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Articleid 50028969

Compile data set for download or QSAR
Found 34 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
D(1A) dopamine receptor


(RAT)		BDBM82247
PNG
(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1 |r|
Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
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 0.300n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50280440
PNG
(8-Chloro-5-cyclohex-2-enyl-3-methyl-2,3,4,5-tetrah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(C1)C1CCCC=C1 |c:20|
Show InChI InChI=1S/C17H22ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h3,5,9-10,12,15,20H,2,4,6-8,11H2,1H3
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 2n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50280435
PNG
(8-Chloro-5-cyclohex-1-enyl-3-methyl-2,3,4,5-tetrah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(C1)C1=CCCCC1 |t:16|
Show InChI InChI=1S/C17H22ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h5,9-10,15,20H,2-4,6-8,11H2,1H3
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 2.10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50280434
PNG
(8-Chloro-3-methyl-5-propyl-2,3,4,5-tetrahydro-1H-b...)
Show SMILES CCCC1CN(C)CCc2cc(Cl)c(O)cc12
Show InChI InChI=1S/C14H20ClNO/c1-3-4-11-9-16(2)6-5-10-7-13(15)14(17)8-12(10)11/h7-8,11,17H,3-6,9H2,1-2H3
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 3.30n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50280443
PNG
(8-Chloro-5-cyclohepta-2,4,6-trienyl-3-methyl-2,3,4...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(C1)C1C=CC=CC=C1 |c:17,19,21|
Show InChI InChI=1S/C18H20ClNO/c1-20-9-8-14-10-17(19)18(21)11-15(14)16(12-20)13-6-4-2-3-5-7-13/h2-7,10-11,13,16,21H,8-9,12H2,1H3
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 3.70n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50280441
PNG
(8-Chloro-5-cyclopent-1-enyl-3-methyl-2,3,4,5-tetra...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(C1)C1=CCCC1 |t:16|
Show InChI InChI=1S/C16H20ClNO/c1-18-7-6-12-8-15(17)16(19)9-13(12)14(10-18)11-4-2-3-5-11/h4,8-9,14,19H,2-3,5-7,10H2,1H3
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 5.10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50280439
PNG
(5-Allyl-8-chloro-3-methyl-2,3,4,5-tetrahydro-1H-be...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(CC=C)C1
Show InChI InChI=1S/C14H18ClNO/c1-3-4-11-9-16(2)6-5-10-7-13(15)14(17)8-12(10)11/h3,7-8,11,17H,1,4-6,9H2,2H3
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 5.70n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50280438
PNG
(8-Chloro-5-cycloheptyl-3-methyl-2,3,4,5-tetrahydro...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(C1)C1CCCCCC1
Show InChI InChI=1S/C18H26ClNO/c1-20-9-8-14-10-17(19)18(21)11-15(14)16(12-20)13-6-4-2-3-5-7-13/h10-11,13,16,21H,2-9,12H2,1H3
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 7.60n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50280431
PNG
(8-Chloro-3-methyl-5-prop-2-ynyl-2,3,4,5-tetrahydro...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(CC#C)C1
Show InChI InChI=1S/C14H16ClNO/c1-3-4-11-9-16(2)6-5-10-7-13(15)14(17)8-12(10)11/h1,7-8,11,17H,4-6,9H2,2H3
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 8.70n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50280430
PNG
(8-Chloro-5-cyclohexyl-3-methyl-2,3,4,5-tetrahydro-...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(C1)C1CCCCC1
Show InChI InChI=1S/C17H24ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h9-10,12,15,20H,2-8,11H2,1H3
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 10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50280437
PNG
(8-Chloro-5-cyclopentyl-3-methyl-2,3,4,5-tetrahydro...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(C1)C1CCCC1
Show InChI InChI=1S/C16H22ClNO/c1-18-7-6-12-8-15(17)16(19)9-13(12)14(10-18)11-4-2-3-5-11/h8-9,11,14,19H,2-7,10H2,1H3
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 13n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50280429
PNG
(7-chloro-3-methyl-2,3,4,5-tetrahydrospiro[3-benzaz...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C2(CCCC2)C1
Show InChI InChI=1S/C15H20ClNO/c1-17-7-4-11-8-13(16)14(18)9-12(11)15(10-17)5-2-3-6-15/h8-9,18H,2-7,10H2,1H3
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 23n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50280432
PNG
(8-Chloro-5-ethoxy-3-methyl-2,3,4,5-tetrahydro-1H-b...)
Show SMILES CCOC1CN(C)CCc2cc(Cl)c(O)cc12
Show InChI InChI=1S/C13H18ClNO2/c1-3-17-13-8-15(2)5-4-9-6-11(14)12(16)7-10(9)13/h6-7,13,16H,3-5,8H2,1-2H3
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 24n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50280436
PNG
(8-Chloro-5-ethylsulfanyl-3-methyl-2,3,4,5-tetrahyd...)
Show SMILES CCSC1CN(C)CCc2cc(Cl)c(O)cc12
Show InChI InChI=1S/C13H18ClNOS/c1-3-17-13-8-15(2)5-4-9-6-11(14)12(16)7-10(9)13/h6-7,13,16H,3-5,8H2,1-2H3
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 33n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50280442
PNG
(8-Chloro-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]az...)
Show SMILES CN1CCc2cc(O)c(Cl)cc2CC1
Show InChI InChI=1S/C11H14ClNO/c1-13-4-2-8-6-10(12)11(14)7-9(8)3-5-13/h6-7,14H,2-5H2,1H3
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 46n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50280428
PNG
(8-Chloro-3-methyl-5-piperidin-1-yl-2,3,4,5-tetrahy...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(C1)N1CCCCC1
Show InChI InChI=1S/C16H23ClN2O/c1-18-8-5-12-9-14(17)16(20)10-13(12)15(11-18)19-6-3-2-4-7-19/h9-10,15,20H,2-8,11H2,1H3
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 100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50280442
PNG
(8-Chloro-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]az...)
Show SMILES CN1CCc2cc(O)c(Cl)cc2CC1
Show InChI InChI=1S/C11H14ClNO/c1-13-4-2-8-6-10(12)11(14)7-9(8)3-5-13/h6-7,14H,2-5H2,1H3
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 265n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2 in rat striatal tissue by [3H]-spiperone displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50280439
PNG
(5-Allyl-8-chloro-3-methyl-2,3,4,5-tetrahydro-1H-be...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(CC=C)C1
Show InChI InChI=1S/C14H18ClNO/c1-3-4-11-9-16(2)6-5-10-7-13(15)14(17)8-12(10)11/h3,7-8,11,17H,1,4-6,9H2,2H3
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 284n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2 in rat striatal tissue by [3H]-spiperone displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50280440
PNG
(8-Chloro-5-cyclohex-2-enyl-3-methyl-2,3,4,5-tetrah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(C1)C1CCCC=C1 |c:20|
Show InChI InChI=1S/C17H22ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h3,5,9-10,12,15,20H,2,4,6-8,11H2,1H3
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 581n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2 in rat striatal tissue by [3H]-spiperone displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50280431
PNG
(8-Chloro-3-methyl-5-prop-2-ynyl-2,3,4,5-tetrahydro...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(CC#C)C1
Show InChI InChI=1S/C14H16ClNO/c1-3-4-11-9-16(2)6-5-10-7-13(15)14(17)8-12(10)11/h1,7-8,11,17H,4-6,9H2,2H3
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 626n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2 in rat striatal tissue by [3H]-spiperone displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM82247
PNG
(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1 |r|
Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
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 760n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2 in rat striatal tissue by [3H]-spiperone displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50280433
PNG
(8-Chloro-5-(3-dimethylamino-propyl)-3-methyl-2,3,4...)
Show SMILES CN(C)CCCC1CN(C)CCc2cc(Cl)c(O)cc12
Show InChI InChI=1S/C16H25ClN2O/c1-18(2)7-4-5-13-11-19(3)8-6-12-9-15(17)16(20)10-14(12)13/h9-10,13,20H,4-8,11H2,1-3H3
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>1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50280434
PNG
(8-Chloro-3-methyl-5-propyl-2,3,4,5-tetrahydro-1H-b...)
Show SMILES CCCC1CN(C)CCc2cc(Cl)c(O)cc12
Show InChI InChI=1S/C14H20ClNO/c1-3-4-11-9-16(2)6-5-10-7-13(15)14(17)8-12(10)11/h7-8,11,17H,3-6,9H2,1-2H3
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 1.16E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2 in rat striatal tissue by [3H]-spiperone displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50280438
PNG
(8-Chloro-5-cycloheptyl-3-methyl-2,3,4,5-tetrahydro...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(C1)C1CCCCCC1
Show InChI InChI=1S/C18H26ClNO/c1-20-9-8-14-10-17(19)18(21)11-15(14)16(12-20)13-6-4-2-3-5-7-13/h10-11,13,16,21H,2-9,12H2,1H3
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 1.19E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2 in rat striatal tissue by [3H]-spiperone displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50280441
PNG
(8-Chloro-5-cyclopent-1-enyl-3-methyl-2,3,4,5-tetra...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(C1)C1=CCCC1 |t:16|
Show InChI InChI=1S/C16H20ClNO/c1-18-7-6-12-8-15(17)16(19)9-13(12)14(10-18)11-4-2-3-5-11/h4,8-9,14,19H,2-3,5-7,10H2,1H3
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 1.54E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2 in rat striatal tissue by [3H]-spiperone displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50280435
PNG
(8-Chloro-5-cyclohex-1-enyl-3-methyl-2,3,4,5-tetrah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(C1)C1=CCCCC1 |t:16|
Show InChI InChI=1S/C17H22ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h5,9-10,15,20H,2-4,6-8,11H2,1H3
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 1.60E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2 in rat striatal tissue by [3H]-spiperone displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50280430
PNG
(8-Chloro-5-cyclohexyl-3-methyl-2,3,4,5-tetrahydro-...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(C1)C1CCCCC1
Show InChI InChI=1S/C17H24ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h9-10,12,15,20H,2-8,11H2,1H3
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 1.78E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2 in rat striatal tissue by [3H]-spiperone displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50280443
PNG
(8-Chloro-5-cyclohepta-2,4,6-trienyl-3-methyl-2,3,4...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(C1)C1C=CC=CC=C1 |c:17,19,21|
Show InChI InChI=1S/C18H20ClNO/c1-20-9-8-14-10-17(19)18(21)11-15(14)16(12-20)13-6-4-2-3-5-7-13/h2-7,10-11,13,16,21H,8-9,12H2,1H3
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 1.80E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2 in rat striatal tissue by [3H]-spiperone displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50280437
PNG
(8-Chloro-5-cyclopentyl-3-methyl-2,3,4,5-tetrahydro...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(C1)C1CCCC1
Show InChI InChI=1S/C16H22ClNO/c1-18-7-6-12-8-15(17)16(19)9-13(12)14(10-18)11-4-2-3-5-11/h8-9,11,14,19H,2-7,10H2,1H3
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 2.05E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2 in rat striatal tissue by [3H]-spiperone displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50280429
PNG
(7-chloro-3-methyl-2,3,4,5-tetrahydrospiro[3-benzaz...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C2(CCCC2)C1
Show InChI InChI=1S/C15H20ClNO/c1-17-7-4-11-8-13(16)14(18)9-12(11)15(10-17)5-2-3-6-15/h8-9,18H,2-7,10H2,1H3
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 2.25E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2 in rat striatal tissue by [3H]-spiperone displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50280436
PNG
(8-Chloro-5-ethylsulfanyl-3-methyl-2,3,4,5-tetrahyd...)
Show SMILES CCSC1CN(C)CCc2cc(Cl)c(O)cc12
Show InChI InChI=1S/C13H18ClNOS/c1-3-17-13-8-15(2)5-4-9-6-11(14)12(16)7-10(9)13/h6-7,13,16H,3-5,8H2,1-2H3
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 2.71E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2 in rat striatal tissue by [3H]-spiperone displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50280428
PNG
(8-Chloro-3-methyl-5-piperidin-1-yl-2,3,4,5-tetrahy...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(C1)N1CCCCC1
Show InChI InChI=1S/C16H23ClN2O/c1-18-8-5-12-9-14(17)16(20)10-13(12)15(11-18)19-6-3-2-4-7-19/h9-10,15,20H,2-8,11H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2 in rat striatal tissue by [3H]-spiperone displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50280432
PNG
(8-Chloro-5-ethoxy-3-methyl-2,3,4,5-tetrahydro-1H-b...)
Show SMILES CCOC1CN(C)CCc2cc(Cl)c(O)cc12
Show InChI InChI=1S/C13H18ClNO2/c1-3-17-13-8-15(2)5-4-9-6-11(14)12(16)7-10(9)13/h6-7,13,16H,3-5,8H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2 in rat striatal tissue by [3H]-spiperone displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50280433
PNG
(8-Chloro-5-(3-dimethylamino-propyl)-3-methyl-2,3,4...)
Show SMILES CN(C)CCCC1CN(C)CCc2cc(Cl)c(O)cc12
Show InChI InChI=1S/C16H25ClN2O/c1-18(2)7-4-5-13-11-19(3)8-6-12-9-15(17)16(20)10-14(12)13/h9-10,13,20H,4-8,11H2,1-3H3
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>1.00E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2 in rat striatal tissue by [3H]-spiperone displacement.

Bioorg Med Chem Lett 2: 399-402 (1992)


Article DOI: 10.1016/S0960-894X(00)80155-9
BindingDB Entry DOI: 10.7270/Q2C53KRS
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%