| Reaction Details |
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 | Report a problem with these data |
| Target | CAAX prenyl protease 2 |
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| Ligand | BDBM50500104 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1541784 (CHEMBL3742598) |
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| IC50 | 38000±n/a nM |
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| Citation |  Mohammed, I; Hampton, SE; Ashall, L; Hildebrandt, ER; Kutlik, RA; Manandhar, SP; Floyd, BJ; Smith, HE; Dozier, JK; Distefano, MD; Schmidt, WK; Dore, TM 8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells. Bioorg Med Chem24:160-78 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| CAAX prenyl protease 2 |
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| Name: | CAAX prenyl protease 2 |
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| Synonyms: | CAAX prenyl protease 2 | FACE-2 | FACE2 | FACE2_HUMAN | Farnesylated proteins-converting enzyme 2 | Prenyl protein specific protease | Prenyl protein-specific endoprotease 2 | RCE1 | RCE1 homolog | RCE1A | RCE1B | hRCE1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35839.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_194935 |
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| Residue: | 329 |
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| Sequence: | MAALGGDGLRLLSVSRPERPPESAALGGLGPGLCCWVSVFSCLSLACSYVGSLYVWKSEL
PRDHPAVIKRRFTSVLVVSSLSPLCVLLWRELTGIQPGTSLLTLMGFRLEGIFPAALLPL
LLTMILFLGPLMQLSMDCPCDLADGLKVVLAPRSWARCLTDMRWLRNQVIAPLTEELVFR
ACMLPMLAPCMGLGPAVFTCPLFFGVAHFHHIIEQLRFRQSSVGNIFLSAAFQFSYTAVF
GAYTAFLFIRTGHLIGPVLCHSFCNYMGFPAVCAALEHPQRRPLLAGYALGVGLFLLLLQ
PLTDPKLYGSLPLCVLLERAGDSEAPLCS
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| BDBM50500104 |
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| n/a |
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| Name | BDBM50500104 |
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| Synonyms: | CHEMBL3739592 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H17N3O3 |
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| Mol. Mass. | 371.3887 |
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| SMILES | OC(=O)c1ccc(NC(c2ccccn2)c2ccc3cccnc3c2O)cc1 |
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| Structure | 
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