BindingDB logo
myBDB logout

PubMed code 30732944

Compile data set for download or QSAR
Found 13 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Estrogen receptor


(Homo sapiens (Human))		BDBM50532101
PNG
(CHEMBL4439408)
Show SMILES Oc1ccc2C3=C(CCOc2c1)c1cc(O)ccc1OC3c1ccc(OCCN2CC(CF)C2)cc1 |c:5|
Show InChI InChI=1S/C29H28FNO5/c30-15-18-16-31(17-18)10-12-34-22-5-1-19(2-6-22)29-28-23(25-13-20(32)4-8-26(25)36-29)9-11-35-27-14-21(33)3-7-24(27)28/h1-8,13-14,18,29,32-33H,9-12,15-17H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.0240n/an/an/an/an/an/a



Genentech Inc.

Curated by ChEMBL


Assay Description
Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...

Bioorg Med Chem Lett 29: 905-911 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.036
BindingDB Entry DOI: 10.7270/Q2Q52T3W
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))		BDBM50532101
PNG
(CHEMBL4439408)
Show SMILES Oc1ccc2C3=C(CCOc2c1)c1cc(O)ccc1OC3c1ccc(OCCN2CC(CF)C2)cc1 |c:5|
Show InChI InChI=1S/C29H28FNO5/c30-15-18-16-31(17-18)10-12-34-22-5-1-19(2-6-22)29-28-23(25-13-20(32)4-8-26(25)36-29)9-11-35-27-14-21(33)3-7-24(27)28/h1-8,13-14,18,29,32-33H,9-12,15-17H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.0240n/an/an/an/an/an/a



Genentech Inc.

Curated by ChEMBL


Assay Description
Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...

Bioorg Med Chem Lett 29: 905-911 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.036
BindingDB Entry DOI: 10.7270/Q2Q52T3W
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))		BDBM368199
PNG
((S)-2-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)...)
Show SMILES CC1=C([C@@H](Oc2ccc(O)cc12)c1ccc(OCCN2CC(CF)C2)cc1)c1cccc(O)c1 |r,t:1|
Show InChI InChI=1S/C28H28FNO4/c1-18-25-14-23(32)7-10-26(25)34-28(27(18)21-3-2-4-22(31)13-21)20-5-8-24(9-6-20)33-12-11-30-16-19(15-29)17-30/h2-10,13-14,19,28,31-32H,11-12,15-17H2,1H3/t28-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/a 0.0300n/an/an/an/an/an/a



Genentech Inc.

Curated by ChEMBL


Assay Description
Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...

Bioorg Med Chem Lett 29: 905-911 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.036
BindingDB Entry DOI: 10.7270/Q2Q52T3W
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Estrogen receptor


(Homo sapiens (Human))		BDBM50532103
PNG
(CHEMBL4464224)
Show SMILES Oc1ccc2C3=C(C(Oc2c1)c1ccc(OCCN2CC(CF)C2)cc1)c1ccc(O)cc1OCC3 |c:5|
Show InChI InChI=1S/C29H28FNO5/c30-15-18-16-31(17-18)10-12-34-22-5-1-19(2-6-22)29-28-24(23-7-3-21(33)14-27(23)36-29)9-11-35-26-13-20(32)4-8-25(26)28/h1-8,13-14,18,29,32-33H,9-12,15-17H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/a 0.0450n/an/an/an/an/an/a



Genentech Inc.

Curated by ChEMBL


Assay Description
Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...

Bioorg Med Chem Lett 29: 905-911 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.036
BindingDB Entry DOI: 10.7270/Q2Q52T3W
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Estrogen receptor


(Homo sapiens (Human))		BDBM50532105
PNG
(CHEMBL4449709)
Show SMILES C[C@@H](COc1ccc(cc1)C1Oc2cc(O)ccc2C2=C1c1ccc(O)cc1OCC2)N1CC[C@@H](CF)C1 |r,c:21|
Show InChI InChI=1S/C31H32FNO5/c1-19(33-12-10-20(16-32)17-33)18-37-24-6-2-21(3-7-24)31-30-26(25-8-4-23(35)15-29(25)38-31)11-13-36-28-14-22(34)5-9-27(28)30/h2-9,14-15,19-20,31,34-35H,10-13,16-18H2,1H3/t19-,20-,31?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.0510n/an/an/an/an/an/a



Genentech Inc.

Curated by ChEMBL


Assay Description
Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...

Bioorg Med Chem Lett 29: 905-911 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.036
BindingDB Entry DOI: 10.7270/Q2Q52T3W
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))		BDBM50532102
PNG
(CHEMBL4437985)
Show SMILES Oc1ccc2C3=C([C@@H](Oc2c1)c1ccc(OCCN2CC(CF)C2)cc1)c1ccc(O)cc1OCC3 |r,c:5|
Show InChI InChI=1S/C29H28FNO5/c30-15-18-16-31(17-18)10-12-34-22-5-1-19(2-6-22)29-28-24(23-7-3-21(33)14-27(23)36-29)9-11-35-26-13-20(32)4-8-25(26)28/h1-8,13-14,18,29,32-33H,9-12,15-17H2/t29-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/a 0.0550n/an/an/an/an/an/a



Genentech Inc.

Curated by ChEMBL


Assay Description
Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...

Bioorg Med Chem Lett 29: 905-911 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.036
BindingDB Entry DOI: 10.7270/Q2Q52T3W
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Estrogen receptor


(Homo sapiens (Human))		BDBM50532098
PNG
(CHEMBL4464058)
Show SMILES Oc1ccc2C3=C([C@H](Oc2c1)c1ccc(OCCN2CC(CF)C2)cc1)c1ccc(O)cc1OCC3 |r,c:5|
Show InChI InChI=1S/C29H28FNO5/c30-15-18-16-31(17-18)10-12-34-22-5-1-19(2-6-22)29-28-24(23-7-3-21(33)14-27(23)36-29)9-11-35-26-13-20(32)4-8-25(26)28/h1-8,13-14,18,29,32-33H,9-12,15-17H2/t29-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/a 0.0590n/an/an/an/an/an/a



Genentech Inc.

Curated by ChEMBL


Assay Description
Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...

Bioorg Med Chem Lett 29: 905-911 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.036
BindingDB Entry DOI: 10.7270/Q2Q52T3W
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Estrogen receptor


(Homo sapiens (Human))		BDBM50532106
PNG
(CHEMBL4539802)
Show SMILES Oc1ccc2C3=C(C(Oc2c1)c1ccc(OCCN2CC[C@@H](CF)C2)cc1)c1ccc(O)cc1OCC3 |r,c:5|
Show InChI InChI=1S/C30H30FNO5/c31-17-19-9-11-32(18-19)12-14-35-23-5-1-20(2-6-23)30-29-25(24-7-3-22(34)16-28(24)37-30)10-13-36-27-15-21(33)4-8-26(27)29/h1-8,15-16,19,30,33-34H,9-14,17-18H2/t19-,30?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.0760n/an/an/an/an/an/a



Genentech Inc.

Curated by ChEMBL


Assay Description
Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...

Bioorg Med Chem Lett 29: 905-911 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.036
BindingDB Entry DOI: 10.7270/Q2Q52T3W
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))		BDBM50532104
PNG
(CHEMBL1087419)
Show SMILES Oc1ccc2C3=C(C(Oc2c1)c1ccc(OCCN2CCCCC2)cc1)c1ccc(O)cc1OCC3 |c:5|
Show InChI InChI=1S/C30H31NO5/c32-21-7-11-26-27(18-21)35-16-12-25-24-10-6-22(33)19-28(24)36-30(29(25)26)20-4-8-23(9-5-20)34-17-15-31-13-2-1-3-14-31/h4-11,18-19,30,32-33H,1-3,12-17H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.280n/an/an/an/an/an/a



Genentech Inc.

Curated by ChEMBL


Assay Description
Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...

Bioorg Med Chem Lett 29: 905-911 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.036
BindingDB Entry DOI: 10.7270/Q2Q52T3W
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))		BDBM50532099
PNG
(CHEMBL4443826)
Show SMILES Oc1ccc2OC(C3=C(CCOc4ccc(O)cc34)c2c1)c1ccc(OCCN2CC(CF)C2)cc1 |t:7|
Show InChI InChI=1S/C29H28FNO5/c30-15-18-16-31(17-18)10-12-34-22-5-1-19(2-6-22)29-28-23(24-13-20(32)4-8-27(24)36-29)9-11-35-26-7-3-21(33)14-25(26)28/h1-8,13-14,18,29,32-33H,9-12,15-17H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.20n/an/an/an/an/an/a



Genentech Inc.

Curated by ChEMBL


Assay Description
Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...

Bioorg Med Chem Lett 29: 905-911 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.036
BindingDB Entry DOI: 10.7270/Q2Q52T3W
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))		BDBM50532099
PNG
(CHEMBL4443826)
Show SMILES Oc1ccc2OC(C3=C(CCOc4ccc(O)cc34)c2c1)c1ccc(OCCN2CC(CF)C2)cc1 |t:7|
Show InChI InChI=1S/C29H28FNO5/c30-15-18-16-31(17-18)10-12-34-22-5-1-19(2-6-22)29-28-23(24-13-20(32)4-8-27(24)36-29)9-11-35-26-7-3-21(33)14-25(26)28/h1-8,13-14,18,29,32-33H,9-12,15-17H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.20n/an/an/an/an/an/a



Genentech Inc.

Curated by ChEMBL


Assay Description
Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...

Bioorg Med Chem Lett 29: 905-911 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.036
BindingDB Entry DOI: 10.7270/Q2Q52T3W
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))		BDBM50532100
PNG
(CHEMBL4464146)
Show SMILES Oc1ccc2C3=C(C(Oc2c1)c1ccc(OCCN2CC(CF)C2)cc1)c1cc(O)ccc1OCC3 |c:5|
Show InChI InChI=1S/C29H28FNO5/c30-15-18-16-31(17-18)10-12-34-22-5-1-19(2-6-22)29-28-24(23-7-3-21(33)14-27(23)36-29)9-11-35-26-8-4-20(32)13-25(26)28/h1-8,13-14,18,29,32-33H,9-12,15-17H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 9.60n/an/an/an/an/an/a



Genentech Inc.

Curated by ChEMBL


Assay Description
Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...

Bioorg Med Chem Lett 29: 905-911 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.036
BindingDB Entry DOI: 10.7270/Q2Q52T3W
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))		BDBM50532100
PNG
(CHEMBL4464146)
Show SMILES Oc1ccc2C3=C(C(Oc2c1)c1ccc(OCCN2CC(CF)C2)cc1)c1cc(O)ccc1OCC3 |c:5|
Show InChI InChI=1S/C29H28FNO5/c30-15-18-16-31(17-18)10-12-34-22-5-1-19(2-6-22)29-28-24(23-7-3-21(33)14-27(23)36-29)9-11-35-26-8-4-20(32)13-25(26)28/h1-8,13-14,18,29,32-33H,9-12,15-17H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 9.60n/an/an/an/an/an/a



Genentech Inc.

Curated by ChEMBL


Assay Description
Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...

Bioorg Med Chem Lett 29: 905-911 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.036
BindingDB Entry DOI: 10.7270/Q2Q52T3W
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%