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PubMed code 27083471

Compile data set for download or QSAR
Found 46 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cholinesterase


(Equus caballus (Horse))
BDBM8961
PNG
(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Show SMILES Nc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)
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n/an/a 5.20n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50161803
PNG
(CHEMBL3785375)
Show SMILES COc1cc(\C=C2/CN(C)C\C(=C/c3cc(OC)c(OC)c(OC)c3Br)C2=O)c(Br)c(OC)c1OC
Show InChI InChI=1S/C26H29Br2NO7/c1-29-12-16(8-14-10-18(31-2)23(33-4)25(35-6)20(14)27)22(30)17(13-29)9-15-11-19(32-3)24(34-5)26(36-7)21(15)28/h8-11H,12-13H2,1-7H3/b16-8+,17-9+
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n/an/a 37n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM8961
PNG
(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Show SMILES Nc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)
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n/an/a 38n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM8960
PNG
((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Show SMILES COc1cc2CC(CC3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC
Show InChI InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3
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n/an/a 57n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50161797
PNG
(CHEMBL3785402)
Show SMILES COc1cc(\C=C2/CC(C\C(=C/c3cc(OC)c(OC)c(OC)c3Br)C2=O)C(C)C)c(Br)c(OC)c1OC
Show InChI InChI=1S/C29H34Br2O7/c1-15(2)16-9-19(11-17-13-21(33-3)26(35-5)28(37-7)23(17)30)25(32)20(10-16)12-18-14-22(34-4)27(36-6)29(38-8)24(18)31/h11-16H,9-10H2,1-8H3/b19-11+,20-12+
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n/an/a 510n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50161802
PNG
(CHEMBL3787299)
Show SMILES COc1ccc(\C=C2/CN(C)C\C(=C/c3ccc(OC)c(OC)c3Cl)C2=O)c(Cl)c1OC
Show InChI InChI=1S/C24H25Cl2NO5/c1-27-12-16(10-14-6-8-18(29-2)23(31-4)20(14)25)22(28)17(13-27)11-15-7-9-19(30-3)24(32-5)21(15)26/h6-11H,12-13H2,1-5H3/b16-10+,17-11+
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n/an/a 630n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50161796
PNG
(CHEMBL3787250)
Show SMILES COc1ccc(\C=C2/CC(C\C(=C/c3ccc(OC)c(OC)c3Cl)C2=O)C(C)C)c(Cl)c1OC
Show InChI InChI=1S/C27H30Cl2O5/c1-15(2)18-13-19(11-16-7-9-21(31-3)26(33-5)23(16)28)25(30)20(14-18)12-17-8-10-22(32-4)27(34-6)24(17)29/h7-12,15,18H,13-14H2,1-6H3/b19-11+,20-12+
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n/an/a 920n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50161801
PNG
(CHEMBL3787510)
Show SMILES COc1cccc(\C=C2/CN(C)C\C(=C/c3cccc(OC)c3Cl)C2=O)c1Cl
Show InChI InChI=1S/C22H21Cl2NO3/c1-25-12-16(10-14-6-4-8-18(27-2)20(14)23)22(26)17(13-25)11-15-7-5-9-19(28-3)21(15)24/h4-11H,12-13H2,1-3H3/b16-10+,17-11+
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n/an/a 1.20E+3n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50161795
PNG
(CHEMBL3787274)
Show SMILES COc1cccc(\C=C2/CC(C\C(=C/c3cccc(OC)c3Cl)C2=O)C(C)C)c1Cl
Show InChI InChI=1S/C25H26Cl2O3/c1-15(2)18-13-19(11-16-7-5-9-21(29-3)23(16)26)25(28)20(14-18)12-17-8-6-10-22(30-4)24(17)27/h5-12,15,18H,13-14H2,1-4H3/b19-11+,20-12+
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n/an/a 1.30E+3n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50161809
PNG
(CHEMBL3787119)
Show SMILES COc1cc(\C=C2/COC\C(=C/c3cc(OC)c(OC)c(OC)c3Br)C2=O)c(Br)c(OC)c1OC
Show InChI InChI=1S/C25H26Br2O8/c1-29-17-9-13(19(26)24(33-5)22(17)31-3)7-15-11-35-12-16(21(15)28)8-14-10-18(30-2)23(32-4)25(34-6)20(14)27/h7-10H,11-12H2,1-6H3/b15-7+,16-8+
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n/an/a 1.50E+3n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50161794
PNG
(CHEMBL3786129)
Show SMILES COc1cc(\C=C2/CC(C)C\C(=C/c3cc(OC)c(OC)c(OC)c3Br)C2=O)c(Br)c(OC)c1OC
Show InChI InChI=1S/C27H30Br2O7/c1-14-8-17(10-15-12-19(31-2)24(33-4)26(35-6)21(15)28)23(30)18(9-14)11-16-13-20(32-3)25(34-5)27(36-7)22(16)29/h10-14H,8-9H2,1-7H3/b17-10+,18-11+
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n/an/a 1.50E+3n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50161800
PNG
(CHEMBL3786742)
Show SMILES COc1cc(\C=C2/CNC\C(=C/c3cc(OC)c(OC)c(OC)c3Br)C2=O)c(Br)c(OC)c1OC
Show InChI InChI=1S/C25H27Br2NO7/c1-30-17-9-13(19(26)24(34-5)22(17)32-3)7-15-11-28-12-16(21(15)29)8-14-10-18(31-2)23(33-4)25(35-6)20(14)27/h7-10,28H,11-12H2,1-6H3/b15-7+,16-8+
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n/an/a 1.90E+3n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50161793
PNG
(CHEMBL3785504)
Show SMILES COc1ccc(\C=C2/CC(C)C\C(=C/c3ccc(OC)c(OC)c3Cl)C2=O)c(Cl)c1OC
Show InChI InChI=1S/C25H26Cl2O5/c1-14-10-17(12-15-6-8-19(29-2)24(31-4)21(15)26)23(28)18(11-14)13-16-7-9-20(30-3)25(32-5)22(16)27/h6-9,12-14H,10-11H2,1-5H3/b17-12+,18-13+
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n/an/a 2.10E+3n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Cholinesterase


(Equus caballus (Horse))
BDBM50161802
PNG
(CHEMBL3787299)
Show SMILES COc1ccc(\C=C2/CN(C)C\C(=C/c3ccc(OC)c(OC)c3Cl)C2=O)c(Cl)c1OC
Show InChI InChI=1S/C24H25Cl2NO5/c1-27-12-16(10-14-6-8-18(29-2)23(31-4)20(14)25)22(28)17(13-27)11-15-7-9-19(30-3)24(32-5)21(15)26/h6-11H,12-13H2,1-5H3/b16-10+,17-11+
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n/an/a 2.90E+3n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50161799
PNG
(CHEMBL3787626)
Show SMILES COc1ccc(\C=C2/CNC\C(=C/c3ccc(OC)c(OC)c3Cl)C2=O)c(Cl)c1OC
Show InChI InChI=1S/C23H23Cl2NO5/c1-28-17-7-5-13(19(24)22(17)30-3)9-15-11-26-12-16(21(15)27)10-14-6-8-18(29-2)23(31-4)20(14)25/h5-10,26H,11-12H2,1-4H3/b15-9+,16-10+
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n/an/a 3.70E+3n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50161798
PNG
(CHEMBL3785522)
Show SMILES COc1cccc(\C=C2/CNC\C(=C/c3cccc(OC)c3Cl)C2=O)c1Cl
Show InChI InChI=1S/C21H19Cl2NO3/c1-26-17-7-3-5-13(19(17)22)9-15-11-24-12-16(21(15)25)10-14-6-4-8-18(27-2)20(14)23/h3-10,24H,11-12H2,1-2H3/b15-9+,16-10+
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n/an/a 5.20E+3n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50161792
PNG
(CHEMBL3786205)
Show SMILES COc1cccc(\C=C2/CC(C)C\C(=C/c3cccc(OC)c3Cl)C2=O)c1Cl
Show InChI InChI=1S/C23H22Cl2O3/c1-14-10-17(12-15-6-4-8-19(27-2)21(15)24)23(26)18(11-14)13-16-7-5-9-20(28-3)22(16)25/h4-9,12-14H,10-11H2,1-3H3/b17-12+,18-13+
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n/an/a 5.60E+3n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Cholinesterase


(Equus caballus (Horse))
BDBM8960
PNG
((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Show SMILES COc1cc2CC(CC3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC
Show InChI InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3
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n/an/a 6.50E+3n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50161808
PNG
(CHEMBL3785460)
Show SMILES COc1ccc(\C=C2/COC\C(=C/c3ccc(OC)c(OC)c3Cl)C2=O)c(Cl)c1OC
Show InChI InChI=1S/C23H22Cl2O6/c1-27-17-7-5-13(19(24)22(17)29-3)9-15-11-31-12-16(21(15)26)10-14-6-8-18(28-2)23(30-4)20(14)25/h5-10H,11-12H2,1-4H3/b15-9+,16-10+
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n/an/a 7.20E+3n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50161807
PNG
(CHEMBL3786918)
Show SMILES COc1cccc(\C=C2/COC\C(=C/c3cccc(OC)c3Cl)C2=O)c1Cl
Show InChI InChI=1S/C21H18Cl2O4/c1-25-17-7-3-5-13(19(17)22)9-15-11-27-12-16(21(15)24)10-14-6-4-8-18(26-2)20(14)23/h3-10H,11-12H2,1-2H3/b15-9+,16-10+
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n/an/a 9.50E+3n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Cholinesterase


(Equus caballus (Horse))
BDBM50161803
PNG
(CHEMBL3785375)
Show SMILES COc1cc(\C=C2/CN(C)C\C(=C/c3cc(OC)c(OC)c(OC)c3Br)C2=O)c(Br)c(OC)c1OC
Show InChI InChI=1S/C26H29Br2NO7/c1-29-12-16(8-14-10-18(31-2)23(33-4)25(35-6)20(14)27)22(30)17(13-29)9-15-11-19(32-3)24(34-5)26(36-7)21(15)28/h8-11H,12-13H2,1-7H3/b16-8+,17-9+
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n/an/a 1.05E+4n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Cholinesterase


(Equus caballus (Horse))
BDBM50161793
PNG
(CHEMBL3785504)
Show SMILES COc1ccc(\C=C2/CC(C)C\C(=C/c3ccc(OC)c(OC)c3Cl)C2=O)c(Cl)c1OC
Show InChI InChI=1S/C25H26Cl2O5/c1-14-10-17(12-15-6-8-19(29-2)24(31-4)21(15)26)23(28)18(11-14)13-16-7-9-20(30-3)25(32-5)22(16)27/h6-9,12-14H,10-11H2,1-5H3/b17-12+,18-13+
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n/an/a 1.12E+4n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50161774
PNG
(CHEMBL3785268)
Show SMILES COc1cc(\C=C2/CCC\C(=C/c3cc(OC)c(OC)c(OC)c3Br)C2=O)c(Br)c(OC)c1OC
Show InChI InChI=1S/C26H28Br2O7/c1-30-18-12-16(20(27)25(34-5)23(18)32-3)10-14-8-7-9-15(22(14)29)11-17-13-19(31-2)24(33-4)26(35-6)21(17)28/h10-13H,7-9H2,1-6H3/b14-10+,15-11+
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n/an/a 1.26E+4n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Cholinesterase


(Equus caballus (Horse))
BDBM50161799
PNG
(CHEMBL3787626)
Show SMILES COc1ccc(\C=C2/CNC\C(=C/c3ccc(OC)c(OC)c3Cl)C2=O)c(Cl)c1OC
Show InChI InChI=1S/C23H23Cl2NO5/c1-28-17-7-5-13(19(24)22(17)30-3)9-15-11-26-12-16(21(15)27)10-14-6-8-18(29-2)23(31-4)20(14)25/h5-10,26H,11-12H2,1-4H3/b15-9+,16-10+
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n/an/a 1.67E+4n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50161773
PNG
(CHEMBL3786643)
Show SMILES COc1ccc(\C=C2/CCC\C(=C/c3ccc(OC)c(OC)c3Cl)C2=O)c(Cl)c1OC
Show InChI InChI=1S/C24H24Cl2O5/c1-28-18-10-8-14(20(25)23(18)30-3)12-16-6-5-7-17(22(16)27)13-15-9-11-19(29-2)24(31-4)21(15)26/h8-13H,5-7H2,1-4H3/b16-12+,17-13+
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n/an/a 1.75E+4n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Cholinesterase


(Equus caballus (Horse))
BDBM50161794
PNG
(CHEMBL3786129)
Show SMILES COc1cc(\C=C2/CC(C)C\C(=C/c3cc(OC)c(OC)c(OC)c3Br)C2=O)c(Br)c(OC)c1OC
Show InChI InChI=1S/C27H30Br2O7/c1-14-8-17(10-15-12-19(31-2)24(33-4)26(35-6)21(15)28)23(30)18(9-14)11-16-13-20(32-3)25(34-5)27(36-7)22(16)29/h10-14H,8-9H2,1-7H3/b17-10+,18-11+
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n/an/a 1.95E+4n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50161772
PNG
(CHEMBL3786095)
Show SMILES COc1cccc(\C=C2/CCC\C(=C/c3cccc(OC)c3Cl)C2=O)c1Cl
Show InChI InChI=1S/C22H20Cl2O3/c1-26-18-10-4-6-14(20(18)23)12-16-8-3-9-17(22(16)25)13-15-7-5-11-19(27-2)21(15)24/h4-7,10-13H,3,8-9H2,1-2H3/b16-12+,17-13+
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n/an/a 2.24E+4n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Cholinesterase


(Equus caballus (Horse))
BDBM50161792
PNG
(CHEMBL3786205)
Show SMILES COc1cccc(\C=C2/CC(C)C\C(=C/c3cccc(OC)c3Cl)C2=O)c1Cl
Show InChI InChI=1S/C23H22Cl2O3/c1-14-10-17(12-15-6-4-8-19(27-2)21(15)24)23(26)18(11-14)13-16-7-5-9-20(28-3)22(16)25/h4-9,12-14H,10-11H2,1-3H3/b17-12+,18-13+
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n/an/a 4.97E+4n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Cholinesterase


(Equus caballus (Horse))
BDBM50161800
PNG
(CHEMBL3786742)
Show SMILES COc1cc(\C=C2/CNC\C(=C/c3cc(OC)c(OC)c(OC)c3Br)C2=O)c(Br)c(OC)c1OC
Show InChI InChI=1S/C25H27Br2NO7/c1-30-17-9-13(19(26)24(34-5)22(17)32-3)7-15-11-28-12-16(21(15)29)8-14-10-18(31-2)23(33-4)25(35-6)20(14)27/h7-10,28H,11-12H2,1-6H3/b15-7+,16-8+
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n/an/a 6.88E+4n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50161806
PNG
(CHEMBL3786242)
Show SMILES COc1cc(\C=C2/CN(Cc3ccccc3)C\C(=C/c3cc(OC)c(OC)c(OC)c3Br)C2=O)c(Br)c(OC)c1OC
Show InChI InChI=1S/C32H33Br2NO7/c1-37-24-14-20(26(33)31(41-5)29(24)39-3)12-22-17-35(16-19-10-8-7-9-11-19)18-23(28(22)36)13-21-15-25(38-2)30(40-4)32(42-6)27(21)34/h7-15H,16-18H2,1-6H3/b22-12+,23-13+
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n/an/a>1.00E+5n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Cholinesterase


(Equus caballus (Horse))
BDBM50161808
PNG
(CHEMBL3785460)
Show SMILES COc1ccc(\C=C2/COC\C(=C/c3ccc(OC)c(OC)c3Cl)C2=O)c(Cl)c1OC
Show InChI InChI=1S/C23H22Cl2O6/c1-27-17-7-5-13(19(24)22(17)29-3)9-15-11-31-12-16(21(15)26)10-14-6-8-18(28-2)23(30-4)20(14)25/h5-10H,11-12H2,1-4H3/b15-9+,16-10+
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n/an/a>1.00E+5n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Cholinesterase


(Equus caballus (Horse))
BDBM50161806
PNG
(CHEMBL3786242)
Show SMILES COc1cc(\C=C2/CN(Cc3ccccc3)C\C(=C/c3cc(OC)c(OC)c(OC)c3Br)C2=O)c(Br)c(OC)c1OC
Show InChI InChI=1S/C32H33Br2NO7/c1-37-24-14-20(26(33)31(41-5)29(24)39-3)12-22-17-35(16-19-10-8-7-9-11-19)18-23(28(22)36)13-21-15-25(38-2)30(40-4)32(42-6)27(21)34/h7-15H,16-18H2,1-6H3/b22-12+,23-13+
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n/an/a>1.00E+5n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50161805
PNG
(CHEMBL3787471)
Show SMILES COc1ccc(\C=C2/CN(Cc3ccccc3)C\C(=C/c3ccc(OC)c(OC)c3Cl)C2=O)c(Cl)c1OC
Show InChI InChI=1S/C30H29Cl2NO5/c1-35-24-12-10-20(26(31)29(24)37-3)14-22-17-33(16-19-8-6-5-7-9-19)18-23(28(22)34)15-21-11-13-25(36-2)30(38-4)27(21)32/h5-15H,16-18H2,1-4H3/b22-14+,23-15+
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n/an/a>1.00E+5n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Cholinesterase


(Equus caballus (Horse))
BDBM50161796
PNG
(CHEMBL3787250)
Show SMILES COc1ccc(\C=C2/CC(C\C(=C/c3ccc(OC)c(OC)c3Cl)C2=O)C(C)C)c(Cl)c1OC
Show InChI InChI=1S/C27H30Cl2O5/c1-15(2)18-13-19(11-16-7-9-21(31-3)26(33-5)23(16)28)25(30)20(14-18)12-17-8-10-22(32-4)27(34-6)24(17)29/h7-12,15,18H,13-14H2,1-6H3/b19-11+,20-12+
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n/an/a>1.00E+5n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Cholinesterase


(Equus caballus (Horse))
BDBM50161805
PNG
(CHEMBL3787471)
Show SMILES COc1ccc(\C=C2/CN(Cc3ccccc3)C\C(=C/c3ccc(OC)c(OC)c3Cl)C2=O)c(Cl)c1OC
Show InChI InChI=1S/C30H29Cl2NO5/c1-35-24-12-10-20(26(31)29(24)37-3)14-22-17-33(16-19-8-6-5-7-9-19)18-23(28(22)34)15-21-11-13-25(36-2)30(38-4)27(21)32/h5-15H,16-18H2,1-4H3/b22-14+,23-15+
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n/an/a>1.00E+5n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Cholinesterase


(Equus caballus (Horse))
BDBM50161774
PNG
(CHEMBL3785268)
Show SMILES COc1cc(\C=C2/CCC\C(=C/c3cc(OC)c(OC)c(OC)c3Br)C2=O)c(Br)c(OC)c1OC
Show InChI InChI=1S/C26H28Br2O7/c1-30-18-12-16(20(27)25(34-5)23(18)32-3)10-14-8-7-9-15(22(14)29)11-17-13-19(31-2)24(33-4)26(35-6)21(17)28/h10-13H,7-9H2,1-6H3/b14-10+,15-11+
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n/an/a>1.00E+5n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Cholinesterase


(Equus caballus (Horse))
BDBM50161804
PNG
(CHEMBL3786212)
Show SMILES COc1cccc(\C=C2/CN(Cc3ccccc3)C\C(=C/c3cccc(OC)c3Cl)C2=O)c1Cl
Show InChI InChI=1S/C28H25Cl2NO3/c1-33-24-12-6-10-20(26(24)29)14-22-17-31(16-19-8-4-3-5-9-19)18-23(28(22)32)15-21-11-7-13-25(34-2)27(21)30/h3-15H,16-18H2,1-2H3/b22-14+,23-15+
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n/an/a>1.00E+5n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Cholinesterase


(Equus caballus (Horse))
BDBM50161797
PNG
(CHEMBL3785402)
Show SMILES COc1cc(\C=C2/CC(C\C(=C/c3cc(OC)c(OC)c(OC)c3Br)C2=O)C(C)C)c(Br)c(OC)c1OC
Show InChI InChI=1S/C29H34Br2O7/c1-15(2)16-9-19(11-17-13-21(33-3)26(35-5)28(37-7)23(17)30)25(32)20(10-16)12-18-14-22(34-4)27(36-6)29(38-8)24(18)31/h11-16H,9-10H2,1-8H3/b19-11+,20-12+
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n/an/a>1.00E+5n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Cholinesterase


(Equus caballus (Horse))
BDBM50161773
PNG
(CHEMBL3786643)
Show SMILES COc1ccc(\C=C2/CCC\C(=C/c3ccc(OC)c(OC)c3Cl)C2=O)c(Cl)c1OC
Show InChI InChI=1S/C24H24Cl2O5/c1-28-18-10-8-14(20(25)23(18)30-3)12-16-6-5-7-17(22(16)27)13-15-9-11-19(29-2)24(31-4)21(15)26/h8-13H,5-7H2,1-4H3/b16-12+,17-13+
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n/an/a>1.00E+5n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Cholinesterase


(Equus caballus (Horse))
BDBM50161801
PNG
(CHEMBL3787510)
Show SMILES COc1cccc(\C=C2/CN(C)C\C(=C/c3cccc(OC)c3Cl)C2=O)c1Cl
Show InChI InChI=1S/C22H21Cl2NO3/c1-25-12-16(10-14-6-4-8-18(27-2)20(14)23)22(26)17(13-25)11-15-7-5-9-19(28-3)21(15)24/h4-11H,12-13H2,1-3H3/b16-10+,17-11+
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n/an/a>1.00E+5n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Cholinesterase


(Equus caballus (Horse))
BDBM50161809
PNG
(CHEMBL3787119)
Show SMILES COc1cc(\C=C2/COC\C(=C/c3cc(OC)c(OC)c(OC)c3Br)C2=O)c(Br)c(OC)c1OC
Show InChI InChI=1S/C25H26Br2O8/c1-29-17-9-13(19(26)24(33-5)22(17)31-3)7-15-11-35-12-16(21(15)28)8-14-10-18(30-2)23(32-4)25(34-6)20(14)27/h7-10H,11-12H2,1-6H3/b15-7+,16-8+
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n/an/a>1.00E+5n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Cholinesterase


(Equus caballus (Horse))
BDBM50161807
PNG
(CHEMBL3786918)
Show SMILES COc1cccc(\C=C2/COC\C(=C/c3cccc(OC)c3Cl)C2=O)c1Cl
Show InChI InChI=1S/C21H18Cl2O4/c1-25-17-7-3-5-13(19(17)22)9-15-11-27-12-16(21(15)24)10-14-6-4-8-18(26-2)20(14)23/h3-10H,11-12H2,1-2H3/b15-9+,16-10+
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n/an/a>1.00E+5n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Cholinesterase


(Equus caballus (Horse))
BDBM50161795
PNG
(CHEMBL3787274)
Show SMILES COc1cccc(\C=C2/CC(C\C(=C/c3cccc(OC)c3Cl)C2=O)C(C)C)c1Cl
Show InChI InChI=1S/C25H26Cl2O3/c1-15(2)18-13-19(11-16-7-5-9-21(29-3)23(16)26)25(28)20(14-18)12-17-8-6-10-22(30-4)24(17)27/h5-12,15,18H,13-14H2,1-4H3/b19-11+,20-12+
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n/an/a>1.00E+5n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Cholinesterase


(Equus caballus (Horse))
BDBM50161772
PNG
(CHEMBL3786095)
Show SMILES COc1cccc(\C=C2/CCC\C(=C/c3cccc(OC)c3Cl)C2=O)c1Cl
Show InChI InChI=1S/C22H20Cl2O3/c1-26-18-10-4-6-14(20(18)23)12-16-8-3-9-17(22(16)25)13-15-7-5-11-19(27-2)21(15)24/h4-7,10-13H,3,8-9H2,1-2H3/b16-12+,17-13+
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n/an/a>1.00E+5n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Cholinesterase


(Equus caballus (Horse))
BDBM50161798
PNG
(CHEMBL3785522)
Show SMILES COc1cccc(\C=C2/CNC\C(=C/c3cccc(OC)c3Cl)C2=O)c1Cl
Show InChI InChI=1S/C21H19Cl2NO3/c1-26-17-7-3-5-13(19(17)22)9-15-11-24-12-16(21(15)25)10-14-6-4-8-18(27-2)20(14)23/h3-10,24H,11-12H2,1-2H3/b15-9+,16-10+
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n/an/a>1.00E+5n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 min...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50161804
PNG
(CHEMBL3786212)
Show SMILES COc1cccc(\C=C2/CN(Cc3ccccc3)C\C(=C/c3cccc(OC)c3Cl)C2=O)c1Cl
Show InChI InChI=1S/C28H25Cl2NO3/c1-33-24-12-6-10-20(26(24)29)14-22-17-31(16-19-8-4-3-5-9-19)18-23(28(22)32)15-21-11-7-13-25(34-2)27(21)30/h3-15H,16-18H2,1-2H3/b22-14+,23-15+
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n/an/a>1.00E+5n/an/an/an/an/an/a



Wuhan University of Technology

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mi...


Bioorg Med Chem 24: 2352-9 (2016)


Article DOI: 10.1016/j.bmc.2016.04.015
BindingDB Entry DOI: 10.7270/Q2S46TVJ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%