Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Transcription activator BRG1 (Homo sapiens (Human)) | BDBM50184973 (CHEMBL3822828) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cambridge Curated by ChEMBL | Assay Description Inhibition of His6-tagged human recombinant SMARCA4 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells after 30 mins using biotinyla... | J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription activator BRG1 (Homo sapiens (Human)) | BDBM50184975 (CHEMBL3823214) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cambridge Curated by ChEMBL | Assay Description Inhibition of His6-tagged human recombinant SMARCA4 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells after 30 mins using biotinyla... | J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription activator BRG1 (Homo sapiens (Human)) | BDBM50184974 (CHEMBL3823057) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cambridge Curated by ChEMBL | Assay Description Inhibition of His6-tagged human recombinant SMARCA4 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells after 30 mins using biotinyla... | J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription activator BRG1 (Homo sapiens (Human)) | BDBM50184972 (CHEMBL3823525) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cambridge Curated by ChEMBL | Assay Description Inhibition of His6-tagged human recombinant SMARCA4 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells after 30 mins using biotinyla... | J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription activator BRG1 (Homo sapiens (Human)) | BDBM50184971 (CHEMBL3823210) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cambridge Curated by ChEMBL | Assay Description Inhibition of His6-tagged human recombinant SMARCA4 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells after 30 mins using biotinyla... | J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription activator BRG1 (Homo sapiens (Human)) | BDBM50184976 (CHEMBL3823365) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cambridge Curated by ChEMBL | Assay Description Inhibition of His6-tagged human recombinant SMARCA4 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells after 30 mins using biotinyla... | J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription activator BRG1 (Homo sapiens (Human)) | BDBM50184981 (CHEMBL3823055) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 2.03E+3 | n/a | n/a | n/a | n/a | n/a |
University of Cambridge Curated by ChEMBL | Assay Description Binding affinity to His6-tagged human recombinant SMARCA4 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microcalorime... | J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein polybromo-1 (Homo sapiens (Human)) | BDBM50184972 (CHEMBL3823525) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a |
University of Cambridge Curated by ChEMBL | Assay Description Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca... | J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein polybromo-1 (Homo sapiens (Human)) | BDBM50184973 (CHEMBL3822828) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a |
University of Cambridge Curated by ChEMBL | Assay Description Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca... | J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein polybromo-1 (Homo sapiens (Human)) | BDBM50184981 (CHEMBL3823055) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a |
University of Cambridge Curated by ChEMBL | Assay Description Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca... | J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription activator BRG1 (Homo sapiens (Human)) | BDBM50158688 (CHEMBL3752911) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a |
University of Cambridge Curated by ChEMBL | Assay Description Binding affinity to His6-tagged human recombinant SMARCA4 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microcalorime... | J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Protein polybromo-1 (Homo sapiens (Human)) | BDBM50184979 (CHEMBL3822689) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 124 | n/a | n/a | n/a | n/a | n/a |
University of Cambridge Curated by ChEMBL | Assay Description Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca... | J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Probable global transcription activator SNF2L2 (Homo sapiens (Human)) | BDBM50184979 (CHEMBL3822689) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 262 | n/a | n/a | n/a | n/a | n/a |
University of Cambridge Curated by ChEMBL | Assay Description Binding affinity to His6-tagged human recombinant SMARCA2B bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microcalorim... | J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein polybromo-1 (Homo sapiens (Human)) | BDBM50184980 (CHEMBL3824067) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 142 | n/a | n/a | n/a | n/a | n/a |
University of Cambridge Curated by ChEMBL | Assay Description Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca... | J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein polybromo-1 (Homo sapiens (Human)) | BDBM50184977 (CHEMBL3823132) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 137 | n/a | n/a | n/a | n/a | n/a |
University of Cambridge Curated by ChEMBL | Assay Description Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca... | J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription activator BRG1 (Homo sapiens (Human)) | BDBM50184979 (CHEMBL3822689) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 417 | n/a | n/a | n/a | n/a | n/a |
University of Cambridge Curated by ChEMBL | Assay Description Binding affinity to His6-tagged human recombinant SMARCA4 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microcalorime... | J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein polybromo-1 (Homo sapiens (Human)) | BDBM50158688 (CHEMBL3752911) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a |
University of Cambridge Curated by ChEMBL | Assay Description Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca... | J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein polybromo-1 (Homo sapiens (Human)) | BDBM50184978 (CHEMBL3823524) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 127 | n/a | n/a | n/a | n/a | n/a |
University of Cambridge Curated by ChEMBL | Assay Description Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca... | J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH | |||||||||||
More data for this Ligand-Target Pair |