Affinity Data by PubMed id=27847273

PubMed code 27847273

Found 13 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50095469 ((5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol \|...) Show SMILES OCc1ccc(o1)-c1nn(Cc2ccccc2)c2ccccc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tokyo Institute of Innovative Research Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1 transcriptional activity in human HeLa cells measured after 12 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 26: 5887-5890 (2016) Article DOI: 10.1016/j.bmcl.2016.11.009 BindingDB Entry DOI: 10.7270/Q2X350G6
Tokyo Institute of Innovative Research Curated by ChEMBL					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50204471 (CHEMBL3927498) Show SMILES OCc1ccc(s1)-c1nc(-c2ccccc2)c2ccccn12 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tokyo Institute of Innovative Research Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1 transcriptional activity in human HeLa cells measured after 12 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 26: 5887-5890 (2016) Article DOI: 10.1016/j.bmcl.2016.11.009 BindingDB Entry DOI: 10.7270/Q2X350G6
Tokyo Institute of Innovative Research Curated by ChEMBL					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50204481 (CHEMBL3899458) Show SMILES OCc1ccc(o1)-c1nc(-c2ccccc2CO)c2ccccn12 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tokyo Institute of Innovative Research Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1 transcriptional activity in human HeLa cells measured after 12 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 26: 5887-5890 (2016) Article DOI: 10.1016/j.bmcl.2016.11.009 BindingDB Entry DOI: 10.7270/Q2X350G6
Tokyo Institute of Innovative Research Curated by ChEMBL					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50204482 (CHEMBL3918550) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tokyo Institute of Innovative Research Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1 transcriptional activity in human HeLa cells measured after 12 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 26: 5887-5890 (2016) Article DOI: 10.1016/j.bmcl.2016.11.009 BindingDB Entry DOI: 10.7270/Q2X350G6
Tokyo Institute of Innovative Research Curated by ChEMBL					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50204459 (CHEMBL3936460) Show SMILES OCc1ccc(s1)-c1nc(-c2ccncc2)c2ccccn12 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tokyo Institute of Innovative Research Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1 transcriptional activity in human HeLa cells measured after 12 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 26: 5887-5890 (2016) Article DOI: 10.1016/j.bmcl.2016.11.009 BindingDB Entry DOI: 10.7270/Q2X350G6
Tokyo Institute of Innovative Research Curated by ChEMBL					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50204484 (CHEMBL3908512) Show SMILES OCc1ccc(s1)-c1nc(-c2ccccc2CO)c2ccccn12 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tokyo Institute of Innovative Research Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1 transcriptional activity in human HeLa cells measured after 12 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 26: 5887-5890 (2016) Article DOI: 10.1016/j.bmcl.2016.11.009 BindingDB Entry DOI: 10.7270/Q2X350G6
Tokyo Institute of Innovative Research Curated by ChEMBL					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50204489 (CHEMBL3918157) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tokyo Institute of Innovative Research Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1 transcriptional activity in human HeLa cells measured after 12 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 26: 5887-5890 (2016) Article DOI: 10.1016/j.bmcl.2016.11.009 BindingDB Entry DOI: 10.7270/Q2X350G6
Tokyo Institute of Innovative Research Curated by ChEMBL					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50204472 (CHEMBL3915177) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tokyo Institute of Innovative Research Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1 transcriptional activity in human HeLa cells measured after 12 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 26: 5887-5890 (2016) Article DOI: 10.1016/j.bmcl.2016.11.009 BindingDB Entry DOI: 10.7270/Q2X350G6
Tokyo Institute of Innovative Research Curated by ChEMBL					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50204473 (CHEMBL3946046) Show SMILES Cc1ccc(cc1)-c1nc(-c2ccc(CO)o2)n2ccccc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tokyo Institute of Innovative Research Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1 transcriptional activity in human HeLa cells measured after 12 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 26: 5887-5890 (2016) Article DOI: 10.1016/j.bmcl.2016.11.009 BindingDB Entry DOI: 10.7270/Q2X350G6
Tokyo Institute of Innovative Research Curated by ChEMBL					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50204477 (CHEMBL3892315) Show SMILES OCc1ccc(o1)-c1nc(Cc2ccccc2)c2ccccn12 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tokyo Institute of Innovative Research Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1 transcriptional activity in human HeLa cells measured after 12 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 26: 5887-5890 (2016) Article DOI: 10.1016/j.bmcl.2016.11.009 BindingDB Entry DOI: 10.7270/Q2X350G6
Tokyo Institute of Innovative Research Curated by ChEMBL					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50204494 (CHEMBL3918408) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tokyo Institute of Innovative Research Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1 transcriptional activity in human HeLa cells measured after 12 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 26: 5887-5890 (2016) Article DOI: 10.1016/j.bmcl.2016.11.009 BindingDB Entry DOI: 10.7270/Q2X350G6
Tokyo Institute of Innovative Research Curated by ChEMBL					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50204470 (CHEMBL3961295) Show SMILES OCc1ccc(o1)-c1nc(-c2ccccc2)c2ccccn12 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tokyo Institute of Innovative Research Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1 transcriptional activity in human HeLa cells measured after 12 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 26: 5887-5890 (2016) Article DOI: 10.1016/j.bmcl.2016.11.009 BindingDB Entry DOI: 10.7270/Q2X350G6
Tokyo Institute of Innovative Research Curated by ChEMBL					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50204474 (CHEMBL3940432) Show SMILES COc1ccccc1-c1nc(-c2ccc(CO)o2)n2ccccc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tokyo Institute of Innovative Research Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1 transcriptional activity in human HeLa cells measured after 12 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 26: 5887-5890 (2016) Article DOI: 10.1016/j.bmcl.2016.11.009 BindingDB Entry DOI: 10.7270/Q2X350G6
Tokyo Institute of Innovative Research Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%