BindingDB logo
myBDB logout

PubMed code 27994760

Compile data set for download or QSAR
Found 25 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50440863
PNG
(CHEMBL2431716)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC(CC1)c1ccccc1 |r|
Show InChI InChI=1S/C30H42N4O4/c1-3-21(2)27(30(37)34-18-15-24(16-19-34)23-12-8-5-9-13-23)33-28(35)25(20-22-10-6-4-7-11-22)32-29(36)26-14-17-31-38-26/h5,8-9,12-14,17,21-22,24-25,27H,3-4,6-7,10-11,15-16,18-20H2,1-2H3,(H,32,36)(H,33,35)/t21-,25-,27-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human PAR2 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 20 mins followed by...

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50440863
PNG
(CHEMBL2431716)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC(CC1)c1ccccc1 |r|
Show InChI InChI=1S/C30H42N4O4/c1-3-21(2)27(30(37)34-18-15-24(16-19-34)23-12-8-5-9-13-23)33-28(35)25(20-22-10-6-4-7-11-22)32-29(36)26-14-17-31-38-26/h5,8-9,12-14,17,21-22,24-25,27H,3-4,6-7,10-11,15-16,18-20H2,1-2H3,(H,32,36)(H,33,35)/t21-,25-,27-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 109n/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human PAR2 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 20 mins followed by...

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50440863
PNG
(CHEMBL2431716)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC(CC1)c1ccccc1 |r|
Show InChI InChI=1S/C30H42N4O4/c1-3-21(2)27(30(37)34-18-15-24(16-19-34)23-12-8-5-9-13-23)33-28(35)25(20-22-10-6-4-7-11-22)32-29(36)26-14-17-31-38-26/h5,8-9,12-14,17,21-22,24-25,27H,3-4,6-7,10-11,15-16,18-20H2,1-2H3,(H,32,36)(H,33,35)/t21-,25-,27-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 700n/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-stimulated intracellular calcium release preincubated for 30...

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50440863
PNG
(CHEMBL2431716)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC(CC1)c1ccccc1 |r|
Show InChI InChI=1S/C30H42N4O4/c1-3-21(2)27(30(37)34-18-15-24(16-19-34)23-12-8-5-9-13-23)33-28(35)25(20-22-10-6-4-7-11-22)32-29(36)26-14-17-31-38-26/h5,8-9,12-14,17,21-22,24-25,27H,3-4,6-7,10-11,15-16,18-20H2,1-2H3,(H,32,36)(H,33,35)/t21-,25-,27-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 700n/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-stimulated intracellular calcium release preincubated for 30...

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50440868
PNG
(CHEMBL2431617)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC2(CC1)C=Cc1ccccc21 |r,c:35|
Show InChI InChI=1S/C32H42N4O4/c1-3-22(2)28(31(39)36-19-16-32(17-20-36)15-13-24-11-7-8-12-25(24)32)35-29(37)26(21-23-9-5-4-6-10-23)34-30(38)27-14-18-33-40-27/h7-8,11-15,18,22-23,26,28H,3-6,9-10,16-17,19-21H2,1-2H3,(H,34,38)(H,35,37)/t22-,26-,28-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.10E+3n/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-stimulated intracellular calcium release preincubated for 30...

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50440868
PNG
(CHEMBL2431617)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC2(CC1)C=Cc1ccccc21 |r,c:35|
Show InChI InChI=1S/C32H42N4O4/c1-3-22(2)28(31(39)36-19-16-32(17-20-36)15-13-24-11-7-8-12-25(24)32)35-29(37)26(21-23-9-5-4-6-10-23)34-30(38)27-14-18-33-40-27/h7-8,11-15,18,22-23,26,28H,3-6,9-10,16-17,19-21H2,1-2H3,(H,34,38)(H,35,37)/t22-,26-,28-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.10E+3n/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-stimulated intracellular calcium release preincubated for 30...

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50203292
PNG
(CHEMBL3902670)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cc(N)no1)C(=O)N1CCC2(CC1)C=Cc1ccccc21 |r,c:36|
Show InChI InChI=1S/C32H43N5O4/c1-3-21(2)28(31(40)37-17-15-32(16-18-37)14-13-23-11-7-8-12-24(23)32)35-29(38)25(19-22-9-5-4-6-10-22)34-30(39)26-20-27(33)36-41-26/h7-8,11-14,20-22,25,28H,3-6,9-10,15-19H2,1-2H3,(H2,33,36)(H,34,39)(H,35,38)/t21-,25-,28-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.20E+3n/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-stimulated intracellular calcium release preincubated for 30...

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50203292
PNG
(CHEMBL3902670)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cc(N)no1)C(=O)N1CCC2(CC1)C=Cc1ccccc21 |r,c:36|
Show InChI InChI=1S/C32H43N5O4/c1-3-21(2)28(31(40)37-17-15-32(16-18-37)14-13-23-11-7-8-12-24(23)32)35-29(38)25(19-22-9-5-4-6-10-22)34-30(39)26-20-27(33)36-41-26/h7-8,11-14,20-22,25,28H,3-6,9-10,15-19H2,1-2H3,(H2,33,36)(H,34,39)(H,35,38)/t21-,25-,28-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.26E+3n/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-stimulated intracellular calcium release preincubated for 30...

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50203296
PNG
(CHEMBL3959120)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC2(CC1)CCc1ccccc1O2 |r|
Show InChI InChI=1S/C32H44N4O5/c1-3-22(2)28(31(39)36-19-16-32(17-20-36)15-13-24-11-7-8-12-26(24)40-32)35-29(37)25(21-23-9-5-4-6-10-23)34-30(38)27-14-18-33-41-27/h7-8,11-12,14,18,22-23,25,28H,3-6,9-10,13,15-17,19-21H2,1-2H3,(H,34,38)(H,35,37)/t22-,25-,28-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.90E+3n/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-stimulated intracellular calcium release preincubated for 30...

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50203296
PNG
(CHEMBL3959120)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC2(CC1)CCc1ccccc1O2 |r|
Show InChI InChI=1S/C32H44N4O5/c1-3-22(2)28(31(39)36-19-16-32(17-20-36)15-13-24-11-7-8-12-26(24)40-32)35-29(37)25(21-23-9-5-4-6-10-23)34-30(38)27-14-18-33-41-27/h7-8,11-12,14,18,22-23,25,28H,3-6,9-10,13,15-17,19-21H2,1-2H3,(H,34,38)(H,35,37)/t22-,25-,28-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-stimulated intracellular calcium release preincubated for 30...

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50440863
PNG
(CHEMBL2431716)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC(CC1)c1ccccc1 |r|
Show InChI InChI=1S/C30H42N4O4/c1-3-21(2)27(30(37)34-18-15-24(16-19-34)23-12-8-5-9-13-23)33-28(35)25(20-22-10-6-4-7-11-22)32-29(36)26-14-17-31-38-26/h5,8-9,12-14,17,21-22,24-25,27H,3-4,6-7,10-11,15-16,18-20H2,1-2H3,(H,32,36)(H,33,35)/t21-,25-,27-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.20E+3n/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of endogenous trypsin-stimulated intracellular calcium release by Fluo-3 AM d...

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50203291
PNG
(CHEMBL3916411)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1c[nH]cn1)C(=O)N1CCC2(CC1)C=Cc1ccccc21 |r,c:35|
Show InChI InChI=1S/C32H43N5O3/c1-3-22(2)28(31(40)37-17-15-32(16-18-37)14-13-24-11-7-8-12-25(24)32)36-29(38)26(19-23-9-5-4-6-10-23)35-30(39)27-20-33-21-34-27/h7-8,11-14,20-23,26,28H,3-6,9-10,15-19H2,1-2H3,(H,33,34)(H,35,39)(H,36,38)/t22-,26-,28-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.10E+3n/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-stimulated intracellular calcium release preincubated for 30...

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50203291
PNG
(CHEMBL3916411)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1c[nH]cn1)C(=O)N1CCC2(CC1)C=Cc1ccccc21 |r,c:35|
Show InChI InChI=1S/C32H43N5O3/c1-3-22(2)28(31(40)37-17-15-32(16-18-37)14-13-24-11-7-8-12-25(24)32)36-29(38)26(19-23-9-5-4-6-10-23)35-30(39)27-20-33-21-34-27/h7-8,11-14,20-23,26,28H,3-6,9-10,15-19H2,1-2H3,(H,33,34)(H,35,39)(H,36,38)/t22-,26-,28-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.16E+3n/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-stimulated intracellular calcium release preincubated for 30...

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50440868
PNG
(CHEMBL2431617)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC2(CC1)C=Cc1ccccc21 |r,c:35|
Show InChI InChI=1S/C32H42N4O4/c1-3-22(2)28(31(39)36-19-16-32(17-20-36)15-13-24-11-7-8-12-25(24)32)35-29(37)26(21-23-9-5-4-6-10-23)34-30(38)27-14-18-33-40-27/h7-8,11-15,18,22-23,26,28H,3-6,9-10,16-17,19-21H2,1-2H3,(H,34,38)(H,35,37)/t22-,26-,28-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.60E+3n/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of endogenous trypsin-stimulated intracellular calcium release by Fluo-3 AM d...

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50440863
PNG
(CHEMBL2431716)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC(CC1)c1ccccc1 |r|
Show InChI InChI=1S/C30H42N4O4/c1-3-21(2)27(30(37)34-18-15-24(16-19-34)23-12-8-5-9-13-23)33-28(35)25(20-22-10-6-4-7-11-22)32-29(36)26-14-17-31-38-26/h5,8-9,12-14,17,21-22,24-25,27H,3-4,6-7,10-11,15-16,18-20H2,1-2H3,(H,32,36)(H,33,35)/t21-,25-,27-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.50E+3n/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Antagonist activity at PAR2 in human PC3 cells assessed as inhibition of 2f-LIGRLO-NH2-stimulated intracellular calcium release preincubated for 30 m...

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50440863
PNG
(CHEMBL2431716)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC(CC1)c1ccccc1 |r|
Show InChI InChI=1S/C30H42N4O4/c1-3-21(2)27(30(37)34-18-15-24(16-19-34)23-12-8-5-9-13-23)33-28(35)25(20-22-10-6-4-7-11-22)32-29(36)26-14-17-31-38-26/h5,8-9,12-14,17,21-22,24-25,27H,3-4,6-7,10-11,15-16,18-20H2,1-2H3,(H,32,36)(H,33,35)/t21-,25-,27-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.50E+3n/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Antagonist activity at PAR2 in human PC3 cells assessed as inhibition of endogenous trypsin-stimulated intracellular calcium release by Fluo-3 AM dye...

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50203295
PNG
(CHEMBL3914547)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCCC[C@H]1C(=O)NC(C)(C)C |r|
Show InChI InChI=1S/C29H47N5O5/c1-6-19(2)24(28(38)34-17-11-10-14-22(34)26(36)33-29(3,4)5)32-25(35)21(18-20-12-8-7-9-13-20)31-27(37)23-15-16-30-39-23/h15-16,19-22,24H,6-14,17-18H2,1-5H3,(H,31,37)(H,32,35)(H,33,36)/t19-,21-,22-,24-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.94E+3n/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-stimulated intracellular calcium release preincubated for 30...

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50203295
PNG
(CHEMBL3914547)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCCC[C@H]1C(=O)NC(C)(C)C |r|
Show InChI InChI=1S/C29H47N5O5/c1-6-19(2)24(28(38)34-17-11-10-14-22(34)26(36)33-29(3,4)5)32-25(35)21(18-20-12-8-7-9-13-20)31-27(37)23-15-16-30-39-23/h15-16,19-22,24H,6-14,17-18H2,1-5H3,(H,31,37)(H,32,35)(H,33,36)/t19-,21-,22-,24-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.60E+3n/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-stimulated intracellular calcium release preincubated for 30...

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50203293
PNG
(CHEMBL3930659)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cc(CN)no1)C(=O)N1CCC2(CC1)C=Cc1ccccc21 |r,c:37|
Show InChI InChI=1S/C33H45N5O4/c1-3-22(2)29(32(41)38-17-15-33(16-18-38)14-13-24-11-7-8-12-26(24)33)36-30(39)27(19-23-9-5-4-6-10-23)35-31(40)28-20-25(21-34)37-42-28/h7-8,11-14,20,22-23,27,29H,3-6,9-10,15-19,21,34H2,1-2H3,(H,35,40)(H,36,39)/t22-,27-,29-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 8.90E+3n/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-stimulated intracellular calcium release preincubated for 30...

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50203293
PNG
(CHEMBL3930659)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cc(CN)no1)C(=O)N1CCC2(CC1)C=Cc1ccccc21 |r,c:37|
Show InChI InChI=1S/C33H45N5O4/c1-3-22(2)29(32(41)38-17-15-33(16-18-38)14-13-24-11-7-8-12-26(24)33)36-30(39)27(19-23-9-5-4-6-10-23)35-31(40)28-20-25(21-34)37-42-28/h7-8,11-14,20,22-23,27,29H,3-6,9-10,15-19,21,34H2,1-2H3,(H,35,40)(H,36,39)/t22-,27-,29-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 8.90E+3n/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-stimulated intracellular calcium release preincubated for 30...

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50203290
PNG
(CHEMBL3896632)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC2(CC1)CC(=O)c1ccccc1O2 |r|
Show InChI InChI=1S/C32H42N4O6/c1-3-21(2)28(31(40)36-17-14-32(15-18-36)20-25(37)23-11-7-8-12-26(23)41-32)35-29(38)24(19-22-9-5-4-6-10-22)34-30(39)27-13-16-33-42-27/h7-8,11-13,16,21-22,24,28H,3-6,9-10,14-15,17-20H2,1-2H3,(H,34,39)(H,35,38)/t21-,24-,28-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 700n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at PAR2 in human HT-29 cells assessed as increase in intracellular calcium release incubated for 30 mins measured for 60 secs by Flu...

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50440863
PNG
(CHEMBL2431716)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC(CC1)c1ccccc1 |r|
Show InChI InChI=1S/C30H42N4O4/c1-3-21(2)27(30(37)34-18-15-24(16-19-34)23-12-8-5-9-13-23)33-28(35)25(20-22-10-6-4-7-11-22)32-29(36)26-14-17-31-38-26/h5,8-9,12-14,17,21-22,24-25,27H,3-4,6-7,10-11,15-16,18-20H2,1-2H3,(H,32,36)(H,33,35)/t21-,25-,27-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 2.00E+3n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human PAR2 expressed in CHO cells assessed as induction of ERK1/2 phosphorylation incubated for 10 mins measured after 2 hrs

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50440863
PNG
(CHEMBL2431716)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC(CC1)c1ccccc1 |r|
Show InChI InChI=1S/C30H42N4O4/c1-3-21(2)27(30(37)34-18-15-24(16-19-34)23-12-8-5-9-13-23)33-28(35)25(20-22-10-6-4-7-11-22)32-29(36)26-14-17-31-38-26/h5,8-9,12-14,17,21-22,24-25,27H,3-4,6-7,10-11,15-16,18-20H2,1-2H3,(H,32,36)(H,33,35)/t21-,25-,27-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 2.20E+3n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at human PAR2 expressed in CHO cells assessed as induction of ERK1/2 phosphorylation incubated for 10 mins measured after 2 hrs

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50203297
PNG
(CHEMBL3956750)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC2(CC1)OC(=O)c1ccccc21 |r|
Show InChI InChI=1S/C31H40N4O6/c1-3-20(2)26(29(38)35-17-14-31(15-18-35)23-12-8-7-11-22(23)30(39)40-31)34-27(36)24(19-21-9-5-4-6-10-21)33-28(37)25-13-16-32-41-25/h7-8,11-13,16,20-21,24,26H,3-6,9-10,14-15,17-19H2,1-2H3,(H,33,37)(H,34,36)/t20-,24-,26-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 700n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at PAR2 in human HT-29 cells assessed as increase in intracellular calcium release incubated for 30 mins measured for 60 secs by Flu...

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
Proteinase-activated receptor 2


(Homo sapiens (Human))		BDBM50203294
PNG
(CHEMBL3947297)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC2(CC1)C1OC1c1ccccc21 |r|
Show InChI InChI=1S/C32H42N4O5/c1-3-20(2)26(31(39)36-17-14-32(15-18-36)23-12-8-7-11-22(23)27-28(32)40-27)35-29(37)24(19-21-9-5-4-6-10-21)34-30(38)25-13-16-33-41-25/h7-8,11-13,16,20-21,24,26-28H,3-6,9-10,14-15,17-19H2,1-2H3,(H,34,38)(H,35,37)/t20-,24-,26-,27?,28?/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/an/an/a 700n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Agonist activity at PAR2 in human HT-29 cells assessed as increase in intracellular calcium release incubated for 30 mins measured for 60 secs by Flu...

ACS Med Chem Lett 7: 1179-1184 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00306
BindingDB Entry DOI: 10.7270/Q2PN97MR
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%