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Articleid 50029494

Compile data set for download or QSAR
Found 15 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50284967
PNG
(1-[1-(2,6-Dichloro-phenyl)-1H-benzoimidazol-2-yl]-...)
Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)Nc1nc2ccccc2n1-c1c(Cl)cccc1Cl |(13.12,-3.34,;13.91,-4.67,;12.42,-5.07,;15.45,-4.67,;16.2,-3.32,;17.76,-3.31,;18.53,-4.64,;17.76,-5.98,;18.53,-7.31,;17.78,-8.64,;20.07,-7.3,;16.22,-5.98,;15.47,-7.33,;13.93,-7.33,;13.14,-6,;13.17,-8.66,;11.63,-8.68,;10.71,-7.43,;9.25,-7.92,;7.91,-7.15,;6.58,-7.93,;6.58,-9.47,;7.91,-10.24,;9.25,-9.46,;10.72,-9.92,;10.72,-11.46,;9.36,-12.23,;8.05,-11.44,;9.36,-13.75,;10.69,-14.54,;12.02,-13.77,;12.02,-12.23,;13.37,-11.46,)|
Show InChI InChI=1S/C26H26Cl2N4O/c1-15(2)17-9-7-10-18(16(3)4)23(17)30-26(33)31-25-29-21-13-5-6-14-22(21)32(25)24-19(27)11-8-12-20(24)28/h5-16H,1-4H3,(H2,29,30,31,33)
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n/an/a 11n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards acyl CoA cholesterol acyltransferase (ACAT) of cholesterol-fed rabbits by the displacement of [14C]-oleolyl-CoA

Bioorg Med Chem Lett 5: 1829-1832 (1995)


Article DOI: 10.1016/0960-894X(95)00296-6
BindingDB Entry DOI: 10.7270/Q2VD6ZDR
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50284976
PNG
(1-[1-(2-Chloro-phenyl)-1H-benzoimidazol-2-yl]-3-(2...)
Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)Nc1nc2ccccc2n1-c1ccccc1Cl |(20.07,-7.3,;18.53,-7.31,;17.78,-8.64,;17.76,-5.98,;18.53,-4.64,;17.76,-3.31,;16.2,-3.32,;15.45,-4.67,;13.91,-4.67,;13.12,-3.34,;12.42,-5.07,;16.22,-5.98,;15.47,-7.33,;13.93,-7.33,;13.14,-6,;13.17,-8.66,;11.63,-8.68,;10.71,-7.43,;9.25,-7.92,;7.91,-7.15,;6.58,-7.93,;6.58,-9.47,;7.91,-10.24,;9.25,-9.46,;10.72,-9.92,;10.72,-11.46,;12.02,-12.23,;12.02,-13.77,;10.69,-14.54,;9.36,-13.75,;9.36,-12.23,;8.05,-11.44,)|
Show InChI InChI=1S/C26H27ClN4O/c1-16(2)18-10-9-11-19(17(3)4)24(18)29-26(32)30-25-28-21-13-6-8-15-23(21)31(25)22-14-7-5-12-20(22)27/h5-17H,1-4H3,(H2,28,29,30,32)
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n/an/a 18n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards acyl CoA cholesterol acyltransferase (ACAT) of cholesterol-fed rabbits by the displacement of [14C]-oleolyl-CoA

Bioorg Med Chem Lett 5: 1829-1832 (1995)


Article DOI: 10.1016/0960-894X(95)00296-6
BindingDB Entry DOI: 10.7270/Q2VD6ZDR
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50284971
PNG
(1-(2,6-Diisopropyl-phenyl)-3-(1-o-tolyl-1H-benzoim...)
Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)Nc1nc2ccccc2n1-c1ccccc1C |(20.07,-7.3,;18.53,-7.31,;17.78,-8.64,;17.76,-5.98,;18.53,-4.64,;17.76,-3.31,;16.2,-3.32,;15.45,-4.67,;13.91,-4.67,;13.12,-3.34,;12.42,-5.07,;16.22,-5.98,;15.47,-7.33,;13.93,-7.33,;13.14,-6,;13.17,-8.66,;11.63,-8.68,;10.71,-7.43,;9.25,-7.92,;7.91,-7.15,;6.58,-7.93,;6.58,-9.47,;7.91,-10.24,;9.25,-9.46,;10.72,-9.92,;10.72,-11.46,;12.02,-12.23,;12.02,-13.77,;10.69,-14.54,;9.36,-13.75,;9.36,-12.23,;8.05,-11.44,)|
Show InChI InChI=1S/C27H30N4O/c1-17(2)20-12-10-13-21(18(3)4)25(20)29-27(32)30-26-28-22-14-7-9-16-24(22)31(26)23-15-8-6-11-19(23)5/h6-18H,1-5H3,(H2,28,29,30,32)
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n/an/a 19n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards acyl CoA cholesterol acyltransferase (ACAT) of cholesterol-fed rabbits by the displacement of [14C]-oleolyl-CoA

Bioorg Med Chem Lett 5: 1829-1832 (1995)


Article DOI: 10.1016/0960-894X(95)00296-6
BindingDB Entry DOI: 10.7270/Q2VD6ZDR
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50284972
PNG
(1-(2,6-Diisopropyl-phenyl)-3-[1-(2-methoxy-phenyl)...)
Show SMILES COc1ccccc1-n1c(NC(=O)Nc2c(cccc2C(C)C)C(C)C)nc2ccccc12 |(7.05,-13.56,;7.82,-12.23,;9.36,-12.23,;9.36,-13.75,;10.69,-14.54,;12.02,-13.77,;12.02,-12.23,;10.72,-11.46,;10.72,-9.92,;11.63,-8.68,;13.17,-8.66,;13.93,-7.33,;13.14,-6,;15.47,-7.33,;16.22,-5.98,;17.76,-5.98,;18.53,-4.64,;17.76,-3.31,;16.2,-3.32,;15.45,-4.67,;13.91,-4.67,;13.12,-3.34,;12.42,-5.07,;18.53,-7.31,;20.07,-7.3,;17.78,-8.64,;10.71,-7.43,;9.25,-7.92,;7.91,-7.15,;6.58,-7.93,;6.58,-9.47,;7.91,-10.24,;9.25,-9.46,)|
Show InChI InChI=1S/C27H30N4O2/c1-17(2)19-11-10-12-20(18(3)4)25(19)29-27(32)30-26-28-21-13-6-7-14-22(21)31(26)23-15-8-9-16-24(23)33-5/h6-18H,1-5H3,(H2,28,29,30,32)
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n/an/a 20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards acyl CoA cholesterol acyltransferase (ACAT) of cholesterol-fed rabbits by the displacement of [14C]-oleolyl-CoA

Bioorg Med Chem Lett 5: 1829-1832 (1995)


Article DOI: 10.1016/0960-894X(95)00296-6
BindingDB Entry DOI: 10.7270/Q2VD6ZDR
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50284979
PNG
(1-[1-(3-Chloro-phenyl)-1H-benzoimidazol-2-yl]-3-(2...)
Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)Nc1nc2ccccc2n1-c1cccc(Cl)c1
Show InChI InChI=1S/C26H27ClN4O/c1-16(2)20-11-8-12-21(17(3)4)24(20)29-26(32)30-25-28-22-13-5-6-14-23(22)31(25)19-10-7-9-18(27)15-19/h5-17H,1-4H3,(H2,28,29,30,32)
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n/an/a 20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards acyl CoA cholesterol acyltransferase (ACAT) of cholesterol-fed rabbits by the displacement of [14C]-oleolyl-CoA

Bioorg Med Chem Lett 5: 1829-1832 (1995)


Article DOI: 10.1016/0960-894X(95)00296-6
BindingDB Entry DOI: 10.7270/Q2VD6ZDR
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50284973
PNG
(1-[1-(2-Bromo-phenyl)-1H-benzoimidazol-2-yl]-3-(2,...)
Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)Nc1nc2ccccc2n1-c1ccccc1Br |(20.07,-7.3,;18.53,-7.31,;17.78,-8.64,;17.76,-5.98,;18.53,-4.64,;17.76,-3.31,;16.2,-3.32,;15.45,-4.67,;13.91,-4.67,;13.12,-3.34,;12.42,-5.07,;16.22,-5.98,;15.47,-7.33,;13.93,-7.33,;13.14,-6,;13.17,-8.66,;11.63,-8.68,;10.71,-7.43,;9.25,-7.92,;7.91,-7.15,;6.58,-7.93,;6.58,-9.47,;7.91,-10.24,;9.25,-9.46,;10.72,-9.92,;10.72,-11.46,;12.02,-12.23,;12.02,-13.77,;10.69,-14.54,;9.36,-13.75,;9.36,-12.23,;8.05,-11.44,)|
Show InChI InChI=1S/C26H27BrN4O/c1-16(2)18-10-9-11-19(17(3)4)24(18)29-26(32)30-25-28-21-13-6-8-15-23(21)31(25)22-14-7-5-12-20(22)27/h5-17H,1-4H3,(H2,28,29,30,32)
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n/an/a 22n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards acyl CoA cholesterol acyltransferase (ACAT) of cholesterol-fed rabbits by the displacement of [14C]-oleolyl-CoA

Bioorg Med Chem Lett 5: 1829-1832 (1995)


Article DOI: 10.1016/0960-894X(95)00296-6
BindingDB Entry DOI: 10.7270/Q2VD6ZDR
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50284965
PNG
(1-[3-(2-Chloro-phenyl)-3H-imidazo[4,5-b]pyridin-2-...)
Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)Nc1nc2cccnc2n1-c1ccccc1Cl |(20.07,-7.3,;18.53,-7.31,;17.78,-8.64,;17.76,-5.98,;18.53,-4.64,;17.76,-3.31,;16.2,-3.32,;15.45,-4.67,;13.91,-4.67,;13.12,-3.34,;12.42,-5.07,;16.22,-5.98,;15.47,-7.33,;13.93,-7.33,;13.14,-6,;13.17,-8.66,;11.63,-8.68,;10.71,-7.43,;9.25,-7.92,;7.91,-7.15,;6.58,-7.93,;6.58,-9.47,;7.91,-10.24,;9.25,-9.46,;10.72,-9.92,;10.72,-11.46,;12.02,-12.23,;12.02,-13.77,;10.69,-14.54,;9.36,-13.75,;9.36,-12.23,;7.82,-12.23,)|
Show InChI InChI=1S/C25H26ClN5O/c1-15(2)17-9-7-10-18(16(3)4)22(17)29-25(32)30-24-28-20-12-8-14-27-23(20)31(24)21-13-6-5-11-19(21)26/h5-16H,1-4H3,(H2,28,29,30,32)
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n/an/a 33n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards acyl CoA cholesterol acyltransferase (ACAT) of cholesterol-fed rabbits by the displacement of [14C]-oleolyl-CoA

Bioorg Med Chem Lett 5: 1829-1832 (1995)


Article DOI: 10.1016/0960-894X(95)00296-6
BindingDB Entry DOI: 10.7270/Q2VD6ZDR
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50284978
PNG
(1-(2,6-Diisopropyl-phenyl)-3-[1-(2-dimethylamino-p...)
Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)Nc1nc2ccccc2n1-c1ccccc1N(C)C |(12.42,-5.07,;13.91,-4.67,;13.12,-3.34,;15.45,-4.67,;16.2,-3.32,;17.76,-3.31,;18.53,-4.64,;17.76,-5.98,;18.53,-7.31,;17.78,-8.64,;20.07,-7.3,;16.22,-5.98,;15.47,-7.33,;13.93,-7.33,;13.14,-6,;13.17,-8.66,;11.63,-8.68,;10.71,-7.43,;9.25,-7.92,;7.91,-7.15,;6.58,-7.93,;6.58,-9.47,;7.91,-10.24,;9.25,-9.46,;10.72,-9.92,;10.72,-11.46,;12.02,-12.23,;12.02,-13.77,;10.69,-14.54,;9.36,-13.75,;9.36,-12.23,;7.82,-12.23,;7.05,-10.88,;7.05,-13.56,)|
Show InChI InChI=1S/C28H33N5O/c1-18(2)20-12-11-13-21(19(3)4)26(20)30-28(34)31-27-29-22-14-7-8-15-23(22)33(27)25-17-10-9-16-24(25)32(5)6/h7-19H,1-6H3,(H2,29,30,31,34)
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n/an/a 41n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards acyl CoA cholesterol acyltransferase (ACAT) of cholesterol-fed rabbits by the displacement of [14C]-oleolyl-CoA

Bioorg Med Chem Lett 5: 1829-1832 (1995)


Article DOI: 10.1016/0960-894X(95)00296-6
BindingDB Entry DOI: 10.7270/Q2VD6ZDR
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50284970
PNG
(1-(2,6-Diisopropyl-phenyl)-3-(1-phenyl-1H-benzoimi...)
Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)Nc1nc2ccccc2n1-c1ccccc1
Show InChI InChI=1S/C26H28N4O/c1-17(2)20-13-10-14-21(18(3)4)24(20)28-26(31)29-25-27-22-15-8-9-16-23(22)30(25)19-11-6-5-7-12-19/h5-18H,1-4H3,(H2,27,28,29,31)
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n/an/a 66n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards acyl CoA cholesterol acyltransferase (ACAT) of cholesterol-fed rabbits by the displacement of [14C]-oleolyl-CoA

Bioorg Med Chem Lett 5: 1829-1832 (1995)


Article DOI: 10.1016/0960-894X(95)00296-6
BindingDB Entry DOI: 10.7270/Q2VD6ZDR
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50284974
PNG
(1-(2,6-Diisopropyl-phenyl)-3-[1-(2-trifluoromethyl...)
Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)Nc1nc2ccccc2n1-c1ccccc1C(F)(F)F |(17.78,-8.64,;18.53,-7.31,;20.07,-7.3,;17.76,-5.98,;18.53,-4.64,;17.76,-3.31,;16.2,-3.32,;15.45,-4.67,;13.91,-4.67,;13.12,-3.34,;12.42,-5.07,;16.22,-5.98,;15.47,-7.33,;13.93,-7.33,;13.14,-6,;13.17,-8.66,;11.63,-8.68,;10.71,-7.43,;9.25,-7.92,;7.91,-7.15,;6.58,-7.93,;6.58,-9.47,;7.91,-10.24,;9.25,-9.46,;10.72,-9.92,;10.72,-11.46,;12.02,-12.23,;12.02,-13.77,;10.69,-14.54,;9.36,-13.75,;9.36,-12.23,;7.82,-12.21,;6.42,-12.21,;6.81,-10.95,;6.8,-13.46,)|
Show InChI InChI=1S/C27H27F3N4O/c1-16(2)18-10-9-11-19(17(3)4)24(18)32-26(35)33-25-31-21-13-6-8-15-23(21)34(25)22-14-7-5-12-20(22)27(28,29)30/h5-17H,1-4H3,(H2,31,32,33,35)
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n/an/a 72n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards acyl CoA cholesterol acyltransferase (ACAT) of cholesterol-fed rabbits by the displacement of [14C]-oleolyl-CoA

Bioorg Med Chem Lett 5: 1829-1832 (1995)


Article DOI: 10.1016/0960-894X(95)00296-6
BindingDB Entry DOI: 10.7270/Q2VD6ZDR
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50284969
PNG
(1-(2,6-Diisopropyl-phenyl)-3-[1-(2-methyl-pyridin-...)
Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)Nc1nc2ccccc2n1-c1cccnc1C |(18.51,-8.76,;16.97,-8.77,;16.2,-10.11,;16.2,-7.44,;16.96,-6.1,;16.18,-4.77,;14.64,-4.79,;13.88,-6.12,;12.34,-6.14,;11.56,-4.81,;10.85,-6.54,;14.65,-7.45,;13.89,-8.78,;12.35,-8.8,;11.57,-7.47,;11.6,-10.13,;10.06,-10.13,;9.13,-8.9,;7.68,-9.39,;6.33,-8.62,;5,-9.39,;5,-10.93,;6.33,-11.7,;7.68,-10.93,;9.15,-11.39,;9.15,-12.93,;7.8,-13.68,;7.79,-15.22,;9.11,-15.99,;10.45,-15.22,;10.46,-13.7,;11.79,-12.93,)|
Show InChI InChI=1S/C26H29N5O/c1-16(2)19-10-8-11-20(17(3)4)24(19)29-26(32)30-25-28-21-12-6-7-13-23(21)31(25)22-14-9-15-27-18(22)5/h6-17H,1-5H3,(H2,28,29,30,32)
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n/an/a 100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards acyl CoA cholesterol acyltransferase (ACAT) of cholesterol-fed rabbits by the displacement of [14C]-oleolyl-CoA

Bioorg Med Chem Lett 5: 1829-1832 (1995)


Article DOI: 10.1016/0960-894X(95)00296-6
BindingDB Entry DOI: 10.7270/Q2VD6ZDR
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50284975
PNG
(1-[1-(3-Chloro-pyridin-2-yl)-1H-benzoimidazol-2-yl...)
Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)Nc1nc2ccccc2n1-c1ncccc1Cl |(18.51,-8.76,;16.97,-8.77,;16.2,-10.11,;16.2,-7.44,;16.96,-6.1,;16.18,-4.77,;14.64,-4.79,;13.88,-6.12,;12.34,-6.14,;11.56,-4.81,;10.85,-6.54,;14.65,-7.45,;13.89,-8.78,;12.35,-8.8,;11.57,-7.47,;11.6,-10.13,;10.06,-10.13,;9.13,-8.9,;7.68,-9.39,;6.33,-8.62,;5,-9.39,;5,-10.93,;6.33,-11.7,;7.68,-10.93,;9.15,-11.39,;9.15,-12.93,;7.8,-13.68,;7.79,-15.22,;9.11,-15.99,;10.45,-15.22,;10.46,-13.7,;11.79,-12.93,)|
Show InChI InChI=1S/C25H26ClN5O/c1-15(2)17-9-7-10-18(16(3)4)22(17)29-25(32)30-24-28-20-12-5-6-13-21(20)31(24)23-19(26)11-8-14-27-23/h5-16H,1-4H3,(H2,28,29,30,32)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards acyl CoA cholesterol acyltransferase (ACAT) of cholesterol-fed rabbits by the displacement of [14C]-oleolyl-CoA

Bioorg Med Chem Lett 5: 1829-1832 (1995)


Article DOI: 10.1016/0960-894X(95)00296-6
BindingDB Entry DOI: 10.7270/Q2VD6ZDR
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50284977
PNG
(1-(2,6-Diisopropyl-phenyl)-3-[1-(2-hydroxy-phenyl)...)
Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)Nc1nc2ccccc2n1-c1ccccc1O |(20.07,-7.3,;18.53,-7.31,;17.78,-8.64,;17.76,-5.98,;18.53,-4.64,;17.76,-3.31,;16.2,-3.32,;15.45,-4.67,;13.91,-4.67,;13.12,-3.34,;12.42,-5.07,;16.22,-5.98,;15.47,-7.33,;13.93,-7.33,;13.14,-6,;13.17,-8.66,;11.63,-8.68,;10.71,-7.43,;9.25,-7.92,;7.91,-7.15,;6.58,-7.93,;6.58,-9.47,;7.91,-10.24,;9.25,-9.46,;10.72,-9.92,;10.72,-11.46,;12.02,-12.23,;12.02,-13.77,;10.69,-14.54,;9.36,-13.75,;9.36,-12.23,;7.82,-12.23,)|
Show InChI InChI=1S/C26H28N4O2/c1-16(2)18-10-9-11-19(17(3)4)24(18)28-26(32)29-25-27-20-12-5-6-13-21(20)30(25)22-14-7-8-15-23(22)31/h5-17,31H,1-4H3,(H2,27,28,29,32)
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n/an/a 200n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards acyl CoA cholesterol acyltransferase (ACAT) of cholesterol-fed rabbits by the displacement of [14C]-oleolyl-CoA

Bioorg Med Chem Lett 5: 1829-1832 (1995)


Article DOI: 10.1016/0960-894X(95)00296-6
BindingDB Entry DOI: 10.7270/Q2VD6ZDR
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50284968
PNG
(1-[1-(4-Chloro-phenyl)-1H-benzoimidazol-2-yl]-3-(2...)
Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)Nc1nc2ccccc2n1-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H27ClN4O/c1-16(2)20-8-7-9-21(17(3)4)24(20)29-26(32)30-25-28-22-10-5-6-11-23(22)31(25)19-14-12-18(27)13-15-19/h5-17H,1-4H3,(H2,28,29,30,32)
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n/an/a 280n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards acyl CoA cholesterol acyltransferase (ACAT) of cholesterol-fed rabbits by the displacement of [14C]-oleolyl-CoA

Bioorg Med Chem Lett 5: 1829-1832 (1995)


Article DOI: 10.1016/0960-894X(95)00296-6
BindingDB Entry DOI: 10.7270/Q2VD6ZDR
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50284966
PNG
(1-[1-(2-Chloro-phenyl)-1H-benzoimidazol-2-yl]-3-(2...)
Show SMILES Cc1cccc(C)c1NC(=O)Nc1nc2ccccc2n1-c1ccccc1Cl |(16.97,-8.77,;16.2,-7.44,;16.96,-6.1,;16.18,-4.77,;14.64,-4.79,;13.88,-6.12,;12.34,-6.14,;14.65,-7.45,;13.89,-8.78,;12.35,-8.8,;11.57,-7.47,;11.6,-10.13,;10.06,-10.13,;9.13,-8.9,;7.68,-9.39,;6.33,-8.62,;5,-9.39,;5,-10.93,;6.33,-11.7,;7.68,-10.93,;9.15,-11.39,;9.15,-12.93,;10.46,-13.7,;10.45,-15.22,;9.11,-15.99,;7.79,-15.22,;7.8,-13.68,;6.47,-12.9,)|
Show InChI InChI=1S/C22H19ClN4O/c1-14-8-7-9-15(2)20(14)25-22(28)26-21-24-17-11-4-6-13-19(17)27(21)18-12-5-3-10-16(18)23/h3-13H,1-2H3,(H2,24,25,26,28)
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n/an/a 420n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards acyl CoA cholesterol acyltransferase (ACAT) of cholesterol-fed rabbits by the displacement of [14C]-oleolyl-CoA

Bioorg Med Chem Lett 5: 1829-1832 (1995)


Article DOI: 10.1016/0960-894X(95)00296-6
BindingDB Entry DOI: 10.7270/Q2VD6ZDR
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%