Affinity Data by PubMed id=26617968

PubMed code 26617968

Found 4 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dihydrofolate reductase (Homo sapiens (Human))	BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Chemical Technology Curated by ChEMBL					Assay Description Inhibition of human DHFR using 45 uM DHF as substrate by spectrophotometry				ACS Med Chem Lett 6: 1140-4 (2015) Article DOI: 10.1021/acsmedchemlett.5b00367 BindingDB Entry DOI: 10.7270/Q25H7J3Z
Institute of Chemical Technology Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydrofolate reductase (Mycobacterium tuberculosis)	BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	8.30	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Chemical Technology Curated by ChEMBL					Assay Description Inhibition of recombinant Mycobacterium tuberculosis DHFR using 45 uM DHF as substrate by spectrophotometry				ACS Med Chem Lett 6: 1140-4 (2015) Article DOI: 10.1021/acsmedchemlett.5b00367 BindingDB Entry DOI: 10.7270/Q25H7J3Z
Institute of Chemical Technology Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydrofolate reductase (Mycobacterium tuberculosis)	BDBM50138163 (CHEMBL3752202) Show SMILES Cc1cccc(Oc2ccc(cc2)-c2nc(N)nc(N)n2)c1C Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.59E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Chemical Technology Curated by ChEMBL					Assay Description Inhibition of recombinant Mycobacterium tuberculosis DHFR using 45 uM DHF as substrate by spectrophotometry				ACS Med Chem Lett 6: 1140-4 (2015) Article DOI: 10.1021/acsmedchemlett.5b00367 BindingDB Entry DOI: 10.7270/Q25H7J3Z
Institute of Chemical Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50138163 (CHEMBL3752202) Show SMILES Cc1cccc(Oc2ccc(cc2)-c2nc(N)nc(N)n2)c1C Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Chemical Technology Curated by ChEMBL					Assay Description Inhibition of human DHFR using 45 uM DHF as substrate by spectrophotometry				ACS Med Chem Lett 6: 1140-4 (2015) Article DOI: 10.1021/acsmedchemlett.5b00367 BindingDB Entry DOI: 10.7270/Q25H7J3Z
Institute of Chemical Technology Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%