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PubMed code 28741954

Compile data set for download or QSAR
Found 22 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Oxysterols receptor LXR-alpha


(Homo sapiens (Human))		BDBM50257934
PNG
(CHEMBL4104778)
Show SMILES [H][C@@]1(CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)C[C@H](O)[C@H](C)C(C)C |r,t:6,8|
Show InChI InChI=1S/C28H46O2/c1-17(2)19(4)26(30)15-18(3)23-9-10-24-22-8-7-20-16-21(29)11-13-27(20,5)25(22)12-14-28(23,24)6/h7-8,17-19,21,23-26,29-30H,9-16H2,1-6H3/t18-,19-,21+,23-,24+,25+,26+,27+,28-/m1/s1
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n/an/an/an/a 8.07E+3n/an/an/an/a



Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia , Via del Liceo, 1-06123 Perugia, Italy.

Curated by ChEMBL


Assay Description
Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay

J Med Chem 60: 6548-6562 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00091
BindingDB Entry DOI: 10.7270/Q2GH9MDC
More data for this
Ligand-Target Pair
Oxysterols receptor LXR-alpha


(Homo sapiens (Human))		BDBM50257936
PNG
(CHEMBL4059545)
Show SMILES [H][C@@]1(CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)C(=O)C[C@H](C)C(C)C |r,t:6,8|
Show InChI InChI=1S/C28H44O2/c1-17(2)18(3)15-26(30)19(4)23-9-10-24-22-8-7-20-16-21(29)11-13-27(20,5)25(22)12-14-28(23,24)6/h7-8,17-19,21,23-25,29H,9-16H2,1-6H3/t18-,19-,21-,23+,24-,25-,27-,28+/m0/s1
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n/an/an/an/a 8.51E+3n/an/an/an/a



Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia , Via del Liceo, 1-06123 Perugia, Italy.

Curated by ChEMBL


Assay Description
Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay

J Med Chem 60: 6548-6562 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00091
BindingDB Entry DOI: 10.7270/Q2GH9MDC
More data for this
Ligand-Target Pair
Oxysterols receptor LXR-alpha


(Homo sapiens (Human))		BDBM50257930
PNG
(CHEMBL4061349)
Show SMILES [H][C@]1(O[C@@]1([H])[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@@H](CC)C(C)C |r,t:17|
Show InChI InChI=1S/C29H48O2/c1-7-21(17(2)3)27-26(31-27)18(4)23-10-11-24-22-9-8-19-16-20(30)12-14-28(19,5)25(22)13-15-29(23,24)6/h8,17-18,20-27,30H,7,9-16H2,1-6H3/t18-,20-,21-,22-,23+,24-,25-,26-,27-,28-,29+/m0/s1
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n/an/an/an/a 1.64E+4n/an/an/an/a



Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia , Via del Liceo, 1-06123 Perugia, Italy.

Curated by ChEMBL


Assay Description
Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay

J Med Chem 60: 6548-6562 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00091
BindingDB Entry DOI: 10.7270/Q2GH9MDC
More data for this
Ligand-Target Pair
Oxysterols receptor LXR-beta


(Homo sapiens (Human))		BDBM50257933
PNG
(CHEMBL4086897)
Show SMILES [H][C@@]1(CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)[C@@H](O)C[C@H](C)C(C)C |r,t:6,8|
Show InChI InChI=1S/C28H46O2/c1-17(2)18(3)15-26(30)19(4)23-9-10-24-22-8-7-20-16-21(29)11-13-27(20,5)25(22)12-14-28(23,24)6/h7-8,17-19,21,23-26,29-30H,9-16H2,1-6H3/t18-,19-,21-,23+,24-,25-,26-,27-,28+/m0/s1
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n/an/an/an/a 1.96E+3n/an/an/an/a



Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia , Via del Liceo, 1-06123 Perugia, Italy.

Curated by ChEMBL


Assay Description
Activation of GAL4 fused human LXR beta expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay

J Med Chem 60: 6548-6562 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00091
BindingDB Entry DOI: 10.7270/Q2GH9MDC
More data for this
Ligand-Target Pair
Oxysterols receptor LXR-beta


(Homo sapiens (Human))		BDBM50257930
PNG
(CHEMBL4061349)
Show SMILES [H][C@]1(O[C@@]1([H])[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@@H](CC)C(C)C |r,t:17|
Show InChI InChI=1S/C29H48O2/c1-7-21(17(2)3)27-26(31-27)18(4)23-10-11-24-22-9-8-19-16-20(30)12-14-28(19,5)25(22)13-15-29(23,24)6/h8,17-18,20-27,30H,7,9-16H2,1-6H3/t18-,20-,21-,22-,23+,24-,25-,26-,27-,28-,29+/m0/s1
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n/an/an/an/a 1.27E+4n/an/an/an/a



Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia , Via del Liceo, 1-06123 Perugia, Italy.

Curated by ChEMBL


Assay Description
Activation of GAL4 fused human LXR beta expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay

J Med Chem 60: 6548-6562 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00091
BindingDB Entry DOI: 10.7270/Q2GH9MDC
More data for this
Ligand-Target Pair
Oxysterols receptor LXR-alpha


(Homo sapiens (Human))		BDBM50257931
PNG
(CHEMBL4073435)
Show SMILES [H][C@@]1(CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CC(=O)[C@H](C)C(C)C |r,t:6,8|
Show InChI InChI=1S/C28H44O2/c1-17(2)19(4)26(30)15-18(3)23-9-10-24-22-8-7-20-16-21(29)11-13-27(20,5)25(22)12-14-28(23,24)6/h7-8,17-19,21,23-25,29H,9-16H2,1-6H3/t18-,19-,21+,23-,24+,25+,27+,28-/m1/s1
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n/an/an/an/a 5.58E+3n/an/an/an/a



Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia , Via del Liceo, 1-06123 Perugia, Italy.

Curated by ChEMBL


Assay Description
Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay

J Med Chem 60: 6548-6562 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00091
BindingDB Entry DOI: 10.7270/Q2GH9MDC
More data for this
Ligand-Target Pair
Oxysterols receptor LXR-beta


(Homo sapiens (Human))		BDBM50257928
PNG
(CHEMBL4070016)
Show SMILES [H][C@]1(O[C@@]1([H])[C@@H](C)[C@@]1([H])CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)C(C)C |r,t:14,16|
Show InChI InChI=1S/C28H44O2/c1-16(2)17(3)25-26(30-25)18(4)22-9-10-23-21-8-7-19-15-20(29)11-13-27(19,5)24(21)12-14-28(22,23)6/h7-8,16-18,20,22-26,29H,9-15H2,1-6H3/t17-,18+,20+,22-,23+,24+,25+,26+,27+,28-/m1/s1
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n/an/an/an/a 1.96E+3n/an/an/an/a



Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia , Via del Liceo, 1-06123 Perugia, Italy.

Curated by ChEMBL


Assay Description
Activation of GAL4 fused human LXR beta expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay

J Med Chem 60: 6548-6562 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00091
BindingDB Entry DOI: 10.7270/Q2GH9MDC
More data for this
Ligand-Target Pair
Oxysterols receptor LXR-alpha


(Homo sapiens (Human))		BDBM50257938
PNG
(CHEMBL4089508)
Show SMILES [H][C@@]1(O[C@]1([H])[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@@H](CC)C(C)C |r,t:17|
Show InChI InChI=1S/C29H48O2/c1-7-21(17(2)3)27-26(31-27)18(4)23-10-11-24-22-9-8-19-16-20(30)12-14-28(19,5)25(22)13-15-29(23,24)6/h8,17-18,20-27,30H,7,9-16H2,1-6H3/t18-,20-,21-,22-,23+,24-,25-,26+,27+,28-,29+/m0/s1
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n/an/an/an/a 2.09E+3n/an/an/an/a



Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia , Via del Liceo, 1-06123 Perugia, Italy.

Curated by ChEMBL


Assay Description
Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay

J Med Chem 60: 6548-6562 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00091
BindingDB Entry DOI: 10.7270/Q2GH9MDC
More data for this
Ligand-Target Pair
Oxysterols receptor LXR-alpha


(Homo sapiens (Human))		BDBM50257928
PNG
(CHEMBL4070016)
Show SMILES [H][C@]1(O[C@@]1([H])[C@@H](C)[C@@]1([H])CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)C(C)C |r,t:14,16|
Show InChI InChI=1S/C28H44O2/c1-16(2)17(3)25-26(30-25)18(4)22-9-10-23-21-8-7-19-15-20(29)11-13-27(19,5)24(21)12-14-28(22,23)6/h7-8,16-18,20,22-26,29H,9-15H2,1-6H3/t17-,18+,20+,22-,23+,24+,25+,26+,27+,28-/m1/s1
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n/an/an/an/a 1.50E+3n/an/an/an/a



Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia , Via del Liceo, 1-06123 Perugia, Italy.

Curated by ChEMBL


Assay Description
Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay

J Med Chem 60: 6548-6562 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00091
BindingDB Entry DOI: 10.7270/Q2GH9MDC
More data for this
Ligand-Target Pair
Oxysterols receptor LXR-alpha


(Homo sapiens (Human))		BDBM50257932
PNG
(CHEMBL4085972)
Show SMILES [H][C@@]1(CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)C[C@@H](O)[C@H](C)C(C)C |r,t:6,8|
Show InChI InChI=1S/C28H46O2/c1-17(2)19(4)26(30)15-18(3)23-9-10-24-22-8-7-20-16-21(29)11-13-27(20,5)25(22)12-14-28(23,24)6/h7-8,17-19,21,23-26,29-30H,9-16H2,1-6H3/t18-,19-,21+,23-,24+,25+,26-,27+,28-/m1/s1
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n/an/an/an/a 1.58E+4n/an/an/an/a



Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia , Via del Liceo, 1-06123 Perugia, Italy.

Curated by ChEMBL


Assay Description
Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay

J Med Chem 60: 6548-6562 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00091
BindingDB Entry DOI: 10.7270/Q2GH9MDC
More data for this
Ligand-Target Pair
Oxysterols receptor LXR-beta


(Homo sapiens (Human))		BDBM50257937
PNG
(CHEMBL4094610)
Show SMILES [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)[C@H](O)C[C@@H](CC)C(C)C |r,t:9|
Show InChI InChI=1S/C29H50O2/c1-7-20(18(2)3)16-27(31)19(4)24-10-11-25-23-9-8-21-17-22(30)12-14-28(21,5)26(23)13-15-29(24,25)6/h8,18-20,22-27,30-31H,7,9-17H2,1-6H3/t19-,20+,22-,23-,24+,25-,26-,27+,28-,29+/m0/s1
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n/an/an/an/a 2.31E+3n/an/an/an/a



Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia , Via del Liceo, 1-06123 Perugia, Italy.

Curated by ChEMBL


Assay Description
Activation of GAL4 fused human LXR beta expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay

J Med Chem 60: 6548-6562 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00091
BindingDB Entry DOI: 10.7270/Q2GH9MDC
More data for this
Ligand-Target Pair
Oxysterols receptor LXR-beta


(Homo sapiens (Human))		BDBM50257935
PNG
(CHEMBL4067156)
Show SMILES [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)C[C@@H](O)[C@@H](CC)C(C)C |r,t:9|
Show InChI InChI=1S/C29H50O2/c1-7-22(18(2)3)27(31)16-19(4)24-10-11-25-23-9-8-20-17-21(30)12-14-28(20,5)26(23)13-15-29(24,25)6/h8,18-19,21-27,30-31H,7,9-17H2,1-6H3/t19-,21+,22+,23+,24-,25+,26+,27-,28+,29-/m1/s1
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n/an/an/an/a 2.70E+3n/an/an/an/a



Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia , Via del Liceo, 1-06123 Perugia, Italy.

Curated by ChEMBL


Assay Description
Activation of GAL4 fused human LXR beta expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay

J Med Chem 60: 6548-6562 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00091
BindingDB Entry DOI: 10.7270/Q2GH9MDC
More data for this
Ligand-Target Pair
Oxysterols receptor LXR-alpha


(Homo sapiens (Human))		BDBM50257929
PNG
(CHEMBL4097209)
Show SMILES [H][C@@]1(O[C@]1([H])[C@@H](C)[C@@]1([H])CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)C(C)C |r,t:14,16|
Show InChI InChI=1S/C28H44O2/c1-16(2)17(3)25-26(30-25)18(4)22-9-10-23-21-8-7-19-15-20(29)11-13-27(19,5)24(21)12-14-28(22,23)6/h7-8,16-18,20,22-26,29H,9-15H2,1-6H3/t17-,18+,20+,22-,23+,24+,25-,26-,27+,28-/m1/s1
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n/an/an/an/a 4.11E+3n/an/an/an/a



Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia , Via del Liceo, 1-06123 Perugia, Italy.

Curated by ChEMBL


Assay Description
Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay

J Med Chem 60: 6548-6562 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00091
BindingDB Entry DOI: 10.7270/Q2GH9MDC
More data for this
Ligand-Target Pair
Oxysterols receptor LXR-alpha


(Homo sapiens (Human))		BDBM50257935
PNG
(CHEMBL4067156)
Show SMILES [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)C[C@@H](O)[C@@H](CC)C(C)C |r,t:9|
Show InChI InChI=1S/C29H50O2/c1-7-22(18(2)3)27(31)16-19(4)24-10-11-25-23-9-8-20-17-21(30)12-14-28(20,5)26(23)13-15-29(24,25)6/h8,18-19,21-27,30-31H,7,9-17H2,1-6H3/t19-,21+,22+,23+,24-,25+,26+,27-,28+,29-/m1/s1
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n/an/an/an/a 3.20E+3n/an/an/an/a



Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia , Via del Liceo, 1-06123 Perugia, Italy.

Curated by ChEMBL


Assay Description
Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay

J Med Chem 60: 6548-6562 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00091
BindingDB Entry DOI: 10.7270/Q2GH9MDC
More data for this
Ligand-Target Pair
Oxysterols receptor LXR-beta


(Homo sapiens (Human))		BDBM20177
PNG
((1S,2R,5S,10S,11S,14R,15S)-14-[(2S,3R)-3-hydroxy-6...)
Show SMILES [H][C@@](O)(CCC(C)C)[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@]([H])(O)CC[C@]4(C)[C@@]3([H])CC[C@]12C |r,t:19|
Show InChI InChI=1S/C27H46O2/c1-17(2)6-11-25(29)18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20-,21-,22+,23-,24-,25+,26-,27+/m0/s1
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n/an/an/an/a 4.75E+3n/an/an/an/a



Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia , Via del Liceo, 1-06123 Perugia, Italy.

Curated by ChEMBL


Assay Description
Activation of GAL4 fused human LXR beta expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay

J Med Chem 60: 6548-6562 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00091
BindingDB Entry DOI: 10.7270/Q2GH9MDC
More data for this
Ligand-Target Pair
Oxysterols receptor LXR-alpha


(Homo sapiens (Human))		BDBM50257939
PNG
(CHEMBL4078083)
Show SMILES [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CC(=O)[C@@H](CC)C(C)C |r,t:9|
Show InChI InChI=1S/C29H48O2/c1-7-22(18(2)3)27(31)16-19(4)24-10-11-25-23-9-8-20-17-21(30)12-14-28(20,5)26(23)13-15-29(24,25)6/h8,18-19,21-26,30H,7,9-17H2,1-6H3/t19-,21+,22+,23+,24-,25+,26+,28+,29-/m1/s1
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n/an/an/an/a 1.45E+4n/an/an/an/a



Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia , Via del Liceo, 1-06123 Perugia, Italy.

Curated by ChEMBL


Assay Description
Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay

J Med Chem 60: 6548-6562 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00091
BindingDB Entry DOI: 10.7270/Q2GH9MDC
More data for this
Ligand-Target Pair
Oxysterols receptor LXR-beta


(Homo sapiens (Human))		BDBM50257939
PNG
(CHEMBL4078083)
Show SMILES [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CC(=O)[C@@H](CC)C(C)C |r,t:9|
Show InChI InChI=1S/C29H48O2/c1-7-22(18(2)3)27(31)16-19(4)24-10-11-25-23-9-8-20-17-21(30)12-14-28(20,5)26(23)13-15-29(24,25)6/h8,18-19,21-26,30H,7,9-17H2,1-6H3/t19-,21+,22+,23+,24-,25+,26+,28+,29-/m1/s1
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n/an/an/an/a 6.02E+3n/an/an/an/a



Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia , Via del Liceo, 1-06123 Perugia, Italy.

Curated by ChEMBL


Assay Description
Activation of GAL4 fused human LXR beta expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay

J Med Chem 60: 6548-6562 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00091
BindingDB Entry DOI: 10.7270/Q2GH9MDC
More data for this
Ligand-Target Pair
Oxysterols receptor LXR-alpha


(Homo sapiens (Human))		BDBM50257933
PNG
(CHEMBL4086897)
Show SMILES [H][C@@]1(CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)[C@@H](O)C[C@H](C)C(C)C |r,t:6,8|
Show InChI InChI=1S/C28H46O2/c1-17(2)18(3)15-26(30)19(4)23-9-10-24-22-8-7-20-16-21(29)11-13-27(20,5)25(22)12-14-28(23,24)6/h7-8,17-19,21,23-26,29-30H,9-16H2,1-6H3/t18-,19-,21-,23+,24-,25-,26-,27-,28+/m0/s1
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n/an/an/an/a 6.61E+3n/an/an/an/a



Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia , Via del Liceo, 1-06123 Perugia, Italy.

Curated by ChEMBL


Assay Description
Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay

J Med Chem 60: 6548-6562 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00091
BindingDB Entry DOI: 10.7270/Q2GH9MDC
More data for this
Ligand-Target Pair
Oxysterols receptor LXR-beta


(Homo sapiens (Human))		BDBM50257929
PNG
(CHEMBL4097209)
Show SMILES [H][C@@]1(O[C@]1([H])[C@@H](C)[C@@]1([H])CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)C(C)C |r,t:14,16|
Show InChI InChI=1S/C28H44O2/c1-16(2)17(3)25-26(30-25)18(4)22-9-10-23-21-8-7-19-15-20(29)11-13-27(19,5)24(21)12-14-28(22,23)6/h7-8,16-18,20,22-26,29H,9-15H2,1-6H3/t17-,18+,20+,22-,23+,24+,25-,26-,27+,28-/m1/s1
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n/an/an/an/a 7.20E+3n/an/an/an/a



Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia , Via del Liceo, 1-06123 Perugia, Italy.

Curated by ChEMBL


Assay Description
Activation of GAL4 fused human LXR beta expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay

J Med Chem 60: 6548-6562 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00091
BindingDB Entry DOI: 10.7270/Q2GH9MDC
More data for this
Ligand-Target Pair
Oxysterols receptor LXR-beta


(Homo sapiens (Human))		BDBM50257938
PNG
(CHEMBL4089508)
Show SMILES [H][C@@]1(O[C@]1([H])[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@@H](CC)C(C)C |r,t:17|
Show InChI InChI=1S/C29H48O2/c1-7-21(17(2)3)27-26(31-27)18(4)23-10-11-24-22-9-8-19-16-20(30)12-14-28(19,5)25(22)13-15-29(23,24)6/h8,17-18,20-27,30H,7,9-16H2,1-6H3/t18-,20-,21-,22-,23+,24-,25-,26+,27+,28-,29+/m0/s1
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n/an/an/an/a 3.79E+3n/an/an/an/a



Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia , Via del Liceo, 1-06123 Perugia, Italy.

Curated by ChEMBL


Assay Description
Activation of GAL4 fused human LXR beta expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay

J Med Chem 60: 6548-6562 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00091
BindingDB Entry DOI: 10.7270/Q2GH9MDC
More data for this
Ligand-Target Pair
Oxysterols receptor LXR-alpha


(Homo sapiens (Human))		BDBM20177
PNG
((1S,2R,5S,10S,11S,14R,15S)-14-[(2S,3R)-3-hydroxy-6...)
Show SMILES [H][C@@](O)(CCC(C)C)[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@]([H])(O)CC[C@]4(C)[C@@]3([H])CC[C@]12C |r,t:19|
Show InChI InChI=1S/C27H46O2/c1-17(2)6-11-25(29)18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20-,21-,22+,23-,24-,25+,26-,27+/m0/s1
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n/an/an/an/a 6.71E+3n/an/an/an/a



Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia , Via del Liceo, 1-06123 Perugia, Italy.

Curated by ChEMBL


Assay Description
Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay

J Med Chem 60: 6548-6562 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00091
BindingDB Entry DOI: 10.7270/Q2GH9MDC
More data for this
Ligand-Target Pair
Oxysterols receptor LXR-alpha


(Homo sapiens (Human))		BDBM50257937
PNG
(CHEMBL4094610)
Show SMILES [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)[C@H](O)C[C@@H](CC)C(C)C |r,t:9|
Show InChI InChI=1S/C29H50O2/c1-7-20(18(2)3)16-27(31)19(4)24-10-11-25-23-9-8-21-17-22(30)12-14-28(21,5)26(23)13-15-29(24,25)6/h8,18-20,22-27,30-31H,7,9-17H2,1-6H3/t19-,20+,22-,23-,24+,25-,26-,27+,28-,29+/m0/s1
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n/an/an/an/a 6.93E+3n/an/an/an/a



Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia , Via del Liceo, 1-06123 Perugia, Italy.

Curated by ChEMBL


Assay Description
Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay

J Med Chem 60: 6548-6562 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00091
BindingDB Entry DOI: 10.7270/Q2GH9MDC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%