Reaction Details |
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Target | Procathepsin L |
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Ligand | BDBM50306646 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_611257 (CHEMBL1068286) |
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IC50 | 131±n/a nM |
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Citation | Kishore Kumar, GD; Chavarria, GE; Charlton-Sevcik, AK; Arispe, WM; Macdonough, MT; Strecker, TE; Chen, SE; Siim, BG; Chaplin, DJ; Trawick, ML; Pinney, KG Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors. Bioorg Med Chem Lett20:1415-9 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Procathepsin L |
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Name: | Procathepsin L |
Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
Type: | Enzyme |
Mol. Mass.: | 37557.19 |
Organism: | Homo sapiens (Human) |
Description: | Purchased from Calbiochem (San Diego, CA). |
Residue: | 333 |
Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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BDBM50306646 |
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n/a |
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Name | BDBM50306646 |
Synonyms: | CHEMBL606452 | [(3-Bromophenyl)-(3-chlorophenyl)-ketone]thiosemicarbazone |
Type | Small organic molecule |
Emp. Form. | C14H11BrClN3S |
Mol. Mass. | 368.679 |
SMILES | NC(=S)NN=C(c1cccc(Cl)c1)c1cccc(Br)c1 |w:4.3| |
Structure |
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