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Articleid 50029838

Compile data set for download or QSAR
Found 61 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288548
PNG
(2-Acridin-9-yl-2-benzo[1,3]dioxol-5-yl-ethanol | C...)
Show SMILES OCC(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C22H17NO3/c24-12-17(14-9-10-20-21(11-14)26-13-25-20)22-15-5-1-3-7-18(15)23-19-8-4-2-6-16(19)22/h1-11,17,24H,12-13H2
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n/an/a 900n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288548
PNG
(2-Acridin-9-yl-2-benzo[1,3]dioxol-5-yl-ethanol | C...)
Show SMILES OCC(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C22H17NO3/c24-12-17(14-9-10-20-21(11-14)26-13-25-20)22-15-5-1-3-7-18(15)23-19-8-4-2-6-16(19)22/h1-11,17,24H,12-13H2
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n/an/a 900n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288543
PNG
(Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetaldehyde | ...)
Show SMILES O=CC(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C22H15NO3/c24-12-17(14-9-10-20-21(11-14)26-13-25-20)22-15-5-1-3-7-18(15)23-19-8-4-2-6-16(19)22/h1-12,17H,13H2
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n/an/a 1.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288538
PNG
((Acridin-9-yloxy)-benzo[1,3]dioxol-5-yl-acetic aci...)
Show SMILES COC(=O)C(Oc1c2ccccc2nc2ccccc12)c1ccc2OCOc2c1
Show InChI InChI=1S/C23H17NO5/c1-26-23(25)21(14-10-11-19-20(12-14)28-13-27-19)29-22-15-6-2-4-8-17(15)24-18-9-5-3-7-16(18)22/h2-12,21H,13H2,1H3
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n/an/a 2.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288545
PNG
(Benzo[1,3]dioxol-5-yl-(2-methyl-quinolin-4-yl)-ace...)
Show SMILES COC(=O)C(c1ccc2OCOc2c1)c1cc(C)nc2ccccc12
Show InChI InChI=1S/C20H17NO4/c1-12-9-15(14-5-3-4-6-16(14)21-12)19(20(22)23-2)13-7-8-17-18(10-13)25-11-24-17/h3-10,19H,11H2,1-2H3
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n/an/a 2.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288537
PNG
(Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid met...)
Show SMILES COC(=O)C(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C23H17NO4/c1-26-23(25)21(14-10-11-19-20(12-14)28-13-27-19)22-15-6-2-4-8-17(15)24-18-9-5-3-7-16(18)22/h2-12,21H,13H2,1H3
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n/an/a 2.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288537
PNG
(Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid met...)
Show SMILES COC(=O)C(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C23H17NO4/c1-26-23(25)21(14-10-11-19-20(12-14)28-13-27-19)22-15-6-2-4-8-17(15)24-18-9-5-3-7-16(18)22/h2-12,21H,13H2,1H3
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n/an/a 4.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288538
PNG
((Acridin-9-yloxy)-benzo[1,3]dioxol-5-yl-acetic aci...)
Show SMILES COC(=O)C(Oc1c2ccccc2nc2ccccc12)c1ccc2OCOc2c1
Show InChI InChI=1S/C23H17NO5/c1-26-23(25)21(14-10-11-19-20(12-14)28-13-27-19)29-22-15-6-2-4-8-17(15)24-18-9-5-3-7-16(18)22/h2-12,21H,13H2,1H3
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n/an/a 4.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288532
PNG
(Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid ter...)
Show SMILES CC(C)(C)OC(=O)C(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C26H23NO4/c1-26(2,3)31-25(28)23(16-12-13-21-22(14-16)30-15-29-21)24-17-8-4-6-10-19(17)27-20-11-7-5-9-18(20)24/h4-14,23H,15H2,1-3H3
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n/an/a 5.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288537
PNG
(Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid met...)
Show SMILES COC(=O)C(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C23H17NO4/c1-26-23(25)21(14-10-11-19-20(12-14)28-13-27-19)22-15-6-2-4-8-17(15)24-18-9-5-3-7-16(18)22/h2-12,21H,13H2,1H3
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n/an/a 5.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288550
PNG
(Benzo[1,3]dioxol-5-yl-(1,2,3,4-tetrahydro-acridin-...)
Show SMILES COC(=O)C(c1ccc2OCOc2c1)c1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C23H21NO4/c1-26-23(25)21(14-10-11-19-20(12-14)28-13-27-19)22-15-6-2-4-8-17(15)24-18-9-5-3-7-16(18)22/h2,4,6,8,10-12,21H,3,5,7,9,13H2,1H3
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n/an/a 7.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288557
PNG
(Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid ben...)
Show SMILES O=C(OCc1ccccc1)C(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C29H21NO4/c31-29(32-17-19-8-2-1-3-9-19)27(20-14-15-25-26(16-20)34-18-33-25)28-21-10-4-6-12-23(21)30-24-13-7-5-11-22(24)28/h1-16,27H,17-18H2
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n/an/a 7.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288536
PNG
(2-Acridin-9-yl-2-benzo[1,3]dioxol-5-yl-acetamide |...)
Show SMILES NC(=O)C(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C22H16N2O3/c23-22(25)20(13-9-10-18-19(11-13)27-12-26-18)21-14-5-1-3-7-16(14)24-17-8-4-2-6-15(17)21/h1-11,20H,12H2,(H2,23,25)
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n/an/a 7.90E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288541
PNG
(Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid 4-m...)
Show SMILES COc1ccc(COC(=O)C(c2ccc3OCOc3c2)c2c3ccccc3nc3ccccc23)cc1
Show InChI InChI=1S/C30H23NO5/c1-33-21-13-10-19(11-14-21)17-34-30(32)28(20-12-15-26-27(16-20)36-18-35-26)29-22-6-2-4-8-24(22)31-25-9-5-3-7-23(25)29/h2-16,28H,17-18H2,1H3
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n/an/a 8.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288536
PNG
(2-Acridin-9-yl-2-benzo[1,3]dioxol-5-yl-acetamide |...)
Show SMILES NC(=O)C(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C22H16N2O3/c23-22(25)20(13-9-10-18-19(11-13)27-12-26-18)21-14-5-1-3-7-16(14)24-17-8-4-2-6-15(17)21/h1-11,20H,12H2,(H2,23,25)
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n/an/a 8.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288539
PNG
(Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid ben...)
Show SMILES O=C(OCc1ccc2OCOc2c1)C(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C30H21NO6/c32-30(33-15-18-9-11-24-26(13-18)36-16-34-24)28(19-10-12-25-27(14-19)37-17-35-25)29-20-5-1-3-7-22(20)31-23-8-4-2-6-21(23)29/h1-14,28H,15-17H2
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n/an/a 8.70E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288548
PNG
(2-Acridin-9-yl-2-benzo[1,3]dioxol-5-yl-ethanol | C...)
Show SMILES OCC(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C22H17NO3/c24-12-17(14-9-10-20-21(11-14)26-13-25-20)22-15-5-1-3-7-18(15)23-19-8-4-2-6-16(19)22/h1-11,17,24H,12-13H2
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n/an/a 1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288550
PNG
(Benzo[1,3]dioxol-5-yl-(1,2,3,4-tetrahydro-acridin-...)
Show SMILES COC(=O)C(c1ccc2OCOc2c1)c1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C23H21NO4/c1-26-23(25)21(14-10-11-19-20(12-14)28-13-27-19)22-15-6-2-4-8-17(15)24-18-9-5-3-7-16(18)22/h2,4,6,8,10-12,21H,3,5,7,9,13H2,1H3
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n/an/a 1.10E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288550
PNG
(Benzo[1,3]dioxol-5-yl-(1,2,3,4-tetrahydro-acridin-...)
Show SMILES COC(=O)C(c1ccc2OCOc2c1)c1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C23H21NO4/c1-26-23(25)21(14-10-11-19-20(12-14)28-13-27-19)22-15-6-2-4-8-17(15)24-18-9-5-3-7-16(18)22/h2,4,6,8,10-12,21H,3,5,7,9,13H2,1H3
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n/an/a 1.20E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth mu...

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288546
PNG
(2-Benzo[1,3]dioxol-5-yl-2-(2-methyl-quinolin-4-yl)...)
Show SMILES Cc1cc(C(C(N)=O)c2ccc3OCOc3c2)c2ccccc2n1
Show InChI InChI=1S/C19H16N2O3/c1-11-8-14(13-4-2-3-5-15(13)21-11)18(19(20)22)12-6-7-16-17(9-12)24-10-23-16/h2-9,18H,10H2,1H3,(H2,20,22)
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n/an/a 1.30E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288543
PNG
(Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetaldehyde | ...)
Show SMILES O=CC(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C22H15NO3/c24-12-17(14-9-10-20-21(11-14)26-13-25-20)22-15-5-1-3-7-18(15)23-19-8-4-2-6-16(19)22/h1-12,17H,13H2
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n/an/a 2.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288553
PNG
(Benzo[1,3]dioxol-5-yl-(2-phenyl-quinolin-4-yl)-ace...)
Show SMILES COC(=O)C(c1ccc2OCOc2c1)c1cc(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C25H19NO4/c1-28-25(27)24(17-11-12-22-23(13-17)30-15-29-22)19-14-21(16-7-3-2-4-8-16)26-20-10-6-5-9-18(19)20/h2-14,24H,15H2,1H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288556
PNG
(2-Acridin-9-yl-3-benzo[1,3]dioxol-5-yl-propionic a...)
Show SMILES COC(=O)C(Cc1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C24H19NO4/c1-27-24(26)18(12-15-10-11-21-22(13-15)29-14-28-21)23-16-6-2-4-8-19(16)25-20-9-5-3-7-17(20)23/h2-11,13,18H,12,14H2,1H3
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TBA

Curated by ChEMBL


Assay Description
Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth mu...

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288547
PNG
(Acridin-9-yl-(2,2-dimethyl-benzo[1,3]dioxol-5-yl)-...)
Show SMILES COC(=O)C(c1ccc2OC(C)(C)Oc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C25H21NO4/c1-25(2)29-20-13-12-15(14-21(20)30-25)22(24(27)28-3)23-16-8-4-6-10-18(16)26-19-11-7-5-9-17(19)23/h4-14,22H,1-3H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288549
PNG
(Benzo[1,3]dioxol-5-yl-(3,4-dimethoxy-acridin-9-yl)...)
Show SMILES COC(=O)C(c1ccc2OCOc2c1)c1c2ccccc2nc2c(OC)c(OC)ccc12
Show InChI InChI=1S/C25H21NO6/c1-28-19-11-9-16-22(15-6-4-5-7-17(15)26-23(16)24(19)29-2)21(25(27)30-3)14-8-10-18-20(12-14)32-13-31-18/h4-12,21H,13H2,1-3H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288544
PNG
(Acridin-9-yl-(4-methoxy-phenyl)-acetic acid methyl...)
Show SMILES COC(=O)C(c1ccc(OC)cc1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C23H19NO3/c1-26-16-13-11-15(12-14-16)21(23(25)27-2)22-17-7-3-5-9-19(17)24-20-10-6-4-8-18(20)22/h3-14,21H,1-2H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288534
PNG
(3-Anthracen-9-yl-2-benzo[1,3]dioxol-5-yl-propionic...)
Show SMILES COC(=O)C(Cc1c2ccccc2cc2ccccc12)c1ccc2OCOc2c1
Show InChI InChI=1S/C25H20O4/c1-27-25(26)21(18-10-11-23-24(13-18)29-15-28-23)14-22-19-8-4-2-6-16(19)12-17-7-3-5-9-20(17)22/h2-13,21H,14-15H2,1H3
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TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288558
PNG
(Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid 4-c...)
Show SMILES Clc1ccc(COC(=O)C(c2ccc3OCOc3c2)c2c3ccccc3nc3ccccc23)cc1
Show InChI InChI=1S/C29H20ClNO4/c30-20-12-9-18(10-13-20)16-33-29(32)27(19-11-14-25-26(15-19)35-17-34-25)28-21-5-1-3-7-23(21)31-24-8-4-2-6-22(24)28/h1-15,27H,16-17H2
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n/an/a>2.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288544
PNG
(Acridin-9-yl-(4-methoxy-phenyl)-acetic acid methyl...)
Show SMILES COC(=O)C(c1ccc(OC)cc1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C23H19NO3/c1-26-16-13-11-15(12-14-16)21(23(25)27-2)22-17-7-3-5-9-19(17)24-20-10-6-4-8-18(20)22/h3-14,21H,1-2H3
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TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288558
PNG
(Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid 4-c...)
Show SMILES Clc1ccc(COC(=O)C(c2ccc3OCOc3c2)c2c3ccccc3nc3ccccc23)cc1
Show InChI InChI=1S/C29H20ClNO4/c30-20-12-9-18(10-13-20)16-33-29(32)27(19-11-14-25-26(15-19)35-17-34-25)28-21-5-1-3-7-23(21)31-24-8-4-2-6-22(24)28/h1-15,27H,16-17H2
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n/an/a>2.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288556
PNG
(2-Acridin-9-yl-3-benzo[1,3]dioxol-5-yl-propionic a...)
Show SMILES COC(=O)C(Cc1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C24H19NO4/c1-27-24(26)18(12-15-10-11-21-22(13-15)29-14-28-21)23-16-6-2-4-8-19(16)25-20-9-5-3-7-17(20)23/h2-11,13,18H,12,14H2,1H3
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TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288555
PNG
(Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid 4-t...)
Show SMILES CC(C)(C)c1ccc(COC(=O)C(c2ccc3OCOc3c2)c2c3ccccc3nc3ccccc23)cc1
Show InChI InChI=1S/C33H29NO4/c1-33(2,3)23-15-12-21(13-16-23)19-36-32(35)30(22-14-17-28-29(18-22)38-20-37-28)31-24-8-4-6-10-26(24)34-27-11-7-5-9-25(27)31/h4-18,30H,19-20H2,1-3H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288554
PNG
(Acridin-9-yl-(4-nitro-phenyl)-acetic acid methyl e...)
Show SMILES COC(=O)C(c1ccc(cc1)[N+]([O-])=O)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C22H16N2O4/c1-28-22(25)20(14-10-12-15(13-11-14)24(26)27)21-16-6-2-4-8-18(16)23-19-9-5-3-7-17(19)21/h2-13,20H,1H3
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TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288554
PNG
(Acridin-9-yl-(4-nitro-phenyl)-acetic acid methyl e...)
Show SMILES COC(=O)C(c1ccc(cc1)[N+]([O-])=O)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C22H16N2O4/c1-28-22(25)20(14-10-12-15(13-11-14)24(26)27)21-16-6-2-4-8-18(16)23-19-9-5-3-7-17(19)21/h2-13,20H,1H3
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TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288531
PNG
(Benzo[1,3]dioxol-5-yl-(10,11-dihydro-5H-dibenzo[a,...)
Show SMILES COC(=O)C(C1c2ccccc2CCc2ccccc12)c1ccc2OCOc2c1
Show InChI InChI=1S/C25H22O4/c1-27-25(26)23(18-12-13-21-22(14-18)29-15-28-21)24-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)24/h2-9,12-14,23-24H,10-11,15H2,1H3
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TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288549
PNG
(Benzo[1,3]dioxol-5-yl-(3,4-dimethoxy-acridin-9-yl)...)
Show SMILES COC(=O)C(c1ccc2OCOc2c1)c1c2ccccc2nc2c(OC)c(OC)ccc12
Show InChI InChI=1S/C25H21NO6/c1-28-19-11-9-16-22(15-6-4-5-7-17(15)26-23(16)24(19)29-2)21(25(27)30-3)14-8-10-18-20(12-14)32-13-31-18/h4-12,21H,13H2,1-3H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth mu...

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288555
PNG
(Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid 4-t...)
Show SMILES CC(C)(C)c1ccc(COC(=O)C(c2ccc3OCOc3c2)c2c3ccccc3nc3ccccc23)cc1
Show InChI InChI=1S/C33H29NO4/c1-33(2,3)23-15-12-21(13-16-23)19-36-32(35)30(22-14-17-28-29(18-22)38-20-37-28)31-24-8-4-6-10-26(24)34-27-11-7-5-9-25(27)31/h4-18,30H,19-20H2,1-3H3
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TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288552
PNG
(Acridin-9-yl-(4-chloro-phenyl)-acetic acid methyl ...)
Show SMILES COC(=O)C(c1ccc(Cl)cc1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C22H16ClNO2/c1-26-22(25)20(14-10-12-15(23)13-11-14)21-16-6-2-4-8-18(16)24-19-9-5-3-7-17(19)21/h2-13,20H,1H3
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TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288540
PNG
(9-Benzo[1,3]dioxol-5-ylmethyl-acridine | CHEMBL999...)
Show SMILES C(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C21H15NO2/c1-3-7-18-15(5-1)17(16-6-2-4-8-19(16)22-18)11-14-9-10-20-21(12-14)24-13-23-20/h1-10,12H,11,13H2
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n/an/a>2.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288553
PNG
(Benzo[1,3]dioxol-5-yl-(2-phenyl-quinolin-4-yl)-ace...)
Show SMILES COC(=O)C(c1ccc2OCOc2c1)c1cc(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C25H19NO4/c1-28-25(27)24(17-11-12-22-23(13-17)30-15-29-22)19-14-21(16-7-3-2-4-8-16)26-20-10-6-5-9-18(19)20/h2-14,24H,15H2,1H3
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TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288551
PNG
(Acridin-9-yl-(3,4-dimethoxy-phenyl)-acetic acid me...)
Show SMILES COC(=O)C(c1ccc(OC)c(OC)c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C24H21NO4/c1-27-20-13-12-15(14-21(20)28-2)22(24(26)29-3)23-16-8-4-6-10-18(16)25-19-11-7-5-9-17(19)23/h4-14,22H,1-3H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288533
PNG
(2-Benzo[1,3]dioxol-5-yl-3,3-diphenyl-propionic aci...)
Show SMILES COC(=O)C(C(c1ccccc1)c1ccccc1)c1ccc2OCOc2c1
Show InChI InChI=1S/C23H20O4/c1-25-23(24)22(18-12-13-19-20(14-18)27-15-26-19)21(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-14,21-22H,15H2,1H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288542
PNG
(Benzo[1,3]dioxol-5-yl-(10-oxy-acridin-9-yl)-acetic...)
Show SMILES COC(=O)C(c1ccc2OCOc2c1)c1c2ccccc2[n+]([O-])c2ccccc12
Show InChI InChI=1S/C23H17NO5/c1-27-23(25)21(14-10-11-19-20(12-14)29-13-28-19)22-15-6-2-4-8-17(15)24(26)18-9-5-3-7-16(18)22/h2-12,21H,13H2,1H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288533
PNG
(2-Benzo[1,3]dioxol-5-yl-3,3-diphenyl-propionic aci...)
Show SMILES COC(=O)C(C(c1ccccc1)c1ccccc1)c1ccc2OCOc2c1
Show InChI InChI=1S/C23H20O4/c1-25-23(24)22(18-12-13-19-20(14-18)27-15-26-19)21(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-14,21-22H,15H2,1H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288540
PNG
(9-Benzo[1,3]dioxol-5-ylmethyl-acridine | CHEMBL999...)
Show SMILES C(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C21H15NO2/c1-3-7-18-15(5-1)17(16-6-2-4-8-19(16)22-18)11-14-9-10-20-21(12-14)24-13-23-20/h1-10,12H,11,13H2
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n/an/a>2.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth mu...

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288547
PNG
(Acridin-9-yl-(2,2-dimethyl-benzo[1,3]dioxol-5-yl)-...)
Show SMILES COC(=O)C(c1ccc2OC(C)(C)Oc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C25H21NO4/c1-25(2)29-20-13-12-15(14-21(20)30-25)22(24(27)28-3)23-16-8-4-6-10-18(16)26-19-11-7-5-9-17(19)23/h4-14,22H,1-3H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288535
PNG
(Acridin-9-yl-(3,4-dichloro-phenyl)-acetic acid met...)
Show SMILES COC(=O)C(c1ccc(Cl)c(Cl)c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C22H15Cl2NO2/c1-27-22(26)20(13-10-11-16(23)17(24)12-13)21-14-6-2-4-8-18(14)25-19-9-5-3-7-15(19)21/h2-12,20H,1H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288542
PNG
(Benzo[1,3]dioxol-5-yl-(10-oxy-acridin-9-yl)-acetic...)
Show SMILES COC(=O)C(c1ccc2OCOc2c1)c1c2ccccc2[n+]([O-])c2ccccc12
Show InChI InChI=1S/C23H17NO5/c1-27-23(25)21(14-10-11-19-20(12-14)29-13-28-19)22-15-6-2-4-8-17(15)24(26)18-9-5-3-7-16(18)22/h2-12,21H,13H2,1H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288552
PNG
(Acridin-9-yl-(4-chloro-phenyl)-acetic acid methyl ...)
Show SMILES COC(=O)C(c1ccc(Cl)cc1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C22H16ClNO2/c1-26-22(25)20(14-10-12-15(23)13-11-14)21-16-6-2-4-8-18(16)24-19-9-5-3-7-17(19)21/h2-13,20H,1H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288531
PNG
(Benzo[1,3]dioxol-5-yl-(10,11-dihydro-5H-dibenzo[a,...)
Show SMILES COC(=O)C(C1c2ccccc2CCc2ccccc12)c1ccc2OCOc2c1
Show InChI InChI=1S/C25H22O4/c1-27-25(26)23(18-12-13-21-22(14-18)29-15-28-21)24-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)24/h2-9,12-14,23-24H,10-11,15H2,1H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288551
PNG
(Acridin-9-yl-(3,4-dimethoxy-phenyl)-acetic acid me...)
Show SMILES COC(=O)C(c1ccc(OC)c(OC)c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C24H21NO4/c1-27-20-13-12-15(14-21(20)28-2)22(24(26)29-3)23-16-8-4-6-10-18(16)25-19-11-7-5-9-17(19)23/h4-14,22H,1-3H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288535
PNG
(Acridin-9-yl-(3,4-dichloro-phenyl)-acetic acid met...)
Show SMILES COC(=O)C(c1ccc(Cl)c(Cl)c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C22H15Cl2NO2/c1-27-22(26)20(13-10-11-16(23)17(24)12-13)21-14-6-2-4-8-18(14)25-19-9-5-3-7-15(19)21/h2-12,20H,1H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288539
PNG
(Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid ben...)
Show SMILES O=C(OCc1ccc2OCOc2c1)C(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C30H21NO6/c32-30(33-15-18-9-11-24-26(13-18)36-16-34-24)28(19-10-12-25-27(14-19)37-17-35-25)29-20-5-1-3-7-22(20)31-23-8-4-2-6-21(23)29/h1-14,28H,15-17H2
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n/an/a 3.30E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288541
PNG
(Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid 4-m...)
Show SMILES COc1ccc(COC(=O)C(c2ccc3OCOc3c2)c2c3ccccc3nc3ccccc23)cc1
Show InChI InChI=1S/C30H23NO5/c1-33-21-13-10-19(11-14-21)17-34-30(32)28(20-12-15-26-27(16-20)36-18-35-26)29-22-6-2-4-8-24(22)31-25-9-5-3-7-23(25)29/h2-16,28H,17-18H2,1H3
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n/an/a 3.40E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288546
PNG
(2-Benzo[1,3]dioxol-5-yl-2-(2-methyl-quinolin-4-yl)...)
Show SMILES Cc1cc(C(C(N)=O)c2ccc3OCOc3c2)c2ccccc2n1
Show InChI InChI=1S/C19H16N2O3/c1-11-8-14(13-4-2-3-5-15(13)21-11)18(19(20)22)12-6-7-16-17(9-12)24-10-23-16/h2-9,18H,10H2,1H3,(H2,20,22)
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n/an/a 3.70E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288557
PNG
(Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid ben...)
Show SMILES O=C(OCc1ccccc1)C(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C29H21NO4/c31-29(32-17-19-8-2-1-3-9-19)27(20-14-15-25-26(16-20)34-18-33-25)28-21-10-4-6-12-23(21)30-24-13-7-5-11-22(24)28/h1-16,27H,17-18H2
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n/an/a 5.70E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288545
PNG
(Benzo[1,3]dioxol-5-yl-(2-methyl-quinolin-4-yl)-ace...)
Show SMILES COC(=O)C(c1ccc2OCOc2c1)c1cc(C)nc2ccccc12
Show InChI InChI=1S/C20H17NO4/c1-12-9-15(14-5-3-4-6-16(14)21-12)19(20(22)23-2)13-7-8-17-18(10-13)25-11-24-17/h3-10,19H,11H2,1-2H3
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n/an/a 6.10E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288532
PNG
(Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid ter...)
Show SMILES CC(C)(C)OC(=O)C(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C26H23NO4/c1-26(2,3)31-25(28)23(16-12-13-21-22(14-16)30-15-29-21)24-17-8-4-6-10-19(17)27-20-11-7-5-9-18(20)24/h4-14,23H,15H2,1-3H3
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n/an/a 6.60E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288534
PNG
(3-Anthracen-9-yl-2-benzo[1,3]dioxol-5-yl-propionic...)
Show SMILES COC(=O)C(Cc1c2ccccc2cc2ccccc12)c1ccc2OCOc2c1
Show InChI InChI=1S/C25H20O4/c1-27-25(26)21(18-10-11-23-24(13-18)29-15-28-23)14-22-19-8-4-2-6-16(19)12-17-7-3-5-9-20(17)22/h2-13,21H,14-15H2,1H3
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n/an/a 7.60E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin-1 receptor


(Homo sapiens (Human))		BDBM50288536
PNG
(2-Acridin-9-yl-2-benzo[1,3]dioxol-5-yl-acetamide |...)
Show SMILES NC(=O)C(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C22H16N2O3/c23-22(25)20(13-9-10-18-19(11-13)27-12-26-18)21-14-5-1-3-7-16(14)24-17-8-4-2-6-15(17)21/h1-11,20H,12H2,(H2,23,25)
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n/an/a 7.70E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]-ET-1 to cloned human Endothelin A receptor expressed in LtK- cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
Endothelin receptor type B


(Homo sapiens (Human))		BDBM50288537
PNG
(Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid met...)
Show SMILES COC(=O)C(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C23H17NO4/c1-26-23(25)21(14-10-11-19-20(12-14)28-13-27-19)22-15-6-2-4-8-17(15)24-18-9-5-3-7-16(18)22/h2-12,21H,13H2,1H3
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Article
n/an/a>2.50E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of binding of [125I]-ET-1 to cloned human Endothelin B receptor expressed in CHO-K1 cells

Bioorg Med Chem Lett 6: 2999-3002 (1996)


Article DOI: 10.1016/S0960-894X(96)00551-3
BindingDB Entry DOI: 10.7270/Q26D5SZK
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%