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PubMed code 2831365

Compile data set for download or QSAR
Found 32 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Alpha-2A adrenergic receptor


(BOVINE)		BDBM50018739
PNG
(1,3,4,5,6,11b-Hexahydro-2H-11-thia-4a-aza-benzo[a]...)
Show SMILES C1CCN2CCc3c(sc4ccccc34)C2C1
Show InChI InChI=1S/C15H17NS/c1-2-7-14-11(5-1)12-8-10-16-9-4-3-6-13(16)15(12)17-14/h1-2,5,7,13H,3-4,6,8-10H2
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 4.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to alpha-2 adrenergic receptor by the displacement of [3H]-clonidine from calf cerebral cortex membranes

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(BOVINE)		BDBM50018739
PNG
(1,3,4,5,6,11b-Hexahydro-2H-11-thia-4a-aza-benzo[a]...)
Show SMILES C1CCN2CCc3c(sc4ccccc34)C2C1
Show InChI InChI=1S/C15H17NS/c1-2-7-14-11(5-1)12-8-10-16-9-4-3-6-13(16)15(12)17-14/h1-2,5,7,13H,3-4,6,8-10H2
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 4.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to alpha-2 adrenergic receptor by the displacement of [3H]-clonidine from calf cerebral cortex membranes

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(CALF)		BDBM50018739
PNG
(1,3,4,5,6,11b-Hexahydro-2H-11-thia-4a-aza-benzo[a]...)
Show SMILES C1CCN2CCc3c(sc4ccccc34)C2C1
Show InChI InChI=1S/C15H17NS/c1-2-7-14-11(5-1)12-8-10-16-9-4-3-6-13(16)15(12)17-14/h1-2,5,7,13H,3-4,6,8-10H2
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 16n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptor

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(BOVINE)		BDBM50018736
PNG
(1,3,4,5,6,11b-Hexahydro-2H-11-oxa-4a-aza-benzo[a]f...)
Show SMILES C1CCN2CCc3c(oc4ccccc34)C2C1
Show InChI InChI=1S/C15H17NO/c1-2-7-14-11(5-1)12-8-10-16-9-4-3-6-13(16)15(12)17-14/h1-2,5,7,13H,3-4,6,8-10H2
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 16n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to alpha-1 adrenergic receptor by the displacement of [3H]-prazosin from calf cerebral cortex membranes

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(BOVINE)		BDBM50018736
PNG
(1,3,4,5,6,11b-Hexahydro-2H-11-oxa-4a-aza-benzo[a]f...)
Show SMILES C1CCN2CCc3c(oc4ccccc34)C2C1
Show InChI InChI=1S/C15H17NO/c1-2-7-14-11(5-1)12-8-10-16-9-4-3-6-13(16)15(12)17-14/h1-2,5,7,13H,3-4,6,8-10H2
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 16n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to alpha-2 adrenergic receptor by the displacement of [3H]-clonidine from calf cerebral cortex membranes

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(CALF)		BDBM50018739
PNG
(1,3,4,5,6,11b-Hexahydro-2H-11-thia-4a-aza-benzo[a]...)
Show SMILES C1CCN2CCc3c(sc4ccccc34)C2C1
Show InChI InChI=1S/C15H17NS/c1-2-7-14-11(5-1)12-8-10-16-9-4-3-6-13(16)15(12)17-14/h1-2,5,7,13H,3-4,6,8-10H2
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 16n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to alpha-1 adrenergic receptor by the displacement of [3H]-prazosin from calf cerebral cortex membranes

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(CALF)		BDBM50018737
PNG
(1,2,3,4,6,7,12,12b-Octahydro-indolo[2,3-a]quinoliz...)
Show SMILES C1CCN2CCc3c([nH]c4ccccc34)C2C1
Show InChI InChI=1S/C15H18N2/c1-2-6-13-11(5-1)12-8-10-17-9-4-3-7-14(17)15(12)16-13/h1-2,5-6,14,16H,3-4,7-10H2
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 38n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to alpha-1 adrenergic receptor by the displacement of [3H]-prazosin from calf cerebral cortex membranes

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(CALF)		BDBM50018737
PNG
(1,2,3,4,6,7,12,12b-Octahydro-indolo[2,3-a]quinoliz...)
Show SMILES C1CCN2CCc3c([nH]c4ccccc34)C2C1
Show InChI InChI=1S/C15H18N2/c1-2-6-13-11(5-1)12-8-10-17-9-4-3-7-14(17)15(12)16-13/h1-2,5-6,14,16H,3-4,7-10H2
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 38n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to alpha-2 adrenergic receptor by the displacement of [3H]-clonidine from calf cerebral cortex membranes

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(BOVINE)		BDBM50018737
PNG
(1,2,3,4,6,7,12,12b-Octahydro-indolo[2,3-a]quinoliz...)
Show SMILES C1CCN2CCc3c([nH]c4ccccc34)C2C1
Show InChI InChI=1S/C15H18N2/c1-2-6-13-11(5-1)12-8-10-17-9-4-3-7-14(17)15(12)16-13/h1-2,5-6,14,16H,3-4,7-10H2
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 60n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptor

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(BOVINE)		BDBM50018737
PNG
(1,2,3,4,6,7,12,12b-Octahydro-indolo[2,3-a]quinoliz...)
Show SMILES C1CCN2CCc3c([nH]c4ccccc34)C2C1
Show InChI InChI=1S/C15H18N2/c1-2-6-13-11(5-1)12-8-10-17-9-4-3-7-14(17)15(12)16-13/h1-2,5-6,14,16H,3-4,7-10H2
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 60n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to alpha-1 adrenergic receptor by the displacement of [3H]-prazosin from calf cerebral cortex membranes

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(CALF)		BDBM50018736
PNG
(1,3,4,5,6,11b-Hexahydro-2H-11-oxa-4a-aza-benzo[a]f...)
Show SMILES C1CCN2CCc3c(oc4ccccc34)C2C1
Show InChI InChI=1S/C15H17NO/c1-2-7-14-11(5-1)12-8-10-16-9-4-3-6-13(16)15(12)17-14/h1-2,5,7,13H,3-4,6,8-10H2
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 110n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for log 1/Ki at alpha-1 adrenergic receptor

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(CALF)		BDBM50018736
PNG
(1,3,4,5,6,11b-Hexahydro-2H-11-oxa-4a-aza-benzo[a]f...)
Show SMILES C1CCN2CCc3c(oc4ccccc34)C2C1
Show InChI InChI=1S/C15H17NO/c1-2-7-14-11(5-1)12-8-10-16-9-4-3-6-13(16)15(12)17-14/h1-2,5,7,13H,3-4,6,8-10H2
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 110n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for log 1/Ki at alpha-1 adrenergic receptor

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(BOVINE)		BDBM50018741
PNG
(4,7,8,9,10,10a-Hexahydro-5H-thieno[2,3-a]quinolizi...)
Show SMILES C1CCN2CCc3ccsc3C2C1
Show InChI InChI=1S/C11H15NS/c1-2-6-12-7-4-9-5-8-13-11(9)10(12)3-1/h5,8,10H,1-4,6-7H2
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 195n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to alpha-2 adrenergic receptor by the displacement of [3H]-clonidine from calf cerebral cortex membranes

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(BOVINE)		BDBM50018741
PNG
(4,7,8,9,10,10a-Hexahydro-5H-thieno[2,3-a]quinolizi...)
Show SMILES C1CCN2CCc3ccsc3C2C1
Show InChI InChI=1S/C11H15NS/c1-2-6-12-7-4-9-5-8-13-11(9)10(12)3-1/h5,8,10H,1-4,6-7H2
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 195n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to alpha-2 adrenergic receptor by the displacement of [3H]-clonidine from calf cerebral cortex membranes

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(BOVINE)		BDBM50018740
PNG
(4,7,8,9,10,10a-Hexahydro-5H-thiazolo[4,5-a]quinoli...)
Show SMILES Nc1nc2C3CCCCN3CCc2s1
Show InChI InChI=1S/C10H15N3S/c11-10-12-9-7-3-1-2-5-13(7)6-4-8(9)14-10/h7H,1-6H2,(H2,11,12)
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 347n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptor

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(BOVINE)		BDBM50018740
PNG
(4,7,8,9,10,10a-Hexahydro-5H-thiazolo[4,5-a]quinoli...)
Show SMILES Nc1nc2C3CCCCN3CCc2s1
Show InChI InChI=1S/C10H15N3S/c11-10-12-9-7-3-1-2-5-13(7)6-4-8(9)14-10/h7H,1-6H2,(H2,11,12)
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 350n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptor

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(CALF)		BDBM50018738
PNG
(1,2,3,4,5,6,11,11b-Octahydro-4a,10,11-triaza-benzo...)
Show SMILES C1CCN2CCc3c([nH]c4ncccc34)C2C1
Show InChI InChI=1S/C14H17N3/c1-2-8-17-9-6-10-11-4-3-7-15-14(11)16-13(10)12(17)5-1/h3-4,7,12H,1-2,5-6,8-9H2,(H,15,16)
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 537n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for log 1/Ki at alpha-1 adrenergic receptor

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(CALF)		BDBM50018738
PNG
(1,2,3,4,5,6,11,11b-Octahydro-4a,10,11-triaza-benzo...)
Show SMILES C1CCN2CCc3c([nH]c4ncccc34)C2C1
Show InChI InChI=1S/C14H17N3/c1-2-8-17-9-6-10-11-4-3-7-15-14(11)16-13(10)12(17)5-1/h3-4,7,12H,1-2,5-6,8-9H2,(H,15,16)
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 540n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for log 1/Ki at alpha-1 adrenergic receptor

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(BOVINE)		BDBM50018738
PNG
(1,2,3,4,5,6,11,11b-Octahydro-4a,10,11-triaza-benzo...)
Show SMILES C1CCN2CCc3c([nH]c4ncccc34)C2C1
Show InChI InChI=1S/C14H17N3/c1-2-8-17-9-6-10-11-4-3-7-15-14(11)16-13(10)12(17)5-1/h3-4,7,12H,1-2,5-6,8-9H2,(H,15,16)
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 660n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to alpha-1 adrenergic receptor by the displacement of [3H]-prazosin from calf cerebral cortex membranes

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(BOVINE)		BDBM50018738
PNG
(1,2,3,4,5,6,11,11b-Octahydro-4a,10,11-triaza-benzo...)
Show SMILES C1CCN2CCc3c([nH]c4ncccc34)C2C1
Show InChI InChI=1S/C14H17N3/c1-2-8-17-9-6-10-11-4-3-7-15-14(11)16-13(10)12(17)5-1/h3-4,7,12H,1-2,5-6,8-9H2,(H,15,16)
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 661n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptor

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(CALF)		BDBM50018741
PNG
(4,7,8,9,10,10a-Hexahydro-5H-thieno[2,3-a]quinolizi...)
Show SMILES C1CCN2CCc3ccsc3C2C1
Show InChI InChI=1S/C11H15NS/c1-2-6-12-7-4-9-5-8-13-11(9)10(12)3-1/h5,8,10H,1-4,6-7H2
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 1.10E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for log 1/Ki at alpha-1 adrenergic receptor

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(CALF)		BDBM50018741
PNG
(4,7,8,9,10,10a-Hexahydro-5H-thieno[2,3-a]quinolizi...)
Show SMILES C1CCN2CCc3ccsc3C2C1
Show InChI InChI=1S/C11H15NS/c1-2-6-12-7-4-9-5-8-13-11(9)10(12)3-1/h5,8,10H,1-4,6-7H2
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 1.10E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptor

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(BOVINE)		BDBM50018735
PNG
(5,6,7,8,9,10-Hexahydro-4bH-4,8a-diaza-phenanthrene...)
Show SMILES C1CCN2CCc3cccnc3C2C1
Show InChI InChI=1S/C12H16N2/c1-2-8-14-9-6-10-4-3-7-13-12(10)11(14)5-1/h3-4,7,11H,1-2,5-6,8-9H2
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 2.00E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptor

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(BOVINE)		BDBM50018735
PNG
(5,6,7,8,9,10-Hexahydro-4bH-4,8a-diaza-phenanthrene...)
Show SMILES C1CCN2CCc3cccnc3C2C1
Show InChI InChI=1S/C12H16N2/c1-2-8-14-9-6-10-4-3-7-13-12(10)11(14)5-1/h3-4,7,11H,1-2,5-6,8-9H2
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 2.00E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for log 1/Ki at alpha-1 adrenergic receptor

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(CALF)		BDBM50018740
PNG
(4,7,8,9,10,10a-Hexahydro-5H-thiazolo[4,5-a]quinoli...)
Show SMILES Nc1nc2C3CCCCN3CCc2s1
Show InChI InChI=1S/C10H15N3S/c11-10-12-9-7-3-1-2-5-13(7)6-4-8(9)14-10/h7H,1-6H2,(H2,11,12)
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 2.80E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to alpha-1 adrenergic receptor by the displacement of [3H]-prazosin from calf cerebral cortex membranes

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(CALF)		BDBM50018740
PNG
(4,7,8,9,10,10a-Hexahydro-5H-thiazolo[4,5-a]quinoli...)
Show SMILES Nc1nc2C3CCCCN3CCc2s1
Show InChI InChI=1S/C10H15N3S/c11-10-12-9-7-3-1-2-5-13(7)6-4-8(9)14-10/h7H,1-6H2,(H2,11,12)
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 2.82E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to alpha-2 adrenergic receptor by the displacement of [3H]-clonidine from calf cerebral cortex membranes

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(CALF)		BDBM50018735
PNG
(5,6,7,8,9,10-Hexahydro-4bH-4,8a-diaza-phenanthrene...)
Show SMILES C1CCN2CCc3cccnc3C2C1
Show InChI InChI=1S/C12H16N2/c1-2-8-14-9-6-10-4-3-7-13-12(10)11(14)5-1/h3-4,7,11H,1-2,5-6,8-9H2
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 3.24E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for log 1/Ki at alpha-1 adrenergic receptor

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(CALF)		BDBM50018735
PNG
(5,6,7,8,9,10-Hexahydro-4bH-4,8a-diaza-phenanthrene...)
Show SMILES C1CCN2CCc3cccnc3C2C1
Show InChI InChI=1S/C12H16N2/c1-2-8-14-9-6-10-4-3-7-13-12(10)11(14)5-1/h3-4,7,11H,1-2,5-6,8-9H2
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 3.25E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for log 1/Ki at alpha-1 adrenergic receptor

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(BOVINE)		BDBM50018734
PNG
(1,4,5,7,8,9,10,10a-Octahydro-pyrazolo[3,4-a]quinol...)
Show SMILES C1CCN2CCc3cn[nH]c3C2C1
Show InChI InChI=1S/C10H15N3/c1-2-5-13-6-4-8-7-11-12-10(8)9(13)3-1/h7,9H,1-6H2,(H,11,12)
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 9.55E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptor

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(BOVINE)		BDBM50018734
PNG
(1,4,5,7,8,9,10,10a-Octahydro-pyrazolo[3,4-a]quinol...)
Show SMILES C1CCN2CCc3cn[nH]c3C2C1
Show InChI InChI=1S/C10H15N3/c1-2-5-13-6-4-8-7-11-12-10(8)9(13)3-1/h7,9H,1-6H2,(H,11,12)
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 9.60E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to alpha-1 adrenergic receptor by the displacement of [3H]-prazosin from calf cerebral cortex membranes

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(CALF)		BDBM50018734
PNG
(1,4,5,7,8,9,10,10a-Octahydro-pyrazolo[3,4-a]quinol...)
Show SMILES C1CCN2CCc3cn[nH]c3C2C1
Show InChI InChI=1S/C10H15N3/c1-2-5-13-6-4-8-7-11-12-10(8)9(13)3-1/h7,9H,1-6H2,(H,11,12)
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 2.40E+4n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to alpha-2 adrenergic receptor by the displacement of [3H]-clonidine from calf cerebral cortex membranes

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(CALF)		BDBM50018734
PNG
(1,4,5,7,8,9,10,10a-Octahydro-pyrazolo[3,4-a]quinol...)
Show SMILES C1CCN2CCc3cn[nH]c3C2C1
Show InChI InChI=1S/C10H15N3/c1-2-5-13-6-4-8-7-11-12-10(8)9(13)3-1/h7,9H,1-6H2,(H,11,12)
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 2.40E+4n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to alpha-1 adrenergic receptor by the displacement of [3H]-prazosin from calf cerebral cortex membranes

J Med Chem 31: 641-5 (1988)


BindingDB Entry DOI: 10.7270/Q208649B
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%