Affinity Data by PubMed id=28300404

PubMed code 28300404

Found 4 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tumor necrosis factor (Homo sapiens (Human))	BDBM50237357 (CHEMBL4060030) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen R&D LLC Curated by ChEMBL					Assay Description Binding affinity to human TNF-alpha soluble domain assessed as decrease in complex formation with human TNFR2 extracellular domain preincubated for 1...				J Med Chem 60: 3511-3517 (2017) Article DOI: 10.1021/acs.jmedchem.6b01836 BindingDB Entry DOI: 10.7270/Q24X5B23
Janssen R&D LLC Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50373071 (CHEMBL255489) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen R&D LLC Curated by ChEMBL					Assay Description Binding affinity to human TNF-alpha soluble domain assessed as decrease in complex formation with human TNFR2 extracellular domain preincubated for 1...				J Med Chem 60: 3511-3517 (2017) Article DOI: 10.1021/acs.jmedchem.6b01836 BindingDB Entry DOI: 10.7270/Q24X5B23
Janssen R&D LLC Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50237357 (CHEMBL4060030) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen R&D LLC Curated by ChEMBL					Assay Description Binding affinity to human TNF-alpha soluble domain assessed as decrease in complex formation with human TNFR1 extracellular domain preincubated for 1...				J Med Chem 60: 3511-3517 (2017) Article DOI: 10.1021/acs.jmedchem.6b01836 BindingDB Entry DOI: 10.7270/Q24X5B23
Janssen R&D LLC Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50373071 (CHEMBL255489) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen R&D LLC Curated by ChEMBL					Assay Description Binding affinity to human TNF-alpha soluble domain assessed as decrease in complex formation with human TNFR1 extracellular domain preincubated for 1...				J Med Chem 60: 3511-3517 (2017) Article DOI: 10.1021/acs.jmedchem.6b01836 BindingDB Entry DOI: 10.7270/Q24X5B23
Janssen R&D LLC Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

* indicates data uncertainty>20%