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PubMed code 28076826

Compile data set for download or QSAR
Found 27 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50230317
PNG
(CHEMBL4091022)
Show SMILES CSc1nc(NCc2ccccc2)c2ccn(Cc3ccc(F)cc3)c2n1
Show InChI InChI=1S/C21H19FN4S/c1-27-21-24-19(23-13-15-5-3-2-4-6-15)18-11-12-26(20(18)25-21)14-16-7-9-17(22)10-8-16/h2-12H,13-14H2,1H3,(H,23,24,25)
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 500n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length N-terminal His6-tagged Src expressed in Sf21 cells using KVEKIGEGTYGVVYK as substrate after 10 mins in pr...

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50230313
PNG
(CHEMBL4068876)
Show SMILES CSc1nc(Nc2cccc(Cl)c2)c2ccn(CC(Cl)c3ccccc3)c2n1
Show InChI InChI=1S/C21H18Cl2N4S/c1-28-21-25-19(24-16-9-5-8-15(22)12-16)17-10-11-27(20(17)26-21)13-18(23)14-6-3-2-4-7-14/h2-12,18H,13H2,1H3,(H,24,25,26)
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 700n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length N-terminal His6-tagged Src expressed in Sf21 cells using KVEKIGEGTYGVVYK as substrate after 10 mins in pr...

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50230311
PNG
(CHEMBL4063136)
Show SMILES CSc1nc(NCCc2ccccc2)c2ccn(Cc3ccc(F)cc3)c2n1
Show InChI InChI=1S/C22H21FN4S/c1-28-22-25-20(24-13-11-16-5-3-2-4-6-16)19-12-14-27(21(19)26-22)15-17-7-9-18(23)10-8-17/h2-10,12,14H,11,13,15H2,1H3,(H,24,25,26)
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 800n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length N-terminal His6-tagged Src expressed in Sf21 cells using KVEKIGEGTYGVVYK as substrate after 10 mins in pr...

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50230318
PNG
(CHEMBL4103914)
Show SMILES CSc1nc(Nc2ccccc2)c2ccn(CC(Cl)c3ccccc3)c2n1
Show InChI InChI=1S/C21H19ClN4S/c1-27-21-24-19(23-16-10-6-3-7-11-16)17-12-13-26(20(17)25-21)14-18(22)15-8-4-2-5-9-15/h2-13,18H,14H2,1H3,(H,23,24,25)
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 1.50E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length N-terminal His6-tagged Src expressed in Sf21 cells using KVEKIGEGTYGVVYK as substrate after 10 mins in pr...

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50230316
PNG
(CHEMBL4088440)
Show SMILES CSc1nc(N2CCCC2)c2ccn(Cc3ccc(F)cc3)c2n1
Show InChI InChI=1S/C18H19FN4S/c1-24-18-20-16(22-9-2-3-10-22)15-8-11-23(17(15)21-18)12-13-4-6-14(19)7-5-13/h4-8,11H,2-3,9-10,12H2,1H3
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 2.00E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length N-terminal His6-tagged Src expressed in Sf21 cells using KVEKIGEGTYGVVYK as substrate after 10 mins in pr...

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50230321
PNG
(CHEMBL4073713)
Show SMILES CSc1nc(N2CCCCC2)c2ccn(Cc3ccc(F)cc3)c2n1
Show InChI InChI=1S/C19H21FN4S/c1-25-19-21-17(23-10-3-2-4-11-23)16-9-12-24(18(16)22-19)13-14-5-7-15(20)8-6-14/h5-9,12H,2-4,10-11,13H2,1H3
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 2.50E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length N-terminal His6-tagged Src expressed in Sf21 cells using KVEKIGEGTYGVVYK as substrate after 10 mins in pr...

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50230319
PNG
(CHEMBL4060213)
Show SMILES CCCCNc1nc(SC)nc2n(Cc3ccc(F)cc3)ccc12
Show InChI InChI=1S/C18H21FN4S/c1-3-4-10-20-16-15-9-11-23(17(15)22-18(21-16)24-2)12-13-5-7-14(19)8-6-13/h5-9,11H,3-4,10,12H2,1-2H3,(H,20,21,22)
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 3.00E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length N-terminal His6-tagged Src expressed in Sf21 cells using KVEKIGEGTYGVVYK as substrate after 10 mins in pr...

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50230320
PNG
(CHEMBL4100526)
Show SMILES CSc1nc(N2CCOCC2)c2ccn(Cc3ccc(F)cc3)c2n1
Show InChI InChI=1S/C18H19FN4OS/c1-25-18-20-16(22-8-10-24-11-9-22)15-6-7-23(17(15)21-18)12-13-2-4-14(19)5-3-13/h2-7H,8-12H2,1H3
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 4.70E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length N-terminal His6-tagged Src expressed in Sf21 cells using KVEKIGEGTYGVVYK as substrate after 10 mins in pr...

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50230312
PNG
(CHEMBL4098763)
Show SMILES CSc1nc(NCCc2ccc(Cl)cc2)c2ccn(Cc3ccc(F)cc3)c2n1
Show InChI InChI=1S/C22H20ClFN4S/c1-29-22-26-20(25-12-10-15-2-6-17(23)7-3-15)19-11-13-28(21(19)27-22)14-16-4-8-18(24)9-5-16/h2-9,11,13H,10,12,14H2,1H3,(H,25,26,27)
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 5.00E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length N-terminal His6-tagged Src expressed in Sf21 cells using KVEKIGEGTYGVVYK as substrate after 10 mins in pr...

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50230315
PNG
(CHEMBL4096164)
Show SMILES CSc1nc(NCc2ccccc2)c2ccn(CC(Cl)c3ccccc3)c2n1
Show InChI InChI=1S/C22H21ClN4S/c1-28-22-25-20(24-14-16-8-4-2-5-9-16)18-12-13-27(21(18)26-22)15-19(23)17-10-6-3-7-11-17/h2-13,19H,14-15H2,1H3,(H,24,25,26)
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 6.00E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length N-terminal His6-tagged Src expressed in Sf21 cells using KVEKIGEGTYGVVYK as substrate after 10 mins in pr...

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))		BDBM50230311
PNG
(CHEMBL4063136)
Show SMILES CSc1nc(NCCc2ccccc2)c2ccn(Cc3ccc(F)cc3)c2n1
Show InChI InChI=1S/C22H21FN4S/c1-28-22-25-20(24-13-11-16-5-3-2-4-6-16)19-12-14-27(21(19)26-22)15-17-7-9-18(23)10-8-17/h2-10,12,14H,11,13,15H2,1H3,(H,24,25,26)
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n/an/a 3.08E+4n/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length N-terminal His6-tagged Fyn expressed in baculovirus infected Sf21 cells using KVEKIGEGTYGVVYK as substrat...

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))		BDBM50230317
PNG
(CHEMBL4091022)
Show SMILES CSc1nc(NCc2ccccc2)c2ccn(Cc3ccc(F)cc3)c2n1
Show InChI InChI=1S/C21H19FN4S/c1-27-21-24-19(23-13-15-5-3-2-4-6-15)18-11-12-26(20(18)25-21)14-16-7-9-17(22)10-8-16/h2-12H,13-14H2,1H3,(H,23,24,25)
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n/an/a 4.32E+4n/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length N-terminal His6-tagged Fyn expressed in baculovirus infected Sf21 cells using KVEKIGEGTYGVVYK as substrat...

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM50230313
PNG
(CHEMBL4068876)
Show SMILES CSc1nc(Nc2cccc(Cl)c2)c2ccn(CC(Cl)c3ccccc3)c2n1
Show InChI InChI=1S/C21H18Cl2N4S/c1-28-21-25-19(24-16-9-5-8-15(22)12-16)17-10-11-27(20(17)26-21)13-18(23)14-6-3-2-4-7-14/h2-12,18H,13H2,1H3,(H,24,25,26)
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n/an/a 5.50E+4n/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of Flt3 (unknown origin) using KVEKIGEGTYGVVYK as substrate after 10 mins in presence of [gamma-33P]ATP by scintillation counting method

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))		BDBM50230321
PNG
(CHEMBL4073713)
Show SMILES CSc1nc(N2CCCCC2)c2ccn(Cc3ccc(F)cc3)c2n1
Show InChI InChI=1S/C19H21FN4S/c1-25-19-21-17(23-10-3-2-4-11-23)16-9-12-24(18(16)22-19)13-14-5-7-15(20)8-6-14/h5-9,12H,2-4,10-11,13H2,1H3
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n/an/a 5.71E+4n/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length N-terminal His6-tagged Fyn expressed in baculovirus infected Sf21 cells using KVEKIGEGTYGVVYK as substrat...

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))		BDBM50230313
PNG
(CHEMBL4068876)
Show SMILES CSc1nc(Nc2cccc(Cl)c2)c2ccn(CC(Cl)c3ccccc3)c2n1
Show InChI InChI=1S/C21H18Cl2N4S/c1-28-21-25-19(24-16-9-5-8-15(22)12-16)17-10-11-27(20(17)26-21)13-18(23)14-6-3-2-4-7-14/h2-12,18H,13H2,1H3,(H,24,25,26)
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n/an/a 5.82E+4n/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length N-terminal His6-tagged Fyn expressed in baculovirus infected Sf21 cells using KVEKIGEGTYGVVYK as substrat...

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM50230317
PNG
(CHEMBL4091022)
Show SMILES CSc1nc(NCc2ccccc2)c2ccn(Cc3ccc(F)cc3)c2n1
Show InChI InChI=1S/C21H19FN4S/c1-27-21-24-19(23-13-15-5-3-2-4-6-15)18-11-12-26(20(18)25-21)14-16-7-9-17(22)10-8-16/h2-12H,13-14H2,1H3,(H,23,24,25)
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n/an/a 6.00E+4n/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of Flt3 (unknown origin) using KVEKIGEGTYGVVYK as substrate after 10 mins in presence of [gamma-33P]ATP by scintillation counting method

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM50230320
PNG
(CHEMBL4100526)
Show SMILES CSc1nc(N2CCOCC2)c2ccn(Cc3ccc(F)cc3)c2n1
Show InChI InChI=1S/C18H19FN4OS/c1-25-18-20-16(22-8-10-24-11-9-22)15-6-7-23(17(15)21-18)12-13-2-4-14(19)5-3-13/h2-7H,8-12H2,1H3
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n/an/a 6.10E+4n/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of Flt3 (unknown origin) using KVEKIGEGTYGVVYK as substrate after 10 mins in presence of [gamma-33P]ATP by scintillation counting method

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM50230321
PNG
(CHEMBL4073713)
Show SMILES CSc1nc(N2CCCCC2)c2ccn(Cc3ccc(F)cc3)c2n1
Show InChI InChI=1S/C19H21FN4S/c1-25-19-21-17(23-10-3-2-4-11-23)16-9-12-24(18(16)22-19)13-14-5-7-15(20)8-6-14/h5-9,12H,2-4,10-11,13H2,1H3
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n/an/a 6.10E+4n/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of Flt3 (unknown origin) using KVEKIGEGTYGVVYK as substrate after 10 mins in presence of [gamma-33P]ATP by scintillation counting method

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))		BDBM50230318
PNG
(CHEMBL4103914)
Show SMILES CSc1nc(Nc2ccccc2)c2ccn(CC(Cl)c3ccccc3)c2n1
Show InChI InChI=1S/C21H19ClN4S/c1-27-21-24-19(23-16-10-6-3-7-11-16)17-12-13-26(20(17)25-21)14-18(22)15-8-4-2-5-9-15/h2-13,18H,14H2,1H3,(H,23,24,25)
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n/an/a 6.20E+4n/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length N-terminal His6-tagged Fyn expressed in baculovirus infected Sf21 cells using KVEKIGEGTYGVVYK as substrat...

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM50230316
PNG
(CHEMBL4088440)
Show SMILES CSc1nc(N2CCCC2)c2ccn(Cc3ccc(F)cc3)c2n1
Show InChI InChI=1S/C18H19FN4S/c1-24-18-20-16(22-9-2-3-10-22)15-8-11-23(17(15)21-18)12-13-4-6-14(19)7-5-13/h4-8,11H,2-3,9-10,12H2,1H3
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n/an/a 6.40E+4n/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of Flt3 (unknown origin) using KVEKIGEGTYGVVYK as substrate after 10 mins in presence of [gamma-33P]ATP by scintillation counting method

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM50230315
PNG
(CHEMBL4096164)
Show SMILES CSc1nc(NCc2ccccc2)c2ccn(CC(Cl)c3ccccc3)c2n1
Show InChI InChI=1S/C22H21ClN4S/c1-28-22-25-20(24-14-16-8-4-2-5-9-16)18-12-13-27(21(18)26-22)15-19(23)17-10-6-3-7-11-17/h2-13,19H,14-15H2,1H3,(H,24,25,26)
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n/an/a 6.80E+4n/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of Flt3 (unknown origin) using KVEKIGEGTYGVVYK as substrate after 10 mins in presence of [gamma-33P]ATP by scintillation counting method

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50230317
PNG
(CHEMBL4091022)
Show SMILES CSc1nc(NCc2ccccc2)c2ccn(Cc3ccc(F)cc3)c2n1
Show InChI InChI=1S/C21H19FN4S/c1-27-21-24-19(23-13-15-5-3-2-4-6-15)18-11-12-26(20(18)25-21)14-16-7-9-17(22)10-8-16/h2-12H,13-14H2,1H3,(H,23,24,25)
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n/an/a 7.00E+4n/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of Abl (unknown origin)

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))		BDBM50230312
PNG
(CHEMBL4098763)
Show SMILES CSc1nc(NCCc2ccc(Cl)cc2)c2ccn(Cc3ccc(F)cc3)c2n1
Show InChI InChI=1S/C22H20ClFN4S/c1-29-22-26-20(25-12-10-15-2-6-17(23)7-3-15)19-11-13-28(21(19)27-22)14-16-4-8-18(24)9-5-16/h2-9,11,13H,10,12,14H2,1H3,(H,25,26,27)
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n/an/a 7.04E+4n/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length N-terminal His6-tagged Fyn expressed in baculovirus infected Sf21 cells using KVEKIGEGTYGVVYK as substrat...

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM50230318
PNG
(CHEMBL4103914)
Show SMILES CSc1nc(Nc2ccccc2)c2ccn(CC(Cl)c3ccccc3)c2n1
Show InChI InChI=1S/C21H19ClN4S/c1-27-21-24-19(23-16-10-6-3-7-11-16)17-12-13-26(20(17)25-21)14-18(22)15-8-4-2-5-9-15/h2-13,18H,14H2,1H3,(H,23,24,25)
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n/an/a 7.20E+4n/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of Flt3 (unknown origin) using KVEKIGEGTYGVVYK as substrate after 10 mins in presence of [gamma-33P]ATP by scintillation counting method

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM50230312
PNG
(CHEMBL4098763)
Show SMILES CSc1nc(NCCc2ccc(Cl)cc2)c2ccn(Cc3ccc(F)cc3)c2n1
Show InChI InChI=1S/C22H20ClFN4S/c1-29-22-26-20(25-12-10-15-2-6-17(23)7-3-15)19-11-13-28(21(19)27-22)14-16-4-8-18(24)9-5-16/h2-9,11,13H,10,12,14H2,1H3,(H,25,26,27)
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n/an/a 7.60E+4n/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of Flt3 (unknown origin) using KVEKIGEGTYGVVYK as substrate after 10 mins in presence of [gamma-33P]ATP by scintillation counting method

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))		BDBM50230316
PNG
(CHEMBL4088440)
Show SMILES CSc1nc(N2CCCC2)c2ccn(Cc3ccc(F)cc3)c2n1
Show InChI InChI=1S/C18H19FN4S/c1-24-18-20-16(22-9-2-3-10-22)15-8-11-23(17(15)21-18)12-13-4-6-14(19)7-5-13/h4-8,11H,2-3,9-10,12H2,1H3
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n/an/a 7.60E+4n/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length N-terminal His6-tagged Fyn expressed in baculovirus infected Sf21 cells using KVEKIGEGTYGVVYK as substrat...

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))		BDBM50230315
PNG
(CHEMBL4096164)
Show SMILES CSc1nc(NCc2ccccc2)c2ccn(CC(Cl)c3ccccc3)c2n1
Show InChI InChI=1S/C22H21ClN4S/c1-28-22-25-20(24-14-16-8-4-2-5-9-16)18-12-13-27(21(18)26-22)15-19(23)17-10-6-3-7-11-17/h2-13,19H,14-15H2,1H3,(H,24,25,26)
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n/an/a 8.86E+4n/an/an/an/an/an/a



Universit£ degli Studi di Genova

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length N-terminal His6-tagged Fyn expressed in baculovirus infected Sf21 cells using KVEKIGEGTYGVVYK as substrat...

Eur J Med Chem 127: 369-378 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.036
BindingDB Entry DOI: 10.7270/Q2959KTB
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%