BindingDB logo
myBDB logout

PubMed code 27976894

Compile data set for download or QSAR
Found 90 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259839
PNG
(CHEMBL4100677)
Show SMILES Oc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1[N+]([O-])=O
Show InChI InChI=1S/C10H4BrN5O5/c11-5-2-3-1-4(9-12-14-15-13-9)10(18)21-8(3)6(7(5)17)16(19)20/h1-2,17H,(H,12,13,14,15)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 8.60n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259842
PNG
(CHEMBL4079816)
Show SMILES Oc1c(cc2cc(-c3nnn[nH]3)c(=O)oc2c1[N+]([O-])=O)[N+]([O-])=O
Show InChI InChI=1S/C10H4N6O7/c17-7-5(15(19)20)2-3-1-4(9-11-13-14-12-9)10(18)23-8(3)6(7)16(21)22/h1-2,17H,(H,11,12,13,14)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259853
PNG
(CHEMBL4092954)
Show SMILES Oc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1Br
Show InChI InChI=1S/C10H4Br2N4O3/c11-5-2-3-1-4(9-13-15-16-14-9)10(18)19-8(3)6(12)7(5)17/h1-2,17H,(H,13,14,15,16)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259845
PNG
(CHEMBL4082281)
Show SMILES OC(=O)c1cc2cc(Br)c(O)c([N+]([O-])=O)c2oc1=O
Show InChI InChI=1S/C10H4BrNO7/c11-5-2-3-1-4(9(14)15)10(16)19-8(3)6(7(5)13)12(17)18/h1-2,13H,(H,14,15)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 31n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259843
PNG
(CHEMBL4081238)
Show SMILES OC(=O)c1cc2cc(Br)c(O)c(Br)c2oc1=O
Show InChI InChI=1S/C10H4Br2O5/c11-5-2-3-1-4(9(14)15)10(16)17-8(3)6(12)7(5)13/h1-2,13H,(H,14,15)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 56n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259841
PNG
(CHEMBL4085211)
Show SMILES [O-][N+](=O)c1cc(Br)cc2cc(-c3nnn[nH]3)c(=O)oc12
Show InChI InChI=1S/C10H4BrN5O4/c11-5-1-4-2-6(9-12-14-15-13-9)10(17)20-8(4)7(3-5)16(18)19/h1-3H,(H,12,13,14,15)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 330n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259852
PNG
(CHEMBL4065291)
Show SMILES Brc1cc(Br)c2oc(=O)c(cc2c1)-c1nnn[nH]1
Show InChI InChI=1S/C10H4Br2N4O2/c11-5-1-4-2-6(9-13-15-16-14-9)10(17)18-8(4)7(12)3-5/h1-3H,(H,13,14,15,16)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 380n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259854
PNG
(CHEMBL4103143)
Show SMILES COc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1Br
Show InChI InChI=1S/C11H6Br2N4O3/c1-19-9-6(12)3-4-2-5(10-14-16-17-15-10)11(18)20-8(4)7(9)13/h2-3H,1H3,(H,14,15,16,17)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 460n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259878
PNG
(CHEMBL4073902)
Show SMILES Oc1cc2oc(=O)c(cc2cc1Br)-c1nnn[nH]1
Show InChI InChI=1S/C10H5BrN4O3/c11-6-2-4-1-5(9-12-14-15-13-9)10(17)18-8(4)3-7(6)16/h1-3,16H,(H,12,13,14,15)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 483n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259864
PNG
(CHEMBL4093683)
Show SMILES COc1c(Br)cc2cc(C#N)c(=O)oc2c1Br
Show InChI InChI=1S/C11H5Br2NO3/c1-16-10-7(12)3-5-2-6(4-14)11(15)17-9(5)8(10)13/h2-3H,1H3
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 590n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259865
PNG
(CHEMBL4066109)
Show SMILES [O-][N+](=O)c1cc(Br)cc2cc(C#N)c(=O)oc12
Show InChI InChI=1S/C10H3BrN2O4/c11-7-2-5-1-6(4-12)10(14)17-9(5)8(3-7)13(15)16/h1-3H
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 650n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259844
PNG
(CHEMBL4105535)
Show SMILES COc1c(Br)cc2cc(C(O)=O)c(=O)oc2c1Br
Show InChI InChI=1S/C11H6Br2O5/c1-17-9-6(12)3-4-2-5(10(14)15)11(16)18-8(4)7(9)13/h2-3H,1H3,(H,14,15)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 750n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259859
PNG
(CHEMBL1830823)
Show SMILES OC(=O)c1cc2cc(Br)cc(Br)c2oc1=O
Show InChI InChI=1S/C10H4Br2O4/c11-5-1-4-2-6(9(13)14)10(15)16-8(4)7(12)3-5/h1-3H,(H,13,14)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.08E+3n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259866
PNG
(CHEMBL4081445)
Show SMILES COc1c(Br)cc2cc(C#N)c(=O)oc2c1[N+]([O-])=O
Show InChI InChI=1S/C11H5BrN2O5/c1-18-10-7(12)3-5-2-6(4-13)11(15)19-9(5)8(10)14(16)17/h2-3H,1H3
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.69E+3n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259856
PNG
(CHEMBL1600989)
Show SMILES OC(=O)c1cc2cc(Cl)cc(Cl)c2oc1=O
Show InChI InChI=1S/C10H4Cl2O4/c11-5-1-4-2-6(9(13)14)10(15)16-8(4)7(12)3-5/h1-3H,(H,13,14)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.30E+3n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259888
PNG
(CHEMBL4084237)
Show SMILES COc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1[N+]([O-])=O
Show InChI InChI=1S/C11H6BrN5O5/c1-21-9-6(12)3-4-2-5(10-13-15-16-14-10)11(18)22-8(4)7(9)17(19)20/h2-3H,1H3,(H,13,14,15,16)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.82E+3n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259846
PNG
(CHEMBL4103860)
Show SMILES Oc1c(Br)cc2cc(C#N)c(=O)oc2c1Br
Show InChI InChI=1S/C10H3Br2NO3/c11-6-2-4-1-5(3-13)10(15)16-9(4)7(12)8(6)14/h1-2,14H
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.89E+3n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259860
PNG
(CHEMBL4096323)
Show SMILES OC(=O)c1cc2cc(Br)cc([N+]([O-])=O)c2oc1=O
Show InChI InChI=1S/C10H4BrNO6/c11-5-1-4-2-6(9(13)14)10(15)18-8(4)7(3-5)12(16)17/h1-3H,(H,13,14)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.75E+3n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259858
PNG
(CHEMBL4077503)
Show SMILES OC(=O)c1cc2cc(Br)c(O)cc2oc1=O
Show InChI InChI=1S/C10H5BrO5/c11-6-2-4-1-5(9(13)14)10(15)16-8(4)3-7(6)12/h1-3,12H,(H,13,14)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.76E+3n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259884
PNG
(CHEMBL1765162)
Show SMILES O=c1oc2ccccc2cc1-c1nn[nH]n1
Show InChI InChI=1S/C10H6N4O2/c15-10-7(9-11-13-14-12-9)5-6-3-1-2-4-8(6)16-10/h1-5H,(H,11,12,13,14)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5.08E+3n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259840
PNG
(CHEMBL4078055)
Show SMILES Clc1cc(Cl)c2oc(=O)c(cc2c1)C#N
Show InChI InChI=1S/C10H3Cl2NO2/c11-7-2-5-1-6(4-13)10(14)15-9(5)8(12)3-7/h1-3H
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 8.61E+3n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259863
PNG
(CHEMBL4085935)
Show SMILES Oc1cc2oc(=O)c(cc2cc1Br)C#N
Show InChI InChI=1S/C10H4BrNO3/c11-7-2-5-1-6(4-12)10(14)15-9(5)3-8(7)13/h1-3,13H
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 9.33E+3n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259886
PNG
(CHEMBL2333943)
Show SMILES OC(=O)c1cc2cc(Br)ccc2oc1=O
Show InChI InChI=1S/C10H5BrO4/c11-6-1-2-8-5(3-6)4-7(9(12)13)10(14)15-8/h1-4H,(H,12,13)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.13E+4n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259855
PNG
(CHEMBL1414071)
Show SMILES OC(=O)c1cc2cc(Cl)ccc2oc1=O
Show InChI InChI=1S/C10H5ClO4/c11-6-1-2-8-5(3-6)4-7(9(12)13)10(14)15-8/h1-4H,(H,12,13)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.32E+4n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259879
PNG
(CHEMBL4062531)
Show SMILES COc1cc2oc(=O)c(cc2cc1Br)-c1nnn[nH]1
Show InChI InChI=1S/C11H7BrN4O3/c1-18-9-4-8-5(3-7(9)12)2-6(11(17)19-8)10-13-15-16-14-10/h2-4H,1H3,(H,13,14,15,16)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.41E+4n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259861
PNG
(CHEMBL4096105)
Show SMILES Brc1cc(Br)c2oc(=O)c(cc2c1)C#N
Show InChI InChI=1S/C10H3Br2NO2/c11-7-2-5-1-6(4-13)10(14)15-9(5)8(12)3-7/h1-3H
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.49E+4n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259885
PNG
(CHEMBL4088382)
Show SMILES Clc1ccc2oc(=O)c(cc2c1)C#N
Show InChI InChI=1S/C10H4ClNO2/c11-8-1-2-9-6(4-8)3-7(5-12)10(13)14-9/h1-4H
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.14E+4n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50131066
PNG
(2-Oxo-2H-chromene-3-carboxylic acid | CHEMBL83294)
Show SMILES OC(=O)c1cc2ccccc2oc1=O
Show InChI InChI=1S/C10H6O4/c11-9(12)7-5-6-3-1-2-4-8(6)14-10(7)13/h1-5H,(H,11,12)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 1.00E+5n/an/an/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells assessed as induction of cell desensitization to 1 uM zaprinast preincubated for 1 hr followed by zapr...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259843
PNG
(CHEMBL4081238)
Show SMILES OC(=O)c1cc2cc(Br)c(O)c(Br)c2oc1=O
Show InChI InChI=1S/C10H4Br2O5/c11-5-2-3-1-4(9(14)15)10(16)17-8(3)6(12)7(5)13/h1-2,13H,(H,14,15)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 150n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM14363
PNG
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)
Show SMILES CCCOc1ccccc1-c1nc2nn[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 340n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259878
PNG
(CHEMBL4073902)
Show SMILES Oc1cc2oc(=O)c(cc2cc1Br)-c1nnn[nH]1
Show InChI InChI=1S/C10H5BrN4O3/c11-6-2-4-1-5(9-12-14-15-13-9)10(17)18-8(4)3-7(6)16/h1-3,16H,(H,12,13,14,15)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 710n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM38549
PNG
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Show SMILES OC(=O)c1cc2ccccc2c(Cc2c(O)c(cc3ccccc23)C(O)=O)c1O
Show InChI InChI=1S/C23H16O6/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h1-10,24-25H,11H2,(H,26,27)(H,28,29)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
PC cid
PC sid
PDB
UniChem

Similars
Article
PubMed
n/an/an/an/a 500n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259853
PNG
(CHEMBL4092954)
Show SMILES Oc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1Br
Show InChI InChI=1S/C10H4Br2N4O3/c11-5-2-3-1-4(9-13-15-16-14-9)10(18)19-8(3)6(12)7(5)17/h1-2,17H,(H,13,14,15,16)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.54E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at TEV protease cleavage site linked GAL4-VP16-fused GPR35 in human Tango GPR35-bla U2OS cells assessed as induction of TEV protease...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259842
PNG
(CHEMBL4079816)
Show SMILES Oc1c(cc2cc(-c3nnn[nH]3)c(=O)oc2c1[N+]([O-])=O)[N+]([O-])=O
Show InChI InChI=1S/C10H4N6O7/c17-7-5(15(19)20)2-3-1-4(9-11-13-14-12-9)10(18)23-8(3)6(7)16(21)22/h1-2,17H,(H,11,12,13,14)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 288n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at TEV protease cleavage site linked GAL4-VP16-fused GPR35 in human Tango GPR35-bla U2OS cells assessed as induction of TEV protease...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259839
PNG
(CHEMBL4100677)
Show SMILES Oc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1[N+]([O-])=O
Show InChI InChI=1S/C10H4BrN5O5/c11-5-2-3-1-4(9-12-14-15-13-9)10(18)21-8(3)6(7(5)17)16(19)20/h1-2,17H,(H,12,13,14,15)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 5.80n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259864
PNG
(CHEMBL4093683)
Show SMILES COc1c(Br)cc2cc(C#N)c(=O)oc2c1Br
Show InChI InChI=1S/C11H5Br2NO3/c1-16-10-7(12)3-5-2-6(4-14)11(15)17-9(5)8(10)13/h2-3H,1H3
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 8.22E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at TEV protease cleavage site linked GAL4-VP16-fused GPR35 in human Tango GPR35-bla U2OS cells assessed as induction of TEV protease...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM14363
PNG
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)
Show SMILES CCCOc1ccccc1-c1nc2nn[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 4.20E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259889
PNG
(Lodoxamide)
Show SMILES OC(=O)C(=O)Nc1cc(cc(NC(=O)C(O)=O)c1Cl)C#N
Show InChI InChI=1S/C11H6ClN3O6/c12-7-5(14-8(16)10(18)19)1-4(3-13)2-6(7)15-9(17)11(20)21/h1-2H,(H,14,16)(H,15,17)(H,18,19)(H,20,21)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/an/an/a 4.00E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM38549
PNG
(2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazino...)
Show SMILES OC(=O)c1cc2ccccc2c(Cc2c(O)c(cc3ccccc23)C(O)=O)c1O
Show InChI InChI=1S/C23H16O6/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h1-10,24-25H,11H2,(H,26,27)(H,28,29)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
PC cid
PC sid
PDB
UniChem

Similars
Article
PubMed
n/an/an/an/a 2n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO-K1 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50233945
PNG
(CHEBI:18344 | Kynurenic Acid | TRANSTORINE)
Show SMILES OC(=O)c1cc(=O)c2ccccc2[nH]1
Show InChI InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.52E+5n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO-K1 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259858
PNG
(CHEMBL4077503)
Show SMILES OC(=O)c1cc2cc(Br)c(O)cc2oc1=O
Show InChI InChI=1S/C10H5BrO5/c11-6-2-4-1-5(9(13)14)10(15)16-8(4)3-7(6)12/h1-3,12H,(H,13,14)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 4.34E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259843
PNG
(CHEMBL4081238)
Show SMILES OC(=O)c1cc2cc(Br)c(O)c(Br)c2oc1=O
Show InChI InChI=1S/C10H4Br2O5/c11-5-2-3-1-4(9(14)15)10(16)17-8(3)6(12)7(5)13/h1-2,13H,(H,14,15)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 3.63E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at TEV protease cleavage site linked GAL4-VP16-fused GPR35 in human Tango GPR35-bla U2OS cells assessed as induction of TEV protease...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259852
PNG
(CHEMBL4065291)
Show SMILES Brc1cc(Br)c2oc(=O)c(cc2c1)-c1nnn[nH]1
Show InChI InChI=1S/C10H4Br2N4O2/c11-5-1-4-2-6(9-13-15-16-14-9)10(17)18-8(4)7(12)3-5/h1-3H,(H,13,14,15,16)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 930n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259855
PNG
(CHEMBL1414071)
Show SMILES OC(=O)c1cc2cc(Cl)ccc2oc1=O
Show InChI InChI=1S/C10H5ClO4/c11-6-1-2-8-5(3-6)4-7(9(12)13)10(14)15-8/h1-4H,(H,12,13)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.35E+4n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259843
PNG
(CHEMBL4081238)
Show SMILES OC(=O)c1cc2cc(Br)c(O)c(Br)c2oc1=O
Show InChI InChI=1S/C10H4Br2O5/c11-5-2-3-1-4(9(14)15)10(16)17-8(3)6(12)7(5)13/h1-2,13H,(H,14,15)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 150n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at TEV protease cleavage site linked GAL4-VP16-fused GPR35 in human Tango GPR35-bla U2OS cells assessed as induction of TEV protease...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259839
PNG
(CHEMBL4100677)
Show SMILES Oc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1[N+]([O-])=O
Show InChI InChI=1S/C10H4BrN5O5/c11-5-2-3-1-4(9-12-14-15-13-9)10(18)21-8(3)6(7(5)17)16(19)20/h1-2,17H,(H,12,13,14,15)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 197n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at TEV protease cleavage site linked GAL4-VP16-fused GPR35 in human Tango GPR35-bla U2OS cells assessed as induction of TEV protease...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259844
PNG
(CHEMBL4105535)
Show SMILES COc1c(Br)cc2cc(C(O)=O)c(=O)oc2c1Br
Show InChI InChI=1S/C11H6Br2O5/c1-17-9-6(12)3-4-2-5(10(14)15)11(16)18-8(4)7(9)13/h2-3H,1H3,(H,14,15)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 887n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at TEV protease cleavage site linked GAL4-VP16-fused GPR35 in human Tango GPR35-bla U2OS cells assessed as induction of TEV protease...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50440033
PNG
(CROMOLYN | Crolom | Cromoglicic Acid)
Show SMILES OC(COc1cccc2oc(cc(=O)c12)C(O)=O)COc1cccc2oc(cc(=O)c12)C(O)=O
Show InChI InChI=1S/C23H16O11/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

DrugBank
MCE
KEGG
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 7.00E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259845
PNG
(CHEMBL4082281)
Show SMILES OC(=O)c1cc2cc(Br)c(O)c([N+]([O-])=O)c2oc1=O
Show InChI InChI=1S/C10H4BrNO7/c11-5-2-3-1-4(9(14)15)10(16)19-8(3)6(7(5)13)12(17)18/h1-2,13H,(H,14,15)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 51n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at TEV protease cleavage site linked GAL4-VP16-fused GPR35 in human Tango GPR35-bla U2OS cells assessed as induction of TEV protease...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259845
PNG
(CHEMBL4082281)
Show SMILES OC(=O)c1cc2cc(Br)c(O)c([N+]([O-])=O)c2oc1=O
Show InChI InChI=1S/C10H4BrNO7/c11-5-2-3-1-4(9(14)15)10(16)19-8(3)6(7(5)13)12(17)18/h1-2,13H,(H,14,15)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 51n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259841
PNG
(CHEMBL4085211)
Show SMILES [O-][N+](=O)c1cc(Br)cc2cc(-c3nnn[nH]3)c(=O)oc12
Show InChI InChI=1S/C10H4BrN5O4/c11-5-1-4-2-6(9-12-14-15-13-9)10(17)20-8(4)7(3-5)16(18)19/h1-3H,(H,12,13,14,15)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 333n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM14363
PNG
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)
Show SMILES CCCOc1ccccc1-c1nc2nn[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 160n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO-K1 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259866
PNG
(CHEMBL4081445)
Show SMILES COc1c(Br)cc2cc(C#N)c(=O)oc2c1[N+]([O-])=O
Show InChI InChI=1S/C11H5BrN2O5/c1-18-10-7(12)3-5-2-6(4-13)11(15)19-9(5)8(10)14(16)17/h2-3H,1H3
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 2.91E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259885
PNG
(CHEMBL4088382)
Show SMILES Clc1ccc2oc(=O)c(cc2c1)C#N
Show InChI InChI=1S/C10H4ClNO2/c11-8-1-2-9-6(4-8)3-7(5-12)10(13)14-9/h1-4H
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 2.14E+4n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at TEV protease cleavage site linked GAL4-VP16-fused GPR35 in human Tango GPR35-bla U2OS cells assessed as induction of TEV protease...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259856
PNG
(CHEMBL1600989)
Show SMILES OC(=O)c1cc2cc(Cl)cc(Cl)c2oc1=O
Show InChI InChI=1S/C10H4Cl2O4/c11-5-1-4-2-6(9(13)14)10(15)16-8(4)7(12)3-5/h1-3H,(H,13,14)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 2.02E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at TEV protease cleavage site linked GAL4-VP16-fused GPR35 in human Tango GPR35-bla U2OS cells assessed as induction of TEV protease...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50436001
PNG
(CHEMBL2392174 | CHEMBL2425818)
Show SMILES COc1ccc(cc1)C(=O)Nc1cc(Br)cc2c1oc(cc2=O)C(O)=O
Show InChI InChI=1S/C18H12BrNO6/c1-25-11-4-2-9(3-5-11)17(22)20-13-7-10(19)6-12-14(21)8-15(18(23)24)26-16(12)13/h2-8H,1H3,(H,20,22)(H,23,24)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 12n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259860
PNG
(CHEMBL4096323)
Show SMILES OC(=O)c1cc2cc(Br)cc([N+]([O-])=O)c2oc1=O
Show InChI InChI=1S/C10H4BrNO6/c11-5-1-4-2-6(9(13)14)10(15)18-8(4)7(3-5)12(16)17/h1-3H,(H,13,14)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 4.27E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at TEV protease cleavage site linked GAL4-VP16-fused GPR35 in human Tango GPR35-bla U2OS cells assessed as induction of TEV protease...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259852
PNG
(CHEMBL4065291)
Show SMILES Brc1cc(Br)c2oc(=O)c(cc2c1)-c1nnn[nH]1
Show InChI InChI=1S/C10H4Br2N4O2/c11-5-1-4-2-6(9-13-15-16-14-9)10(17)18-8(4)7(12)3-5/h1-3H,(H,13,14,15,16)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 7.05E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at TEV protease cleavage site linked GAL4-VP16-fused GPR35 in human Tango GPR35-bla U2OS cells assessed as induction of TEV protease...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259861
PNG
(CHEMBL4096105)
Show SMILES Brc1cc(Br)c2oc(=O)c(cc2c1)C#N
Show InChI InChI=1S/C10H3Br2NO2/c11-7-2-5-1-6(4-13)10(14)15-9(5)8(12)3-7/h1-3H
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.77E+4n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259886
PNG
(CHEMBL2333943)
Show SMILES OC(=O)c1cc2cc(Br)ccc2oc1=O
Show InChI InChI=1S/C10H5BrO4/c11-6-1-2-8-5(3-6)4-7(9(12)13)10(14)15-8/h1-4H,(H,12,13)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.08E+4n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259888
PNG
(CHEMBL4084237)
Show SMILES COc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1[N+]([O-])=O
Show InChI InChI=1S/C11H6BrN5O5/c1-21-9-6(12)3-4-2-5(10-13-15-16-14-10)11(18)22-8(4)7(9)17(19)20/h2-3H,1H3,(H,13,14,15,16)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 2.66E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259846
PNG
(CHEMBL4103860)
Show SMILES Oc1c(Br)cc2cc(C#N)c(=O)oc2c1Br
Show InChI InChI=1S/C10H3Br2NO3/c11-6-2-4-1-5(3-13)10(15)16-9(4)7(12)8(6)14/h1-2,14H
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 2.33E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259859
PNG
(CHEMBL1830823)
Show SMILES OC(=O)c1cc2cc(Br)cc(Br)c2oc1=O
Show InChI InChI=1S/C10H4Br2O4/c11-5-1-4-2-6(9(13)14)10(15)16-8(4)7(12)3-5/h1-3H,(H,13,14)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.75E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM14363
PNG
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)
Show SMILES CCCOc1ccccc1-c1nc2nn[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 3.52E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at TEV protease cleavage site linked GAL4-VP16-fused GPR35 in human Tango GPR35-bla U2OS cells assessed as induction of TEV protease...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259852
PNG
(CHEMBL4065291)
Show SMILES Brc1cc(Br)c2oc(=O)c(cc2c1)-c1nnn[nH]1
Show InChI InChI=1S/C10H4Br2N4O2/c11-5-1-4-2-6(9-13-15-16-14-9)10(17)18-8(4)7(12)3-5/h1-3H,(H,13,14,15,16)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 931n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM357857
PNG
(Aphthasol | US10214536, Amlexanox)
Show SMILES CC(C)c1ccc2oc3nc(N)c(cc3c(=O)c2c1)C(O)=O
Show InChI InChI=1S/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7H,1-2H3,(H2,17,18)(H,20,21)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/an/an/an/a 4.00E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259842
PNG
(CHEMBL4079816)
Show SMILES Oc1c(cc2cc(-c3nnn[nH]3)c(=O)oc2c1[N+]([O-])=O)[N+]([O-])=O
Show InChI InChI=1S/C10H4N6O7/c17-7-5(15(19)20)2-3-1-4(9-11-13-14-12-9)10(18)23-8(3)6(7)16(21)22/h1-2,17H,(H,11,12,13,14)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 14n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259844
PNG
(CHEMBL4105535)
Show SMILES COc1c(Br)cc2cc(C(O)=O)c(=O)oc2c1Br
Show InChI InChI=1S/C11H6Br2O5/c1-17-9-6(12)3-4-2-5(10(14)15)11(16)18-8(4)7(9)13/h2-3H,1H3,(H,14,15)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 890n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50440033
PNG
(CROMOLYN | Crolom | Cromoglicic Acid)
Show SMILES OC(COc1cccc2oc(cc(=O)c12)C(O)=O)COc1cccc2oc(cc(=O)c12)C(O)=O
Show InChI InChI=1S/C23H16O11/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

DrugBank
MCE
KEGG
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 52n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO-K1 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259845
PNG
(CHEMBL4082281)
Show SMILES OC(=O)c1cc2cc(Br)c(O)c([N+]([O-])=O)c2oc1=O
Show InChI InChI=1S/C10H4BrNO7/c11-5-2-3-1-4(9(14)15)10(16)19-8(3)6(7(5)13)12(17)18/h1-2,13H,(H,14,15)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 479n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at TEV protease cleavage site linked GAL4-VP16-fused GPR35 in human Tango GPR35-bla U2OS cells assessed as induction of TEV protease...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259846
PNG
(CHEMBL4103860)
Show SMILES Oc1c(Br)cc2cc(C#N)c(=O)oc2c1Br
Show InChI InChI=1S/C10H3Br2NO3/c11-6-2-4-1-5(3-13)10(15)16-9(4)7(12)8(6)14/h1-2,14H
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 2.33E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at TEV protease cleavage site linked GAL4-VP16-fused GPR35 in human Tango GPR35-bla U2OS cells assessed as induction of TEV protease...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM35525
PNG
(3,3''''-methylenebis(4-hydroxy-coumarin | 3,3''''-...)
Show SMILES Oc1c(Cc2c(O)c3ccccc3oc2=O)c(=O)oc2ccccc12
Show InChI InChI=1S/C19H12O6/c20-16-10-5-1-3-7-14(10)24-18(22)12(16)9-13-17(21)11-6-2-4-8-15(11)25-19(13)23/h1-8,20-21H,9H2
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.30E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259865
PNG
(CHEMBL4066109)
Show SMILES [O-][N+](=O)c1cc(Br)cc2cc(C#N)c(=O)oc12
Show InChI InChI=1S/C10H3BrN2O4/c11-7-2-5-1-6(4-12)10(14)17-9(5)8(3-7)13(15)16/h1-3H
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 700n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259854
PNG
(CHEMBL4103143)
Show SMILES COc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1Br
Show InChI InChI=1S/C11H6Br2N4O3/c1-19-9-6(12)3-4-2-5(10-14-16-17-15-10)11(18)20-8(4)7(9)13/h2-3H,1H3,(H,14,15,16,17)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.41E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259853
PNG
(CHEMBL4092954)
Show SMILES Oc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1Br
Show InChI InChI=1S/C10H4Br2N4O3/c11-5-2-3-1-4(9-13-15-16-14-9)10(18)19-8(3)6(12)7(5)17/h1-2,17H,(H,13,14,15,16)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 68n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259853
PNG
(CHEMBL4092954)
Show SMILES Oc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1Br
Show InChI InChI=1S/C10H4Br2N4O3/c11-5-2-3-1-4(9-13-15-16-14-9)10(18)19-8(3)6(12)7(5)17/h1-2,17H,(H,13,14,15,16)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 67n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at TEV protease cleavage site linked GAL4-VP16-fused GPR35 in human Tango GPR35-bla U2OS cells assessed as induction of TEV protease...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259854
PNG
(CHEMBL4103143)
Show SMILES COc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1Br
Show InChI InChI=1S/C11H6Br2N4O3/c1-19-9-6(12)3-4-2-5(10-14-16-17-15-10)11(18)20-8(4)7(9)13/h2-3H,1H3,(H,14,15,16,17)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.41E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at TEV protease cleavage site linked GAL4-VP16-fused GPR35 in human Tango GPR35-bla U2OS cells assessed as induction of TEV protease...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259879
PNG
(CHEMBL4062531)
Show SMILES COc1cc2oc(=O)c(cc2cc1Br)-c1nnn[nH]1
Show InChI InChI=1S/C11H7BrN4O3/c1-18-9-4-8-5(3-7(9)12)2-6(11(17)19-8)10-13-15-16-14-10/h2-4H,1H3,(H,13,14,15,16)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.48E+4n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259841
PNG
(CHEMBL4085211)
Show SMILES [O-][N+](=O)c1cc(Br)cc2cc(-c3nnn[nH]3)c(=O)oc12
Show InChI InChI=1S/C10H4BrN5O4/c11-5-1-4-2-6(9-12-14-15-13-9)10(17)20-8(4)7(3-5)16(18)19/h1-3H,(H,12,13,14,15)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 330n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259884
PNG
(CHEMBL1765162)
Show SMILES O=c1oc2ccccc2cc1-c1nn[nH]n1
Show InChI InChI=1S/C10H6N4O2/c15-10-7(9-11-13-14-12-9)5-6-3-1-2-4-8(6)16-10/h1-5H,(H,11,12,13,14)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 6.76E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50357187
PNG
(CHEMBL1914576)
Show SMILES [#6]-[#6]1=[#6](C#N)\[#6](-[#8]C1([#6])c1ccc(Cl)c(Cl)c1)=[#6](\C#N)C#N |c:1|
Show InChI InChI=1S/C16H9Cl2N3O/c1-9-12(8-21)15(10(6-19)7-20)22-16(9,2)11-3-4-13(17)14(18)5-11/h3-5H,1-2H3
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 32n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO-K1 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259854
PNG
(CHEMBL4103143)
Show SMILES COc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1Br
Show InChI InChI=1S/C11H6Br2N4O3/c1-19-9-6(12)3-4-2-5(10-14-16-17-15-10)11(18)20-8(4)7(9)13/h2-3H,1H3,(H,14,15,16,17)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.41E+4n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at TEV protease cleavage site linked GAL4-VP16-fused GPR35 in human Tango GPR35-bla U2OS cells assessed as induction of TEV protease...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259863
PNG
(CHEMBL4085935)
Show SMILES Oc1cc2oc(=O)c(cc2cc1Br)C#N
Show InChI InChI=1S/C10H4BrNO3/c11-7-2-5-1-6(4-12)10(14)15-9(5)3-8(7)13/h1-3,13H
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 9.27E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50233945
PNG
(CHEBI:18344 | Kynurenic Acid | TRANSTORINE)
Show SMILES OC(=O)c1cc(=O)c2ccccc2[nH]1
Show InChI InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 2.17E+5n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259840
PNG
(CHEMBL4078055)
Show SMILES Clc1cc(Cl)c2oc(=O)c(cc2c1)C#N
Show InChI InChI=1S/C10H3Cl2NO2/c11-7-2-5-1-6(4-13)10(14)15-9(5)8(12)3-7/h1-3H
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 8.61E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at TEV protease cleavage site linked GAL4-VP16-fused GPR35 in human Tango GPR35-bla U2OS cells assessed as induction of TEV protease...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259859
PNG
(CHEMBL1830823)
Show SMILES OC(=O)c1cc2cc(Br)cc(Br)c2oc1=O
Show InChI InChI=1S/C10H4Br2O4/c11-5-1-4-2-6(9(13)14)10(15)16-8(4)7(12)3-5/h1-3H,(H,13,14)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.75E+3n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at TEV protease cleavage site linked GAL4-VP16-fused GPR35 in human Tango GPR35-bla U2OS cells assessed as induction of TEV protease...

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50131066
PNG
(2-Oxo-2H-chromene-3-carboxylic acid | CHEMBL83294)
Show SMILES OC(=O)c1cc2ccccc2oc1=O
Show InChI InChI=1S/C10H6O4/c11-9(12)7-5-6-3-1-2-4-8(6)14-10(7)13/h1-5H,(H,11,12)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 9.23E+4n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259887
PNG
(CHEMBL3277775)
Show SMILES OC(=O)c1cc(=O)c2c(ccc3c2[nH]c(cc3=O)C(O)=O)[nH]1
Show InChI InChI=1S/C14H8N2O6/c17-9-3-8(14(21)22)16-12-5(9)1-2-6-11(12)10(18)4-7(15-6)13(19)20/h1-4H,(H,15,18)(H,16,17)(H,19,20)(H,21,22)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 13n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50259865
PNG
(CHEMBL4066109)
Show SMILES [O-][N+](=O)c1cc(Br)cc2cc(C#N)c(=O)oc12
Show InChI InChI=1S/C10H3BrN2O4/c11-7-2-5-1-6(4-12)10(14)17-9(5)8(3-7)13(15)16/h1-3H
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 700n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at GPR35 in human HT-29 cells by DMR assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
G-protein coupled receptor 35


(Homo sapiens (Human))		BDBM50357187
PNG
(CHEMBL1914576)
Show SMILES [#6]-[#6]1=[#6](C#N)\[#6](-[#8]C1([#6])c1ccc(Cl)c(Cl)c1)=[#6](\C#N)C#N |c:1|
Show InChI InChI=1S/C16H9Cl2N3O/c1-9-12(8-21)15(10(6-19)7-20)22-16(9,2)11-3-4-13(17)14(18)5-11/h3-5H,1-2H3
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 1.02E+4n/an/an/an/a



Dalian Institute of Chemical Physics

Curated by ChEMBL


Assay Description
Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay

J Med Chem 60: 362-372 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01431
BindingDB Entry DOI: 10.7270/Q2J67KC8
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%