Found 22 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50139469
(CHEMBL3763335)Show SMILES [O-][N+](=O)c1ccc(Cn2cncc2CNc2scc(c2C#N)-c2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C22H16ClN5O2S/c23-17-5-3-16(4-6-17)21-13-31-22(20(21)9-24)26-11-19-10-25-14-27(19)12-15-1-7-18(8-2-15)28(29)30/h1-8,10,13-14,26H,11-12H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR2301
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay |
Eur J Med Chem 109: 173-86 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.045
BindingDB Entry DOI: 10.7270/Q25B04C6 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50139637
(CHEMBL3765675)Show SMILES CCOC(=O)c1sc(N(Cc2cncn2Cc2ccc(cc2)C#N)Cc2cncn2Cc2ccc(cc2)C#N)c(C#N)c1-c1ccc(Cl)cc1 Show InChI InChI=1S/C38H29ClN8O2S/c1-2-49-38(48)36-35(30-11-13-31(39)14-12-30)34(17-42)37(50-36)45(22-32-18-43-24-46(32)20-28-7-3-26(15-40)4-8-28)23-33-19-44-25-47(33)21-29-9-5-27(16-41)6-10-29/h3-14,18-19,24-25H,2,20-23H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR2301
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay |
Eur J Med Chem 109: 173-86 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.045
BindingDB Entry DOI: 10.7270/Q25B04C6 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50139457
(CHEMBL3765006)Show SMILES CCOC(=O)c1sc(NCc2cncn2Cc2ccc(cc2)C#N)c(C#N)c1-c1ccc(Cl)cc1 Show InChI InChI=1S/C26H20ClN5O2S/c1-2-34-26(33)24-23(19-7-9-20(27)10-8-19)22(12-29)25(35-24)31-14-21-13-30-16-32(21)15-18-5-3-17(11-28)4-6-18/h3-10,13,16,31H,2,14-15H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR2301
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay |
Eur J Med Chem 109: 173-86 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.045
BindingDB Entry DOI: 10.7270/Q25B04C6 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50139466
(CHEMBL3765154)Show SMILES COC(=O)[C@H](CCSC)NC(=O)c1sc(NCc2cncn2Cc2ccc(cc2)C#N)c(C#N)c1-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C30H27ClN6O3S2/c1-40-30(39)25(11-12-41-2)36-28(38)27-26(21-7-9-22(31)10-8-21)24(14-33)29(42-27)35-16-23-15-34-18-37(23)17-20-5-3-19(13-32)4-6-20/h3-10,15,18,25,35H,11-12,16-17H2,1-2H3,(H,36,38)/t25-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR2301
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay |
Eur J Med Chem 109: 173-86 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.045
BindingDB Entry DOI: 10.7270/Q25B04C6 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50139468
(CHEMBL3763857)Show SMILES CCOC(=O)c1sc(NCc2cncn2Cc2ccc(cc2)[N+]([O-])=O)c(C#N)c1-c1ccc(Cl)cc1 Show InChI InChI=1S/C25H20ClN5O4S/c1-2-35-25(32)23-22(17-5-7-18(26)8-6-17)21(11-27)24(36-23)29-13-20-12-28-15-30(20)14-16-3-9-19(10-4-16)31(33)34/h3-10,12,15,29H,2,13-14H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR2301
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay |
Eur J Med Chem 109: 173-86 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.045
BindingDB Entry DOI: 10.7270/Q25B04C6 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50139472
(CHEMBL3763746)Show SMILES CCOC(=O)c1sc(N(Cc2cncn2Cc2ccc(cc2)C#N)C(=O)OC(C)(C)C)c(C#N)c1-c1ccc(Cl)cc1 Show InChI InChI=1S/C31H28ClN5O4S/c1-5-40-29(38)27-26(22-10-12-23(32)13-11-22)25(15-34)28(42-27)37(30(39)41-31(2,3)4)18-24-16-35-19-36(24)17-21-8-6-20(14-33)7-9-21/h6-13,16,19H,5,17-18H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR2301
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay |
Eur J Med Chem 109: 173-86 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.045
BindingDB Entry DOI: 10.7270/Q25B04C6 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50139477
(CHEMBL3765776)Show SMILES CCOC(=O)c1sc(N(Cc2cn(Cc3ccc(cc3)C#N)cn2)C(=O)OC(C)(C)C)c(C#N)c1-c1ccc(Cl)cc1 Show InChI InChI=1S/C31H28ClN5O4S/c1-5-40-29(38)27-26(22-10-12-23(32)13-11-22)25(15-34)28(42-27)37(30(39)41-31(2,3)4)18-24-17-36(19-35-24)16-21-8-6-20(14-33)7-9-21/h6-13,17,19H,5,16,18H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR2301
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay |
Eur J Med Chem 109: 173-86 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.045
BindingDB Entry DOI: 10.7270/Q25B04C6 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50139458
(CHEMBL3764994)Show SMILES Clc1ccc(cc1)-c1csc(NCc2cncn2Cc2ccc(cc2)C#N)c1C#N Show InChI InChI=1S/C23H16ClN5S/c24-19-7-5-18(6-8-19)22-14-30-23(21(22)10-26)28-12-20-11-27-15-29(20)13-17-3-1-16(9-25)2-4-17/h1-8,11,14-15,28H,12-13H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR2301
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay |
Eur J Med Chem 109: 173-86 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.045
BindingDB Entry DOI: 10.7270/Q25B04C6 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50139478
(CHEMBL3764593)Show SMILES CC(C)(C)OC(=O)N(Cc1cn(Cc2ccc(cc2)C#N)cn1)c1sc(C(O)=O)c(c1C#N)-c1ccc(Cl)cc1 Show InChI InChI=1S/C29H24ClN5O4S/c1-29(2,3)39-28(38)35(16-22-15-34(17-33-22)14-19-6-4-18(12-31)5-7-19)26-23(13-32)24(25(40-26)27(36)37)20-8-10-21(30)11-9-20/h4-11,15,17H,14,16H2,1-3H3,(H,36,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR2301
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay |
Eur J Med Chem 109: 173-86 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.045
BindingDB Entry DOI: 10.7270/Q25B04C6 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50139473
(CHEMBL3763689)Show SMILES CC(C)(C)OC(=O)N(Cc1cncn1Cc1ccc(cc1)C#N)c1sc(C(O)=O)c(c1C#N)-c1ccc(Cl)cc1 Show InChI InChI=1S/C29H24ClN5O4S/c1-29(2,3)39-28(38)35(16-22-14-33-17-34(22)15-19-6-4-18(12-31)5-7-19)26-23(13-32)24(25(40-26)27(36)37)20-8-10-21(30)11-9-20/h4-11,14,17H,15-16H2,1-3H3,(H,36,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 640 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR2301
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay |
Eur J Med Chem 109: 173-86 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.045
BindingDB Entry DOI: 10.7270/Q25B04C6 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50139474
(CHEMBL3765605)Show SMILES COC(=O)[C@H](CCSC)NC(=O)c1sc(N(Cc2cncn2Cc2ccc(cc2)C#N)C(=O)OC(C)(C)C)c(C#N)c1-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C35H35ClN6O5S2/c1-35(2,3)47-34(45)42(20-26-18-39-21-41(26)19-23-8-6-22(16-37)7-9-23)32-27(17-38)29(24-10-12-25(36)13-11-24)30(49-32)31(43)40-28(14-15-48-5)33(44)46-4/h6-13,18,21,28H,14-15,19-20H2,1-5H3,(H,40,43)/t28-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 680 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR2301
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay |
Eur J Med Chem 109: 173-86 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.045
BindingDB Entry DOI: 10.7270/Q25B04C6 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50139638
(CHEMBL3763294)Show SMILES OC(=O)c1sc(N(Cc2cncn2Cc2ccc(cc2)C#N)Cc2cncn2Cc2ccc(cc2)C#N)c(C#N)c1-c1ccc(Cl)cc1 Show InChI InChI=1S/C36H25ClN8O2S/c37-29-11-9-28(10-12-29)33-32(15-40)35(48-34(33)36(46)47)43(20-30-16-41-22-44(30)18-26-5-1-24(13-38)2-6-26)21-31-17-42-23-45(31)19-27-7-3-25(14-39)4-8-27/h1-12,16-17,22-23H,18-21H2,(H,46,47) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 970 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR2301
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay |
Eur J Med Chem 109: 173-86 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.045
BindingDB Entry DOI: 10.7270/Q25B04C6 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50139476
(CHEMBL3765688)Show SMILES CC(C)(C)OC(=O)N(Cc1cncn1Cc1ccc(cc1)[N+]([O-])=O)c1sc(C(O)=O)c(c1C#N)-c1ccc(Cl)cc1 Show InChI InChI=1S/C28H24ClN5O6S/c1-28(2,3)40-27(37)33(15-21-13-31-16-32(21)14-17-4-10-20(11-5-17)34(38)39)25-22(12-30)23(24(41-25)26(35)36)18-6-8-19(29)9-7-18/h4-11,13,16H,14-15H2,1-3H3,(H,35,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 980 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR2301
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay |
Eur J Med Chem 109: 173-86 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.045
BindingDB Entry DOI: 10.7270/Q25B04C6 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50139643
(CHEMBL3765693)Show SMILES OC(=O)c1sc(N=[N+]=[N-])c(C#N)c1-c1ccc(Cl)cc1 Show InChI InChI=1S/C12H5ClN4O2S/c13-7-3-1-6(2-4-7)9-8(5-14)11(16-17-15)20-10(9)12(18)19/h1-4H,(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR2301
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay |
Eur J Med Chem 109: 173-86 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.045
BindingDB Entry DOI: 10.7270/Q25B04C6 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50139642
(CHEMBL3764832)Show SMILES CCOC(=O)c1sc(N=[N+]=[N-])c(C#N)c1-c1ccc(Cl)cc1 Show InChI InChI=1S/C14H9ClN4O2S/c1-2-21-14(20)12-11(8-3-5-9(15)6-4-8)10(7-16)13(22-12)18-19-17/h3-6H,2H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR2301
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay |
Eur J Med Chem 109: 173-86 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.045
BindingDB Entry DOI: 10.7270/Q25B04C6 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50139475
(CHEMBL3764732)Show SMILES CCOC(=O)c1sc(N(Cc2cncn2Cc2ccc(cc2)[N+]([O-])=O)C(=O)OC(C)(C)C)c(C#N)c1-c1ccc(Cl)cc1 Show InChI InChI=1S/C30H28ClN5O6S/c1-5-41-28(37)26-25(20-8-10-21(31)11-9-20)24(14-32)27(43-26)35(29(38)42-30(2,3)4)17-23-15-33-18-34(23)16-19-6-12-22(13-7-19)36(39)40/h6-13,15,18H,5,16-17H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR2301
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay |
Eur J Med Chem 109: 173-86 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.045
BindingDB Entry DOI: 10.7270/Q25B04C6 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50139467
(CHEMBL3763731)Show SMILES CSCC[C@H](NC(=O)c1sc(NCc2cncn2Cc2ccc(cc2)C#N)c(C#N)c1-c1ccc(Cl)cc1)C(O)=O |r| Show InChI InChI=1S/C29H25ClN6O3S2/c1-40-11-10-24(29(38)39)35-27(37)26-25(20-6-8-21(30)9-7-20)23(13-32)28(41-26)34-15-22-14-33-17-36(22)16-19-4-2-18(12-31)3-5-19/h2-9,14,17,24,34H,10-11,15-16H2,1H3,(H,35,37)(H,38,39)/t24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR2301
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay |
Eur J Med Chem 109: 173-86 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.045
BindingDB Entry DOI: 10.7270/Q25B04C6 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50139644
(CHEMBL3764316)Show SMILES COC(=O)[C@H](CCSC)NC(=O)c1sc(N=[N+]=[N-])c(C#N)c1-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C18H16ClN5O3S2/c1-27-18(26)13(7-8-28-2)22-16(25)15-14(10-3-5-11(19)6-4-10)12(9-20)17(29-15)23-24-21/h3-6,13H,7-8H2,1-2H3,(H,22,25)/t13-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR2301
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay |
Eur J Med Chem 109: 173-86 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.045
BindingDB Entry DOI: 10.7270/Q25B04C6 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50139471
(CHEMBL3763770)Show SMILES Clc1ccc(cc1)-c1csc(NCc2cn(Cc3ccc(cc3)C#N)cn2)c1C#N Show InChI InChI=1S/C23H16ClN5S/c24-19-7-5-18(6-8-19)22-14-30-23(21(22)10-26)27-11-20-13-29(15-28-20)12-17-3-1-16(9-25)2-4-17/h1-8,13-15,27H,11-12H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR2301
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay |
Eur J Med Chem 109: 173-86 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.045
BindingDB Entry DOI: 10.7270/Q25B04C6 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50139641
(CHEMBL3765464)Show SMILES OC(=O)c1sc(NC(=O)Cc2c[nH]cn2)c(C#N)c1-c1ccc(Cl)cc1 Show InChI InChI=1S/C17H11ClN4O3S/c18-10-3-1-9(2-4-10)14-12(6-19)16(26-15(14)17(24)25)22-13(23)5-11-7-20-8-21-11/h1-4,7-8H,5H2,(H,20,21)(H,22,23)(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR2301
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay |
Eur J Med Chem 109: 173-86 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.045
BindingDB Entry DOI: 10.7270/Q25B04C6 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50139470
(CHEMBL3765480)Show SMILES CCOC(=O)c1sc(NCc2cn(Cc3ccc(cc3)C#N)cn2)c(C#N)c1-c1ccc(Cl)cc1 Show InChI InChI=1S/C26H20ClN5O2S/c1-2-34-26(33)24-23(19-7-9-20(27)10-8-19)22(12-29)25(35-24)30-13-21-15-32(16-31-21)14-18-5-3-17(11-28)4-6-18/h3-10,15-16,30H,2,13-14H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR2301
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay |
Eur J Med Chem 109: 173-86 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.045
BindingDB Entry DOI: 10.7270/Q25B04C6 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50139639
(CHEMBL3764435)Show SMILES CCOC(=O)c1sc(NC(=O)Cc2c[nH]cn2)c(C#N)c1-c1ccc(Cl)cc1 Show InChI InChI=1S/C19H15ClN4O3S/c1-2-27-19(26)17-16(11-3-5-12(20)6-4-11)14(8-21)18(28-17)24-15(25)7-13-9-22-10-23-13/h3-6,9-10H,2,7H2,1H3,(H,22,23)(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR2301
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay |
Eur J Med Chem 109: 173-86 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.045
BindingDB Entry DOI: 10.7270/Q25B04C6 |
More data for this
Ligand-Target Pair | |
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