Affinity Data by PubMed id=8230130

PubMed code 8230130

Found 19 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50038176 (7-Chloro-3-nitro-3,4-dihydro-1H-quinolin-2-one \| C...) Show SMILES [O-][N+](=O)C1Cc2ccc(Cl)cc2NC1=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	414	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards NMDA receptor to displace [3H]-L-689,560 from rat cortical membranes				J Med Chem 36: 3397-408 (1993) BindingDB Entry DOI: 10.7270/Q2Z89BFF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50030668 ((7-Chloro-3-nitro-2-oxo-1,2,3,4-tetrahydro-quinoli...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.32E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards NMDA receptor to displace [3H]-L-689,560 from rat cortical membranes				J Med Chem 36: 3397-408 (1993) BindingDB Entry DOI: 10.7270/Q2Z89BFF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50042328 (2-(7-Chloro-3-nitro-2-oxo-1,2,3,4-tetrahydro-quino...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.84E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards NMDA receptor to displace [3H]-L-689,560 from rat cortical membranes				J Med Chem 36: 3397-408 (1993) BindingDB Entry DOI: 10.7270/Q2Z89BFF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50042324 ((7-Chloro-3-nitro-2-oxo-1,2,3,4-tetrahydro-quinoli...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.23E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards NMDA receptor to displace [3H]-L-689,560 from rat cortical membranes				J Med Chem 36: 3397-408 (1993) BindingDB Entry DOI: 10.7270/Q2Z89BFF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50042336 (CHEMBL115023 \| N-Benzyl-2-(7-chloro-3-nitro-2-oxo-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards NMDA receptor to displace [3H]-L-689,560 from rat cortical membranes				J Med Chem 36: 3397-408 (1993) BindingDB Entry DOI: 10.7270/Q2Z89BFF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50042331 (2-(7-Chloro-3-nitro-2-oxo-1,2,3,4-tetrahydro-quino...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.72E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards NMDA receptor to displace [3H]-L-689,560 from rat cortical membranes				J Med Chem 36: 3397-408 (1993) BindingDB Entry DOI: 10.7270/Q2Z89BFF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50042332 (7-Chloro-4-(3-methyl-[1,2,4]oxadiazol-5-ylmethyl)-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	5.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards NMDA receptor to displace [3H]-L-689,560 from rat cortical membranes				J Med Chem 36: 3397-408 (1993) BindingDB Entry DOI: 10.7270/Q2Z89BFF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50042322 (2-(7-Chloro-3-nitro-2-oxo-1,2,3,4-tetrahydro-quino...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	7.43E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards NMDA receptor to displace [3H]-L-689,560 from rat cortical membranes				J Med Chem 36: 3397-408 (1993) BindingDB Entry DOI: 10.7270/Q2Z89BFF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50042326 ((7-Chloro-3-cyano-2-oxo-1,2,3,4-tetrahydro-quinoli...) Show SMILES COC(=O)CC1C(C#N)C(=O)Nc2cc(Cl)ccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards NMDA receptor to displace [3H]-L-689,560 from rat cortical membranes				J Med Chem 36: 3397-408 (1993) BindingDB Entry DOI: 10.7270/Q2Z89BFF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50042337 (2-(7-Chloro-3-nitro-2-oxo-1,2,3,4-tetrahydro-quino...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.24E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards NMDA receptor to displace [3H]-L-689,560 from rat cortical membranes				J Med Chem 36: 3397-408 (1993) BindingDB Entry DOI: 10.7270/Q2Z89BFF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50042329 ((3-Nitro-2-oxo-1,2,3,4-tetrahydro-quinolin-4-yl)-a...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.86E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards NMDA receptor to displace [3H]-L-689,560 from rat cortical membranes				J Med Chem 36: 3397-408 (1993) BindingDB Entry DOI: 10.7270/Q2Z89BFF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50042333 ((7-Chloro-3-nitro-2-oxo-1,2-dihydro-quinolin-4-yl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	9.44E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards NMDA receptor to displace [3H]-L-689,560 from rat cortical membranes				J Med Chem 36: 3397-408 (1993) BindingDB Entry DOI: 10.7270/Q2Z89BFF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50042325 (7-Chloro-4-methoxycarbonylmethyl-2-oxo-1,2-dihydro...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards NMDA receptor to displace [3H]-L-689,560 from rat cortical membranes				J Med Chem 36: 3397-408 (1993) BindingDB Entry DOI: 10.7270/Q2Z89BFF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50042338 (CHEMBL116384 \| [7-Chloro-3-(4-nitro-benzenesulfony...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards NMDA receptor to displace [3H]-L-689,560 from rat cortical membranes				J Med Chem 36: 3397-408 (1993) BindingDB Entry DOI: 10.7270/Q2Z89BFF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50042330 ((3-Benzoyl-7-chloro-2-oxo-1,2,3,4-tetrahydro-quino...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards NMDA receptor to displace [3H]-L-689,560 from rat cortical membranes				J Med Chem 36: 3397-408 (1993) BindingDB Entry DOI: 10.7270/Q2Z89BFF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50042327 ((3-Benzenesulfonyl-7-chloro-2-oxo-1,2,3,4-tetrahyd...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards NMDA receptor to displace [3H]-L-689,560 from rat cortical membranes				J Med Chem 36: 3397-408 (1993) BindingDB Entry DOI: 10.7270/Q2Z89BFF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50042335 ((7-Chloro-3-methanesulfonyl-2-oxo-1,2,3,4-tetrahyd...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards NMDA receptor to displace [3H]-L-689,560 from rat cortical membranes				J Med Chem 36: 3397-408 (1993) BindingDB Entry DOI: 10.7270/Q2Z89BFF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50042323 (7-Chloro-4-methoxycarbonylmethyl-2-oxo-1,2,3,4-tet...) Show SMILES COC(=O)CC1C(C(=O)OC)C(=O)Nc2cc(Cl)ccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards NMDA receptor to displace [3H]-L-689,560 from rat cortical membranes				J Med Chem 36: 3397-408 (1993) BindingDB Entry DOI: 10.7270/Q2Z89BFF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50042334 ((7-Chloro-2-oxo-1,2,3,4-tetrahydro-quinolin-4-yl)-...) Show SMILES COC(=O)CC1CC(=O)Nc2cc(Cl)ccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards NMDA receptor to displace [3H]-L-689,560 from rat cortical membranes				J Med Chem 36: 3397-408 (1993) BindingDB Entry DOI: 10.7270/Q2Z89BFF
					More data for this Ligand-Target Pair

* indicates data uncertainty>20%