Affinity Data by PubMed id=31532644

PubMed code 31532644

Found 8 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50509150 (LY-3154207 \| Ly3154207 \| Mevidalen) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
AMRI UK Ltd Curated by ChEMBL					Assay Description Binding affinity to 5-HT1A receptor (unknown origin) by radioligand displacement assay				J Med Chem 62: 8711-8732 (2019) Article DOI: 10.1021/acs.jmedchem.9b01234 BindingDB Entry DOI: 10.7270/Q2CC140V
AMRI UK Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50509150 (LY-3154207 \| Ly3154207 \| Mevidalen) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	2.30	n/a	n/a	n/a	n/a
AMRI UK Ltd Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced c...				J Med Chem 62: 8711-8732 (2019) Article DOI: 10.1021/acs.jmedchem.9b01234 BindingDB Entry DOI: 10.7270/Q2CC140V
AMRI UK Ltd Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50509149 (CHEMBL3421836) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	76	n/a	n/a	n/a	n/a
AMRI UK Ltd Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP a...				J Med Chem 62: 8711-8732 (2019) Article DOI: 10.1021/acs.jmedchem.9b01234 BindingDB Entry DOI: 10.7270/Q2CC140V
AMRI UK Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50509150 (LY-3154207 \| Ly3154207 \| Mevidalen) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
AMRI UK Ltd Curated by ChEMBL					Assay Description Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation incubated for 60 mins by HTRF assay				J Med Chem 62: 8711-8732 (2019) Article DOI: 10.1021/acs.jmedchem.9b01234 BindingDB Entry DOI: 10.7270/Q2CC140V
AMRI UK Ltd Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50509151 (CHEMBL3421730) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
AMRI UK Ltd Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP a...				J Med Chem 62: 8711-8732 (2019) Article DOI: 10.1021/acs.jmedchem.9b01234 BindingDB Entry DOI: 10.7270/Q2CC140V
AMRI UK Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Mus musculus (Mouse))	BDBM50509150 (LY-3154207 \| Ly3154207 \| Mevidalen) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	62	n/a	n/a	n/a	n/a
AMRI UK Ltd Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mouse D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced c...				J Med Chem 62: 8711-8732 (2019) Article DOI: 10.1021/acs.jmedchem.9b01234 BindingDB Entry DOI: 10.7270/Q2CC140V
AMRI UK Ltd Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50509150 (LY-3154207 \| Ly3154207 \| Mevidalen) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
AMRI UK Ltd Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP a...				J Med Chem 62: 8711-8732 (2019) Article DOI: 10.1021/acs.jmedchem.9b01234 BindingDB Entry DOI: 10.7270/Q2CC140V
AMRI UK Ltd Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
D(1B) dopamine receptor (Homo sapiens (Human))	BDBM50509150 (LY-3154207 \| Ly3154207 \| Mevidalen) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
AMRI UK Ltd Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human D5 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced c...				J Med Chem 62: 8711-8732 (2019) Article DOI: 10.1021/acs.jmedchem.9b01234 BindingDB Entry DOI: 10.7270/Q2CC140V
AMRI UK Ltd Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%