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PubMed code 30006168

Compile data set for download or QSAR
Found 1 hit of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase B-raf


(Homo sapiens (Human))		BDBM50503325
PNG
(CHEMBL4436746)
Show SMILES COc1cc(Cl)cc(c1)-c1nn(cc1-c1ccncc1)-c1cccc(NC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1
Show InChI InChI=1S/C30H20ClF6N5O2/c1-44-25-10-18(9-21(31)14-25)27-26(17-5-7-38-8-6-17)16-42(41-27)24-4-2-3-22(15-24)39-28(43)40-23-12-19(29(32,33)34)11-20(13-23)30(35,36)37/h2-16H,1H3,(H2,39,40,43)
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 390n/an/an/an/an/an/a



University of Sharjah

Curated by ChEMBL


Assay Description
Inhibition of human BRAF V600E mutant using MEK1 (K97R) as substrate after 40 mins in presence of [gamma33P]ATP by scintillation counting method

Eur J Med Chem 156: 230-239 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.008
BindingDB Entry DOI: 10.7270/Q232005G
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%