BindingDB logo
myBDB logout

PubMed code 7678654

Compile data set for download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3148
PNG
(2-pyridinone deriv. 54 | 5-ethyl-3-{[(2-methoxy-5,...)
Show SMILES CCc1cc(NCc2cc(C)c(C)nc2OC)c(=O)[nH]c1C
Show InChI InChI=1S/C17H23N3O2/c1-6-13-8-15(16(21)19-12(13)4)18-9-14-7-10(2)11(3)20-17(14)22-5/h7-8,18H,6,9H2,1-5H3,(H,19,21)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 9n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3142
PNG
(2-pyridinone deriv. 48 | 5-ethyl-3-{[(2-methoxy-5-...)
Show SMILES CCc1cc(NCc2cc(C)ccc2OC)c(=O)[nH]c1C
Show InChI InChI=1S/C17H22N2O2/c1-5-13-9-15(17(20)19-12(13)3)18-10-14-8-11(2)6-7-16(14)21-4/h6-9,18H,5,10H2,1-4H3,(H,19,20)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 23n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3141
PNG
(2-pyridinone deriv. 47 | 5-ethyl-3-{[(2-methoxy-4-...)
Show SMILES CCc1cc(NCc2ccc(C)cc2OC)c(=O)[nH]c1C
Show InChI InChI=1S/C17H22N2O2/c1-5-13-9-15(17(20)19-12(13)3)18-10-14-7-6-11(2)8-16(14)21-4/h6-9,18H,5,10H2,1-4H3,(H,19,20)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 32n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3145
PNG
(2-pyridinone deriv. 51 | 5-ethyl-3-{[(5-ethyl-2-me...)
Show SMILES CCc1ccc(OC)c(CNc2cc(CC)c(C)[nH]c2=O)c1
Show InChI InChI=1S/C18H24N2O2/c1-5-13-7-8-17(22-4)15(9-13)11-19-16-10-14(6-2)12(3)20-18(16)21/h7-10,19H,5-6,11H2,1-4H3,(H,20,21)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 32n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3146
PNG
(2-pyridinone deriv. 52 | 5-ethyl-3-{[(5-ethyl-2-me...)
Show SMILES CCc1cc(CNc2cc(CC)c(C)[nH]c2=O)c(OC)cc1C
Show InChI InChI=1S/C19H26N2O2/c1-6-14-9-16(18(23-5)8-12(14)3)11-20-17-10-15(7-2)13(4)21-19(17)22/h8-10,20H,6-7,11H2,1-5H3,(H,21,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 33n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3147
PNG
(2-pyridinone deriv. 53 | 5-ethyl-3-{[(6-methoxy-2,...)
Show SMILES CCc1cc(NCc2cc3CCCc3cc2OC)c(=O)[nH]c1C
Show InChI InChI=1S/C19H24N2O2/c1-4-13-9-17(19(22)21-12(13)2)20-11-16-8-14-6-5-7-15(14)10-18(16)23-3/h8-10,20H,4-7,11H2,1-3H3,(H,21,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 40n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3121
PNG
(2-pyridinone deriv. 27 | 5-ethyl-3-{[(2-methoxyphe...)
Show SMILES CCc1cc(NCc2ccccc2OC)c(=O)[nH]c1C
Show InChI InChI=1S/C16H20N2O2/c1-4-12-9-14(16(19)18-11(12)2)17-10-13-7-5-6-8-15(13)20-3/h5-9,17H,4,10H2,1-3H3,(H,18,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 265n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3123
PNG
(2-pyridinone deriv. 29 | 3-{[(2-ethoxyphenyl)methy...)
Show SMILES CCOc1ccccc1CNc1cc(CC)c(C)[nH]c1=O
Show InChI InChI=1S/C17H22N2O2/c1-4-13-10-15(17(20)19-12(13)3)18-11-14-8-6-7-9-16(14)21-5-2/h6-10,18H,4-5,11H2,1-3H3,(H,19,20)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 350n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3144
PNG
(2-pyridinone deriv. 50 | 5-ethyl-3-{[(4-ethyl-2-me...)
Show SMILES CCc1ccc(CNc2cc(CC)c(C)[nH]c2=O)c(OC)c1
Show InChI InChI=1S/C18H24N2O2/c1-5-13-7-8-15(17(9-13)22-4)11-19-16-10-14(6-2)12(3)20-18(16)21/h7-10,19H,5-6,11H2,1-4H3,(H,20,21)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 510n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3124
PNG
(2-pyridinone deriv. 30 | 5-ethyl-6-methyl-3-{[(2-n...)
Show SMILES CCc1cc(NCc2ccccc2[N+]([O-])=O)c(=O)[nH]c1C
Show InChI InChI=1S/C15H17N3O3/c1-3-11-8-13(15(19)17-10(11)2)16-9-12-6-4-5-7-14(12)18(20)21/h4-8,16H,3,9H2,1-2H3,(H,17,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 530n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3119
PNG
(2-pyridinone deriv. 25 | 5-ethyl-3-{[(2-methoxypyr...)
Show SMILES CCc1cc(NCc2cccnc2OC)c(=O)[nH]c1C
Show InChI InChI=1S/C15H19N3O2/c1-4-11-8-13(14(19)18-10(11)2)17-9-12-6-5-7-16-15(12)20-3/h5-8,17H,4,9H2,1-3H3,(H,18,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 680n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3125
PNG
(2-pyridinone deriv. 31 | 2-{[(5-ethyl-6-methyl-2-o...)
Show SMILES CCc1cc(NCc2ccccc2C#N)c(=O)[nH]c1C
Show InChI InChI=1S/C16H17N3O/c1-3-12-8-15(16(20)19-11(12)2)18-10-14-7-5-4-6-13(14)9-17/h4-8,18H,3,10H2,1-2H3,(H,19,20)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 790n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3135
PNG
(2-pyridinone deriv. 41 | 5-ethyl-3-{[(3-methoxyphe...)
Show SMILES CCc1cc(NCc2cccc(OC)c2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H20N2O2/c1-4-13-9-15(16(19)18-11(13)2)17-10-12-6-5-7-14(8-12)20-3/h5-9,17H,4,10H2,1-3H3,(H,18,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.25E+3n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3143
PNG
(2-pyridinone deriv. 49 | 5-ethyl-3-{[(2-methoxy-6-...)
Show SMILES CCc1cc(NCc2c(C)cccc2OC)c(=O)[nH]c1C
Show InChI InChI=1S/C17H22N2O2/c1-5-13-9-15(17(20)19-12(13)3)18-10-14-11(2)7-6-8-16(14)21-4/h6-9,18H,5,10H2,1-4H3,(H,19,20)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.30E+3n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3126
PNG
(2-pyridinone deriv. 32 | 5-ethyl-3-{[(2-fluorophen...)
Show SMILES CCc1cc(NCc2ccccc2F)c(=O)[nH]c1C
Show InChI InChI=1S/C15H17FN2O/c1-3-11-8-14(15(19)18-10(11)2)17-9-12-6-4-5-7-13(12)16/h4-8,17H,3,9H2,1-2H3,(H,18,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.40E+3n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3127
PNG
(2-pyridinone deriv. 33 | 3-{[(2-chlorophenyl)methy...)
Show SMILES CCc1cc(NCc2ccccc2Cl)c(=O)[nH]c1C
Show InChI InChI=1S/C15H17ClN2O/c1-3-11-8-14(15(19)18-10(11)2)17-9-12-6-4-5-7-13(12)16/h4-8,17H,3,9H2,1-2H3,(H,18,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.45E+3n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3128
PNG
(2-pyridinone deriv. 34 | 5-ethyl-6-methyl-3-({[2-(...)
Show SMILES CCc1cc(NCc2ccccc2SC)c(=O)[nH]c1C
Show InChI InChI=1S/C16H20N2OS/c1-4-12-9-14(16(19)18-11(12)2)17-10-13-7-5-6-8-15(13)20-3/h5-9,17H,4,10H2,1-3H3,(H,18,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.50E+3n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3139
PNG
(2-pyridinone deriv. 45 | 5-ethyl-3-{[(3-methoxypyr...)
Show SMILES CCc1cc(NCc2ncccc2OC)c(=O)[nH]c1C
Show InChI InChI=1S/C15H19N3O2/c1-4-11-8-12(15(19)18-10(11)2)17-9-13-14(20-3)6-5-7-16-13/h5-8,17H,4,9H2,1-3H3,(H,18,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.55E+3n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3129
PNG
(2-pyridinone deriv. 35 | 5-ethyl-6-methyl-3-{[(2-m...)
Show SMILES CCc1cc(NCc2ccccc2C)c(=O)[nH]c1C
Show InChI InChI=1S/C16H20N2O/c1-4-13-9-15(16(19)18-12(13)3)17-10-14-8-6-5-7-11(14)2/h5-9,17H,4,10H2,1-3H3,(H,18,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.20E+3n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3140
PNG
(2-pyridinone deriv. 46 | 5-ethyl-3-{[(2-methoxy-3-...)
Show SMILES CCc1cc(NCc2cccc(C)c2OC)c(=O)[nH]c1C
Show InChI InChI=1S/C17H22N2O2/c1-5-13-9-15(17(20)19-12(13)3)18-10-14-8-6-7-11(2)16(14)21-4/h6-9,18H,5,10H2,1-4H3,(H,19,20)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.80E+3n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3130
PNG
(2-pyridinone deriv. 36 | 5-ethyl-3-{[(2-hydroxyphe...)
Show SMILES CCc1cc(NCc2ccccc2O)c(=O)[nH]c1C
Show InChI InChI=1S/C15H18N2O2/c1-3-11-8-13(15(19)17-10(11)2)16-9-12-6-4-5-7-14(12)18/h4-8,16,18H,3,9H2,1-2H3,(H,17,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.60E+3n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM1298
PNG
(2-pyridinone deriv. 28 | 3-(benzylamino)-5-ethyl-6...)
Show SMILES CCc1cc(NCc2ccccc2)c(=O)[nH]c1C
Show InChI InChI=1S/C15H18N2O/c1-3-13-9-14(15(18)17-11(13)2)16-10-12-7-5-4-6-8-12/h4-9,16H,3,10H2,1-2H3,(H,17,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5.30E+3n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3131
PNG
(2-pyridinone deriv. 37 | 5-ethyl-3-{[(2-ethylpheny...)
Show SMILES CCc1ccccc1CNc1cc(CC)c(C)[nH]c1=O
Show InChI InChI=1S/C17H22N2O/c1-4-13-8-6-7-9-15(13)11-18-16-10-14(5-2)12(3)19-17(16)20/h6-10,18H,4-5,11H2,1-3H3,(H,19,20)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.90E+3n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3136
PNG
(2-pyridinone deriv. 42 | 5-ethyl-3-{[(4-methoxyphe...)
Show SMILES CCc1cc(NCc2ccc(OC)cc2)c(=O)[nH]c1C
Show InChI InChI=1S/C16H20N2O2/c1-4-13-9-15(16(19)18-11(13)2)17-10-12-5-7-14(20-3)8-6-12/h5-9,17H,4,10H2,1-3H3,(H,18,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 7.50E+3n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3138
PNG
(2-pyridinone deriv. 44 | 5-ethyl-3-{[(4-methoxypyr...)
Show SMILES CCc1cc(NCc2cnccc2OC)c(=O)[nH]c1C
Show InChI InChI=1S/C15H19N3O2/c1-4-11-7-13(15(19)18-10(11)2)17-9-12-8-16-6-5-14(12)20-3/h5-8,17H,4,9H2,1-3H3,(H,18,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.00E+4n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3132
PNG
(2-pyridinone deriv. 38 | 5-ethyl-6-methyl-3-({[2-(...)
Show SMILES CCc1cc(NCc2ccccc2C(F)(F)F)c(=O)[nH]c1C
Show InChI InChI=1S/C16H17F3N2O/c1-3-11-8-14(15(22)21-10(11)2)20-9-12-6-4-5-7-13(12)16(17,18)19/h4-8,20H,3,9H2,1-2H3,(H,21,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.25E+4n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3133
PNG
(2-pyridinone deriv. 39 | 3-{[(2-aminophenyl)methyl...)
Show SMILES CCc1cc(NCc2ccccc2N)c(=O)[nH]c1C
Show InChI InChI=1S/C15H19N3O/c1-3-11-8-14(15(19)18-10(11)2)17-9-12-6-4-5-7-13(12)16/h4-8,17H,3,9,16H2,1-2H3,(H,18,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.80E+4n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3134
PNG
(2-pyridinone deriv. 40 | 5-ethyl-3-({[2-(methoxyme...)
Show SMILES CCc1cc(NCc2ccccc2COC)c(=O)[nH]c1C
Show InChI InChI=1S/C17H22N2O2/c1-4-13-9-16(17(20)19-12(13)2)18-10-14-7-5-6-8-15(14)11-21-3/h5-9,18H,4,10-11H2,1-3H3,(H,19,20)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.55E+4n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3137
PNG
(2-pyridinone deriv. 43 | 5-ethyl-3-{[(3-methoxypyr...)
Show SMILES CCc1cc(NCc2ccncc2OC)c(=O)[nH]c1C
Show InChI InChI=1S/C15H19N3O2/c1-4-11-7-13(15(19)18-10(11)2)17-8-12-5-6-16-9-14(12)20-3/h5-7,9,17H,4,8H2,1-3H3,(H,18,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.10E+5n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM1308
PNG
(2-pyridinone deriv. 26 | 3-Aminopyridin-2(1H)-one ...)
Show SMILES CCc1cc(NCc2cccnc2)c(=O)[nH]c1C
Show InChI InChI=1S/C14H17N3O/c1-3-12-7-13(14(18)17-10(12)2)16-9-11-5-4-6-15-8-11/h4-8,16H,3,9H2,1-2H3,(H,17,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.00E+5n/an/an/an/a8.2n/a



Merck Research Laboratories



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 249-55 (1993)


Article DOI: 10.1021/jm00054a009
BindingDB Entry DOI: 10.7270/Q20863HM
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%