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PubMed code 3361572

Compile data set for download or QSAR
Found 38 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50004566
PNG
(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinaz...)
Show SMILES Nc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccco1
Show InChI InChI=1S/C13H8ClN5O/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h1-6H,(H2,15,16)
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n/an/a 3.30n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatum

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50023492
PNG
(5-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazo...)
Show SMILES Nc1nc2ccc(O)cc2c2nc(nn12)-c1ccco1
Show InChI InChI=1S/C13H9N5O2/c14-13-15-9-4-3-7(19)6-8(9)12-16-11(17-18(12)13)10-2-1-5-20-10/h1-6,19H,(H2,14,15)
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n/an/a 5.5n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatum

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50023492
PNG
(5-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazo...)
Show SMILES Nc1nc2ccc(O)cc2c2nc(nn12)-c1ccco1
Show InChI InChI=1S/C13H9N5O2/c14-13-15-9-4-3-7(19)6-8(9)12-16-11(17-18(12)13)10-2-1-5-20-10/h1-6,19H,(H2,14,15)
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n/an/a 9.5n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50023505
PNG
(2-Furan-2-yl-9-methoxy-[1,2,4]triazolo[1,5-c]quina...)
Show SMILES COc1ccc2nc(N)n3nc(nc3c2c1)-c1ccco1
Show InChI InChI=1S/C14H11N5O2/c1-20-8-4-5-10-9(7-8)13-17-12(11-3-2-6-21-11)18-19(13)14(15)16-10/h2-7H,1H3,(H2,15,16)
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n/an/a 19n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatum

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50023495
PNG
(2-(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]qui...)
Show SMILES OCCNc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccco1
Show InChI InChI=1S/C15H12ClN5O2/c16-9-3-4-11-10(8-9)14-19-13(12-2-1-7-23-12)20-21(14)15(18-11)17-5-6-22/h1-4,7-8,22H,5-6H2,(H,17,18)
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n/an/a 21n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50004566
PNG
(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinaz...)
Show SMILES Nc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccco1
Show InChI InChI=1S/C13H8ClN5O/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h1-6H,(H2,15,16)
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n/an/a 21n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50023500
PNG
((9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quina...)
Show SMILES CC(C)Nc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccco1
Show InChI InChI=1S/C16H14ClN5O/c1-9(2)18-16-19-12-6-5-10(17)8-11(12)15-20-14(21-22(15)16)13-4-3-7-23-13/h3-9H,1-2H3,(H,18,19)
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n/an/a 22n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50023496
PNG
(2-Furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-yl...)
Show SMILES Nc1nc2ccccc2c2nc(nn12)-c1ccco1
Show InChI InChI=1S/C13H9N5O/c14-13-15-9-5-2-1-4-8(9)12-16-11(17-18(12)13)10-6-3-7-19-10/h1-7H,(H2,14,15)
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n/an/a 27n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatum

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50023505
PNG
(2-Furan-2-yl-9-methoxy-[1,2,4]triazolo[1,5-c]quina...)
Show SMILES COc1ccc2nc(N)n3nc(nc3c2c1)-c1ccco1
Show InChI InChI=1S/C14H11N5O2/c1-20-8-4-5-10-9(7-8)13-17-12(11-3-2-6-21-11)18-19(13)14(15)16-10/h2-7H,1H3,(H2,15,16)
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n/an/a 31n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50023496
PNG
(2-Furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-yl...)
Show SMILES Nc1nc2ccccc2c2nc(nn12)-c1ccco1
Show InChI InChI=1S/C13H9N5O/c14-13-15-9-5-2-1-4-8(9)12-16-11(17-18(12)13)10-6-3-7-19-10/h1-7H,(H2,14,15)
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n/an/a 38n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50023495
PNG
(2-(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]qui...)
Show SMILES OCCNc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccco1
Show InChI InChI=1S/C15H12ClN5O2/c16-9-3-4-11-10(8-9)14-19-13(12-2-1-7-23-12)20-21(14)15(18-11)17-5-6-22/h1-4,7-8,22H,5-6H2,(H,17,18)
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n/an/a 56n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatum

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50023493
PNG
(CHEMBL266267 | sec-Butyl-(9-chloro-2-furan-2-yl-[1...)
Show SMILES CCC(C)Nc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccco1
Show InChI InChI=1S/C17H16ClN5O/c1-3-10(2)19-17-20-13-7-6-11(18)9-12(13)16-21-15(22-23(16)17)14-5-4-8-24-14/h4-10H,3H2,1-2H3,(H,19,20)
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n/an/a 61n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50023499
PNG
((9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quina...)
Show SMILES CNc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccco1
Show InChI InChI=1S/C14H10ClN5O/c1-16-14-17-10-5-4-8(15)7-9(10)13-18-12(19-20(13)14)11-3-2-6-21-11/h2-7H,1H3,(H,16,17)
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n/an/a 61n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatum

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50023499
PNG
((9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quina...)
Show SMILES CNc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccco1
Show InChI InChI=1S/C14H10ClN5O/c1-16-14-17-10-5-4-8(15)7-9(10)13-18-12(19-20(13)14)11-3-2-6-21-11/h2-7H,1H3,(H,16,17)
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n/an/a 89n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50023503
PNG
(9-Chloro-2-thiophen-2-yl-[1,2,4]triazolo[1,5-c]qui...)
Show SMILES Nc1nc2ccc(Cl)cc2c2nc(nn12)-c1cccs1
Show InChI InChI=1S/C13H8ClN5S/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h1-6H,(H2,15,16)
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n/an/a 116n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatum

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50023506
PNG
(9-Chloro-2-furan-3-yl-[1,2,4]triazolo[1,5-c]quinaz...)
Show SMILES Nc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccoc1
Show InChI InChI=1S/C13H8ClN5O/c14-8-1-2-10-9(5-8)12-17-11(7-3-4-20-6-7)18-19(12)13(15)16-10/h1-6H,(H2,15,16)
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n/an/a 145n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatum

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50023494
PNG
(9-Benzyloxy-2-furan-2-yl-[1,2,4]triazolo[1,5-c]qui...)
Show SMILES Nc1nc2ccc(OCc3ccccc3)cc2c2nc(nn12)-c1ccco1
Show InChI InChI=1S/C20H15N5O2/c21-20-22-16-9-8-14(27-12-13-5-2-1-3-6-13)11-15(16)19-23-18(24-25(19)20)17-7-4-10-26-17/h1-11H,12H2,(H2,21,22)
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n/an/a 145n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50023493
PNG
(CHEMBL266267 | sec-Butyl-(9-chloro-2-furan-2-yl-[1...)
Show SMILES CCC(C)Nc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccco1
Show InChI InChI=1S/C17H16ClN5O/c1-3-10(2)19-17-20-13-7-6-11(18)9-12(13)16-21-15(22-23(16)17)14-5-4-8-24-14/h4-10H,3H2,1-2H3,(H,19,20)
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n/an/a 158n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatum

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50023500
PNG
((9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quina...)
Show SMILES CC(C)Nc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccco1
Show InChI InChI=1S/C16H14ClN5O/c1-9(2)18-16-19-12-6-5-10(17)8-11(12)15-20-14(21-22(15)16)13-4-3-7-23-13/h3-9H,1-2H3,(H,18,19)
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n/an/a 179n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatum

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50023506
PNG
(9-Chloro-2-furan-3-yl-[1,2,4]triazolo[1,5-c]quinaz...)
Show SMILES Nc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccoc1
Show InChI InChI=1S/C13H8ClN5O/c14-8-1-2-10-9(5-8)12-17-11(7-3-4-20-6-7)18-19(12)13(15)16-10/h1-6H,(H2,15,16)
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n/an/a 295n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50023503
PNG
(9-Chloro-2-thiophen-2-yl-[1,2,4]triazolo[1,5-c]qui...)
Show SMILES Nc1nc2ccc(Cl)cc2c2nc(nn12)-c1cccs1
Show InChI InChI=1S/C13H8ClN5S/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h1-6H,(H2,15,16)
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n/an/a 324n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50023498
PNG
(2-(5-Bromo-furan-2-yl)-9-chloro-[1,2,4]triazolo[1,...)
Show SMILES Nc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccc(Br)o1
Show InChI InChI=1S/C13H7BrClN5O/c14-10-4-3-9(21-10)11-18-12-7-5-6(15)1-2-8(7)17-13(16)20(12)19-11/h1-5H,(H2,16,17)
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n/an/a 531n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatum

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50023501
PNG
(9-Chloro-2-(1H-pyrrol-2-yl)-[1,2,4]triazolo[1,5-c]...)
Show SMILES Nc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccc[nH]1
Show InChI InChI=1S/C13H9ClN6/c14-7-3-4-9-8(6-7)12-18-11(10-2-1-5-16-10)19-20(12)13(15)17-9/h1-6,16H,(H2,15,17)
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n/an/a 610n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50023497
PNG
(9-Chloro-2-(tetrahydro-furan-2-yl)-[1,2,4]triazolo...)
Show SMILES Nc1nc2ccc(Cl)cc2c2nc(nn12)C1CCCO1
Show InChI InChI=1S/C13H12ClN5O/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h3-4,6,10H,1-2,5H2,(H2,15,16)
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n/an/a 827n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50023501
PNG
(9-Chloro-2-(1H-pyrrol-2-yl)-[1,2,4]triazolo[1,5-c]...)
Show SMILES Nc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccc[nH]1
Show InChI InChI=1S/C13H9ClN6/c14-7-3-4-9-8(6-7)12-18-11(10-2-1-5-16-10)19-20(12)13(15)17-9/h1-6,16H,(H2,15,17)
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n/an/a 1.21E+3n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatum

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50023491
PNG
(2-Furan-2-yl-6-methyl-6H-[1,2,4]triazolo[1,5-c]qui...)
Show SMILES Cn1c2ccccc2c2nc(nn2c1=N)-c1ccco1
Show InChI InChI=1S/C14H11N5O/c1-18-10-6-3-2-5-9(10)13-16-12(11-7-4-8-20-11)17-19(13)14(18)15/h2-8,15H,1H3
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n/an/a 1.22E+3n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50023494
PNG
(9-Benzyloxy-2-furan-2-yl-[1,2,4]triazolo[1,5-c]qui...)
Show SMILES Nc1nc2ccc(OCc3ccccc3)cc2c2nc(nn12)-c1ccco1
Show InChI InChI=1S/C20H15N5O2/c21-20-22-16-9-8-14(27-12-13-5-2-1-3-6-13)11-15(16)19-23-18(24-25(19)20)17-7-4-10-26-17/h1-11H,12H2,(H2,21,22)
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n/an/a 1.29E+3n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatum

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50023498
PNG
(2-(5-Bromo-furan-2-yl)-9-chloro-[1,2,4]triazolo[1,...)
Show SMILES Nc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccc(Br)o1
Show InChI InChI=1S/C13H7BrClN5O/c14-10-4-3-9(21-10)11-18-12-7-5-6(15)1-2-8(7)17-13(16)20(12)19-11/h1-5H,(H2,16,17)
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n/an/a 1.57E+3n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50023497
PNG
(9-Chloro-2-(tetrahydro-furan-2-yl)-[1,2,4]triazolo...)
Show SMILES Nc1nc2ccc(Cl)cc2c2nc(nn12)C1CCCO1
Show InChI InChI=1S/C13H12ClN5O/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h3-4,6,10H,1-2,5H2,(H2,15,16)
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n/an/a 1.58E+3n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatum

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50023491
PNG
(2-Furan-2-yl-6-methyl-6H-[1,2,4]triazolo[1,5-c]qui...)
Show SMILES Cn1c2ccccc2c2nc(nn2c1=N)-c1ccco1
Show InChI InChI=1S/C14H11N5O/c1-18-10-6-3-2-5-9(10)13-16-12(11-7-4-8-20-11)17-19(13)14(18)15/h2-8,15H,1H3
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n/an/a 2.91E+3n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatum

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM10847
PNG
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)
Show SMILES Cn1c2nc[nH]c2c(=O)n(C)c1=O
Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)
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n/an/a>1.00E+4n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatum

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50023490
PNG
(CHEMBL7582 | tert-Butyl-(9-chloro-2-furan-2-yl-[1,...)
Show SMILES CC(C)(C)Nc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccco1
Show InChI InChI=1S/C17H16ClN5O/c1-17(2,3)21-16-19-12-7-6-10(18)9-11(12)15-20-14(22-23(15)16)13-5-4-8-24-13/h4-9H,1-3H3,(H,19,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50023490
PNG
(CHEMBL7582 | tert-Butyl-(9-chloro-2-furan-2-yl-[1,...)
Show SMILES CC(C)(C)Nc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccco1
Show InChI InChI=1S/C17H16ClN5O/c1-17(2,3)21-16-19-12-7-6-10(18)9-11(12)15-20-14(22-23(15)16)13-5-4-8-24-13/h4-9H,1-3H3,(H,19,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatum

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50008874
PNG
(9-Chloro-2-furan-2-yl-6H-[1,2,4]triazolo[1,5-c]qui...)
Show SMILES Clc1ccc2[nH]c(=O)n3nc(nc3c2c1)-c1ccco1
Show InChI InChI=1S/C13H7ClN4O2/c14-7-3-4-9-8(6-7)12-16-11(10-2-1-5-20-10)17-18(12)13(19)15-9/h1-6H,(H,15,19)
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n/an/a 1.00E+4n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM50023502
PNG
((9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quina...)
Show SMILES CN(C)c1nc2ccc(Cl)cc2c2nc(nn12)-c1ccco1
Show InChI InChI=1S/C15H12ClN5O/c1-20(2)15-17-11-6-5-9(16)8-10(11)14-18-13(19-21(14)15)12-4-3-7-22-12/h3-8H,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50008874
PNG
(9-Chloro-2-furan-2-yl-6H-[1,2,4]triazolo[1,5-c]qui...)
Show SMILES Clc1ccc2[nH]c(=O)n3nc(nc3c2c1)-c1ccco1
Show InChI InChI=1S/C13H7ClN4O2/c14-7-3-4-9-8(6-7)12-16-11(10-2-1-5-20-10)17-18(12)13(19)15-9/h1-6H,(H,15,19)
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n/an/a>1.00E+4n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatum

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50023502
PNG
((9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quina...)
Show SMILES CN(C)c1nc2ccc(Cl)cc2c2nc(nn12)-c1ccco1
Show InChI InChI=1S/C15H12ClN5O/c1-20(2)15-17-11-6-5-9(16)8-10(11)14-18-13(19-21(14)15)12-4-3-7-22-12/h3-8H,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatum

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))		BDBM10847
PNG
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)
Show SMILES Cn1c2nc[nH]c2c(=O)n(C)c1=O
Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)
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n/an/a>1.00E+4n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of binding towards adenosine A1 receptor using [3H]-N-cyclohexyladenosine ([3H]-CHA) in rat whole brain membranes.

J Med Chem 31: 1014-20 (1988)


BindingDB Entry DOI: 10.7270/Q2T43S4W
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%