Affinity Data by PubMed id=26473791

PubMed code 26473791

Found 20 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50499098 (CHEMBL3735540) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D using 3H-cAMP as substrate after 15 mins by liquid scintillation counting analysis				J Med Chem 58: 8616-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b01222 BindingDB Entry DOI: 10.7270/Q2GH9MZJ
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50499095 (CHEMBL3734974) Show SMILES Oc1ccc2oc(cc2c1)-c1cc(I)c(O)c2ncccc12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D using 3H-cAMP as substrate after 15 mins by liquid scintillation counting analysis				J Med Chem 58: 8616-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b01222 BindingDB Entry DOI: 10.7270/Q2GH9MZJ
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram \| 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	610	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D using 3H-cAMP as substrate after 15 mins by liquid scintillation counting analysis				J Med Chem 58: 8616-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b01222 BindingDB Entry DOI: 10.7270/Q2GH9MZJ
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50499097 (CHEMBL3735115) Show SMILES Oc1ccc(-c2cc3cc(I)cc(I)c3o2)c2cccnc12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D using 3H-cAMP as substrate after 15 mins by liquid scintillation counting analysis				J Med Chem 58: 8616-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b01222 BindingDB Entry DOI: 10.7270/Q2GH9MZJ
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50499090 (CHEMBL3735548) Show SMILES Oc1ccc2cc(oc2c1)-c1cc(I)c(O)c2ncccc12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D using 3H-cAMP as substrate after 15 mins by liquid scintillation counting analysis				J Med Chem 58: 8616-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b01222 BindingDB Entry DOI: 10.7270/Q2GH9MZJ
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50499096 (CHEMBL3736201) Show SMILES Oc1ccc2oc(cc2c1)-c1cc(Cl)c(O)c2ncccc12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	960	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D using 3H-cAMP as substrate after 15 mins by liquid scintillation counting analysis				J Med Chem 58: 8616-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b01222 BindingDB Entry DOI: 10.7270/Q2GH9MZJ
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50499093 (CHEMBL3735104) Show SMILES Oc1ccc2cc(oc2c1)-c1cc(Cl)c(O)c2ncccc12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D using 3H-cAMP as substrate after 15 mins by liquid scintillation counting analysis				J Med Chem 58: 8616-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b01222 BindingDB Entry DOI: 10.7270/Q2GH9MZJ
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50499094 (CHEMBL3735557) Show SMILES Oc1cc(O)c2cc(oc2c1)-c1ccc(O)c2ncccc12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.21E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D using 3H-cAMP as substrate after 15 mins by liquid scintillation counting analysis				J Med Chem 58: 8616-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b01222 BindingDB Entry DOI: 10.7270/Q2GH9MZJ
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50499091 (CHEMBL3735525) Show SMILES Oc1cc(O)c2cc(oc2c1)-c1ccc2cccc(O)c2n1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.01E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D using 3H-cAMP as substrate after 15 mins by liquid scintillation counting analysis				J Med Chem 58: 8616-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b01222 BindingDB Entry DOI: 10.7270/Q2GH9MZJ
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50499084 (CHEMBL3736003) Show SMILES Oc1cccc2cc(oc12)-c1cc(Cl)c(O)c2ncccc12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.08E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D using 3H-cAMP as substrate after 15 mins by liquid scintillation counting analysis				J Med Chem 58: 8616-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b01222 BindingDB Entry DOI: 10.7270/Q2GH9MZJ
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50499092 (CHEMBL3736120) Show SMILES Oc1ccc2oc(cc2c1)-c1ccc(O)c2ncccc12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D using 3H-cAMP as substrate after 15 mins by liquid scintillation counting analysis				J Med Chem 58: 8616-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b01222 BindingDB Entry DOI: 10.7270/Q2GH9MZJ
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50250915 (CHEMBL512578 \| moracin M) Show SMILES Oc1ccc2cc(oc2c1)-c1cc(O)cc(O)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.91E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D using 3H-cAMP as substrate after 15 mins by liquid scintillation counting analysis				J Med Chem 58: 8616-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b01222 BindingDB Entry DOI: 10.7270/Q2GH9MZJ
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50499083 (CHEMBL3735108) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.92E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D using 3H-cAMP as substrate after 15 mins by liquid scintillation counting analysis				J Med Chem 58: 8616-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b01222 BindingDB Entry DOI: 10.7270/Q2GH9MZJ
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50499085 (CHEMBL3736059) Show SMILES Oc1c(Cl)cc(-c2cc3ccccc3o2)c2cccnc12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D using 3H-cAMP as substrate after 15 mins by liquid scintillation counting analysis				J Med Chem 58: 8616-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b01222 BindingDB Entry DOI: 10.7270/Q2GH9MZJ
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50499086 (CHEMBL3736439) Show SMILES Cc1c(oc2ccc(O)cc12)-c1ccc(O)c2ncccc12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.67E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D using 3H-cAMP as substrate after 15 mins by liquid scintillation counting analysis				J Med Chem 58: 8616-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b01222 BindingDB Entry DOI: 10.7270/Q2GH9MZJ
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50499089 (CHEMBL3734795) Show SMILES Oc1ccc2cc(oc2c1)-c1ccc2cccc(O)c2n1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.86E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D using 3H-cAMP as substrate after 15 mins by liquid scintillation counting analysis				J Med Chem 58: 8616-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b01222 BindingDB Entry DOI: 10.7270/Q2GH9MZJ
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50499088 (CHEMBL3735005) Show SMILES Oc1cccc2cc(oc12)-c1ccc(O)c2ncccc12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D using 3H-cAMP as substrate after 15 mins by liquid scintillation counting analysis				J Med Chem 58: 8616-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b01222 BindingDB Entry DOI: 10.7270/Q2GH9MZJ
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM32188 (CLIOQUINOL \| Clioquinol (CQ) \| TG2-36-2 \| cid_2788) Show SMILES Oc1c(I)cc(Cl)c2cccnc12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D using 3H-cAMP as substrate after 15 mins by liquid scintillation counting analysis				J Med Chem 58: 8616-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b01222 BindingDB Entry DOI: 10.7270/Q2GH9MZJ
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50499082 (CHEMBL3736076) Show SMILES Oc1ccc(-c2cc3ccccc3o2)c2cccnc12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D using 3H-cAMP as substrate after 15 mins by liquid scintillation counting analysis				J Med Chem 58: 8616-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b01222 BindingDB Entry DOI: 10.7270/Q2GH9MZJ
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50499087 (CHEMBL3736261) Show SMILES Oc1ccc2cc(oc2c1)-c1ccc(O)c2ncccc12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D using 3H-cAMP as substrate after 15 mins by liquid scintillation counting analysis				J Med Chem 58: 8616-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b01222 BindingDB Entry DOI: 10.7270/Q2GH9MZJ
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%