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PubMed code 28351592

Compile data set for download or QSAR
Found 27 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239134
PNG
(CHEMBL4087516)
Show SMILES FC(F)(F)S(=O)(=O)Nc1ccncc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C13H8F3N3O2S/c14-13(15,16)22(20,21)19-12-5-6-18-8-11(12)10-3-1-9(7-17)2-4-10/h1-6,8H,(H,18,19)
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n/an/a 2n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239146
PNG
(CHEMBL4088988)
Show SMILES FC(F)(F)S(=O)(=O)Nc1ccncc1-c1ccc(C#N)c2ccccc12
Show InChI InChI=1S/C17H10F3N3O2S/c18-17(19,20)26(24,25)23-16-7-8-22-10-15(16)14-6-5-11(9-21)12-3-1-2-4-13(12)14/h1-8,10H,(H,22,23)
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n/an/a 10n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50134635
PNG
(CHEMBL3746329 | US9637484, 3)
Show SMILES OC(=O)C1(CCC1)Sc1ccnc2ccc(Br)cc12
Show InChI InChI=1S/C14H12BrNO2S/c15-9-2-3-11-10(8-9)12(4-7-16-11)19-14(13(17)18)5-1-6-14/h2-4,7-8H,1,5-6H2,(H,17,18)
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n/an/a 33n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM290431
PNG
(CAS No.:1352792-74-5 | RDEA3170 | US10100016, Veri...)
Show SMILES CC(C)(Sc1ccncc1-c1ccc(C#N)c2ccccc12)C(O)=O
Show InChI InChI=1S/C20H16N2O2S/c1-20(2,19(23)24)25-18-9-10-22-12-17(18)16-8-7-13(11-21)14-5-3-4-6-15(14)16/h3-10,12H,1-2H3,(H,23,24)
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n/an/a<50n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239130
PNG
(CHEMBL4078376)
Show SMILES OC(=O)C1(CCC1)Sc1ccccc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C18H15NO2S/c19-12-13-6-8-14(9-7-13)15-4-1-2-5-16(15)22-18(17(20)21)10-3-11-18/h1-2,4-9H,3,10-11H2,(H,20,21)
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n/an/a<50n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of URAT1 (unknown origin) expressed in HEK293 cells assessed as reduction in [14C]uric acid uptake after 10 mins by liquid scintillation c...

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239128
PNG
(CHEMBL4059854 | US10266493, Example 2A | US1091985...)
Show SMILES CC(C)(Sc1ccncc1-c1ccc(cc1)C#N)C(O)=O
Show InChI InChI=1S/C16H14N2O2S/c1-16(2,15(19)20)21-14-7-8-18-10-13(14)12-5-3-11(9-17)4-6-12/h3-8,10H,1-2H3,(H,19,20)
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n/an/a<50n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239129
PNG
(CHEMBL4096685)
Show SMILES Cc1ccc(CC(O)=O)cc1OCc1c(C)cccc1C
Show InChI InChI=1S/C18H20O3/c1-12-5-4-6-13(2)16(12)11-21-17-9-15(10-18(19)20)8-7-14(17)3/h4-9H,10-11H2,1-3H3,(H,19,20)
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n/an/a 80n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239131
PNG
(CHEMBL4100597)
Show SMILES FC(F)(F)S(=O)(=O)Nc1ccnc2ccc(Br)cc12
Show InChI InChI=1S/C10H6BrF3N2O2S/c11-6-1-2-8-7(5-6)9(3-4-15-8)16-19(17,18)10(12,13)14/h1-5H,(H,15,16)
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n/an/a 83n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50158460
PNG
((3,5-dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran...)
Show SMILES CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1
Show InChI InChI=1S/C17H12Br2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3
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n/an/a 120n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239143
PNG
(CHEMBL4104410)
Show SMILES O=S(=O)(Nc1ccncc1-c1ccc(C#N)c2ccccc12)c1ccccc1
Show InChI InChI=1S/C22H15N3O2S/c23-14-16-10-11-20(19-9-5-4-8-18(16)19)21-15-24-13-12-22(21)25-28(26,27)17-6-2-1-3-7-17/h1-13,15H,(H,24,25)
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n/an/a 127n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239137
PNG
(CHEMBL4103898)
Show SMILES CS(=O)(=O)Nc1ccncc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C13H11N3O2S/c1-19(17,18)16-13-6-7-15-9-12(13)11-4-2-10(8-14)3-5-11/h2-7,9H,1H3,(H,15,16)
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n/an/a 203n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239147
PNG
(CHEMBL4066146)
Show SMILES COc1ccc(cc1)-c1cnccc1NS(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C13H11F3N2O3S/c1-21-10-4-2-9(3-5-10)11-8-17-7-6-12(11)18-22(19,20)13(14,15)16/h2-8H,1H3,(H,17,18)
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n/an/a 215n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239136
PNG
(CHEMBL4079640)
Show SMILES COc1ccccc1-c1cnccc1NS(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C13H11F3N2O3S/c1-21-12-5-3-2-4-9(12)10-8-17-7-6-11(10)18-22(19,20)13(14,15)16/h2-8H,1H3,(H,17,18)
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n/an/a 241n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239151
PNG
(CHEMBL4078667)
Show SMILES CS(=O)(=O)Nc1ccncc1-c1ccc(C#N)c2ccccc12
Show InChI InChI=1S/C17H13N3O2S/c1-23(21,22)20-17-8-9-19-11-16(17)15-7-6-12(10-18)13-4-2-3-5-14(13)15/h2-9,11H,1H3,(H,19,20)
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n/an/a 261n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239133
PNG
(CHEMBL4074756)
Show SMILES O=S(=O)(Nc1ccncc1-c1ccc(cc1)C#N)c1ccccc1
Show InChI InChI=1S/C18H13N3O2S/c19-12-14-6-8-15(9-7-14)17-13-20-11-10-18(17)21-24(22,23)16-4-2-1-3-5-16/h1-11,13H,(H,20,21)
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n/an/a 390n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239150
PNG
(CHEMBL4094280)
Show SMILES CC(C)CS(=O)(=O)Nc1ccncc1-c1ccc(C#N)c2ccccc12
Show InChI InChI=1S/C20H19N3O2S/c1-14(2)13-26(24,25)23-20-9-10-22-12-19(20)18-8-7-15(11-21)16-5-3-4-6-17(16)18/h3-10,12,14H,13H2,1-2H3,(H,22,23)
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n/an/a 597n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239145
PNG
(CHEMBL4067774)
Show SMILES CCS(=O)(=O)Nc1ccncc1-c1ccc(C#N)c2ccccc12
Show InChI InChI=1S/C18H15N3O2S/c1-2-24(22,23)21-18-9-10-20-12-17(18)16-8-7-13(11-19)14-5-3-4-6-15(14)16/h3-10,12H,2H2,1H3,(H,20,21)
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n/an/a 713n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239144
PNG
(CHEMBL4066753)
Show SMILES CCCS(=O)(=O)Nc1ccncc1-c1ccc(C#N)c2ccccc12
Show InChI InChI=1S/C19H17N3O2S/c1-2-11-25(23,24)22-19-9-10-21-13-18(19)17-8-7-14(12-20)15-5-3-4-6-16(15)17/h3-10,13H,2,11H2,1H3,(H,21,22)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239141
PNG
(CHEMBL4085591)
Show SMILES O=S(=O)(Nc1ccncc1-c1ccc(C#N)c2ccccc12)c1ccc(cc1)C#N
Show InChI InChI=1S/C23H14N4O2S/c24-13-16-5-8-18(9-6-16)30(28,29)27-23-11-12-26-15-22(23)21-10-7-17(14-25)19-3-1-2-4-20(19)21/h1-12,15H,(H,26,27)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239142
PNG
(CHEMBL4086514)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1ccncc1-c1ccc(C#N)c2ccccc12
Show InChI InChI=1S/C22H14FN3O2S/c23-16-6-8-17(9-7-16)29(27,28)26-22-11-12-25-14-21(22)20-10-5-15(13-24)18-3-1-2-4-19(18)20/h1-12,14H,(H,25,26)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239148
PNG
(CHEMBL4096139)
Show SMILES CS(=O)(=O)Nc1ccncc1-c1cccc(F)c1
Show InChI InChI=1S/C12H11FN2O2S/c1-18(16,17)15-12-5-6-14-8-11(12)9-3-2-4-10(13)7-9/h2-8H,1H3,(H,14,15)
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n/an/a 2.83E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239152
PNG
(CHEMBL4076833)
Show SMILES CS(=O)(=O)Nc1ccnc2ccc(Br)cc12
Show InChI InChI=1S/C10H9BrN2O2S/c1-16(14,15)13-10-4-5-12-9-3-2-7(11)6-8(9)10/h2-6H,1H3,(H,12,13)
KEGG

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n/an/a 3.60E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239132
PNG
(CHEMBL4095219)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1ccncc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C18H12FN3O2S/c19-15-5-7-16(8-6-15)25(23,24)22-18-9-10-21-12-17(18)14-3-1-13(11-20)2-4-14/h1-10,12H,(H,21,22)
KEGG

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n/an/a 4.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239138
PNG
(CHEMBL4068847)
Show SMILES CS(=O)(=O)Nc1ccncc1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H11F3N2O2S/c1-21(19,20)18-12-6-7-17-8-11(12)9-2-4-10(5-3-9)13(14,15)16/h2-8H,1H3,(H,17,18)
KEGG

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n/an/a 4.06E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239139
PNG
(CHEMBL4060192)
Show SMILES COc1cccc(c1)-c1cnccc1NS(C)(=O)=O
Show InChI InChI=1S/C13H14N2O3S/c1-18-11-5-3-4-10(8-11)12-9-14-7-6-13(12)15-19(2,16)17/h3-9H,1-2H3,(H,14,15)
KEGG

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n/an/a 9.84E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239140
PNG
(CHEMBL4088415)
Show SMILES CS(=O)(=O)Nc1ccncc1-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C13H11F3N2O2S/c1-21(19,20)18-12-6-7-17-8-10(12)9-4-2-3-5-11(9)13(14,15)16/h2-8H,1H3,(H,17,18)
KEGG

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n/an/a 1.20E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM50239149
PNG
(CHEMBL4064028)
Show SMILES COc1ccccc1-c1cnccc1NS(C)(=O)=O
Show InChI InChI=1S/C13H14N2O3S/c1-18-13-6-4-3-5-10(13)11-9-14-8-7-12(11)15-19(2,16)17/h3-9H,1-2H3,(H,14,15)
KEGG

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n/an/a 2.09E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...

Bioorg Med Chem Lett 27: 1919-1922 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.041
BindingDB Entry DOI: 10.7270/Q2NK3H6D
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%