Found 27 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Prostacyclin receptor
(Homo sapiens (Human)) | BDBM50163296
(CHEMBL3793911)Show SMILES Cc1ccc(cc1)N(CCN1CCC(CC1)OCC(O)=O)C(=O)c1ccccc1 Show InChI InChI=1S/C23H28N2O4/c1-18-7-9-20(10-8-18)25(23(28)19-5-3-2-4-6-19)16-15-24-13-11-21(12-14-24)29-17-22(26)27/h2-10,21H,11-17H2,1H3,(H,26,27) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 990 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human IP receptor by competitive binding assay |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50163296
(CHEMBL3793911)Show SMILES Cc1ccc(cc1)N(CCN1CCC(CC1)OCC(O)=O)C(=O)c1ccccc1 Show InChI InChI=1S/C23H28N2O4/c1-18-7-9-20(10-8-18)25(23(28)19-5-3-2-4-6-19)16-15-24-13-11-21(12-14-24)29-17-22(26)27/h2-10,21H,11-17H2,1H3,(H,26,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human EP4 receptor by competitive binding assay |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM50163296
(CHEMBL3793911)Show SMILES Cc1ccc(cc1)N(CCN1CCC(CC1)OCC(O)=O)C(=O)c1ccccc1 Show InChI InChI=1S/C23H28N2O4/c1-18-7-9-20(10-8-18)25(23(28)19-5-3-2-4-6-19)16-15-24-13-11-21(12-14-24)29-17-22(26)27/h2-10,21H,11-17H2,1H3,(H,26,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human EP2 receptor by competitive binding assay |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostaglandin F2-alpha receptor
(Homo sapiens (Human)) | BDBM50163296
(CHEMBL3793911)Show SMILES Cc1ccc(cc1)N(CCN1CCC(CC1)OCC(O)=O)C(=O)c1ccccc1 Show InChI InChI=1S/C23H28N2O4/c1-18-7-9-20(10-8-18)25(23(28)19-5-3-2-4-6-19)16-15-24-13-11-21(12-14-24)29-17-22(26)27/h2-10,21H,11-17H2,1H3,(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human FP receptor by competitive binding assay |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50163296
(CHEMBL3793911)Show SMILES Cc1ccc(cc1)N(CCN1CCC(CC1)OCC(O)=O)C(=O)c1ccccc1 Show InChI InChI=1S/C23H28N2O4/c1-18-7-9-20(10-8-18)25(23(28)19-5-3-2-4-6-19)16-15-24-13-11-21(12-14-24)29-17-22(26)27/h2-10,21H,11-17H2,1H3,(H,26,27) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human EP1 receptor by competitive binding assay |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Thromboxane A2 receptor
(Homo sapiens (Human)) | BDBM50163296
(CHEMBL3793911)Show SMILES Cc1ccc(cc1)N(CCN1CCC(CC1)OCC(O)=O)C(=O)c1ccccc1 Show InChI InChI=1S/C23H28N2O4/c1-18-7-9-20(10-8-18)25(23(28)19-5-3-2-4-6-19)16-15-24-13-11-21(12-14-24)29-17-22(26)27/h2-10,21H,11-17H2,1H3,(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human TP receptor by competitive binding assay |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50163296
(CHEMBL3793911)Show SMILES Cc1ccc(cc1)N(CCN1CCC(CC1)OCC(O)=O)C(=O)c1ccccc1 Show InChI InChI=1S/C23H28N2O4/c1-18-7-9-20(10-8-18)25(23(28)19-5-3-2-4-6-19)16-15-24-13-11-21(12-14-24)29-17-22(26)27/h2-10,21H,11-17H2,1H3,(H,26,27) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human EP3 receptor by competitive binding assay |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostacyclin receptor
(Homo sapiens (Human)) | BDBM50163291
(CHEMBL3793903)Show SMILES OC(=O)COc1cccc2N(CCN(C(=O)c3ccccc3)c3ccc(Cl)cc3)CCOc12 Show InChI InChI=1S/C25H23ClN2O5/c26-19-9-11-20(12-10-19)28(25(31)18-5-2-1-3-6-18)14-13-27-15-16-32-24-21(27)7-4-8-22(24)33-17-23(29)30/h1-12H,13-17H2,(H,29,30) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min follo... |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostacyclin receptor
(Homo sapiens (Human)) | BDBM50163296
(CHEMBL3793911)Show SMILES Cc1ccc(cc1)N(CCN1CCC(CC1)OCC(O)=O)C(=O)c1ccccc1 Show InChI InChI=1S/C23H28N2O4/c1-18-7-9-20(10-8-18)25(23(28)19-5-3-2-4-6-19)16-15-24-13-11-21(12-14-24)29-17-22(26)27/h2-10,21H,11-17H2,1H3,(H,26,27) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min follo... |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostacyclin receptor
(Homo sapiens (Human)) | BDBM50163292
(CHEMBL3794451)Show SMILES OC(=O)COC1CCC(CC1)=CCN(C(=O)c1ccccc1)c1ccc(Cl)cc1 |(5.07,-3.24,;4,-3.86,;4,-5.09,;2.66,-3.08,;2.67,-1.54,;1.33,-.77,;1.33,.77,;,1.54,;-1.33,.77,;-1.33,-.77,;,-1.54,;-2.67,1.54,;-4,.77,;-5.34,1.53,;-6.67,.76,;-6.67,-.47,;-8.01,1.53,;-9.34,.76,;-10.68,1.53,;-10.68,3.07,;-9.34,3.84,;-8.01,3.07,;-5.34,3.07,;-6.68,3.84,;-6.68,5.38,;-5.34,6.15,;-5.34,7.39,;-4.01,5.38,;-4.01,3.84,)| Show InChI InChI=1S/C23H24ClNO4/c24-19-8-10-20(11-9-19)25(23(28)18-4-2-1-3-5-18)15-14-17-6-12-21(13-7-17)29-16-22(26)27/h1-5,8-11,14,21H,6-7,12-13,15-16H2,(H,26,27)/b17-14- | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min follo... |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostacyclin receptor
(Homo sapiens (Human)) | BDBM50163306
(CHEMBL3793117)Show SMILES CCc1ccc(cc1)N(CCN1CCC(CC1)OCC(O)=O)C(=O)c1ccccc1 Show InChI InChI=1S/C24H30N2O4/c1-2-19-8-10-21(11-9-19)26(24(29)20-6-4-3-5-7-20)17-16-25-14-12-22(13-15-25)30-18-23(27)28/h3-11,22H,2,12-18H2,1H3,(H,27,28) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min follo... |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostacyclin receptor
(Homo sapiens (Human)) | BDBM50163293
(CHEMBL3793265)Show SMILES OC(=O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)CC1 Show InChI InChI=1S/C22H25ClN2O4/c23-18-6-8-19(9-7-18)25(22(28)17-4-2-1-3-5-17)15-14-24-12-10-20(11-13-24)29-16-21(26)27/h1-9,20H,10-16H2,(H,26,27) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min follo... |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostacyclin receptor
(Homo sapiens (Human)) | BDBM50163051
(CHEMBL3793336)Show SMILES OC(=O)COc1ccc(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C23H20ClNO4/c24-19-8-10-20(11-9-19)25(23(28)18-4-2-1-3-5-18)15-14-17-6-12-21(13-7-17)29-16-22(26)27/h1-13H,14-16H2,(H,26,27) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 740 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min follo... |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostacyclin receptor
(Homo sapiens (Human)) | BDBM50163297
(CHEMBL3793345)Show SMILES COc1ccc(cc1)N(CCN1CCC(CC1)OCC(O)=O)C(=O)c1ccccc1 Show InChI InChI=1S/C23H28N2O5/c1-29-20-9-7-19(8-10-20)25(23(28)18-5-3-2-4-6-18)16-15-24-13-11-21(12-14-24)30-17-22(26)27/h2-10,21H,11-17H2,1H3,(H,26,27) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min follo... |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostacyclin receptor
(Homo sapiens (Human)) | BDBM50163300
(CHEMBL3793957)Show SMILES Cc1ccc(N(CCN2CCC(CC2)OCC(O)=O)C(=O)c2ccccc2)c(C)c1 Show InChI InChI=1S/C24H30N2O4/c1-18-8-9-22(19(2)16-18)26(24(29)20-6-4-3-5-7-20)15-14-25-12-10-21(11-13-25)30-17-23(27)28/h3-9,16,21H,10-15,17H2,1-2H3,(H,27,28) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min follo... |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostacyclin receptor
(Homo sapiens (Human)) | BDBM50163299
(CHEMBL3794283)Show SMILES Cc1cc(C)c(N(CCN2CCC(CC2)OCC(O)=O)C(=O)c2ccccc2)c(C)c1 Show InChI InChI=1S/C25H32N2O4/c1-18-15-19(2)24(20(3)16-18)27(25(30)21-7-5-4-6-8-21)14-13-26-11-9-22(10-12-26)31-17-23(28)29/h4-8,15-16,22H,9-14,17H2,1-3H3,(H,28,29) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min follo... |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostacyclin receptor
(Homo sapiens (Human)) | BDBM50163301
(CHEMBL3794570)Show SMILES Cc1cccc(c1)N(CCN1CCC(CC1)OCC(O)=O)C(=O)c1ccccc1 Show InChI InChI=1S/C23H28N2O4/c1-18-6-5-9-20(16-18)25(23(28)19-7-3-2-4-8-19)15-14-24-12-10-21(11-13-24)29-17-22(26)27/h2-9,16,21H,10-15,17H2,1H3,(H,26,27) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min follo... |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostacyclin receptor
(Homo sapiens (Human)) | BDBM50163298
(CHEMBL3793291)Show SMILES OC(=O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccc(cc2)N2CCCC2)CC1 Show InChI InChI=1S/C26H33N3O4/c30-25(31)20-33-24-12-16-27(17-13-24)18-19-29(26(32)21-6-2-1-3-7-21)23-10-8-22(9-11-23)28-14-4-5-15-28/h1-3,6-11,24H,4-5,12-20H2,(H,30,31) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min follo... |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostacyclin receptor
(Homo sapiens (Human)) | BDBM50163303
(CHEMBL3793247)Show SMILES CC(C)c1ccc(cc1)N(CCN1CCC(CC1)OCC(O)=O)C(=O)c1ccccc1 Show InChI InChI=1S/C25H32N2O4/c1-19(2)20-8-10-22(11-9-20)27(25(30)21-6-4-3-5-7-21)17-16-26-14-12-23(13-15-26)31-18-24(28)29/h3-11,19,23H,12-18H2,1-2H3,(H,28,29) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min follo... |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostacyclin receptor
(Homo sapiens (Human)) | BDBM50163304
(CHEMBL3792456)Show SMILES CCCCc1ccc(cc1)N(CCN1CCC(CC1)OCC(O)=O)C(=O)c1ccccc1 Show InChI InChI=1S/C26H34N2O4/c1-2-3-7-21-10-12-23(13-11-21)28(26(31)22-8-5-4-6-9-22)19-18-27-16-14-24(15-17-27)32-20-25(29)30/h4-6,8-13,24H,2-3,7,14-20H2,1H3,(H,29,30) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min follo... |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostacyclin receptor
(Homo sapiens (Human)) | BDBM50163305
(CHEMBL3792615)Show SMILES CCCc1ccc(cc1)N(CCN1CCC(CC1)OCC(O)=O)C(=O)c1ccccc1 Show InChI InChI=1S/C25H32N2O4/c1-2-6-20-9-11-22(12-10-20)27(25(30)21-7-4-3-5-8-21)18-17-26-15-13-23(14-16-26)31-19-24(28)29/h3-5,7-12,23H,2,6,13-19H2,1H3,(H,28,29) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min follo... |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostacyclin receptor
(Homo sapiens (Human)) | BDBM50163302
(CHEMBL3794058)Show SMILES Cc1ccccc1N(CCN1CCC(CC1)OCC(O)=O)C(=O)c1ccccc1 Show InChI InChI=1S/C23H28N2O4/c1-18-7-5-6-10-21(18)25(23(28)19-8-3-2-4-9-19)16-15-24-13-11-20(12-14-24)29-17-22(26)27/h2-10,20H,11-17H2,1H3,(H,26,27) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min follo... |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostacyclin receptor
(Homo sapiens (Human)) | BDBM50163295
(CHEMBL3793824)Show SMILES OC(=O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccccc2)CC1 Show InChI InChI=1S/C22H26N2O4/c25-21(26)17-28-20-11-13-23(14-12-20)15-16-24(19-9-5-2-6-10-19)22(27)18-7-3-1-4-8-18/h1-10,20H,11-17H2,(H,25,26) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min follo... |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostacyclin receptor
(Homo sapiens (Human)) | BDBM50163150
(CHEMBL3794245)Show SMILES OC(=O)COc1ccc(CCCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C24H22ClNO4/c25-20-10-12-21(13-11-20)26(24(29)19-6-2-1-3-7-19)16-4-5-18-8-14-22(15-9-18)30-17-23(27)28/h1-3,6-15H,4-5,16-17H2,(H,27,28) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min follo... |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostacyclin receptor
(Homo sapiens (Human)) | BDBM50163294
(CHEMBL3793541)Show SMILES Cl.OC(=O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)C1 Show InChI InChI=1S/C21H23ClN2O4.ClH/c22-17-6-8-18(9-7-17)24(21(27)16-4-2-1-3-5-16)13-12-23-11-10-19(14-23)28-15-20(25)26;/h1-9,19H,10-15H2,(H,25,26);1H | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min follo... |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostacyclin receptor
(Homo sapiens (Human)) | BDBM50163148
(CHEMBL3793417)Show SMILES OC(=O)COc1cccc(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)c1 Show InChI InChI=1S/C23H20ClNO4/c24-19-9-11-20(12-10-19)25(23(28)18-6-2-1-3-7-18)14-13-17-5-4-8-21(15-17)29-16-22(26)27/h1-12,15H,13-14,16H2,(H,26,27) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min follo... |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
Prostacyclin receptor
(Homo sapiens (Human)) | BDBM50163215
(CHEMBL3792777)Show SMILES OC(=O)COc1ccc(CN(C(=O)c2ccccc2)c2ccc(Cl)cc2)cc1 Show InChI InChI=1S/14H3N.2O.3Ru/h14*1H3;;;;;/q;;;;;;;;;;;;;;;;+4;2*+5 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min follo... |
Bioorg Med Chem Lett 26: 2360-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.009
BindingDB Entry DOI: 10.7270/Q2Q52RJW |
More data for this
Ligand-Target Pair | |
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