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PubMed code 26706114

Compile data set for download or QSAR
Found 19 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
CAAX prenyl protease 2


(Homo sapiens (Human))		BDBM50500099
PNG
(CHEMBL3741765)
Show SMILES OC(=O)c1ccc(NC(c2ccc3ccccc3c2O)c2c(F)cc(Br)cc2F)cc1
Show InChI InChI=1S/C24H16BrF2NO3/c25-15-11-19(26)21(20(27)12-15)22(28-16-8-5-14(6-9-16)24(30)31)18-10-7-13-3-1-2-4-17(13)23(18)29/h1-12,22,28-29H,(H,30,31)
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n/an/a 3.80E+3n/an/an/an/an/an/a



New York University Abu Dhabi

Curated by ChEMBL


Assay Description
Inhibition of human Rce1-mediated CaaX protease activity using ABZ-KSKTKC(farnesyl)QIIM and ABZ-KSKTKC(farnesyl)VIQI as substrate assessed as residua...

Bioorg Med Chem 24: 160-78 (2016)


Article DOI: 10.1016/j.bmc.2015.11.043
BindingDB Entry DOI: 10.7270/Q2NS0XXQ
More data for this
Ligand-Target Pair
CAAX prenyl protease 2


(Homo sapiens (Human))		BDBM50500092
PNG
(CHEMBL3741937)
Show SMILES OC(=O)c1ccc(NC(c2ccc(Br)cc2)c2ccc3ccccc3c2O)cc1
Show InChI InChI=1S/C24H18BrNO3/c25-18-10-5-16(6-11-18)22(26-19-12-7-17(8-13-19)24(28)29)21-14-9-15-3-1-2-4-20(15)23(21)27/h1-14,22,26-27H,(H,28,29)
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n/an/a 3.90E+3n/an/an/an/an/an/a



New York University Abu Dhabi

Curated by ChEMBL


Assay Description
Inhibition of human Rce1-mediated CaaX protease activity using ABZ-KSKTKC(farnesyl)QIIM and ABZ-KSKTKC(farnesyl)VIQI as substrate assessed as residua...

Bioorg Med Chem 24: 160-78 (2016)


Article DOI: 10.1016/j.bmc.2015.11.043
BindingDB Entry DOI: 10.7270/Q2NS0XXQ
More data for this
Ligand-Target Pair
CAAX prenyl protease 2


(Homo sapiens (Human))		BDBM50500097
PNG
(CHEMBL3740962)
Show SMILES OC(=O)c1ccc(NC(c2ccccc2)c2ccc3ccccc3c2O)cc1
Show InChI InChI=1S/C24H19NO3/c26-23-20-9-5-4-6-16(20)12-15-21(23)22(17-7-2-1-3-8-17)25-19-13-10-18(11-14-19)24(27)28/h1-15,22,25-26H,(H,27,28)
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n/an/a 4.20E+3n/an/an/an/an/an/a



New York University Abu Dhabi

Curated by ChEMBL


Assay Description
Inhibition of human Rce1-mediated CaaX protease activity using ABZ-KSKTKC(farnesyl)QIIM and ABZ-KSKTKC(farnesyl)VIQI as substrate assessed as residua...

Bioorg Med Chem 24: 160-78 (2016)


Article DOI: 10.1016/j.bmc.2015.11.043
BindingDB Entry DOI: 10.7270/Q2NS0XXQ
More data for this
Ligand-Target Pair
CAAX prenyl protease 2


(Homo sapiens (Human))		BDBM50500105
PNG
(CHEMBL3740249)
Show SMILES Oc1c(ccc2ccccc12)C(Nc1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H19NO/c25-23-20-14-8-7-9-17(20)15-16-21(23)22(18-10-3-1-4-11-18)24-19-12-5-2-6-13-19/h1-16,22,24-25H
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n/an/a 4.90E+3n/an/an/an/an/an/a



New York University Abu Dhabi

Curated by ChEMBL


Assay Description
Inhibition of human Rce1-mediated CaaX protease activity using ABZ-KSKTKC(farnesyl)QIIM and ABZ-KSKTKC(farnesyl)VIQI as substrate assessed as residua...

Bioorg Med Chem 24: 160-78 (2016)


Article DOI: 10.1016/j.bmc.2015.11.043
BindingDB Entry DOI: 10.7270/Q2NS0XXQ
More data for this
Ligand-Target Pair
CAAX prenyl protease 2


(Homo sapiens (Human))		BDBM50500103
PNG
(CHEMBL3742211)
Show SMILES CC(C)(C)c1ccc(NC(c2ccccc2)c2ccc3ccccc3c2O)cc1
Show InChI InChI=1S/C27H27NO/c1-27(2,3)21-14-16-22(17-15-21)28-25(20-10-5-4-6-11-20)24-18-13-19-9-7-8-12-23(19)26(24)29/h4-18,25,28-29H,1-3H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



New York University Abu Dhabi

Curated by ChEMBL


Assay Description
Inhibition of human Rce1-mediated CaaX protease activity using ABZ-KSKTKC(farnesyl)QIIM and ABZ-KSKTKC(farnesyl)VIQI as substrate assessed as residua...

Bioorg Med Chem 24: 160-78 (2016)


Article DOI: 10.1016/j.bmc.2015.11.043
BindingDB Entry DOI: 10.7270/Q2NS0XXQ
More data for this
Ligand-Target Pair
CAAX prenyl protease 2


(Homo sapiens (Human))		BDBM50500098
PNG
(CHEMBL3741101)
Show SMILES OC(=O)c1cccc(NC(c2ccccc2)c2ccc3ccccc3c2O)c1
Show InChI InChI=1S/C24H19NO3/c26-23-20-12-5-4-7-16(20)13-14-21(23)22(17-8-2-1-3-9-17)25-19-11-6-10-18(15-19)24(27)28/h1-15,22,25-26H,(H,27,28)
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n/an/a 5.30E+3n/an/an/an/an/an/a



New York University Abu Dhabi

Curated by ChEMBL


Assay Description
Inhibition of human Rce1-mediated CaaX protease activity using ABZ-KSKTKC(farnesyl)QIIM and ABZ-KSKTKC(farnesyl)VIQI as substrate assessed as residua...

Bioorg Med Chem 24: 160-78 (2016)


Article DOI: 10.1016/j.bmc.2015.11.043
BindingDB Entry DOI: 10.7270/Q2NS0XXQ
More data for this
Ligand-Target Pair
CAAX prenyl protease 2


(Homo sapiens (Human))		BDBM50500106
PNG
(CHEMBL3741673)
Show SMILES Oc1c(cc(Br)c2ccccc12)C(Nc1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H18BrNO/c24-21-15-20(23(26)19-14-8-7-13-18(19)21)22(16-9-3-1-4-10-16)25-17-11-5-2-6-12-17/h1-15,22,25-26H
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n/an/a 5.40E+3n/an/an/an/an/an/a



New York University Abu Dhabi

Curated by ChEMBL


Assay Description
Inhibition of human Rce1-mediated CaaX protease activity using ABZ-KSKTKC(farnesyl)QIIM and ABZ-KSKTKC(farnesyl)VIQI as substrate assessed as residua...

Bioorg Med Chem 24: 160-78 (2016)


Article DOI: 10.1016/j.bmc.2015.11.043
BindingDB Entry DOI: 10.7270/Q2NS0XXQ
More data for this
Ligand-Target Pair
CAAX prenyl protease 2


(Homo sapiens (Human))		BDBM50500094
PNG
(CHEMBL3740203)
Show SMILES OC(=O)c1ccc(NC(c2ccc(Br)cc2)c2ccc3cccnc3c2O)cc1
Show InChI InChI=1S/C23H17BrN2O3/c24-17-8-3-15(4-9-17)20(26-18-10-5-16(6-11-18)23(28)29)19-12-7-14-2-1-13-25-21(14)22(19)27/h1-13,20,26-27H,(H,28,29)
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n/an/a 6.70E+3n/an/an/an/an/an/a



New York University Abu Dhabi

Curated by ChEMBL


Assay Description
Inhibition of human Rce1-mediated CaaX protease activity using ABZ-KSKTKC(farnesyl)QIIM and ABZ-KSKTKC(farnesyl)VIQI as substrate assessed as residua...

Bioorg Med Chem 24: 160-78 (2016)


Article DOI: 10.1016/j.bmc.2015.11.043
BindingDB Entry DOI: 10.7270/Q2NS0XXQ
More data for this
Ligand-Target Pair
CAAX prenyl protease 2


(Homo sapiens (Human))		BDBM50500101
PNG
(CHEMBL1979298)
Show SMILES OC(=O)c1ccc(NC(c2ccccc2)c2ccc3cccnc3c2O)cc1
Show InChI InChI=1S/C23H18N2O3/c26-22-19(13-10-16-7-4-14-24-21(16)22)20(15-5-2-1-3-6-15)25-18-11-8-17(9-12-18)23(27)28/h1-14,20,25-26H,(H,27,28)
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n/an/a 6.90E+3n/an/an/an/an/an/a



New York University Abu Dhabi

Curated by ChEMBL


Assay Description
Inhibition of human Rce1-mediated CaaX protease activity using ABZ-KSKTKC(farnesyl)QIIM and ABZ-KSKTKC(farnesyl)VIQI as substrate assessed as residua...

Bioorg Med Chem 24: 160-78 (2016)


Article DOI: 10.1016/j.bmc.2015.11.043
BindingDB Entry DOI: 10.7270/Q2NS0XXQ
More data for this
Ligand-Target Pair
CAAX prenyl protease 2


(Homo sapiens (Human))		BDBM50500091
PNG
(CHEMBL3740563)
Show SMILES Cc1ccc(cc1)C(Nc1ccc(cc1)C(O)=O)c1ccc2cccnc2c1O
Show InChI InChI=1S/C24H20N2O3/c1-15-4-6-17(7-5-15)21(26-19-11-8-18(9-12-19)24(28)29)20-13-10-16-3-2-14-25-22(16)23(20)27/h2-14,21,26-27H,1H3,(H,28,29)
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n/an/a 7.10E+3n/an/an/an/an/an/a



New York University Abu Dhabi

Curated by ChEMBL


Assay Description
Inhibition of human Rce1-mediated CaaX protease activity using ABZ-KSKTKC(farnesyl)QIIM and ABZ-KSKTKC(farnesyl)VIQI as substrate assessed as residua...

Bioorg Med Chem 24: 160-78 (2016)


Article DOI: 10.1016/j.bmc.2015.11.043
BindingDB Entry DOI: 10.7270/Q2NS0XXQ
More data for this
Ligand-Target Pair
CAAX prenyl protease 2


(Homo sapiens (Human))		BDBM50500100
PNG
(CHEMBL3740034)
Show SMILES OC(=O)c1ccc(NC(c2ccc(F)cc2)c2ccc3cccnc3c2O)cc1
Show InChI InChI=1S/C23H17FN2O3/c24-17-8-3-15(4-9-17)20(26-18-10-5-16(6-11-18)23(28)29)19-12-7-14-2-1-13-25-21(14)22(19)27/h1-13,20,26-27H,(H,28,29)
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n/an/a 8.20E+3n/an/an/an/an/an/a



New York University Abu Dhabi

Curated by ChEMBL


Assay Description
Inhibition of human Rce1-mediated CaaX protease activity using ABZ-KSKTKC(farnesyl)QIIM and ABZ-KSKTKC(farnesyl)VIQI as substrate assessed as residua...

Bioorg Med Chem 24: 160-78 (2016)


Article DOI: 10.1016/j.bmc.2015.11.043
BindingDB Entry DOI: 10.7270/Q2NS0XXQ
More data for this
Ligand-Target Pair
CAAX prenyl protease 2


(Homo sapiens (Human))		BDBM50500095
PNG
(CHEMBL2003928)
Show SMILES Cc1ccc(NC(c2ccccc2)c2ccc3cccnc3c2O)cc1
Show InChI InChI=1S/C23H20N2O/c1-16-9-12-19(13-10-16)25-21(17-6-3-2-4-7-17)20-14-11-18-8-5-15-24-22(18)23(20)26/h2-15,21,25-26H,1H3
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n/an/a 8.80E+3n/an/an/an/an/an/a



New York University Abu Dhabi

Curated by ChEMBL


Assay Description
Inhibition of human Rce1-mediated CaaX protease activity using ABZ-KSKTKC(farnesyl)QIIM and ABZ-KSKTKC(farnesyl)VIQI as substrate assessed as residua...

Bioorg Med Chem 24: 160-78 (2016)


Article DOI: 10.1016/j.bmc.2015.11.043
BindingDB Entry DOI: 10.7270/Q2NS0XXQ
More data for this
Ligand-Target Pair
CAAX prenyl protease 2


(Homo sapiens (Human))		BDBM50500107
PNG
(CHEMBL3741464)
Show SMILES Oc1c(ccc2cccnc12)C(Nc1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H18N2O/c25-22-19(14-13-17-10-7-15-23-21(17)22)20(16-8-3-1-4-9-16)24-18-11-5-2-6-12-18/h1-15,20,24-25H
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n/an/a 8.90E+3n/an/an/an/an/an/a



New York University Abu Dhabi

Curated by ChEMBL


Assay Description
Inhibition of human Rce1-mediated CaaX protease activity using ABZ-KSKTKC(farnesyl)QIIM and ABZ-KSKTKC(farnesyl)VIQI as substrate assessed as residua...

Bioorg Med Chem 24: 160-78 (2016)


Article DOI: 10.1016/j.bmc.2015.11.043
BindingDB Entry DOI: 10.7270/Q2NS0XXQ
More data for this
Ligand-Target Pair
CAAX prenyl protease 2


(Homo sapiens (Human))		BDBM50500102
PNG
(CHEMBL3740606)
Show SMILES Oc1c(ccc2ccccc12)C(Nc1ccccc1)c1c(F)cc(Br)cc1F
Show InChI InChI=1S/C23H16BrF2NO/c24-15-12-19(25)21(20(26)13-15)22(27-16-7-2-1-3-8-16)18-11-10-14-6-4-5-9-17(14)23(18)28/h1-13,22,27-28H
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n/an/a 9.40E+3n/an/an/an/an/an/a



New York University Abu Dhabi

Curated by ChEMBL


Assay Description
Inhibition of human Rce1-mediated CaaX protease activity using ABZ-KSKTKC(farnesyl)QIIM and ABZ-KSKTKC(farnesyl)VIQI as substrate assessed as residua...

Bioorg Med Chem 24: 160-78 (2016)


Article DOI: 10.1016/j.bmc.2015.11.043
BindingDB Entry DOI: 10.7270/Q2NS0XXQ
More data for this
Ligand-Target Pair
CAAX prenyl protease 2


(Homo sapiens (Human))		BDBM50500109
PNG
(CHEMBL3740547)
Show SMILES OC(=O)c1ccc(NC(C2CCCCC2)c2ccc3cccnc3c2O)cc1
Show InChI InChI=1S/C23H24N2O3/c26-22-19(13-10-16-7-4-14-24-21(16)22)20(15-5-2-1-3-6-15)25-18-11-8-17(9-12-18)23(27)28/h4,7-15,20,25-26H,1-3,5-6H2,(H,27,28)
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n/an/a 9.80E+3n/an/an/an/an/an/a



New York University Abu Dhabi

Curated by ChEMBL


Assay Description
Inhibition of human Rce1-mediated CaaX protease activity using ABZ-KSKTKC(farnesyl)QIIM and ABZ-KSKTKC(farnesyl)VIQI as substrate assessed as residua...

Bioorg Med Chem 24: 160-78 (2016)


Article DOI: 10.1016/j.bmc.2015.11.043
BindingDB Entry DOI: 10.7270/Q2NS0XXQ
More data for this
Ligand-Target Pair
CAAX prenyl protease 2


(Homo sapiens (Human))		BDBM50500093
PNG
(CHEMBL2006267)
Show SMILES Oc1c(ccc2cccnc12)C(Nc1ccccc1)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C22H17N3O3/c26-22-19(13-10-15-5-4-14-23-21(15)22)20(24-17-6-2-1-3-7-17)16-8-11-18(12-9-16)25(27)28/h1-14,20,24,26H
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n/an/a 1.10E+4n/an/an/an/an/an/a



New York University Abu Dhabi

Curated by ChEMBL


Assay Description
Inhibition of human Rce1-mediated CaaX protease activity using ABZ-KSKTKC(farnesyl)QIIM and ABZ-KSKTKC(farnesyl)VIQI as substrate assessed as residua...

Bioorg Med Chem 24: 160-78 (2016)


Article DOI: 10.1016/j.bmc.2015.11.043
BindingDB Entry DOI: 10.7270/Q2NS0XXQ
More data for this
Ligand-Target Pair
CAAX prenyl protease 2


(Homo sapiens (Human))		BDBM50500096
PNG
(CHEMBL3739720)
Show SMILES OC(=O)c1ccc(NC(c2cccnc2)c2ccc3cccnc3c2O)cc1
Show InChI InChI=1S/C22H17N3O3/c26-21-18(10-7-14-3-2-12-24-20(14)21)19(16-4-1-11-23-13-16)25-17-8-5-15(6-9-17)22(27)28/h1-13,19,25-26H,(H,27,28)
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n/an/a 1.40E+4n/an/an/an/an/an/a



New York University Abu Dhabi

Curated by ChEMBL


Assay Description
Inhibition of human Rce1-mediated CaaX protease activity using ABZ-KSKTKC(farnesyl)QIIM and ABZ-KSKTKC(farnesyl)VIQI as substrate assessed as residua...

Bioorg Med Chem 24: 160-78 (2016)


Article DOI: 10.1016/j.bmc.2015.11.043
BindingDB Entry DOI: 10.7270/Q2NS0XXQ
More data for this
Ligand-Target Pair
CAAX prenyl protease 2


(Homo sapiens (Human))		BDBM50500108
PNG
(CHEMBL3740917)
Show SMILES OC(=O)c1ccc(NC(c2ccc(cc2)C#N)c2ccc3cccnc3c2O)cc1
Show InChI InChI=1S/C24H17N3O3/c25-14-15-3-5-17(6-4-15)21(27-19-10-7-18(8-11-19)24(29)30)20-12-9-16-2-1-13-26-22(16)23(20)28/h1-13,21,27-28H,(H,29,30)
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n/an/a 1.60E+4n/an/an/an/an/an/a



New York University Abu Dhabi

Curated by ChEMBL


Assay Description
Inhibition of human Rce1-mediated CaaX protease activity using ABZ-KSKTKC(farnesyl)QIIM and ABZ-KSKTKC(farnesyl)VIQI as substrate assessed as residua...

Bioorg Med Chem 24: 160-78 (2016)


Article DOI: 10.1016/j.bmc.2015.11.043
BindingDB Entry DOI: 10.7270/Q2NS0XXQ
More data for this
Ligand-Target Pair
CAAX prenyl protease 2


(Homo sapiens (Human))		BDBM50500104
PNG
(CHEMBL3739592)
Show SMILES OC(=O)c1ccc(NC(c2ccccn2)c2ccc3cccnc3c2O)cc1
Show InChI InChI=1S/C22H17N3O3/c26-21-17(11-8-14-4-3-13-24-19(14)21)20(18-5-1-2-12-23-18)25-16-9-6-15(7-10-16)22(27)28/h1-13,20,25-26H,(H,27,28)
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n/an/a 3.80E+4n/an/an/an/an/an/a



New York University Abu Dhabi

Curated by ChEMBL


Assay Description
Inhibition of human Rce1-mediated CaaX protease activity using ABZ-KSKTKC(farnesyl)QIIM and ABZ-KSKTKC(farnesyl)VIQI as substrate assessed as residua...

Bioorg Med Chem 24: 160-78 (2016)


Article DOI: 10.1016/j.bmc.2015.11.043
BindingDB Entry DOI: 10.7270/Q2NS0XXQ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%