm201079g
BindingDB Entry DOI: 10.7270/Q2X067F0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50417914
PNG
(CHEMBL1668585 | US8618114, 1.2.2(1))
Show SMILES CNc1nn2ccc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H14N4O2S/c1-10-8-9-18-14(16-10)12(13(15-2)17-18)21(19,20)11-6-4-3-5-7-11/h3-9H,1-2H3,(H,15,17)
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 1.45n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...

Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
Plasmepsin II


(Plasmodium falciparum)		BDBM50001069
PNG
(CHEMBL3236063)
Show SMILES Cc1cc(NCc2ccnc3ccccc23)cc(C)c1OCC(=O)N[C@@H](Cc1ccccc1)[C@H](O)C(=O)N1CSC(C)(C)[C@H]1C(=O)N[C@@H]1[C@H](O)Cc2ccccc12 |r|
Show InChI InChI=1S/C45H49N5O6S/c1-27-20-32(47-24-31-18-19-46-35-17-11-10-15-33(31)35)21-28(2)41(27)56-25-38(52)48-36(22-29-12-6-5-7-13-29)40(53)44(55)50-26-57-45(3,4)42(50)43(54)49-39-34-16-9-8-14-30(34)23-37(39)51/h5-21,36-37,39-40,42,47,51,53H,22-26H2,1-4H3,(H,48,52)(H,49,54)/t36-,37+,39-,40-,42+/m0/s1
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 1.70n/an/an/an/an/an/an/an/a



Kyoto Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin 2

Bioorg Med Chem Lett 24: 1698-701 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.051
BindingDB Entry DOI: 10.7270/Q27S7Q8N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50322093
PNG
(3-(phenylsulfonyl)-N-(thiophen-2-ylmethyl)thieno[2...)
Show SMILES O=S(=O)(c1nnn2c3ccsc3c(NCc3cccs3)nc12)c1ccccc1
Show InChI InChI=1S/C18H13N5O2S3/c24-28(25,13-6-2-1-3-7-13)18-17-20-16(19-11-12-5-4-9-26-12)15-14(8-10-27-15)23(17)22-21-18/h1-10H,11H2,(H,19,20)
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 1.70n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant 5HT6 receptor expressed in HEK293 cells by radioligand displacement assay

Bioorg Med Chem 18: 5282-90 (2010)


Article DOI: 10.1016/j.bmc.2010.05.051
BindingDB Entry DOI: 10.7270/Q2F190QT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50340730
PNG
(5,7-Dimethyl-2-(ethylthio)-3-phenylsulfonyl-pyrazo...)
Show SMILES CCSc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H17N3O2S2/c1-4-22-16-14(23(20,21)13-8-6-5-7-9-13)15-17-11(2)10-12(3)19(15)18-16/h5-10H,4H2,1-3H3
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 1.91n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...

Eur J Med Chem 46: 1189-97 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.038
BindingDB Entry DOI: 10.7270/Q2HT2PMN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50340726
PNG
(5,7-dimethyl-2-(methylthio)-3-(phenylsulfonyl)pyra...)
Show SMILES CSc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H15N3O2S2/c1-10-9-11(2)18-14(16-10)13(15(17-18)21-3)22(19,20)12-7-5-4-6-8-12/h4-9H,1-3H3
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 2n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor

Eur J Med Chem 46: 1189-97 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.038
BindingDB Entry DOI: 10.7270/Q2HT2PMN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50417937
PNG
(CHEMBL1668594)
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccc(O)cc1
Show InChI InChI=1S/C15H16N4O3S/c1-9-8-10(2)19-15(17-9)13(14(16-3)18-19)23(21,22)12-6-4-11(20)5-7-12/h4-8,20H,1-3H3,(H,16,18)
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 2n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...

Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50316295
PNG
(CHEMBL1099284 | N-(3-Fluorophenyl)-2-methyl-2,3,4,...)
Show SMILES CN1CCc2[nH]c3ccc(cc3c2C1)S(=O)(=O)Nc1cccc(F)c1
Show InChI InChI=1S/C18H18FN3O2S/c1-22-8-7-18-16(11-22)15-10-14(5-6-17(15)20-18)25(23,24)21-13-4-2-3-12(19)9-13/h2-6,9-10,20-21H,7-8,11H2,1H3
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 2.10n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant 5HT6 receptor by radioligand displacement assay

Eur J Med Chem 45: 782-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.10.035
BindingDB Entry DOI: 10.7270/Q2542NR1
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50417905
PNG
(CHEMBL1668569 | US8618114, 1.1.7(1))
Show SMILES CSc1nn2c(C)cc(CO)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H15N3O3S2/c1-10-8-11(9-19)16-14-13(15(22-2)17-18(10)14)23(20,21)12-6-4-3-5-7-12/h3-8,19H,9H2,1-2H3
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 2.14n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...

Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
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