Found 54 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50169690
(CHEMBL3806137)Show SMILES [H][C@@]12CC[C@@]([H])(CN1C(=O)c1ccon1)N(C2)c1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1 |r| Show InChI InChI=1S/C22H28N6O3/c1-22(2,3)13-28-17-7-8-18(23-19(17)25(4)21(28)30)26-11-15-6-5-14(26)12-27(15)20(29)16-9-10-31-24-16/h7-10,14-15H,5-6,11-13H2,1-4H3/t14-,15-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 540 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Time dependent inhibition of CYP3A4 in human liver microsomes |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50169621
(CHEMBL3806176)Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)N1CCCc2ccccc12 Show InChI InChI=1S/C21H26N4O/c1-21(2,3)14-25-17-11-12-18(22-19(17)23(4)20(25)26)24-13-7-9-15-8-5-6-10-16(15)24/h5-6,8,10-12H,7,9,13-14H2,1-4H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu5 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50169690
(CHEMBL3806137)Show SMILES [H][C@@]12CC[C@@]([H])(CN1C(=O)c1ccon1)N(C2)c1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1 |r| Show InChI InChI=1S/C22H28N6O3/c1-22(2,3)13-28-17-7-8-18(23-19(17)25(4)21(28)30)26-11-15-6-5-14(26)12-27(15)20(29)16-9-10-31-24-16/h7-10,14-15H,5-6,11-13H2,1-4H3/t14-,15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 75 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of rat mGlu2 receptor assessed as potentiation of glutamate-induced effect by Fluo-4AM staining-based FLIPR assay |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50169689
(CHEMBL3805203)Show SMILES [H][C@@]12CC[C@@]([H])(CN1C(=O)c1csnn1)N(C2)c1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1 |r| Show InChI InChI=1S/C21H27N7O2S/c1-21(2,3)12-28-16-7-8-17(22-18(16)25(4)20(28)30)26-9-14-6-5-13(26)10-27(14)19(29)15-11-31-24-23-15/h7-8,11,13-14H,5-6,9-10,12H2,1-4H3/t13-,14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 637 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Agonist activity at recombinant human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect preincubated for 5 m... |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Homo sapiens (Human)) | BDBM50169619
(CHEMBL3804910)Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)N1CC2CCC1CN2C(=O)OC(C)(C)C Show InChI InChI=1S/C23H35N5O3/c1-22(2,3)14-28-17-10-11-18(24-19(17)25(7)20(28)29)26-12-16-9-8-15(26)13-27(16)21(30)31-23(4,5)6/h10-11,15-16H,8-9,12-14H2,1-7H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu3 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Homo sapiens (Human)) | BDBM50169693
(CHEMBL3805139)Show SMILES [H][C@@]12CC[C@@]([H])(C=C1c1ccc3n(CC(C)(C)C)c(=O)n(C)c3n1)N(C2)C(=O)c1ccon1 |r,c:6| Show InChI InChI=1S/C23H27N5O3/c1-23(2,3)13-28-19-8-7-17(24-20(19)26(4)22(28)30)16-11-15-6-5-14(16)12-27(15)21(29)18-9-10-31-25-18/h7-11,14-15H,5-6,12-13H2,1-4H3/t14-,15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu3 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 4
(Homo sapiens (Human)) | BDBM50169693
(CHEMBL3805139)Show SMILES [H][C@@]12CC[C@@]([H])(C=C1c1ccc3n(CC(C)(C)C)c(=O)n(C)c3n1)N(C2)C(=O)c1ccon1 |r,c:6| Show InChI InChI=1S/C23H27N5O3/c1-23(2,3)13-28-19-8-7-17(24-20(19)26(4)22(28)30)16-11-15-6-5-14(16)12-27(15)21(29)18-9-10-31-25-18/h7-11,14-15H,5-6,12-13H2,1-4H3/t14-,15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu4 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50169618
(CHEMBL3806226)Show InChI InChI=1S/C18H27N5O/c1-18(2,3)11-23-14-7-8-15(20-16(14)21(4)17(23)24)22-10-12-5-6-13(22)9-19-12/h7-8,12-13,19H,5-6,9-11H2,1-4H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu5 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 6
(Homo sapiens (Human)) | BDBM50169693
(CHEMBL3805139)Show SMILES [H][C@@]12CC[C@@]([H])(C=C1c1ccc3n(CC(C)(C)C)c(=O)n(C)c3n1)N(C2)C(=O)c1ccon1 |r,c:6| Show InChI InChI=1S/C23H27N5O3/c1-23(2,3)13-28-19-8-7-17(24-20(19)26(4)22(28)30)16-11-15-6-5-14(16)12-27(15)21(29)18-9-10-31-25-18/h7-11,14-15H,5-6,12-13H2,1-4H3/t14-,15-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu6 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50169620
(CHEMBL3804903)Show InChI InChI=1S/C17H26N4O/c1-17(2,3)12-21-13-8-9-14(20-10-6-5-7-11-20)18-15(13)19(4)16(21)22/h8-9H,5-7,10-12H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 430 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect preinc... |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50169622
(CHEMBL3805883)Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)N1CCCC2CCCCC12 Show InChI InChI=1S/C21H32N4O/c1-21(2,3)14-25-17-11-12-18(22-19(17)23(4)20(25)26)24-13-7-9-15-8-5-6-10-16(15)24/h11-12,15-16H,5-10,13-14H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect preinc... |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50169690
(CHEMBL3806137)Show SMILES [H][C@@]12CC[C@@]([H])(CN1C(=O)c1ccon1)N(C2)c1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1 |r| Show InChI InChI=1S/C22H28N6O3/c1-22(2,3)13-28-17-7-8-18(23-19(17)25(4)21(28)30)26-11-15-6-5-14(26)12-27(15)20(29)16-9-10-31-24-16/h7-10,14-15H,5-6,11-13H2,1-4H3/t14-,15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 668 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Agonist activity at recombinant human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect preincubated for 5 m... |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Homo sapiens (Human)) | BDBM50169621
(CHEMBL3806176)Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)N1CCCc2ccccc12 Show InChI InChI=1S/C21H26N4O/c1-21(2,3)14-25-17-11-12-18(22-19(17)23(4)20(25)26)24-13-7-9-15-8-5-6-10-16(15)24/h5-6,8,10-12H,7,9,13-14H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu3 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 4
(Homo sapiens (Human)) | BDBM50169619
(CHEMBL3804910)Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)N1CC2CCC1CN2C(=O)OC(C)(C)C Show InChI InChI=1S/C23H35N5O3/c1-22(2,3)14-28-17-10-11-18(24-19(17)25(7)20(28)29)26-12-16-9-8-15(26)13-27(16)21(30)31-23(4,5)6/h10-11,15-16H,8-9,12-14H2,1-7H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu4 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 6
(Homo sapiens (Human)) | BDBM50169690
(CHEMBL3806137)Show SMILES [H][C@@]12CC[C@@]([H])(CN1C(=O)c1ccon1)N(C2)c1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1 |r| Show InChI InChI=1S/C22H28N6O3/c1-22(2,3)13-28-17-7-8-18(23-19(17)25(4)21(28)30)26-11-15-6-5-14(26)12-27(15)20(29)16-9-10-31-24-16/h7-10,14-15H,5-6,11-13H2,1-4H3/t14-,15-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu6 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50169621
(CHEMBL3806176)Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)N1CCCc2ccccc12 Show InChI InChI=1S/C21H26N4O/c1-21(2,3)14-25-17-11-12-18(22-19(17)23(4)20(25)26)24-13-7-9-15-8-5-6-10-16(15)24/h5-6,8,10-12H,7,9,13-14H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 332 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect preinc... |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Homo sapiens (Human)) | BDBM50169620
(CHEMBL3804903)Show InChI InChI=1S/C17H26N4O/c1-17(2,3)12-21-13-8-9-14(20-10-6-5-7-11-20)18-15(13)19(4)16(21)22/h8-9H,5-7,10-12H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu3 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Homo sapiens (Human)) | BDBM50169690
(CHEMBL3806137)Show SMILES [H][C@@]12CC[C@@]([H])(CN1C(=O)c1ccon1)N(C2)c1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1 |r| Show InChI InChI=1S/C22H28N6O3/c1-22(2,3)13-28-17-7-8-18(23-19(17)25(4)21(28)30)26-11-15-6-5-14(26)12-27(15)20(29)16-9-10-31-24-16/h7-10,14-15H,5-6,11-13H2,1-4H3/t14-,15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu3 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Homo sapiens (Human)) | BDBM50145198
(CHEMBL3765778)Show SMILES Cc1ccc(cc1-c1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1)C(C)(C)O Show InChI InChI=1S/C22H29N3O2/c1-14-8-9-15(22(5,6)27)12-16(14)17-10-11-18-19(23-17)24(7)20(26)25(18)13-21(2,3)4/h8-12,27H,13H2,1-7H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu3 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 6
(Homo sapiens (Human)) | BDBM50169621
(CHEMBL3806176)Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)N1CCCc2ccccc12 Show InChI InChI=1S/C21H26N4O/c1-21(2,3)14-25-17-11-12-18(22-19(17)23(4)20(25)26)24-13-7-9-15-8-5-6-10-16(15)24/h5-6,8,10-12H,7,9,13-14H2,1-4H3 | Reactome pathway
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PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu6 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50169689
(CHEMBL3805203)Show SMILES [H][C@@]12CC[C@@]([H])(CN1C(=O)c1csnn1)N(C2)c1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1 |r| Show InChI InChI=1S/C21H27N7O2S/c1-21(2,3)12-28-16-7-8-17(22-18(16)25(4)20(28)30)26-9-14-6-5-13(26)10-27(14)19(29)15-11-31-24-23-15/h7-8,11,13-14H,5-6,9-10,12H2,1-4H3/t13-,14-/m0/s1 | PDB
UniProtKB/SwissProt
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| Article
PubMed
| n/a | n/a | n/a | n/a | 29 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect preinc... |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50169692
(CHEMBL3805005)Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)C1CCN(CC1)C(=O)c1ccon1 Show InChI InChI=1S/C21H27N5O3/c1-21(2,3)13-26-17-6-5-15(22-18(17)24(4)20(26)28)14-7-10-25(11-8-14)19(27)16-9-12-29-23-16/h5-6,9,12,14H,7-8,10-11,13H2,1-4H3 | PDB
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| n/a | n/a | n/a | n/a | 531 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect preinc... |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Homo sapiens (Human)) | BDBM50169622
(CHEMBL3805883)Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)N1CCCC2CCCCC12 Show InChI InChI=1S/C21H32N4O/c1-21(2,3)14-25-17-11-12-18(22-19(17)23(4)20(25)26)24-13-7-9-15-8-5-6-10-16(15)24/h11-12,15-16H,5-10,13-14H2,1-4H3 | PDB
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| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu3 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 4
(Homo sapiens (Human)) | BDBM50169689
(CHEMBL3805203)Show SMILES [H][C@@]12CC[C@@]([H])(CN1C(=O)c1csnn1)N(C2)c1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1 |r| Show InChI InChI=1S/C21H27N7O2S/c1-21(2,3)12-28-16-7-8-17(22-18(16)25(4)20(28)30)26-9-14-6-5-13(26)10-27(14)19(29)15-11-31-24-23-15/h7-8,11,13-14H,5-6,9-10,12H2,1-4H3/t13-,14-/m0/s1 | PDB
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| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu4 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50169619
(CHEMBL3804910)Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)N1CC2CCC1CN2C(=O)OC(C)(C)C Show InChI InChI=1S/C23H35N5O3/c1-22(2,3)14-28-17-10-11-18(24-19(17)25(7)20(28)29)26-12-16-9-8-15(26)13-27(16)21(30)31-23(4,5)6/h10-11,15-16H,8-9,12-14H2,1-7H3 | PDB
MMDB
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DrugBank
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| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu5 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50169689
(CHEMBL3805203)Show SMILES [H][C@@]12CC[C@@]([H])(CN1C(=O)c1csnn1)N(C2)c1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1 |r| Show InChI InChI=1S/C21H27N7O2S/c1-21(2,3)12-28-16-7-8-17(22-18(16)25(4)20(28)30)26-9-14-6-5-13(26)10-27(14)19(29)15-11-31-24-23-15/h7-8,11,13-14H,5-6,9-10,12H2,1-4H3/t13-,14-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu5 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 6
(Homo sapiens (Human)) | BDBM50169622
(CHEMBL3805883)Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)N1CCCC2CCCCC12 Show InChI InChI=1S/C21H32N4O/c1-21(2,3)14-25-17-11-12-18(22-19(17)23(4)20(25)26)24-13-7-9-15-8-5-6-10-16(15)24/h11-12,15-16H,5-10,13-14H2,1-4H3 | Reactome pathway
KEGG
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PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu6 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50169616
(CHEMBL3805017)Show SMILES Cc1cc(CN2CC3CCC2CN3c2ccc3n(CC(C)(C)C)c(=O)n(C)c3n2)no1 Show InChI InChI=1S/C23H32N6O2/c1-15-10-16(25-31-15)11-27-12-18-7-6-17(27)13-28(18)20-9-8-19-21(24-20)26(5)22(30)29(19)14-23(2,3)4/h8-10,17-18H,6-7,11-14H2,1-5H3 | PDB
UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 149 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect preinc... |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Homo sapiens (Human)) | BDBM50169689
(CHEMBL3805203)Show SMILES [H][C@@]12CC[C@@]([H])(CN1C(=O)c1csnn1)N(C2)c1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1 |r| Show InChI InChI=1S/C21H27N7O2S/c1-21(2,3)12-28-16-7-8-17(22-18(16)25(4)20(28)30)26-9-14-6-5-13(26)10-27(14)19(29)15-11-31-24-23-15/h7-8,11,13-14H,5-6,9-10,12H2,1-4H3/t13-,14-/m0/s1 | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu3 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 4
(Homo sapiens (Human)) | BDBM50169690
(CHEMBL3806137)Show SMILES [H][C@@]12CC[C@@]([H])(CN1C(=O)c1ccon1)N(C2)c1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1 |r| Show InChI InChI=1S/C22H28N6O3/c1-22(2,3)13-28-17-7-8-18(23-19(17)25(4)21(28)30)26-11-15-6-5-14(26)12-27(15)20(29)16-9-10-31-24-16/h7-10,14-15H,5-6,11-13H2,1-4H3/t14-,15-/m0/s1 | PDB
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| CHEMBL
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UniChem
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| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu4 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50169690
(CHEMBL3806137)Show SMILES [H][C@@]12CC[C@@]([H])(CN1C(=O)c1ccon1)N(C2)c1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1 |r| Show InChI InChI=1S/C22H28N6O3/c1-22(2,3)13-28-17-7-8-18(23-19(17)25(4)21(28)30)26-11-15-6-5-14(26)12-27(15)20(29)16-9-10-31-24-16/h7-10,14-15H,5-6,11-13H2,1-4H3/t14-,15-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu5 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50169693
(CHEMBL3805139)Show SMILES [H][C@@]12CC[C@@]([H])(C=C1c1ccc3n(CC(C)(C)C)c(=O)n(C)c3n1)N(C2)C(=O)c1ccon1 |r,c:6| Show InChI InChI=1S/C23H27N5O3/c1-23(2,3)13-28-19-8-7-17(24-20(19)26(4)22(28)30)16-11-15-6-5-14(16)12-27(15)21(29)18-9-10-31-25-18/h7-11,14-15H,5-6,12-13H2,1-4H3/t14-,15-/m0/s1 | PDB
UniProtKB/SwissProt
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GoogleScholar
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| CHEMBL
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UniChem
Patents
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| Article
PubMed
| n/a | n/a | n/a | n/a | 16 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect preinc... |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 4
(Homo sapiens (Human)) | BDBM50145198
(CHEMBL3765778)Show SMILES Cc1ccc(cc1-c1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1)C(C)(C)O Show InChI InChI=1S/C22H29N3O2/c1-14-8-9-15(22(5,6)27)12-16(14)17-10-11-18-19(23-17)24(7)20(26)25(18)13-21(2,3)4/h8-12,27H,13H2,1-7H3 | PDB
UniProtKB/SwissProt
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UniChem
Similars
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PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu4 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 6
(Homo sapiens (Human)) | BDBM50169620
(CHEMBL3804903)Show InChI InChI=1S/C17H26N4O/c1-17(2,3)12-21-13-8-9-14(20-10-6-5-7-11-20)18-15(13)19(4)16(21)22/h8-9H,5-7,10-12H2,1-4H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu6 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 6
(Homo sapiens (Human)) | BDBM50169618
(CHEMBL3806226)Show InChI InChI=1S/C18H27N5O/c1-18(2,3)11-23-14-7-8-15(20-16(14)21(4)17(23)24)22-10-12-5-6-13(22)9-19-12/h7-8,12-13,19H,5-6,9-11H2,1-4H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu6 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 6
(Homo sapiens (Human)) | BDBM50169689
(CHEMBL3805203)Show SMILES [H][C@@]12CC[C@@]([H])(CN1C(=O)c1csnn1)N(C2)c1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1 |r| Show InChI InChI=1S/C21H27N7O2S/c1-21(2,3)12-28-16-7-8-17(22-18(16)25(4)20(28)30)26-9-14-6-5-13(26)10-27(14)19(29)15-11-31-24-23-15/h7-8,11,13-14H,5-6,9-10,12H2,1-4H3/t13-,14-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu6 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50169619
(CHEMBL3804910)Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)N1CC2CCC1CN2C(=O)OC(C)(C)C Show InChI InChI=1S/C23H35N5O3/c1-22(2,3)14-28-17-10-11-18(24-19(17)25(7)20(28)29)26-12-16-9-8-15(26)13-27(16)21(30)31-23(4,5)6/h10-11,15-16H,8-9,12-14H2,1-7H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | n/a | n/a | 125 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect preinc... |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50169650
(CHEMBL3805900)Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)N1CC2CCC1CN2C(=O)c1cccnc1 Show InChI InChI=1S/C24H30N6O2/c1-24(2,3)15-30-19-9-10-20(26-21(19)27(4)23(30)32)28-13-18-8-7-17(28)14-29(18)22(31)16-6-5-11-25-12-16/h5-6,9-12,17-18H,7-8,13-15H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
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PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 115 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect preinc... |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50169690
(CHEMBL3806137)Show SMILES [H][C@@]12CC[C@@]([H])(CN1C(=O)c1ccon1)N(C2)c1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1 |r| Show InChI InChI=1S/C22H28N6O3/c1-22(2,3)13-28-17-7-8-18(23-19(17)25(4)21(28)30)26-11-15-6-5-14(26)12-27(15)20(29)16-9-10-31-24-16/h7-10,14-15H,5-6,11-13H2,1-4H3/t14-,15-/m0/s1 | PDB
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| n/a | n/a | n/a | n/a | 29 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect preinc... |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 4
(Homo sapiens (Human)) | BDBM50169621
(CHEMBL3806176)Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)N1CCCc2ccccc12 Show InChI InChI=1S/C21H26N4O/c1-21(2,3)14-25-17-11-12-18(22-19(17)23(4)20(25)26)24-13-7-9-15-8-5-6-10-16(15)24/h5-6,8,10-12H,7,9,13-14H2,1-4H3 | PDB
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| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu4 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 4
(Homo sapiens (Human)) | BDBM50169618
(CHEMBL3806226)Show InChI InChI=1S/C18H27N5O/c1-18(2,3)11-23-14-7-8-15(20-16(14)21(4)17(23)24)22-10-12-5-6-13(22)9-19-12/h7-8,12-13,19H,5-6,9-11H2,1-4H3 | PDB
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| CHEMBL
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| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu4 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50169620
(CHEMBL3804903)Show InChI InChI=1S/C17H26N4O/c1-17(2,3)12-21-13-8-9-14(20-10-6-5-7-11-20)18-15(13)19(4)16(21)22/h8-9H,5-7,10-12H2,1-4H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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| CHEMBL
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UniChem
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| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu5 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50169693
(CHEMBL3805139)Show SMILES [H][C@@]12CC[C@@]([H])(C=C1c1ccc3n(CC(C)(C)C)c(=O)n(C)c3n1)N(C2)C(=O)c1ccon1 |r,c:6| Show InChI InChI=1S/C23H27N5O3/c1-23(2,3)13-28-19-8-7-17(24-20(19)26(4)22(28)30)16-11-15-6-5-14(16)12-27(15)21(29)18-9-10-31-25-18/h7-11,14-15H,5-6,12-13H2,1-4H3/t14-,15-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu5 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50145198
(CHEMBL3765778)Show SMILES Cc1ccc(cc1-c1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1)C(C)(C)O Show InChI InChI=1S/C22H29N3O2/c1-14-8-9-15(22(5,6)27)12-16(14)17-10-11-18-19(23-17)24(7)20(26)25(18)13-21(2,3)4/h8-12,27H,13H2,1-7H3 | PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu5 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 6
(Homo sapiens (Human)) | BDBM50169619
(CHEMBL3804910)Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)N1CC2CCC1CN2C(=O)OC(C)(C)C Show InChI InChI=1S/C23H35N5O3/c1-22(2,3)14-28-17-10-11-18(24-19(17)25(7)20(28)29)26-12-16-9-8-15(26)13-27(16)21(30)31-23(4,5)6/h10-11,15-16H,8-9,12-14H2,1-7H3 | Reactome pathway
KEGG
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| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu6 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 6
(Homo sapiens (Human)) | BDBM50145198
(CHEMBL3765778)Show SMILES Cc1ccc(cc1-c1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1)C(C)(C)O Show InChI InChI=1S/C22H29N3O2/c1-14-8-9-15(22(5,6)27)12-16(14)17-10-11-18-19(23-17)24(7)20(26)25(18)13-21(2,3)4/h8-12,27H,13H2,1-7H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
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UniChem
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PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu6 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50169617
(CHEMBL3804845)Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)N1CC2CCC1CN2c1ncccn1 Show InChI InChI=1S/C22H29N7O/c1-22(2,3)14-29-17-8-9-18(25-19(17)26(4)21(29)30)27-12-16-7-6-15(27)13-28(16)20-23-10-5-11-24-20/h5,8-11,15-16H,6-7,12-14H2,1-4H3 | PDB
UniProtKB/SwissProt
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PubMed
| n/a | n/a | n/a | n/a | 37 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect preinc... |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50169623
(CHEMBL3805718)Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)N1CC2CCC1CN2C(=O)c1ccccc1 Show InChI InChI=1S/C25H31N5O2/c1-25(2,3)16-30-20-12-13-21(26-22(20)27(4)24(30)32)28-14-19-11-10-18(28)15-29(19)23(31)17-8-6-5-7-9-17/h5-9,12-13,18-19H,10-11,14-16H2,1-4H3 | PDB
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| Article
PubMed
| n/a | n/a | n/a | n/a | 36 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect preinc... |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Homo sapiens (Human)) | BDBM50169618
(CHEMBL3806226)Show InChI InChI=1S/C18H27N5O/c1-18(2,3)11-23-14-7-8-15(20-16(14)21(4)17(23)24)22-10-12-5-6-13(22)9-19-12/h7-8,12-13,19H,5-6,9-11H2,1-4H3 | PDB
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PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu3 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 4
(Homo sapiens (Human)) | BDBM50169622
(CHEMBL3805883)Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)N1CCCC2CCCCC12 Show InChI InChI=1S/C21H32N4O/c1-21(2,3)14-25-17-11-12-18(22-19(17)23(4)20(25)26)24-13-7-9-15-8-5-6-10-16(15)24/h11-12,15-16H,5-10,13-14H2,1-4H3 | PDB
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PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu4 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 4
(Homo sapiens (Human)) | BDBM50169620
(CHEMBL3804903)Show InChI InChI=1S/C17H26N4O/c1-17(2,3)12-21-13-8-9-14(20-10-6-5-7-11-20)18-15(13)19(4)16(21)22/h8-9H,5-7,10-12H2,1-4H3 | PDB
UniProtKB/SwissProt
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GoogleScholar
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UniChem
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| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu4 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50169622
(CHEMBL3805883)Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)N1CCCC2CCCCC12 Show InChI InChI=1S/C21H32N4O/c1-21(2,3)14-25-17-11-12-18(22-19(17)23(4)20(25)26)24-13-7-9-15-8-5-6-10-16(15)24/h11-12,15-16H,5-10,13-14H2,1-4H3 | PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of mGlu5 receptor (unknown origin) |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50169618
(CHEMBL3806226)Show InChI InChI=1S/C18H27N5O/c1-18(2,3)11-23-14-7-8-15(20-16(14)21(4)17(23)24)22-10-12-5-6-13(22)9-19-12/h7-8,12-13,19H,5-6,9-11H2,1-4H3 | PDB
UniProtKB/SwissProt
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PC sid
UniChem
Similars
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PubMed
| n/a | n/a | n/a | n/a | 1.29E+3 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect preinc... |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50145198
(CHEMBL3765778)Show SMILES Cc1ccc(cc1-c1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1)C(C)(C)O Show InChI InChI=1S/C22H29N3O2/c1-14-8-9-15(22(5,6)27)12-16(14)17-10-11-18-19(23-17)24(7)20(26)25(18)13-21(2,3)4/h8-12,27H,13H2,1-7H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 63 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect preinc... |
ACS Med Chem Lett 7: 312-7 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K |
More data for this
Ligand-Target Pair | |
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