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PubMed code 28902994

Compile data set for download or QSAR
Found 55 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241542
PNG
(CHEMBL4065348)
Show SMILES O\N=c1/cc(oc2ccccc12)-c1cc2ccccc2[nH]1
Show InChI InChI=1S/C17H12N2O2/c20-19-14-10-17(21-16-8-4-2-6-12(14)16)15-9-11-5-1-3-7-13(11)18-15/h1-10,18,20H/b19-14+
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n/an/an/an/a>3.00E+4n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241591
PNG
(CHEMBL4078081)
Show SMILES O\N=c1/cc(oc2ccc(OC(F)(F)F)cc12)-c1cc2ccccc2cn1
Show InChI InChI=1S/C19H11F3N2O3/c20-19(21,22)27-13-5-6-17-14(8-13)15(24-25)9-18(26-17)16-7-11-3-1-2-4-12(11)10-23-16/h1-10,25H/b24-15+
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n/an/an/an/a 1.63E+3n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241556
PNG
(CHEMBL4083118)
Show SMILES O\N=c1/cc(oc2cc(CCc3ccccc3)ccc12)-c1cc2ccccc2cn1
Show InChI InChI=1S/C26H20N2O2/c29-28-23-16-26(24-15-20-8-4-5-9-21(20)17-27-24)30-25-14-19(12-13-22(23)25)11-10-18-6-2-1-3-7-18/h1-9,12-17,29H,10-11H2/b28-23+
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n/an/an/an/a 1.74E+3n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241575
PNG
(CHEMBL4067875)
Show SMILES O\N=c1/cc(oc2ccc(OCCN3CCOCC3)cc12)-c1cc2cccn2cn1
Show InChI InChI=1S/C22H22N4O4/c27-24-19-14-22(20-12-16-2-1-5-26(16)15-23-20)30-21-4-3-17(13-18(19)21)29-11-8-25-6-9-28-10-7-25/h1-5,12-15,27H,6-11H2/b24-19+
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n/an/an/an/a 46n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241587
PNG
(CHEMBL4082331)
Show SMILES O\N=c1/cc(oc2ccccc12)-c1ccc2ncccc2c1
Show InChI InChI=1S/C18H12N2O2/c21-20-16-11-18(22-17-6-2-1-5-14(16)17)13-7-8-15-12(10-13)4-3-9-19-15/h1-11,21H/b20-16+
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n/an/an/an/a 6.99E+3n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241593
PNG
(CHEMBL4092850)
Show SMILES Cc1cc(CCCOc2ccc3oc(c\c(=N/O)c3c2)-c2cc3cccn3cn2)ccn1
Show InChI InChI=1S/C25H22N4O3/c1-17-12-18(8-9-26-17)4-3-11-31-20-6-7-24-21(14-20)22(28-30)15-25(32-24)23-13-19-5-2-10-29(19)16-27-23/h2,5-10,12-16,30H,3-4,11H2,1H3/b28-22+
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n/an/an/an/a 19n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241541
PNG
(CHEMBL4087749)
Show SMILES O\N=c1/cc(oc2ccccc12)-c1cc2ccccc2o1
Show InChI InChI=1S/C17H11NO3/c19-18-13-10-17(21-15-8-4-2-6-12(13)15)16-9-11-5-1-3-7-14(11)20-16/h1-10,19H/b18-13+
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n/an/an/an/a>3.00E+4n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241543
PNG
(CHEMBL4060429)
Show SMILES O\N=c1/cc(oc2ccccc12)-c1cnc2ccccc2c1
Show InChI InChI=1S/C18H12N2O2/c21-20-16-10-18(22-17-8-4-2-6-14(16)17)13-9-12-5-1-3-7-15(12)19-11-13/h1-11,21H/b20-16+
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n/an/an/an/a 3.96E+3n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241544
PNG
(CHEMBL4081595)
Show SMILES O\N=c1/cc(oc2ccccc12)-c1cc2ccccc2cn1
Show InChI InChI=1S/C18H12N2O2/c21-20-15-10-18(22-17-8-4-3-7-14(15)17)16-9-12-5-1-2-6-13(12)11-19-16/h1-11,21H/b20-15+
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n/an/an/an/a 310n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241560
PNG
(CHEMBL4064041)
Show SMILES COCCOc1ccc2oc(c\c(=N/O)c2c1)-c1cc2ccccc2cn1
Show InChI InChI=1S/C21H18N2O4/c1-25-8-9-26-16-6-7-20-17(11-16)18(23-24)12-21(27-20)19-10-14-4-2-3-5-15(14)13-22-19/h2-7,10-13,24H,8-9H2,1H3/b23-18+
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n/an/an/an/a 750n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241564
PNG
(CHEMBL4096136)
Show SMILES O\N=c1/cc(oc2ccc(Br)cc12)-c1cc2ccccc2cn1
Show InChI InChI=1S/C18H11BrN2O2/c19-13-5-6-17-14(8-13)15(21-22)9-18(23-17)16-7-11-3-1-2-4-12(11)10-20-16/h1-10,22H/b21-15+
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n/an/an/an/a 690n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241568
PNG
(CHEMBL4100586)
Show SMILES CN(C)C(=O)N1CC(C1)Oc1ccc2oc(c\c(=N/O)c2c1)-c1cc2cccn2cn1
Show InChI InChI=1S/C22H21N5O4/c1-25(2)22(28)27-11-16(12-27)30-15-5-6-20-17(9-15)18(24-29)10-21(31-20)19-8-14-4-3-7-26(14)13-23-19/h3-10,13,16,29H,11-12H2,1-2H3/b24-18+
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n/an/an/an/a 35n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241569
PNG
(CHEMBL4062426)
Show SMILES CN(C)C1CCN(CCOc2ccc3oc(c\c(=N/O)c3c2)-c2cc3cccn3cn2)CC1
Show InChI InChI=1S/C25H29N5O3/c1-28(2)18-7-10-29(11-8-18)12-13-32-20-5-6-24-21(15-20)22(27-31)16-25(33-24)23-14-19-4-3-9-30(19)17-26-23/h3-6,9,14-18,31H,7-8,10-13H2,1-2H3/b27-22+
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n/an/an/an/a 165n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241585
PNG
(CHEMBL4077754)
Show SMILES COc1ccc2c(c1)oc(c\c2=N/O)-c1cc2ccccc2cn1
Show InChI InChI=1S/C19H14N2O3/c1-23-14-6-7-15-16(21-22)10-19(24-18(15)9-14)17-8-12-4-2-3-5-13(12)11-20-17/h2-11,22H,1H3/b21-16+
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n/an/an/an/a 1.16E+3n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241551
PNG
(CHEMBL4088412)
Show SMILES O\N=c1/cc(oc2ccc(cc12)C(F)(F)F)-c1cc2ccccc2cn1
Show InChI InChI=1S/C19H11F3N2O2/c20-19(21,22)13-5-6-17-14(8-13)15(24-25)9-18(26-17)16-7-11-3-1-2-4-12(11)10-23-16/h1-10,25H/b24-15+
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n/an/an/an/a 2.47E+3n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241559
PNG
(CHEMBL4093353)
Show SMILES CN1CCN(CCOc2ccc3oc(c\c(=N/O)c3c2)-c2cc3ccccc3cn2)CC1
Show InChI InChI=1S/C25H26N4O3/c1-28-8-10-29(11-9-28)12-13-31-20-6-7-24-21(15-20)22(27-30)16-25(32-24)23-14-18-4-2-3-5-19(18)17-26-23/h2-7,14-17,30H,8-13H2,1H3/b27-22+
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n/an/an/an/a 9.84E+3n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241562
PNG
(CHEMBL4103895)
Show SMILES O\N=c1/cc(oc2cc(Br)ccc12)-c1cc2ccccc2cn1
Show InChI InChI=1S/C18H11BrN2O2/c19-13-5-6-14-15(21-22)9-18(23-17(14)8-13)16-7-11-3-1-2-4-12(11)10-20-16/h1-10,22H/b21-15+
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n/an/an/an/a 1.72E+3n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241565
PNG
(CHEMBL4082167)
Show SMILES O\N=c1/cc(oc2ccc(CCCN3CCC(F)(F)CC3)cc12)-c1cc2sccc2cn1
Show InChI InChI=1S/C24H23F2N3O2S/c25-24(26)6-9-29(10-7-24)8-1-2-16-3-4-21-18(12-16)19(28-30)13-22(31-21)20-14-23-17(15-27-20)5-11-32-23/h3-5,11-15,30H,1-2,6-10H2/b28-19+
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n/an/an/an/a 106n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241579
PNG
(CHEMBL4081211)
Show SMILES CC(=O)N1CC(C1)Oc1ccc2oc(c\c(=N/O)c2c1)-c1cc2sccc2cn1
Show InChI InChI=1S/C21H17N3O4S/c1-12(25)24-10-15(11-24)27-14-2-3-19-16(6-14)17(23-26)7-20(28-19)18-8-21-13(9-22-18)4-5-29-21/h2-9,15,26H,10-11H2,1H3/b23-17+
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n/an/an/an/a 53n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241595
PNG
(CHEMBL4098128)
Show SMILES O\N=c1/cc(oc2ccc(OCCN3CCC(F)(F)CC3)cc12)-c1cc2cccn2cn1
Show InChI InChI=1S/C23H22F2N4O3/c24-23(25)5-8-28(9-6-23)10-11-31-17-3-4-21-18(13-17)19(27-30)14-22(32-21)20-12-16-2-1-7-29(16)15-26-20/h1-4,7,12-15,30H,5-6,8-11H2/b27-19+
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n/an/an/an/a 150n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50116514
PNG
(CHEMBL507522)
Show SMILES [H][C@@]12C[C@@]1(Oc1ccccc1\C2=N\O)C(=O)Nc1ccccc1 |r|
Show InChI InChI=1S/C17H14N2O3/c20-16(18-11-6-2-1-3-7-11)17-10-13(17)15(19-21)12-8-4-5-9-14(12)22-17/h1-9,13,21H,10H2,(H,18,20)/b19-15-/t13-,17-/m0/s1
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n/an/an/an/a 2.50E+3n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of human immunodeficiency virus-1 reverse transcriptase(HIV-1 RT).

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241574
PNG
(CHEMBL4071064)
Show SMILES O\N=c1/cc(oc2ccc(OCCN3CCCC3)cc12)-c1cc2cccn2cn1
Show InChI InChI=1S/C22H22N4O3/c27-24-19-14-22(20-12-16-4-3-9-26(16)15-23-20)29-21-6-5-17(13-18(19)21)28-11-10-25-7-1-2-8-25/h3-6,9,12-15,27H,1-2,7-8,10-11H2/b24-19+
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n/an/an/an/a 2.34E+3n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241567
PNG
(CHEMBL4072094)
Show SMILES O\N=c1/cc(oc2ccc(OCCCc3cccnc3)cc12)-c1cc2cccn2cn1
Show InChI InChI=1S/C24H20N4O3/c29-27-21-14-24(22-12-18-6-2-10-28(18)16-26-22)31-23-8-7-19(13-20(21)23)30-11-3-5-17-4-1-9-25-15-17/h1-2,4,6-10,12-16,29H,3,5,11H2/b27-21+
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n/an/an/an/a 50n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241578
PNG
(CHEMBL4105462)
Show SMILES CC(=O)N1CCC(COc2ccc3oc(c\c(=N/O)c3c2)-c2cc3sccc3cn2)CC1
Show InChI InChI=1S/C24H23N3O4S/c1-15(28)27-7-4-16(5-8-27)14-30-18-2-3-22-19(10-18)20(26-29)11-23(31-22)21-12-24-17(13-25-21)6-9-32-24/h2-3,6,9-13,16,29H,4-5,7-8,14H2,1H3/b26-20+
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n/an/an/an/a 6n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241580
PNG
(CHEMBL4089083)
Show SMILES O\N=c1/cc(oc2ccc(CCCN3CCOCC3)cc12)-c1cc2sccc2cn1
Show InChI InChI=1S/C23H23N3O3S/c27-25-19-13-22(20-14-23-17(15-24-20)5-11-30-23)29-21-4-3-16(12-18(19)21)2-1-6-26-7-9-28-10-8-26/h3-5,11-15,27H,1-2,6-10H2/b25-19+
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n/an/an/an/a 79n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Rattus norvegicus (Rat))		BDBM50241580
PNG
(CHEMBL4089083)
Show SMILES O\N=c1/cc(oc2ccc(CCCN3CCOCC3)cc12)-c1cc2sccc2cn1
Show InChI InChI=1S/C23H23N3O3S/c27-25-19-13-22(20-14-23-17(15-24-20)5-11-30-23)29-21-4-3-16(12-18(19)21)2-1-6-26-7-9-28-10-8-26/h3-5,11-15,27H,1-2,6-10H2/b25-19+
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n/an/an/an/a 47n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-induced calcium ...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241583
PNG
(CHEMBL4067152)
Show SMILES Cc1ccc2oc(c\c(=N/O)c2c1)-c1cc2ccccc2cn1
Show InChI InChI=1S/C19H14N2O2/c1-12-6-7-18-15(8-12)16(21-22)10-19(23-18)17-9-13-4-2-3-5-14(13)11-20-17/h2-11,22H,1H3/b21-16+
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n/an/an/an/a 980n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241549
PNG
(CHEMBL4068295)
Show SMILES Cn1ccc2cc(ncc12)-c1c\c(=N/O)c2ccccc2o1
Show InChI InChI=1S/C17H13N3O2/c1-20-7-6-11-8-14(18-10-15(11)20)17-9-13(19-21)12-4-2-3-5-16(12)22-17/h2-10,21H,1H3/b19-13+
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n/an/an/an/a 860n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241550
PNG
(CHEMBL4067271)
Show SMILES O\N=c1/cc(oc2ccccc12)-c1cc2cc[nH]c2cn1
Show InChI InChI=1S/C16H11N3O2/c20-19-12-8-16(21-15-4-2-1-3-11(12)15)13-7-10-5-6-17-14(10)9-18-13/h1-9,17,20H/b19-12+
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n/an/an/an/a 50n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241552
PNG
(CHEMBL4085101)
Show SMILES O\N=c1/cc(oc2ccc(OCCN3CCC(F)(F)CC3)cc12)-c1cc2sccc2cn1
Show InChI InChI=1S/C23H21F2N3O3S/c24-23(25)4-6-28(7-5-23)8-9-30-16-1-2-20-17(11-16)18(27-29)12-21(31-20)19-13-22-15(14-26-19)3-10-32-22/h1-3,10-14,29H,4-9H2/b27-18+
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n/an/an/an/a 90n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241561
PNG
(CHEMBL4085608)
Show SMILES O\N=c1/cc(oc2ccc(cc12)C1CC1)-c1cc2ccccc2cn1
Show InChI InChI=1S/C21H16N2O2/c24-23-18-11-21(19-10-14-3-1-2-4-16(14)12-22-19)25-20-8-7-15(9-17(18)20)13-5-6-13/h1-4,7-13,24H,5-6H2/b23-18+
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n/an/an/an/a 1.01E+3n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241566
PNG
(CHEMBL4100168)
Show SMILES O\N=c1/cc(oc2ccc(CCCN3CCC(F)(F)C3)cc12)-c1cc2sccc2cn1
Show InChI InChI=1S/C23H21F2N3O2S/c24-23(25)6-8-28(14-23)7-1-2-15-3-4-20-17(10-15)18(27-29)11-21(30-20)19-12-22-16(13-26-19)5-9-31-22/h3-5,9-13,29H,1-2,6-8,14H2/b27-18+
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n/an/an/an/a 25n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241573
PNG
(CHEMBL4098112)
Show SMILES CN1CCN(CCOc2ccc3oc(c\c(=N/O)c3c2)-c2cc3cccn3cn2)CC1
Show InChI InChI=1S/C23H25N5O3/c1-26-7-9-27(10-8-26)11-12-30-18-4-5-22-19(14-18)20(25-29)15-23(31-22)21-13-17-3-2-6-28(17)16-24-21/h2-6,13-16,29H,7-12H2,1H3/b25-20+
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n/an/an/an/a 1.71E+3n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241576
PNG
(CHEMBL4061970)
Show SMILES O\N=c1/cc(oc2ccc(NC3CCN(CC3)c3ccncn3)cc12)-c1cc2sccc2cn1
Show InChI InChI=1S/C25H22N6O2S/c32-30-20-12-23(21-13-24-16(14-27-21)6-10-34-24)33-22-2-1-18(11-19(20)22)29-17-4-8-31(9-5-17)25-3-7-26-15-28-25/h1-3,6-7,10-15,17,29,32H,4-5,8-9H2/b30-20+
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n/an/an/an/a 53n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241577
PNG
(CHEMBL4070594)
Show SMILES Cc1ncccc1N1CCC(Cc2ccc3oc(c\c(=N/O)c3c2)-c2cc3sccc3cn2)CC1
Show InChI InChI=1S/C28H26N4O2S/c1-18-25(3-2-9-29-18)32-10-6-19(7-11-32)13-20-4-5-26-22(14-20)23(31-33)15-27(34-26)24-16-28-21(17-30-24)8-12-35-28/h2-5,8-9,12,14-17,19,33H,6-7,10-11,13H2,1H3/b31-23+
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n/an/an/an/a 4n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241584
PNG
(CHEMBL4072639)
Show SMILES CN1CCN(CCCNc2ccc3oc(c\c(=N/O)c3c2)-c2cc3ccccc3cn2)CC1
Show InChI InChI=1S/C26H29N5O2/c1-30-11-13-31(14-12-30)10-4-9-27-21-7-8-25-22(16-21)23(29-32)17-26(33-25)24-15-19-5-2-3-6-20(19)18-28-24/h2-3,5-8,15-18,27,32H,4,9-14H2,1H3/b29-23+
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n/an/an/an/a 5.26E+3n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241588
PNG
(CHEMBL4098106)
Show SMILES O\N=c1/cc(oc2ccccc12)-c1cc2cccn2cn1
Show InChI InChI=1S/C16H11N3O2/c20-18-13-9-16(21-15-6-2-1-5-12(13)15)14-8-11-4-3-7-19(11)10-17-14/h1-10,20H/b18-13+
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n/an/an/an/a 110n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241590
PNG
(CHEMBL4067872)
Show SMILES CN1CCCC11CCN(CCOc2ccc3oc(c\c(=N/O)c3c2)-c2cc3sccc3cn2)CC1
Show InChI InChI=1S/C27H30N4O3S/c1-30-9-2-6-27(30)7-10-31(11-8-27)12-13-33-20-3-4-24-21(15-20)22(29-32)16-25(34-24)23-17-26-19(18-28-23)5-14-35-26/h3-5,14-18,32H,2,6-13H2,1H3/b29-22+
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n/an/an/an/a 60n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241594
PNG
(CHEMBL4082573)
Show SMILES CC(=O)N1CCC(CC1)Oc1ccc2oc(c\c(=N/O)c2c1)-c1cc2cccn2cn1
Show InChI InChI=1S/C23H22N4O4/c1-15(28)26-9-6-17(7-10-26)30-18-4-5-22-19(12-18)20(25-29)13-23(31-22)21-11-16-3-2-8-27(16)14-24-21/h2-5,8,11-14,17,29H,6-7,9-10H2,1H3/b25-20+
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n/an/an/an/a 10n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50116514
PNG
(CHEMBL507522)
Show SMILES [H][C@@]12C[C@@]1(Oc1ccccc1\C2=N\O)C(=O)Nc1ccccc1 |r|
Show InChI InChI=1S/C17H14N2O3/c20-16(18-11-6-2-1-3-7-11)17-10-13(17)15(19-21)12-8-4-5-9-14(12)22-17/h1-9,13,21H,10H2,(H,18,20)/b19-15-/t13-,17-/m0/s1
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n/an/an/an/a 2.25E+3n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Inhibitory activity against human immunodeficiency virus-1 reverse transcriptase(HIV-1 RT).

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241554
PNG
(CHEMBL4063474)
Show SMILES O\N=c1/cc(oc2ccc(OCCN3CCOCC3)cc12)-c1cc2sccc2cn1
Show InChI InChI=1S/C22H21N3O4S/c26-24-18-12-21(19-13-22-15(14-23-19)3-10-30-22)29-20-2-1-16(11-17(18)20)28-9-6-25-4-7-27-8-5-25/h1-3,10-14,26H,4-9H2/b24-18+
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n/an/an/an/a 35n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241557
PNG
(CHEMBL4101095)
Show SMILES COCCOc1ccc2c(c1)oc(c\c2=N/O)-c1cc2ccccc2cn1
Show InChI InChI=1S/C21H18N2O4/c1-25-8-9-26-16-6-7-17-18(23-24)12-21(27-20(17)11-16)19-10-14-4-2-3-5-15(14)13-22-19/h2-7,10-13,24H,8-9H2,1H3/b23-18+
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n/an/an/an/a 3.01E+3n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241575
PNG
(CHEMBL4067875)
Show SMILES O\N=c1/cc(oc2ccc(OCCN3CCOCC3)cc12)-c1cc2cccn2cn1
Show InChI InChI=1S/C22H22N4O4/c27-24-19-14-22(20-12-16-2-1-5-26(16)15-23-20)30-21-4-3-17(13-18(19)21)29-11-8-25-6-9-28-10-7-25/h1-5,12-15,27H,6-11H2/b24-19+
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n/an/an/an/a 70n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing chimeric G protein assessed as increase in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241581
PNG
(CHEMBL4079161)
Show SMILES O\N=c1/cc(oc2ccccc12)-c1cc2sccc2cn1
Show InChI InChI=1S/C16H10N2O2S/c19-18-12-7-15(20-14-4-2-1-3-11(12)14)13-8-16-10(9-17-13)5-6-21-16/h1-9,19H/b18-12+
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n/an/an/an/a 200n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241592
PNG
(CHEMBL4090015)
Show SMILES O\N=c1/cc(oc2ccc(O[C@@H]3CCN(C3)c3ccncn3)cc12)-c1cc2sccc2cn1 |r|
Show InChI InChI=1S/C24H19N5O3S/c30-28-19-10-22(20-11-23-15(12-26-20)5-8-33-23)32-21-2-1-16(9-18(19)21)31-17-4-7-29(13-17)24-3-6-25-14-27-24/h1-3,5-6,8-12,14,17,30H,4,7,13H2/b28-19+/t17-/m1/s1
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n/an/an/an/a 17n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241545
PNG
(CHEMBL4059644)
Show SMILES O\N=c1/cc(oc2ccccc12)-c1cc2cnccc2cn1
Show InChI InChI=1S/C17H11N3O2/c21-20-14-8-17(22-16-4-2-1-3-13(14)16)15-7-12-9-18-6-5-11(12)10-19-15/h1-10,21H/b20-14+
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n/an/an/an/a 1.27E+3n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241546
PNG
(CHEMBL4071024)
Show SMILES O\N=c1/cc(oc2ccccc12)-c1cc2ncccc2cn1
Show InChI InChI=1S/C17H11N3O2/c21-20-14-9-17(22-16-6-2-1-5-12(14)16)15-8-13-11(10-19-15)4-3-7-18-13/h1-10,21H/b20-14+
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n/an/an/an/a 240n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241547
PNG
(CHEMBL4097178)
Show SMILES O\N=c1/cc(oc2ccccc12)-c1cc2ccsc2cn1
Show InChI InChI=1S/C16H10N2O2S/c19-18-12-8-15(20-14-4-2-1-3-11(12)14)13-7-10-5-6-21-16(10)9-17-13/h1-9,19H/b18-12+
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n/an/an/an/a 130n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241555
PNG
(CHEMBL4062968)
Show SMILES COCCOc1ccc2oc(c\c(=N/O)c2c1)-c1cc2cccn2cn1
Show InChI InChI=1S/C19H17N3O4/c1-24-7-8-25-14-4-5-18-15(10-14)16(21-23)11-19(26-18)17-9-13-3-2-6-22(13)12-20-17/h2-6,9-12,23H,7-8H2,1H3/b21-16+
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n/an/an/an/a 160n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241563
PNG
(CHEMBL4085967)
Show SMILES COc1ccc2oc(c\c(=N/O)c2c1)-c1cc2ccccc2cn1
Show InChI InChI=1S/C19H14N2O3/c1-23-14-6-7-18-15(9-14)16(21-22)10-19(24-18)17-8-12-4-2-3-5-13(12)11-20-17/h2-11,22H,1H3/b21-16+
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n/an/an/an/a 1.39E+3n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Rattus norvegicus (Rat))		BDBM50241575
PNG
(CHEMBL4067875)
Show SMILES O\N=c1/cc(oc2ccc(OCCN3CCOCC3)cc12)-c1cc2cccn2cn1
Show InChI InChI=1S/C22H22N4O4/c27-24-19-14-22(20-12-16-2-1-5-26(16)15-23-20)30-21-4-3-17(13-18(19)21)29-11-8-25-6-9-28-10-7-25/h1-5,12-15,27H,6-11H2/b24-19+
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n/an/an/an/a 27n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-induced calcium ...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241580
PNG
(CHEMBL4089083)
Show SMILES O\N=c1/cc(oc2ccc(CCCN3CCOCC3)cc12)-c1cc2sccc2cn1
Show InChI InChI=1S/C23H23N3O3S/c27-25-19-13-22(20-14-23-17(15-24-20)5-11-30-23)29-21-4-3-16(12-18(19)21)2-1-6-26-7-9-28-10-8-26/h3-5,11-15,27H,1-2,6-10H2/b25-19+
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n/an/an/an/a>1.50E+4n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing chimeric G protein assessed as increase in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241586
PNG
(CHEMBL4095448)
Show SMILES O\N=c1/cc(\C=C\c2ccccc2)oc2ccccc12
Show InChI InChI=1S/C17H13NO2/c19-18-16-12-14(11-10-13-6-2-1-3-7-13)20-17-9-5-4-8-15(16)17/h1-12,19H/b11-10+,18-16+
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n/an/an/an/a 1.42E+4n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241589
PNG
(CHEMBL4097743)
Show SMILES O\N=c1/cc(oc2ccc(OC3CN(C3)c3cccnc3)cc12)-c1cc2sccc2cn1
Show InChI InChI=1S/C24H18N4O3S/c29-27-20-9-23(21-10-24-15(11-26-21)5-7-32-24)31-22-4-3-17(8-19(20)22)30-18-13-28(14-18)16-2-1-6-25-12-16/h1-12,18,29H,13-14H2/b27-20+
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n/an/an/an/a 4n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50241548
PNG
(CHEMBL4089473)
Show SMILES O\N=c1/cc(oc2ccccc12)-c1cn2cccc2cn1
Show InChI InChI=1S/C16H11N3O2/c20-18-13-8-16(21-15-6-2-1-5-12(13)15)14-10-19-7-3-4-11(19)9-17-14/h1-10,20H/b18-13+
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n/an/an/an/a 280n/an/an/an/a



Prexton Therapeutics

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...

J Med Chem 60: 8515-8537 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00991
BindingDB Entry DOI: 10.7270/Q2GF0WNQ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%