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PubMed code 26927866

Compile Data Set for Download or QSAR

Found 250 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533361
PNG
(CHEMBL4451895)
Show SMILES COc1ccc(cc1)-c1cccc(Nc2cc(=O)n(O)c(=O)[nH]2)c1
Show InChI InChI=1S/C17H15N3O4/c1-24-14-7-5-11(6-8-14)12-3-2-4-13(9-12)18-15-10-16(21)20(23)17(22)19-15/h2-10,18,23H,1H3,(H,19,22)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of re-constituted HIV1 reverse transcriptase RNase H domain fragment

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533382
PNG
(CHEMBL4531566)
Show SMILES On1c(=O)cc(Nc2cccc(c2)-c2ccc(F)cc2)[nH]c1=O
Show InChI InChI=1S/C16H12FN3O3/c17-12-6-4-10(5-7-12)11-2-1-3-13(8-11)18-14-9-15(21)20(23)16(22)19-14/h1-9,18,23H,(H,19,22)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 150n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of re-constituted HIV1 reverse transcriptase RNase H domain fragment

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50468819
PNG
(CHEMBL4281296)
Show SMILES On1c(=O)cc(Nc2ccc(cc2)-c2ccccc2)[nH]c1=O
Show InChI InChI=1S/C16H13N3O3/c20-15-10-14(18-16(21)19(15)22)17-13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-10,17,22H,(H,18,21)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 150n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of re-constituted HIV1 reverse transcriptase RNase H domain fragment

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50468792
PNG
(CHEMBL4280869)
Show SMILES COc1cccc(c1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1
Show InChI InChI=1S/C17H15N3O4/c1-24-14-4-2-3-12(9-14)11-5-7-13(8-6-11)18-15-10-16(21)20(23)17(22)19-15/h2-10,18,23H,1H3,(H,19,22)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 150n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533405
PNG
(CHEMBL4550191)
Show SMILES Oc1ccc(cc1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1
Show InChI InChI=1S/C16H13N3O4/c20-13-7-3-11(4-8-13)10-1-5-12(6-2-10)17-14-9-15(21)19(23)16(22)18-14/h1-9,17,20,23H,(H,18,22)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 180n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533385
PNG
(CHEMBL4474029)
Show SMILES COc1cc(OC)cc(c1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1
Show InChI InChI=1S/C18H17N3O5/c1-25-14-7-12(8-15(9-14)26-2)11-3-5-13(6-4-11)19-16-10-17(22)21(24)18(23)20-16/h3-10,19,24H,1-2H3,(H,20,23)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 190n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533382
PNG
(CHEMBL4531566)
Show SMILES On1c(=O)cc(Nc2cccc(c2)-c2ccc(F)cc2)[nH]c1=O
Show InChI InChI=1S/C16H12FN3O3/c17-12-6-4-10(5-7-12)11-2-1-3-13(8-11)18-14-9-15(21)20(23)16(22)19-14/h1-9,18,23H,(H,19,22)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 200n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533361
PNG
(CHEMBL4451895)
Show SMILES COc1ccc(cc1)-c1cccc(Nc2cc(=O)n(O)c(=O)[nH]2)c1
Show InChI InChI=1S/C17H15N3O4/c1-24-14-7-5-11(6-8-14)12-3-2-4-13(9-12)18-15-10-16(21)20(23)17(22)19-15/h2-10,18,23H,1H3,(H,19,22)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 200n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50468792
PNG
(CHEMBL4280869)
Show SMILES COc1cccc(c1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1
Show InChI InChI=1S/C17H15N3O4/c1-24-14-4-2-3-12(9-14)11-5-7-13(8-6-11)18-15-10-16(21)20(23)17(22)19-15/h2-10,18,23H,1H3,(H,19,22)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 200n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of re-constituted HIV1 reverse transcriptase RNase H domain fragment

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50468846
PNG
(CHEMBL4291913)
Show SMILES On1c(=O)cc(Nc2cccc(c2)-c2ccc(Cl)cc2)[nH]c1=O
Show InChI InChI=1S/C16H12ClN3O3/c17-12-6-4-10(5-7-12)11-2-1-3-13(8-11)18-14-9-15(21)20(23)16(22)19-14/h1-9,18,23H,(H,19,22)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 220n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533367
PNG
(CHEMBL4461191)
Show SMILES Oc1cccc(c1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1
Show InChI InChI=1S/C16H13N3O4/c20-13-3-1-2-11(8-13)10-4-6-12(7-5-10)17-14-9-15(21)19(23)16(22)18-14/h1-9,17,20,23H,(H,18,22)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 220n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533386
PNG
(CHEMBL4466368)
Show SMILES Oc1ccccc1-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1
Show InChI InChI=1S/C16H13N3O4/c20-13-4-2-1-3-12(13)10-5-7-11(8-6-10)17-14-9-15(21)19(23)16(22)18-14/h1-9,17,20,23H,(H,18,22)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 240n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50468819
PNG
(CHEMBL4281296)
Show SMILES On1c(=O)cc(Nc2ccc(cc2)-c2ccccc2)[nH]c1=O
Show InChI InChI=1S/C16H13N3O3/c20-15-10-14(18-16(21)19(15)22)17-13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-10,17,22H,(H,18,21)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 250n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533385
PNG
(CHEMBL4474029)
Show SMILES COc1cc(OC)cc(c1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1
Show InChI InChI=1S/C18H17N3O5/c1-25-14-7-12(8-15(9-14)26-2)11-3-5-13(6-4-11)19-16-10-17(22)21(24)18(23)20-16/h3-10,19,24H,1-2H3,(H,20,23)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 250n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in RNA 5'-end directed cleavage using HTS3...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50468792
PNG
(CHEMBL4280869)
Show SMILES COc1cccc(c1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1
Show InChI InChI=1S/C17H15N3O4/c1-24-14-4-2-3-12(9-14)11-5-7-13(8-6-11)18-15-10-16(21)20(23)17(22)19-15/h2-10,18,23H,1H3,(H,19,22)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 250n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in DNA 3'-end cleavage using HTS2 substrat...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50468792
PNG
(CHEMBL4280869)
Show SMILES COc1cccc(c1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1
Show InChI InChI=1S/C17H15N3O4/c1-24-14-4-2-3-12(9-14)11-5-7-13(8-6-11)18-15-10-16(21)20(23)17(22)19-15/h2-10,18,23H,1H3,(H,19,22)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 250n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in RNA 5'-end directed cleavage using HTS3...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50468819
PNG
(CHEMBL4281296)
Show SMILES On1c(=O)cc(Nc2ccc(cc2)-c2ccccc2)[nH]c1=O
Show InChI InChI=1S/C16H13N3O3/c20-15-10-14(18-16(21)19(15)22)17-13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-10,17,22H,(H,18,21)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 300n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in DNA 3'-end cleavage using HTS2 substrat...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533382
PNG
(CHEMBL4531566)
Show SMILES On1c(=O)cc(Nc2cccc(c2)-c2ccc(F)cc2)[nH]c1=O
Show InChI InChI=1S/C16H12FN3O3/c17-12-6-4-10(5-7-12)11-2-1-3-13(8-11)18-14-9-15(21)20(23)16(22)19-14/h1-9,18,23H,(H,19,22)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 300n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in DNA 3'-end cleavage using HTS2 substrat...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533382
PNG
(CHEMBL4531566)
Show SMILES On1c(=O)cc(Nc2cccc(c2)-c2ccc(F)cc2)[nH]c1=O
Show InChI InChI=1S/C16H12FN3O3/c17-12-6-4-10(5-7-12)11-2-1-3-13(8-11)18-14-9-15(21)20(23)16(22)19-14/h1-9,18,23H,(H,19,22)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 300n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in RNA 5'-end directed cleavage using HTS3...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50468819
PNG
(CHEMBL4281296)
Show SMILES On1c(=O)cc(Nc2ccc(cc2)-c2ccccc2)[nH]c1=O
Show InChI InChI=1S/C16H13N3O3/c20-15-10-14(18-16(21)19(15)22)17-13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-10,17,22H,(H,18,21)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 300n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in RNA 5'-end directed cleavage using HTS3...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533361
PNG
(CHEMBL4451895)
Show SMILES COc1ccc(cc1)-c1cccc(Nc2cc(=O)n(O)c(=O)[nH]2)c1
Show InChI InChI=1S/C17H15N3O4/c1-24-14-7-5-11(6-8-14)12-3-2-4-13(9-12)18-15-10-16(21)20(23)17(22)19-15/h2-10,18,23H,1H3,(H,19,22)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 300n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in DNA 3'-end cleavage using HTS2 substrat...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533377
PNG
(CHEMBL4475877)
Show SMILES COc1ccc(c(OC)c1)-c1cccc(Nc2cc(=O)n(O)c(=O)[nH]2)c1
Show InChI InChI=1S/C18H17N3O5/c1-25-13-6-7-14(15(9-13)26-2)11-4-3-5-12(8-11)19-16-10-17(22)21(24)18(23)20-16/h3-10,19,24H,1-2H3,(H,20,23)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 310n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533385
PNG
(CHEMBL4474029)
Show SMILES COc1cc(OC)cc(c1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1
Show InChI InChI=1S/C18H17N3O5/c1-25-14-7-12(8-15(9-14)26-2)11-3-5-13(6-4-11)19-16-10-17(22)21(24)18(23)20-16/h3-10,19,24H,1-2H3,(H,20,23)
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n/an/a 320n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in DNA 3'-end cleavage using HTS2 substrat...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50533385
PNG
(CHEMBL4474029)
Show SMILES COc1cc(OC)cc(c1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1
Show InChI InChI=1S/C18H17N3O5/c1-25-14-7-12(8-15(9-14)26-2)11-3-5-13(6-4-11)19-16-10-17(22)21(24)18(23)20-16/h3-10,19,24H,1-2H3,(H,20,23)
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n/an/a 340n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of polymerase activity of HIV1 reverse transcriptase using poly(rA)-oligo(dT)16 and [3H]-TTP incubated for 20 mins by liquid scintillation...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50468846
PNG
(CHEMBL4291913)
Show SMILES On1c(=O)cc(Nc2cccc(c2)-c2ccc(Cl)cc2)[nH]c1=O
Show InChI InChI=1S/C16H12ClN3O3/c17-12-6-4-10(5-7-12)11-2-1-3-13(8-11)18-14-9-15(21)20(23)16(22)19-14/h1-9,18,23H,(H,19,22)
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n/an/a 370n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in RNA 5'-end directed cleavage using HTS3...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533405
PNG
(CHEMBL4550191)
Show SMILES Oc1ccc(cc1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1
Show InChI InChI=1S/C16H13N3O4/c20-13-7-3-11(4-8-13)10-1-5-12(6-2-10)17-14-9-15(21)19(23)16(22)18-14/h1-9,17,20,23H,(H,18,22)
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n/an/a 370n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in RNA 5'-end directed cleavage using HTS3...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533376
PNG
(CHEMBL4453169)
Show SMILES Cc1ccc(cc1)-c1cccc(Nc2cc(=O)n(O)c(=O)[nH]2)c1
Show InChI InChI=1S/C17H15N3O3/c1-11-5-7-12(8-6-11)13-3-2-4-14(9-13)18-15-10-16(21)20(23)17(22)19-15/h2-10,18,23H,1H3,(H,19,22)
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n/an/a 380n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533353
PNG
(CHEMBL4549947)
Show SMILES Cc1ccc(cc1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1
Show InChI InChI=1S/C17H15N3O3/c1-11-2-4-12(5-3-11)13-6-8-14(9-7-13)18-15-10-16(21)20(23)17(22)19-15/h2-10,18,23H,1H3,(H,19,22)
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n/an/a 400n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of re-constituted HIV1 reverse transcriptase RNase H domain fragment

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533392
PNG
(CHEMBL4529253)
Show SMILES COc1ccc(cc1)-c1cccc(Oc2cc(=O)n(O)c(=O)n2C)c1
Show InChI InChI=1S/C18H16N2O5/c1-19-17(11-16(21)20(23)18(19)22)25-15-5-3-4-13(10-15)12-6-8-14(24-2)9-7-12/h3-11,23H,1-2H3
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n/an/a 400n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533361
PNG
(CHEMBL4451895)
Show SMILES COc1ccc(cc1)-c1cccc(Nc2cc(=O)n(O)c(=O)[nH]2)c1
Show InChI InChI=1S/C17H15N3O4/c1-24-14-7-5-11(6-8-14)12-3-2-4-13(9-12)18-15-10-16(21)20(23)17(22)19-15/h2-10,18,23H,1H3,(H,19,22)
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n/an/a 400n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in RNA 5'-end directed cleavage using HTS3...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM23399
PNG
(4-{1-[(4-fluorophenyl)methyl]-1H-pyrrol-2-yl}-2,4-...)
Show SMILES OC(=O)C(=O)CC(=O)c1cccn1Cc1ccc(F)cc1
Show InChI InChI=1S/C15H12FNO4/c16-11-5-3-10(4-6-11)9-17-7-1-2-12(17)13(18)8-14(19)15(20)21/h1-7H,8-9H2,(H,20,21)
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n/an/a 400n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of HIV integrase pre-incubated for 10 mins before addition of oligo-5'-biotin ATGTGGAAAATCTCTAGCA annealed with ACTGCTAGAGATTTTCCACAT 3'-C...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533353
PNG
(CHEMBL4549947)
Show SMILES Cc1ccc(cc1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1
Show InChI InChI=1S/C17H15N3O3/c1-11-2-4-12(5-3-11)13-6-8-14(9-7-13)18-15-10-16(21)20(23)17(22)19-15/h2-10,18,23H,1H3,(H,19,22)
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n/an/a 400n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533367
PNG
(CHEMBL4461191)
Show SMILES Oc1cccc(c1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1
Show InChI InChI=1S/C16H13N3O4/c20-13-3-1-2-11(8-13)10-4-6-12(7-5-10)17-14-9-15(21)19(23)16(22)18-14/h1-9,17,20,23H,(H,18,22)
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n/an/a 400n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in RNA 5'-end directed cleavage using HTS3...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533367
PNG
(CHEMBL4461191)
Show SMILES Oc1cccc(c1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1
Show InChI InChI=1S/C16H13N3O4/c20-13-3-1-2-11(8-13)10-4-6-12(7-5-10)17-14-9-15(21)19(23)16(22)18-14/h1-9,17,20,23H,(H,18,22)
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n/an/a 430n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in DNA 3'-end cleavage using HTS2 substrat...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533376
PNG
(CHEMBL4453169)
Show SMILES Cc1ccc(cc1)-c1cccc(Nc2cc(=O)n(O)c(=O)[nH]2)c1
Show InChI InChI=1S/C17H15N3O3/c1-11-5-7-12(8-6-11)13-3-2-4-14(9-13)18-15-10-16(21)20(23)17(22)19-15/h2-10,18,23H,1H3,(H,19,22)
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n/an/a 440n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in RNA 5'-end directed cleavage using HTS3...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533405
PNG
(CHEMBL4550191)
Show SMILES Oc1ccc(cc1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1
Show InChI InChI=1S/C16H13N3O4/c20-13-7-3-11(4-8-13)10-1-5-12(6-2-10)17-14-9-15(21)19(23)16(22)18-14/h1-9,17,20,23H,(H,18,22)
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n/an/a 450n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in DNA 3'-end cleavage using HTS2 substrat...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533376
PNG
(CHEMBL4453169)
Show SMILES Cc1ccc(cc1)-c1cccc(Nc2cc(=O)n(O)c(=O)[nH]2)c1
Show InChI InChI=1S/C17H15N3O3/c1-11-5-7-12(8-6-11)13-3-2-4-14(9-13)18-15-10-16(21)20(23)17(22)19-15/h2-10,18,23H,1H3,(H,19,22)
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n/an/a 450n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in DNA 3'-end cleavage using HTS2 substrat...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50468846
PNG
(CHEMBL4291913)
Show SMILES On1c(=O)cc(Nc2cccc(c2)-c2ccc(Cl)cc2)[nH]c1=O
Show InChI InChI=1S/C16H12ClN3O3/c17-12-6-4-10(5-7-12)11-2-1-3-13(8-11)18-14-9-15(21)20(23)16(22)19-14/h1-9,18,23H,(H,19,22)
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n/an/a 450n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in DNA 3'-end cleavage using HTS2 substrat...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533386
PNG
(CHEMBL4466368)
Show SMILES Oc1ccccc1-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1
Show InChI InChI=1S/C16H13N3O4/c20-13-4-2-1-3-12(13)10-5-7-11(8-6-10)17-14-9-15(21)19(23)16(22)18-14/h1-9,17,20,23H,(H,18,22)
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n/an/a 460n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in RNA 5'-end directed cleavage using HTS3...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533354
PNG
(CHEMBL4455962)
Show SMILES On1c(=O)cc(Nc2ccc(cc2)-c2ccc(Cl)cc2)[nH]c1=O
Show InChI InChI=1S/C16H12ClN3O3/c17-12-5-1-10(2-6-12)11-3-7-13(8-4-11)18-14-9-15(21)20(23)16(22)19-14/h1-9,18,23H,(H,19,22)
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n/an/a 470n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533372
PNG
(CHEMBL4454510)
Show SMILES COc1cccc(OC)c1-c1cccc(Nc2cc(=O)n(O)c(=O)[nH]2)c1
Show InChI InChI=1S/C18H17N3O5/c1-25-13-7-4-8-14(26-2)17(13)11-5-3-6-12(9-11)19-15-10-16(22)21(24)18(23)20-15/h3-10,19,24H,1-2H3,(H,20,23)
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n/an/a 470n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in RNA 5'-end directed cleavage using HTS3...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533386
PNG
(CHEMBL4466368)
Show SMILES Oc1ccccc1-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1
Show InChI InChI=1S/C16H13N3O4/c20-13-4-2-1-3-12(13)10-5-7-11(8-6-10)17-14-9-15(21)19(23)16(22)18-14/h1-9,17,20,23H,(H,18,22)
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n/an/a 490n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in DNA 3'-end cleavage using HTS2 substrat...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533353
PNG
(CHEMBL4549947)
Show SMILES Cc1ccc(cc1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1
Show InChI InChI=1S/C17H15N3O3/c1-11-2-4-12(5-3-11)13-6-8-14(9-7-13)18-15-10-16(21)20(23)17(22)19-15/h2-10,18,23H,1H3,(H,19,22)
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n/an/a 500n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in RNA 5'-end directed cleavage using HTS3...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533403
PNG
(CHEMBL4563882)
Show SMILES COc1ccc(cc1OC)-c1cccc(Nc2cc(=O)n(O)c(=O)n2C)c1
Show InChI InChI=1S/C19H19N3O5/c1-21-17(11-18(23)22(25)19(21)24)20-14-6-4-5-12(9-14)13-7-8-15(26-2)16(10-13)27-3/h4-11,20,25H,1-3H3
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 500n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533359
PNG
(CHEMBL4472917)
Show SMILES COc1ccc(cc1)-c1cccc(Nc2cc(=O)n(O)c(=O)n2C)c1
Show InChI InChI=1S/C18H17N3O4/c1-20-16(11-17(22)21(24)18(20)23)19-14-5-3-4-13(10-14)12-6-8-15(25-2)9-7-12/h3-11,19,24H,1-2H3
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 500n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533372
PNG
(CHEMBL4454510)
Show SMILES COc1cccc(OC)c1-c1cccc(Nc2cc(=O)n(O)c(=O)[nH]2)c1
Show InChI InChI=1S/C18H17N3O5/c1-25-13-7-4-8-14(26-2)17(13)11-5-3-6-12(9-11)19-15-10-16(22)21(24)18(23)20-15/h3-10,19,24H,1-2H3,(H,20,23)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 510n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533377
PNG
(CHEMBL4475877)
Show SMILES COc1ccc(c(OC)c1)-c1cccc(Nc2cc(=O)n(O)c(=O)[nH]2)c1
Show InChI InChI=1S/C18H17N3O5/c1-25-13-6-7-14(15(9-13)26-2)11-4-3-5-12(8-11)19-16-10-17(22)21(24)18(23)20-16/h3-10,19,24H,1-2H3,(H,20,23)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 540n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in DNA 3'-end cleavage using HTS2 substrat...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533406
PNG
(CHEMBL4471489)
Show SMILES COc1cccc(c1)-c1cccc(Nc2cc(=O)n(O)c(=O)n2C)c1
Show InChI InChI=1S/C18H17N3O4/c1-20-16(11-17(22)21(24)18(20)23)19-14-7-3-5-12(9-14)13-6-4-8-15(10-13)25-2/h3-11,19,24H,1-2H3
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 600n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533354
PNG
(CHEMBL4455962)
Show SMILES On1c(=O)cc(Nc2ccc(cc2)-c2ccc(Cl)cc2)[nH]c1=O
Show InChI InChI=1S/C16H12ClN3O3/c17-12-5-1-10(2-6-12)11-3-7-13(8-4-11)18-14-9-15(21)20(23)16(22)19-14/h1-9,18,23H,(H,19,22)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 600n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in RNA 5'-end directed cleavage using HTS3...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50533352
PNG
(CHEMBL4530415)
Show SMILES COc1cc(OC)cc(c1)-c1cccc(Nc2cc(=O)n(O)c(=O)n2C)c1
Show InChI InChI=1S/C19H19N3O5/c1-21-17(11-18(23)22(25)19(21)24)20-14-6-4-5-12(7-14)13-8-15(26-2)10-16(9-13)27-3/h4-11,20,25H,1-3H3
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 600n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS...

J Med Chem 59: 2648-59 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01879
BindingDB Entry DOI: 10.7270/Q2QN6B8P
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%