| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50288532 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_65478 (CHEMBL873600) |
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| IC50 | 66000±n/a nM |
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| Citation |  Cheng, XM; Lee, C; Klutchko, S; Winters, T; Reynolds, EE; Welch, KM; Flynn, MA; Doherty, AM Synthesis and structure-activity relationships of 9-substituted acridines as endothelin-A receptor antagonists Bioorg Med Chem Lett6:2999-3002 (1996) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48736.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25101 |
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| Residue: | 427 |
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| Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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| BDBM50288532 |
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| n/a |
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| Name | BDBM50288532 |
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| Synonyms: | Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid tert-butyl ester | CHEMBL100874 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H23NO4 |
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| Mol. Mass. | 413.4651 |
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| SMILES | CC(C)(C)OC(=O)C(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12 |
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| Structure | 
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