Affinity Data by PubMed id=28129991

PubMed code 28129991

Found 2 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM74255 ((3-amino-2-methyl-phenyl)amine \| 1,3-Benzenediamin...) Show SMILES Cc1c(N)cccc1N Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johns Hopkins University School of Medicine Curated by ChEMBL					Assay Description Inhibition of full length PI3Kalpha (unknown origin) assessed as reduction in PIP3 formation using PIP2 as substrate after 45 mins by fluorescence po...				Bioorg Med Chem 25: 1481-1486 (2017) Article DOI: 10.1016/j.bmc.2017.01.012 BindingDB Entry DOI: 10.7270/Q2028TQP
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM26188 (α-CA inhibitor, 12 \| 1,2-Dihydroxybenzene, XI...) Show SMILES Oc1ccccc1O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	3.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johns Hopkins University School of Medicine Curated by ChEMBL					Assay Description Inhibition of full length PI3Kalpha (unknown origin) assessed as reduction in PIP3 formation using PIP2 as substrate after 45 mins by fluorescence po...				Bioorg Med Chem 25: 1481-1486 (2017) Article DOI: 10.1016/j.bmc.2017.01.012 BindingDB Entry DOI: 10.7270/Q2028TQP
					More data for this Ligand-Target Pair				3D Structure (crystal)

* indicates data uncertainty>20%