Affinity Data by PubMed id=8568811

PubMed code 8568811

Found 22 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50048961 (4'-((R)-2-Amino-3-mercapto-propylamino)-2'-methoxy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description In vitro inhibition of Farnesyltransferase				J Med Chem 39: 217-23 (1996) Article DOI: 10.1021/jm950414g BindingDB Entry DOI: 10.7270/Q23J3DM7
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50048953 (4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	114	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description In vitro inhibition of Farnesyltransferase				J Med Chem 39: 217-23 (1996) Article DOI: 10.1021/jm950414g BindingDB Entry DOI: 10.7270/Q23J3DM7
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50048955 ((S)-2-[4-((R)-2-Amino-3-mercapto-propionylamino)-b...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description In vitro inhibition of Farnesyltransferase				J Med Chem 39: 217-23 (1996) Article DOI: 10.1021/jm950414g BindingDB Entry DOI: 10.7270/Q23J3DM7
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50108076 ((S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propio...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description In vitro inhibition of Farnesyltransferase				J Med Chem 39: 217-23 (1996) Article DOI: 10.1021/jm950414g BindingDB Entry DOI: 10.7270/Q23J3DM7
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50048952 (4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-2...) Show SMILES N[C@@H](CS)CNc1ccc(cc1)-c1ccccc1C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	543	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of pig brain farnesyltransferase				J Med Chem 39: 217-23 (1996) Article DOI: 10.1021/jm950414g BindingDB Entry DOI: 10.7270/Q23J3DM7
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50048956 ((R)-2-Amino-3-(3'-methyl-biphenyl-4-ylamino)-propa...) Show SMILES Cc1cccc(c1)-c1ccc(NC[C@@H](N)CS)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	710	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description In vitro inhibition of Farnesyltransferase				J Med Chem 39: 217-23 (1996) Article DOI: 10.1021/jm950414g BindingDB Entry DOI: 10.7270/Q23J3DM7
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50048960 (4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	917	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description In vitro inhibition of Farnesyltransferase				J Med Chem 39: 217-23 (1996) Article DOI: 10.1021/jm950414g BindingDB Entry DOI: 10.7270/Q23J3DM7
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50048954 ((R)-2-Amino-3-(biphenyl-4-ylamino)-propane-1-thiol...) Show SMILES N[C@@H](CS)CNc1ccc(cc1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description In vitro inhibition of Farnesyltransferase				J Med Chem 39: 217-23 (1996) Article DOI: 10.1021/jm950414g BindingDB Entry DOI: 10.7270/Q23J3DM7
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50048959 (4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-4...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.58E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description In vitro inhibition of Farnesyltransferase				J Med Chem 39: 217-23 (1996) Article DOI: 10.1021/jm950414g BindingDB Entry DOI: 10.7270/Q23J3DM7
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50048958 (3'-[((R)-2-Amino-3-mercapto-propylamino)-methyl]-b...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description In vitro inhibition of Farnesyltransferase				J Med Chem 39: 217-23 (1996) Article DOI: 10.1021/jm950414g BindingDB Entry DOI: 10.7270/Q23J3DM7
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50048957 (4'-((R)-2-Amino-3-mercapto-propionylamino)-bipheny...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.35E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description In vitro inhibition of Farnesyltransferase				J Med Chem 39: 217-23 (1996) Article DOI: 10.1021/jm950414g BindingDB Entry DOI: 10.7270/Q23J3DM7
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50048958 (3'-[((R)-2-Amino-3-mercapto-propylamino)-methyl]-b...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description In vitro inhibition of Geranylgeranyl transferase type I				J Med Chem 39: 217-23 (1996) Article DOI: 10.1021/jm950414g BindingDB Entry DOI: 10.7270/Q23J3DM7
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50048961 (4'-((R)-2-Amino-3-mercapto-propylamino)-2'-methoxy...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.36E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description In vitro inhibition of Geranylgeranyl transferase type I				J Med Chem 39: 217-23 (1996) Article DOI: 10.1021/jm950414g BindingDB Entry DOI: 10.7270/Q23J3DM7
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50048954 ((R)-2-Amino-3-(biphenyl-4-ylamino)-propane-1-thiol...) Show SMILES N[C@@H](CS)CNc1ccc(cc1)-c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description In vitro inhibition of Geranylgeranyl transferase type I				J Med Chem 39: 217-23 (1996) Article DOI: 10.1021/jm950414g BindingDB Entry DOI: 10.7270/Q23J3DM7
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50048960 (4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description In vitro inhibition of Geranylgeranyl transferase type I				J Med Chem 39: 217-23 (1996) Article DOI: 10.1021/jm950414g BindingDB Entry DOI: 10.7270/Q23J3DM7
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50048956 ((R)-2-Amino-3-(3'-methyl-biphenyl-4-ylamino)-propa...) Show SMILES Cc1cccc(c1)-c1ccc(NC[C@@H](N)CS)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description In vitro inhibition of Geranylgeranyl transferase type I				J Med Chem 39: 217-23 (1996) Article DOI: 10.1021/jm950414g BindingDB Entry DOI: 10.7270/Q23J3DM7
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50048951 (3'-[((R)-2-Amino-3-mercapto-propionylamino)-methyl...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description In vitro inhibition of Geranylgeranyl transferase type I				J Med Chem 39: 217-23 (1996) Article DOI: 10.1021/jm950414g BindingDB Entry DOI: 10.7270/Q23J3DM7
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50048953 (4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description In vitro inhibition of Geranylgeranyl transferase type I				J Med Chem 39: 217-23 (1996) Article DOI: 10.1021/jm950414g BindingDB Entry DOI: 10.7270/Q23J3DM7
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50048957 (4'-((R)-2-Amino-3-mercapto-propionylamino)-bipheny...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description In vitro inhibition of Geranylgeranyl transferase type I				J Med Chem 39: 217-23 (1996) Article DOI: 10.1021/jm950414g BindingDB Entry DOI: 10.7270/Q23J3DM7
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50048959 (4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-4...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description In vitro inhibition of Geranylgeranyl transferase type I				J Med Chem 39: 217-23 (1996) Article DOI: 10.1021/jm950414g BindingDB Entry DOI: 10.7270/Q23J3DM7
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50048951 (3'-[((R)-2-Amino-3-mercapto-propionylamino)-methyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description In vitro inhibition of Farnesyltransferase				J Med Chem 39: 217-23 (1996) Article DOI: 10.1021/jm950414g BindingDB Entry DOI: 10.7270/Q23J3DM7
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50048952 (4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-2...) Show SMILES N[C@@H](CS)CNc1ccc(cc1)-c1ccccc1C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description In vitro inhibition of Geranylgeranyl transferase type I				J Med Chem 39: 217-23 (1996) Article DOI: 10.1021/jm950414g BindingDB Entry DOI: 10.7270/Q23J3DM7
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%