Search and Browse
Download
Enter Data
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM50127140 ((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet  | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 5.95E+4 | n/a | n/a | n/a | n/a | 7.9 | n/a |
Jamia Millia Islamia (A Central University) | Assay Description Relaxation of negatively supercoiled plasmid DNA by human topoisomerase IIα was assayed in 20 無 of reaction buffer (10 mM Tris-HCl, pH 7.9, 150... | Bioorg Chem 69: 77-90 (2016) Article DOI: 10.1016/j.bioorg.2016.10.001 BindingDB Entry DOI: 10.7270/Q21V5CS9 | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM198131 (Ethyl 4-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <1.00E+5 | n/a | n/a | n/a | n/a | 7.9 | n/a |
Jamia Millia Islamia (A Central University) | Assay Description Relaxation of negatively supercoiled plasmid DNA by human topoisomerase IIα was assayed in 20 無 of reaction buffer (10 mM Tris-HCl, pH 7.9, 150... | Bioorg Chem 69: 77-90 (2016) Article DOI: 10.1016/j.bioorg.2016.10.001 BindingDB Entry DOI: 10.7270/Q21V5CS9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM198134 (Ethyl 4-(3-(3-bromophenyl)-1-phenyl-1H-pyrazol-4-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <1.00E+5 | n/a | n/a | n/a | n/a | 7.9 | n/a |
Jamia Millia Islamia (A Central University) | Assay Description Relaxation of negatively supercoiled plasmid DNA by human topoisomerase IIα was assayed in 20 無 of reaction buffer (10 mM Tris-HCl, pH 7.9, 150... | Bioorg Chem 69: 77-90 (2016) Article DOI: 10.1016/j.bioorg.2016.10.001 BindingDB Entry DOI: 10.7270/Q21V5CS9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM198133 (Ethyl 4-(3-(3-bromophenyl)-1-phenyl-1H-pyrazol-4-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <1.00E+5 | n/a | n/a | n/a | n/a | 7.9 | n/a |
Jamia Millia Islamia (A Central University) | Assay Description Relaxation of negatively supercoiled plasmid DNA by human topoisomerase IIα was assayed in 20 無 of reaction buffer (10 mM Tris-HCl, pH 7.9, 150... | Bioorg Chem 69: 77-90 (2016) Article DOI: 10.1016/j.bioorg.2016.10.001 BindingDB Entry DOI: 10.7270/Q21V5CS9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM198135 (Ethyl 4-(3-(3-nitrophenyl)-1-phenyl-1H-pyrazol-4-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <1.00E+5 | n/a | n/a | n/a | n/a | 7.9 | n/a |
Jamia Millia Islamia (A Central University) | Assay Description Relaxation of negatively supercoiled plasmid DNA by human topoisomerase IIα was assayed in 20 無 of reaction buffer (10 mM Tris-HCl, pH 7.9, 150... | Bioorg Chem 69: 77-90 (2016) Article DOI: 10.1016/j.bioorg.2016.10.001 BindingDB Entry DOI: 10.7270/Q21V5CS9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM198132 (Ethyl 4-(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <1.00E+5 | n/a | n/a | n/a | n/a | 7.9 | n/a |
Jamia Millia Islamia (A Central University) | Assay Description Relaxation of negatively supercoiled plasmid DNA by human topoisomerase IIα was assayed in 20 無 of reaction buffer (10 mM Tris-HCl, pH 7.9, 150... | Bioorg Chem 69: 77-90 (2016) Article DOI: 10.1016/j.bioorg.2016.10.001 BindingDB Entry DOI: 10.7270/Q21V5CS9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM198130 (Ethyl 4-(1,3-diphenyl-1H-Pyrazol-4-yl)-2-oxo-6-(py...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.22E+5 | n/a | n/a | n/a | n/a | 7.9 | n/a |
Jamia Millia Islamia (A Central University) | Assay Description Relaxation of negatively supercoiled plasmid DNA by human topoisomerase IIα was assayed in 20 無 of reaction buffer (10 mM Tris-HCl, pH 7.9, 150... | Bioorg Chem 69: 77-90 (2016) Article DOI: 10.1016/j.bioorg.2016.10.001 BindingDB Entry DOI: 10.7270/Q21V5CS9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM198139 (5-(1,3-Diphenyl-1H-pyrazol-4-yl)-3-(pyridin-3-yl)-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.45E+5 | n/a | n/a | n/a | n/a | 7.9 | n/a |
Jamia Millia Islamia (A Central University) | Assay Description Relaxation of negatively supercoiled plasmid DNA by human topoisomerase IIα was assayed in 20 無 of reaction buffer (10 mM Tris-HCl, pH 7.9, 150... | Bioorg Chem 69: 77-90 (2016) Article DOI: 10.1016/j.bioorg.2016.10.001 BindingDB Entry DOI: 10.7270/Q21V5CS9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM198136 (Ethyl 4-(3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.56E+5 | n/a | n/a | n/a | n/a | 7.9 | n/a |
Jamia Millia Islamia (A Central University) | Assay Description Relaxation of negatively supercoiled plasmid DNA by human topoisomerase IIα was assayed in 20 無 of reaction buffer (10 mM Tris-HCl, pH 7.9, 150... | Bioorg Chem 69: 77-90 (2016) Article DOI: 10.1016/j.bioorg.2016.10.001 BindingDB Entry DOI: 10.7270/Q21V5CS9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM198140 (5-(3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-3-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.72E+5 | n/a | n/a | n/a | n/a | 7.9 | n/a |
Jamia Millia Islamia (A Central University) | Assay Description Relaxation of negatively supercoiled plasmid DNA by human topoisomerase IIα was assayed in 20 無 of reaction buffer (10 mM Tris-HCl, pH 7.9, 150... | Bioorg Chem 69: 77-90 (2016) Article DOI: 10.1016/j.bioorg.2016.10.001 BindingDB Entry DOI: 10.7270/Q21V5CS9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM198137 (Ethyl 2-oxo-4-(1-phenyl-3-p-tolyl-1H-pyrazol-4-yl)...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.95E+5 | n/a | n/a | n/a | n/a | 7.9 | n/a |
Jamia Millia Islamia (A Central University) | Assay Description Relaxation of negatively supercoiled plasmid DNA by human topoisomerase IIα was assayed in 20 無 of reaction buffer (10 mM Tris-HCl, pH 7.9, 150... | Bioorg Chem 69: 77-90 (2016) Article DOI: 10.1016/j.bioorg.2016.10.001 BindingDB Entry DOI: 10.7270/Q21V5CS9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM198141 (5-(3-(4-Chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)-3-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.06E+5 | n/a | n/a | n/a | n/a | 7.9 | n/a |
Jamia Millia Islamia (A Central University) | Assay Description Relaxation of negatively supercoiled plasmid DNA by human topoisomerase IIα was assayed in 20 無 of reaction buffer (10 mM Tris-HCl, pH 7.9, 150... | Bioorg Chem 69: 77-90 (2016) Article DOI: 10.1016/j.bioorg.2016.10.001 BindingDB Entry DOI: 10.7270/Q21V5CS9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM198138 (Ethyl 4-(3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.28E+5 | n/a | n/a | n/a | n/a | 7.9 | n/a |
Jamia Millia Islamia (A Central University) | Assay Description Relaxation of negatively supercoiled plasmid DNA by human topoisomerase IIα was assayed in 20 無 of reaction buffer (10 mM Tris-HCl, pH 7.9, 150... | Bioorg Chem 69: 77-90 (2016) Article DOI: 10.1016/j.bioorg.2016.10.001 BindingDB Entry DOI: 10.7270/Q21V5CS9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM198144 (5-(3-(3-Nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)-3-(...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.45E+5 | n/a | n/a | n/a | n/a | 7.9 | n/a |
Jamia Millia Islamia (A Central University) | Assay Description Relaxation of negatively supercoiled plasmid DNA by human topoisomerase IIα was assayed in 20 無 of reaction buffer (10 mM Tris-HCl, pH 7.9, 150... | Bioorg Chem 69: 77-90 (2016) Article DOI: 10.1016/j.bioorg.2016.10.001 BindingDB Entry DOI: 10.7270/Q21V5CS9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM198142 (5-(3-(3-Bromophenyl)-1-phenyl-1H-pyrazol-4-yl)-3-(...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.57E+5 | n/a | n/a | n/a | n/a | 7.9 | n/a |
Jamia Millia Islamia (A Central University) | Assay Description Relaxation of negatively supercoiled plasmid DNA by human topoisomerase IIα was assayed in 20 無 of reaction buffer (10 mM Tris-HCl, pH 7.9, 150... | Bioorg Chem 69: 77-90 (2016) Article DOI: 10.1016/j.bioorg.2016.10.001 BindingDB Entry DOI: 10.7270/Q21V5CS9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM198143 (5-(3-(4-Bromophenyl)-1-phenyl-1H-pyrazol-4-yl)-3-(...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7.03E+5 | n/a | n/a | n/a | n/a | 7.9 | n/a |
Jamia Millia Islamia (A Central University) | Assay Description Relaxation of negatively supercoiled plasmid DNA by human topoisomerase IIα was assayed in 20 無 of reaction buffer (10 mM Tris-HCl, pH 7.9, 150... | Bioorg Chem 69: 77-90 (2016) Article DOI: 10.1016/j.bioorg.2016.10.001 BindingDB Entry DOI: 10.7270/Q21V5CS9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
