Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ATP-dependent translocase ABCB1 bd-vinblastine (Mus musculus (Mouse)) | BDBM227643 (Vinblastine) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.80E+3 | n/a | n/a | n/a | n/a | n/a | 22.5 |
University of Washington | Assay Description For the data shown, 25 nM BD-verapamil was added to various P-gp nanodisc concentrations in the presence of 1 μM empty nanodiscs, and 50 nM BD-v... | Biochemistry 56: 2506-2517 (2017) Article DOI: 10.1021/acs.biochem.6b01245 BindingDB Entry DOI: 10.7270/Q20G3J1N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 bd-verapamil (Mus musculus (Mouse)) | BDBM227643 (Vinblastine) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.75E+4 | n/a | n/a | n/a | n/a | n/a | 22.5 |
University of Washington | Assay Description For the data shown, 25 nM BD-verapamil was added to various P-gp nanodisc concentrations in the presence of 1 μM empty nanodiscs, and 50 nM BD-v... | Biochemistry 56: 2506-2517 (2017) Article DOI: 10.1021/acs.biochem.6b01245 BindingDB Entry DOI: 10.7270/Q20G3J1N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 bd-verapamil (Mus musculus (Mouse)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.73E+5 | n/a | n/a | n/a | n/a | n/a | 22.5 |
University of Washington | Assay Description For the data shown, 25 nM BD-verapamil was added to various P-gp nanodisc concentrations in the presence of 1 μM empty nanodiscs, and 50 nM BD-v... | Biochemistry 56: 2506-2517 (2017) Article DOI: 10.1021/acs.biochem.6b01245 BindingDB Entry DOI: 10.7270/Q20G3J1N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 bd-vinblastine (Mus musculus (Mouse)) | BDBM50001839 (CHEMBL428647 | PACLITAXEL | taxol) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.27E+5 | n/a | n/a | n/a | n/a | n/a | 22.5 |
University of Washington | Assay Description For the data shown, 25 nM BD-verapamil was added to various P-gp nanodisc concentrations in the presence of 1 μM empty nanodiscs, and 50 nM BD-v... | Biochemistry 56: 2506-2517 (2017) Article DOI: 10.1021/acs.biochem.6b01245 BindingDB Entry DOI: 10.7270/Q20G3J1N | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |