Found 47 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50161472
(CHEMBL3785095)Show SMILES Oc1ccc(Br)c2CC(CN3CCC4(CCc5ccccc45)CC3)NCc12 Show InChI InChI=1S/C21H25N3O3S/c1-22-12-14-23(15-13-22)16-17-27-21-9-5-8-20-19(21)10-11-24(20)28(25,26)18-6-3-2-4-7-18/h2-11H,12-17H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50161467
(CHEMBL3785560)Show SMILES Oc1ccc(Cl)c2CC(CN3CCC4(CCc5ccccc45)CC3)NCc12 Show InChI InChI=1S/C23H27ClN2O/c24-21-5-6-22(27)19-14-25-17(13-18(19)21)15-26-11-9-23(10-12-26)8-7-16-3-1-2-4-20(16)23/h1-6,17,25,27H,7-15H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50161471
(CHEMBL3785718)Show InChI InChI=1S/C20H22N2O4S/c23-27(24,17-5-2-1-3-6-17)22-10-9-18-19(22)7-4-8-20(18)26-16-13-21-11-14-25-15-12-21/h1-10H,11-16H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50161400
(CHEMBL3785952)Show SMILES Cc1cc(F)ccc1C1CCN(CC2Cc3c(Cl)ccc(O)c3CN2)CC1 Show InChI InChI=1S/C22H26ClFN2O/c1-14-10-16(24)2-3-18(14)15-6-8-26(9-7-15)13-17-11-19-20(12-25-17)22(27)5-4-21(19)23/h2-5,10,15,17,25,27H,6-9,11-13H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50161399
(CHEMBL3786469)Show InChI InChI=1S/C22H27FN2/c1-16-12-20(23)6-7-22(16)17-8-10-25(11-9-17)15-21-13-18-4-2-3-5-19(18)14-24-21/h2-7,12,17,21,24H,8-11,13-15H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| 3.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50161474
(CHEMBL3787174)Show InChI InChI=1S/C16H16N2O3S/c17-9-11-21-14-6-7-16-13(12-14)8-10-18(16)22(19,20)15-4-2-1-3-5-15/h1-8,10,12H,9,11,17H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50161475
(CHEMBL3785605)Show InChI InChI=1S/C16H16N2O3S/c17-10-12-21-16-8-4-7-15-14(16)9-11-18(15)22(19,20)13-5-2-1-3-6-13/h1-9,11H,10,12,17H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 5.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50161402
(CHEMBL3786899)Show InChI InChI=1S/C23H28N2/c1-2-7-20-16-24-21(15-19(20)6-1)17-25-13-11-23(12-14-25)10-9-18-5-3-4-8-22(18)23/h1-8,21,24H,9-17H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| 8.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50161473
(CHEMBL3785728)Show InChI InChI=1S/C22H27N3O3S/c1-23-12-6-13-24(16-15-23)17-18-28-22-10-5-9-21-20(22)11-14-25(21)29(26,27)19-7-3-2-4-8-19/h2-5,7-11,14H,6,12-13,15-18H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50161476
(CHEMBL3785839)Show SMILES NC(=O)N1Cc2ccccc2CC1CN1CCC2(CCc3ccccc23)CC1 Show InChI InChI=1S/C17H18N2O3S/c1-18-11-13-22-17-9-5-8-16-15(17)10-12-19(16)23(20,21)14-6-3-2-4-7-14/h2-10,12,18H,11,13H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50161403
(CHEMBL3786338)Show InChI InChI=1S/C24H30N2/c1-25-17-21-8-3-2-7-20(21)16-22(25)18-26-14-12-24(13-15-26)11-10-19-6-4-5-9-23(19)24/h2-9,22H,10-18H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50161405
(CHEMBL3787051)Show SMILES CC(=O)N1Cc2ccccc2CC1CN1CCC2(CCc3ccccc23)CC1 Show InChI InChI=1S/C25H30N2O/c1-19(28)27-17-22-8-3-2-7-21(22)16-23(27)18-26-14-12-25(13-15-26)11-10-20-6-4-5-9-24(20)25/h2-9,23H,10-18H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50161475
(CHEMBL3785605)Show InChI InChI=1S/C16H16N2O3S/c17-10-12-21-16-8-4-7-15-14(16)9-11-18(15)22(19,20)13-5-2-1-3-6-13/h1-9,11H,10,12,17H2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 49 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHOK1 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50161403
(CHEMBL3786338)Show InChI InChI=1S/C24H30N2/c1-25-17-21-8-3-2-7-20(21)16-22(25)18-26-14-12-24(13-15-26)11-10-19-6-4-5-9-23(19)24/h2-9,22H,10-18H2,1H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 58 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHOK1 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50161467
(CHEMBL3785560)Show SMILES Oc1ccc(Cl)c2CC(CN3CCC4(CCc5ccccc45)CC3)NCc12 Show InChI InChI=1S/C23H27ClN2O/c24-21-5-6-22(27)19-14-25-17(13-18(19)21)15-26-11-9-23(10-12-26)8-7-16-3-1-2-4-20(16)23/h1-6,17,25,27H,7-15H2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 69 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHOK1 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50161405
(CHEMBL3787051)Show SMILES CC(=O)N1Cc2ccccc2CC1CN1CCC2(CCc3ccccc23)CC1 Show InChI InChI=1S/C25H30N2O/c1-19(28)27-17-22-8-3-2-7-21(22)16-23(27)18-26-14-12-25(13-15-26)11-10-20-6-4-5-9-24(20)25/h2-9,23H,10-18H2,1H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHOK1 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50161476
(CHEMBL3785839)Show SMILES NC(=O)N1Cc2ccccc2CC1CN1CCC2(CCc3ccccc23)CC1 Show InChI InChI=1S/C17H18N2O3S/c1-18-11-13-22-17-9-5-8-16-15(17)10-12-19(16)23(20,21)14-6-3-2-4-7-14/h2-10,12,18H,11,13H2,1H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 108 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHOK1 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50161472
(CHEMBL3785095)Show SMILES Oc1ccc(Br)c2CC(CN3CCC4(CCc5ccccc45)CC3)NCc12 Show InChI InChI=1S/C21H25N3O3S/c1-22-12-14-23(15-13-22)16-17-27-21-9-5-8-20-19(21)10-11-24(20)28(25,26)18-6-3-2-4-7-18/h2-11H,12-17H2,1H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 139 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHOK1 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50161402
(CHEMBL3786899)Show InChI InChI=1S/C23H28N2/c1-2-7-20-16-24-21(15-19(20)6-1)17-25-13-11-23(12-14-25)10-9-18-5-3-4-8-22(18)23/h1-8,21,24H,9-17H2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| 225 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHOK1 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50161404
(CHEMBL3786486)Show InChI InChI=1S/C24H28N2O/c1-25-20(16-19-7-2-4-8-21(19)23(25)27)17-26-14-12-24(13-15-26)11-10-18-6-3-5-9-22(18)24/h2-9,20H,10-17H2,1H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| 231 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHOK1 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50161404
(CHEMBL3786486)Show InChI InChI=1S/C24H28N2O/c1-25-20(16-19-7-2-4-8-21(19)23(25)27)17-26-14-12-24(13-15-26)11-10-18-6-3-5-9-22(18)24/h2-9,20H,10-17H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| >250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50161401
(CHEMBL3786946)Show InChI InChI=1S/C23H26N2O/c26-22(21-15-18-6-1-2-7-19(18)16-24-21)25-13-11-23(12-14-25)10-9-17-5-3-4-8-20(17)23/h1-8,21,24H,9-16H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50161471
(CHEMBL3785718)Show InChI InChI=1S/C20H22N2O4S/c23-27(24,17-5-2-1-3-6-17)22-10-9-18-19(22)7-4-8-20(18)26-16-13-21-11-14-25-15-12-21/h1-10H,11-16H2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 288 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHOK1 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50161474
(CHEMBL3787174)Show InChI InChI=1S/C16H16N2O3S/c17-9-11-21-14-6-7-16-13(12-14)8-10-18(16)22(19,20)15-4-2-1-3-5-15/h1-8,10,12H,9,11,17H2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 289 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHOK1 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50161399
(CHEMBL3786469)Show InChI InChI=1S/C22H27FN2/c1-16-12-20(23)6-7-22(16)17-8-10-25(11-9-17)15-21-13-18-4-2-3-5-19(18)14-24-21/h2-7,12,17,21,24H,8-11,13-15H2,1H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| 342 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHOK1 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50161473
(CHEMBL3785728)Show InChI InChI=1S/C22H27N3O3S/c1-23-12-6-13-24(16-15-23)17-18-28-22-10-5-9-21-20(22)11-14-25(21)29(26,27)19-7-3-2-4-8-19/h2-5,7-11,14H,6,12-13,15-18H2,1H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 392 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHOK1 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50161401
(CHEMBL3786946)Show InChI InChI=1S/C23H26N2O/c26-22(21-15-18-6-1-2-7-19(18)16-24-21)25-13-11-23(12-14-25)10-9-17-5-3-4-8-20(17)23/h1-8,21,24H,9-16H2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >450 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHOK1 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50161400
(CHEMBL3785952)Show SMILES Cc1cc(F)ccc1C1CCN(CC2Cc3c(Cl)ccc(O)c3CN2)CC1 Show InChI InChI=1S/C22H26ClFN2O/c1-14-10-16(24)2-3-18(14)15-6-8-26(9-7-15)13-17-11-19-20(12-25-17)22(27)5-4-21(19)23/h2-5,10,15,17,25,27H,6-9,11-13H2,1H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >450 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHOK1 cells after 45 mins by scintillation proximity assay |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50161467
(CHEMBL3785560)Show SMILES Oc1ccc(Cl)c2CC(CN3CCC4(CCc5ccccc45)CC3)NCc12 Show InChI InChI=1S/C23H27ClN2O/c24-21-5-6-22(27)19-14-25-17(13-18(19)21)15-26-11-9-23(10-12-26)8-7-16-3-1-2-4-20(16)23/h1-6,17,25,27H,7-15H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human NOP receptor expressed in HEK293 cells assessed as inhibition of N/OFQ-induced [35S]GTPgammaS binding after 1.5 hrs by s... |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50161400
(CHEMBL3785952)Show SMILES Cc1cc(F)ccc1C1CCN(CC2Cc3c(Cl)ccc(O)c3CN2)CC1 Show InChI InChI=1S/C22H26ClFN2O/c1-14-10-16(24)2-3-18(14)15-6-8-26(9-7-15)13-17-11-19-20(12-25-17)22(27)5-4-21(19)23/h2-5,10,15,17,25,27H,6-9,11-13H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human NOP receptor expressed in HEK293 cells assessed as inhibition of N/OFQ-induced [35S]GTPgammaS binding after 1.5 hrs by s... |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50161472
(CHEMBL3785095)Show SMILES Oc1ccc(Br)c2CC(CN3CCC4(CCc5ccccc45)CC3)NCc12 Show InChI InChI=1S/C21H25N3O3S/c1-22-12-14-23(15-13-22)16-17-27-21-9-5-8-20-19(21)10-11-24(20)28(25,26)18-6-3-2-4-7-18/h2-11H,12-17H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human NOP receptor expressed in HEK293 cells assessed as inhibition of N/OFQ-induced [35S]GTPgammaS binding after 1.5 hrs by s... |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50161471
(CHEMBL3785718)Show InChI InChI=1S/C20H22N2O4S/c23-27(24,17-5-2-1-3-6-17)22-10-9-18-19(22)7-4-8-20(18)26-16-13-21-11-14-25-15-12-21/h1-10H,11-16H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human NOP receptor expressed in HEK293 cells assessed as inhibition of N/OFQ-induced [35S]GTPgammaS binding after 1.5 hrs by s... |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50161399
(CHEMBL3786469)Show InChI InChI=1S/C22H27FN2/c1-16-12-20(23)6-7-22(16)17-8-10-25(11-9-17)15-21-13-18-4-2-3-5-19(18)14-24-21/h2-7,12,17,21,24H,8-11,13-15H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human NOP receptor expressed in HEK293 cells assessed as inhibition of N/OFQ-induced [35S]GTPgammaS binding after 1.5 hrs by s... |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50161475
(CHEMBL3785605)Show InChI InChI=1S/C16H16N2O3S/c17-10-12-21-16-8-4-7-15-14(16)9-11-18(15)22(19,20)13-5-2-1-3-6-13/h1-9,11H,10,12,17H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 122 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human NOP receptor expressed in HEK293 cells assessed as inhibition of N/OFQ-induced [35S]GTPgammaS binding after 1.5 hrs by s... |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50161399
(CHEMBL3786469)Show InChI InChI=1S/C22H27FN2/c1-16-12-20(23)6-7-22(16)17-8-10-25(11-9-17)15-21-13-18-4-2-3-5-19(18)14-24-21/h2-7,12,17,21,24H,8-11,13-15H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cells after 60 mins by liquid scintillation counting method |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50161473
(CHEMBL3785728)Show InChI InChI=1S/C22H27N3O3S/c1-23-12-6-13-24(16-15-23)17-18-28-22-10-5-9-21-20(22)11-14-25(21)29(26,27)19-7-3-2-4-8-19/h2-5,7-11,14H,6,12-13,15-18H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 227 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human NOP receptor expressed in HEK293 cells assessed as inhibition of N/OFQ-induced [35S]GTPgammaS binding after 1.5 hrs by s... |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50161402
(CHEMBL3786899)Show InChI InChI=1S/C23H28N2/c1-2-7-20-16-24-21(15-19(20)6-1)17-25-13-11-23(12-14-25)10-9-18-5-3-4-8-22(18)23/h1-8,21,24H,9-17H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 248 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human NOP receptor expressed in HEK293 cells assessed as inhibition of N/OFQ-induced [35S]GTPgammaS binding after 1.5 hrs by s... |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50161473
(CHEMBL3785728)Show InChI InChI=1S/C22H27N3O3S/c1-23-12-6-13-24(16-15-23)17-18-28-22-10-5-9-21-20(22)11-14-25(21)29(26,27)19-7-3-2-4-8-19/h2-5,7-11,14H,6,12-13,15-18H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cells after 60 mins by liquid scintillation counting method |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50161405
(CHEMBL3787051)Show SMILES CC(=O)N1Cc2ccccc2CC1CN1CCC2(CCc3ccccc23)CC1 Show InChI InChI=1S/C25H30N2O/c1-19(28)27-17-22-8-3-2-7-21(22)16-23(27)18-26-14-12-25(13-15-26)11-10-20-6-4-5-9-24(20)25/h2-9,23H,10-18H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cells after 60 mins by liquid scintillation counting method |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50161474
(CHEMBL3787174)Show InChI InChI=1S/C16H16N2O3S/c17-9-11-21-14-6-7-16-13(12-14)8-10-18(16)22(19,20)15-4-2-1-3-5-15/h1-8,10,12H,9,11,17H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 683 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human NOP receptor expressed in HEK293 cells assessed as inhibition of N/OFQ-induced [35S]GTPgammaS binding after 1.5 hrs by s... |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50161471
(CHEMBL3785718)Show InChI InChI=1S/C20H22N2O4S/c23-27(24,17-5-2-1-3-6-17)22-10-9-18-19(22)7-4-8-20(18)26-16-13-21-11-14-25-15-12-21/h1-10H,11-16H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 940 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cells after 60 mins by liquid scintillation counting method |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50161400
(CHEMBL3785952)Show SMILES Cc1cc(F)ccc1C1CCN(CC2Cc3c(Cl)ccc(O)c3CN2)CC1 Show InChI InChI=1S/C22H26ClFN2O/c1-14-10-16(24)2-3-18(14)15-6-8-26(9-7-15)13-17-11-19-20(12-25-17)22(27)5-4-21(19)23/h2-5,10,15,17,25,27H,6-9,11-13H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 970 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cells after 60 mins by liquid scintillation counting method |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50161472
(CHEMBL3785095)Show SMILES Oc1ccc(Br)c2CC(CN3CCC4(CCc5ccccc45)CC3)NCc12 Show InChI InChI=1S/C21H25N3O3S/c1-22-12-14-23(15-13-22)16-17-27-21-9-5-8-20-19(21)10-11-24(20)28(25,26)18-6-3-2-4-7-18/h2-11H,12-17H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cells after 60 mins by liquid scintillation counting method |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50161402
(CHEMBL3786899)Show InChI InChI=1S/C23H28N2/c1-2-7-20-16-24-21(15-19(20)6-1)17-25-13-11-23(12-14-25)10-9-18-5-3-4-8-22(18)23/h1-8,21,24H,9-17H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | >1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cells after 60 mins by liquid scintillation counting method |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50161475
(CHEMBL3785605)Show InChI InChI=1S/C16H16N2O3S/c17-10-12-21-16-8-4-7-15-14(16)9-11-18(15)22(19,20)13-5-2-1-3-6-13/h1-9,11H,10,12,17H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cells after 60 mins by liquid scintillation counting method |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50161467
(CHEMBL3785560)Show SMILES Oc1ccc(Cl)c2CC(CN3CCC4(CCc5ccccc45)CC3)NCc12 Show InChI InChI=1S/C23H27ClN2O/c24-21-5-6-22(27)19-14-25-17(13-18(19)21)15-26-11-9-23(10-12-26)8-7-16-3-1-2-4-20(16)23/h1-6,17,25,27H,7-15H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.73E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cells after 60 mins by liquid scintillation counting method |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50161404
(CHEMBL3786486)Show InChI InChI=1S/C24H28N2O/c1-25-20(16-19-7-2-4-8-21(19)23(25)27)17-26-14-12-24(13-15-26)11-10-18-6-3-5-9-22(18)24/h2-9,20H,10-17H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 6.96E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cells after 60 mins by liquid scintillation counting method |
Eur J Med Chem 114: 345-64 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.014
BindingDB Entry DOI: 10.7270/Q2DV1MS3 |
More data for this
Ligand-Target Pair | |
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