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PubMed code 9191950

Compile data set for download or QSAR
Found 20 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50058204
PNG
((S)-2-{[6-((R)-2-Amino-3-mercapto-propylamino)-nap...)
Show SMILES CSCC[C@H](NC(=O)c1cccc2cc(NC[C@@H](N)CS)ccc12)C(O)=O
Show InChI InChI=1S/C19H25N3O3S2/c1-27-8-7-17(19(24)25)22-18(23)16-4-2-3-12-9-14(5-6-15(12)16)21-10-13(20)11-26/h2-6,9,13,17,21,26H,7-8,10-11,20H2,1H3,(H,22,23)(H,24,25)/t13-,17+/m1/s1
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n/an/a 1.80n/an/an/an/an/an/a



Centre de Recherches de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into human Ha-Ras by farnesyltransferase

J Med Chem 40: 1763-7 (1997)


Article DOI: 10.1021/jm9701177
BindingDB Entry DOI: 10.7270/Q2J1029S
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50058199
PNG
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-nap...)
Show SMILES CSCC[C@H](NC(=S)c1cccc2c(NC[C@@H](N)CS)cccc12)C(O)=O
Show InChI InChI=1S/C19H25N3O2S3/c1-27-9-8-17(19(23)24)22-18(26)15-6-2-5-14-13(15)4-3-7-16(14)21-10-12(20)11-25/h2-7,12,17,21,25H,8-11,20H2,1H3,(H,22,26)(H,23,24)/t12-,17+/m1/s1
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n/an/a 4.80n/an/an/an/an/an/a



Centre de Recherches de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into human Ha-Ras by farnesyltransferase

J Med Chem 40: 1763-7 (1997)


Article DOI: 10.1021/jm9701177
BindingDB Entry DOI: 10.7270/Q2J1029S
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50058202
PNG
((S)-2-[(2-{(S)-2-[((R)-2-Amino-3-mercapto-propiony...)
Show SMILES CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](N)CS)C(O)=O
Show InChI InChI=1S/C24H36N4O5S2/c1-14(2)20(27(3)22(30)17(25)13-34)23(31)28-12-16-8-6-5-7-15(16)11-19(28)21(29)26-18(24(32)33)9-10-35-4/h5-8,14,17-20,34H,9-13,25H2,1-4H3,(H,26,29)(H,32,33)/t17-,18-,19-,20-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Centre de Recherches de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into human Ha-Ras by farnesyltransferase

J Med Chem 40: 1763-7 (1997)


Article DOI: 10.1021/jm9701177
BindingDB Entry DOI: 10.7270/Q2J1029S
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50058208
PNG
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-nap...)
Show SMILES CSCC[C@H](NC(=O)c1cccc2c(NC[C@@H](N)CS)cccc12)C(O)=O
Show InChI InChI=1S/C19H25N3O3S2/c1-27-9-8-17(19(24)25)22-18(23)15-6-2-5-14-13(15)4-3-7-16(14)21-10-12(20)11-26/h2-7,12,17,21,26H,8-11,20H2,1H3,(H,22,23)(H,24,25)/t12-,17+/m1/s1
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n/an/a 5.60n/an/an/an/an/an/a



Centre de Recherches de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into human Ha-Ras by farnesyltransferase

J Med Chem 40: 1763-7 (1997)


Article DOI: 10.1021/jm9701177
BindingDB Entry DOI: 10.7270/Q2J1029S
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50058200
PNG
((S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propio...)
Show SMILES CSCC[C@H](NC(=S)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C22H34N4O4S3/c1-13(2)18(26-19(27)15(23)12-31)20(28)24-17(11-14-7-5-4-6-8-14)21(32)25-16(22(29)30)9-10-33-3/h4-8,13,15-18,31H,9-12,23H2,1-3H3,(H,24,28)(H,25,32)(H,26,27)(H,29,30)/t15-,16-,17-,18-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Centre de Recherches de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into human Ha-Ras by farnesyltransferase

J Med Chem 40: 1763-7 (1997)


Article DOI: 10.1021/jm9701177
BindingDB Entry DOI: 10.7270/Q2J1029S
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50058204
PNG
((S)-2-{[6-((R)-2-Amino-3-mercapto-propylamino)-nap...)
Show SMILES CSCC[C@H](NC(=O)c1cccc2cc(NC[C@@H](N)CS)ccc12)C(O)=O
Show InChI InChI=1S/C19H25N3O3S2/c1-27-8-7-17(19(24)25)22-18(23)16-4-2-3-12-9-14(5-6-15(12)16)21-10-13(20)11-26/h2-6,9,13,17,21,26H,7-8,10-11,20H2,1H3,(H,22,23)(H,24,25)/t13-,17+/m1/s1
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n/an/a 17.5n/an/an/an/an/an/a



Centre de Recherches de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into human Ki-Ras by farnesyltransferase

J Med Chem 40: 1763-7 (1997)


Article DOI: 10.1021/jm9701177
BindingDB Entry DOI: 10.7270/Q2J1029S
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM13373
PNG
((2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O |r|
Show InChI InChI=1S/C22H34N4O5S2/c1-13(2)18(26-19(27)15(23)12-32)21(29)25-17(11-14-7-5-4-6-8-14)20(28)24-16(22(30)31)9-10-33-3/h4-8,13,15-18,32H,9-12,23H2,1-3H3,(H,24,28)(H,25,29)(H,26,27)(H,30,31)/t15-,16-,17-,18-/m0/s1
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n/an/a 37n/an/an/an/an/an/a



Centre de Recherches de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into human Ha-Ras by farnesyltransferase

J Med Chem 40: 1763-7 (1997)


Article DOI: 10.1021/jm9701177
BindingDB Entry DOI: 10.7270/Q2J1029S
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50058195
PNG
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-nap...)
Show SMILES CCCC[C@H](NC(=O)c1cccc2c(NC[C@@H](N)CS)cccc12)C(O)=O
Show InChI InChI=1S/C20H27N3O3S/c1-2-3-9-18(20(25)26)23-19(24)16-8-4-7-15-14(16)6-5-10-17(15)22-11-13(21)12-27/h4-8,10,13,18,22,27H,2-3,9,11-12,21H2,1H3,(H,23,24)(H,25,26)/t13-,18+/m1/s1
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n/an/a 44n/an/an/an/an/an/a



Centre de Recherches de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into human Ha-Ras by farnesyltransferase

J Med Chem 40: 1763-7 (1997)


Article DOI: 10.1021/jm9701177
BindingDB Entry DOI: 10.7270/Q2J1029S
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50058198
PNG
((S)-2-{[5-((R)-2-Amino-3-mercapto-propionylamino)-...)
Show SMILES CSCC[C@H](NC(=O)c1cccc2c(NC(=O)[C@@H](N)CS)cccc12)C(O)=O
Show InChI InChI=1S/C19H23N3O4S2/c1-28-9-8-16(19(25)26)22-17(23)13-6-2-5-12-11(13)4-3-7-15(12)21-18(24)14(20)10-27/h2-7,14,16,27H,8-10,20H2,1H3,(H,21,24)(H,22,23)(H,25,26)/t14-,16-/m0/s1
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n/an/a 48n/an/an/an/an/an/a



Centre de Recherches de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into human Ha-Ras by farnesyltransferase

J Med Chem 40: 1763-7 (1997)


Article DOI: 10.1021/jm9701177
BindingDB Entry DOI: 10.7270/Q2J1029S
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50058197
PNG
((S)-2-{[6-((R)-2-Amino-3-mercapto-propionylamino)-...)
Show SMILES CSCC[C@H](NC(=O)c1cccc2cc(NC(=O)[C@@H](N)CS)ccc12)C(O)=O
Show InChI InChI=1S/C19H23N3O4S2/c1-28-8-7-16(19(25)26)22-17(23)14-4-2-3-11-9-12(5-6-13(11)14)21-18(24)15(20)10-27/h2-6,9,15-16,27H,7-8,10,20H2,1H3,(H,21,24)(H,22,23)(H,25,26)/t15-,16-/m0/s1
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n/an/a 60n/an/an/an/an/an/a



Centre de Recherches de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into human Ha-Ras by farnesyltransferase

J Med Chem 40: 1763-7 (1997)


Article DOI: 10.1021/jm9701177
BindingDB Entry DOI: 10.7270/Q2J1029S
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50058193
PNG
((S)-2-{[6-((R)-2-Amino-3-mercapto-propylamino)-nap...)
Show SMILES COC(=O)[C@H](CCSC)NC(=O)c1cccc2cc(NC[C@@H](N)CS)ccc12
Show InChI InChI=1S/C20H27N3O3S2/c1-26-20(25)18(8-9-28-2)23-19(24)17-5-3-4-13-10-15(6-7-16(13)17)22-11-14(21)12-27/h3-7,10,14,18,22,27H,8-9,11-12,21H2,1-2H3,(H,23,24)/t14-,18+/m1/s1
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n/an/a 80n/an/an/an/an/an/a



Centre de Recherches de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into human Ha-Ras by farnesyltransferase

J Med Chem 40: 1763-7 (1997)


Article DOI: 10.1021/jm9701177
BindingDB Entry DOI: 10.7270/Q2J1029S
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50058207
PNG
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-nap...)
Show SMILES CSCC[C@H](N(C)C(=O)c1cccc2c(NC[C@@H](N)CS)cccc12)C(O)=O
Show InChI InChI=1S/C20H27N3O3S2/c1-23(18(20(25)26)9-10-28-2)19(24)16-7-3-6-15-14(16)5-4-8-17(15)22-11-13(21)12-27/h3-8,13,18,22,27H,9-12,21H2,1-2H3,(H,25,26)/t13-,18+/m1/s1
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n/an/a 210n/an/an/an/an/an/a



Centre de Recherches de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into human Ha-Ras by farnesyltransferase

J Med Chem 40: 1763-7 (1997)


Article DOI: 10.1021/jm9701177
BindingDB Entry DOI: 10.7270/Q2J1029S
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50058196
PNG
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-nap...)
Show SMILES COC(=O)[C@H](CCSC)NC(=O)c1cccc2c(NC[C@@H](N)CS)cccc12
Show InChI InChI=1S/C20H27N3O3S2/c1-26-20(25)18(9-10-28-2)23-19(24)16-7-3-6-15-14(16)5-4-8-17(15)22-11-13(21)12-27/h3-8,13,18,22,27H,9-12,21H2,1-2H3,(H,23,24)/t13-,18+/m1/s1
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n/an/a 325n/an/an/an/an/an/a



Centre de Recherches de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into human Ha-Ras by farnesyltransferase

J Med Chem 40: 1763-7 (1997)


Article DOI: 10.1021/jm9701177
BindingDB Entry DOI: 10.7270/Q2J1029S
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50058193
PNG
((S)-2-{[6-((R)-2-Amino-3-mercapto-propylamino)-nap...)
Show SMILES COC(=O)[C@H](CCSC)NC(=O)c1cccc2cc(NC[C@@H](N)CS)ccc12
Show InChI InChI=1S/C20H27N3O3S2/c1-26-20(25)18(8-9-28-2)23-19(24)17-5-3-4-13-10-15(6-7-16(13)17)22-11-14(21)12-27/h3-7,10,14,18,22,27H,8-9,11-12,21H2,1-2H3,(H,23,24)/t14-,18+/m1/s1
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n/an/a 500n/an/an/an/an/an/a



Centre de Recherches de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into human Ki-Ras by farnesyltransferase

J Med Chem 40: 1763-7 (1997)


Article DOI: 10.1021/jm9701177
BindingDB Entry DOI: 10.7270/Q2J1029S
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50058205
PNG
((S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propio...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C23H36N4O5S/c1-4-5-11-17(23(31)32)25-21(29)18(12-15-9-7-6-8-10-15)26-22(30)19(14(2)3)27-20(28)16(24)13-33/h6-10,14,16-19,33H,4-5,11-13,24H2,1-3H3,(H,25,29)(H,26,30)(H,27,28)(H,31,32)/t16-,17-,18-,19-/m0/s1
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n/an/a 950n/an/an/an/an/an/a



Centre de Recherches de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into human Ha-Ras by farnesyltransferase

J Med Chem 40: 1763-7 (1997)


Article DOI: 10.1021/jm9701177
BindingDB Entry DOI: 10.7270/Q2J1029S
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50058197
PNG
((S)-2-{[6-((R)-2-Amino-3-mercapto-propionylamino)-...)
Show SMILES CSCC[C@H](NC(=O)c1cccc2cc(NC(=O)[C@@H](N)CS)ccc12)C(O)=O
Show InChI InChI=1S/C19H23N3O4S2/c1-28-8-7-16(19(25)26)22-17(23)14-4-2-3-11-9-12(5-6-13(11)14)21-18(24)15(20)10-27/h2-6,9,15-16,27H,7-8,10,20H2,1H3,(H,21,24)(H,22,23)(H,25,26)/t15-,16-/m0/s1
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n/an/a 1.25E+3n/an/an/an/an/an/a



Centre de Recherches de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into human Ki-Ras by farnesyltransferase

J Med Chem 40: 1763-7 (1997)


Article DOI: 10.1021/jm9701177
BindingDB Entry DOI: 10.7270/Q2J1029S
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50058206
PNG
((S)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propi...)
Show SMILES CSCC[C@H](N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C23H36N4O5S2/c1-14(2)19(26-20(28)16(24)13-33)21(29)25-17(12-15-8-6-5-7-9-15)22(30)27(3)18(23(31)32)10-11-34-4/h5-9,14,16-19,33H,10-13,24H2,1-4H3,(H,25,29)(H,26,28)(H,31,32)/t16-,17-,18-,19-/m0/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



Centre de Recherches de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into human Ha-Ras by farnesyltransferase

J Med Chem 40: 1763-7 (1997)


Article DOI: 10.1021/jm9701177
BindingDB Entry DOI: 10.7270/Q2J1029S
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50058203
PNG
((S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propio...)
Show SMILES CSCC[C@H](NC[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C22H36N4O4S2/c1-14(2)19(26-20(27)17(23)13-31)21(28)25-16(11-15-7-5-4-6-8-15)12-24-18(22(29)30)9-10-32-3/h4-8,14,16-19,24,31H,9-13,23H2,1-3H3,(H,25,28)(H,26,27)(H,29,30)/t16-,17-,18-,19-/m0/s1
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n/an/a 2.22E+3n/an/an/an/an/an/a



Centre de Recherches de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into human Ha-Ras by farnesyltransferase

J Med Chem 40: 1763-7 (1997)


Article DOI: 10.1021/jm9701177
BindingDB Entry DOI: 10.7270/Q2J1029S
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50058194
PNG
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-nap...)
Show SMILES CSCC[C@H](NCc1cccc2c(NC[C@@H](N)CS)cccc12)C(O)=O
Show InChI InChI=1S/C19H27N3O2S2/c1-26-9-8-18(19(23)24)21-10-13-4-2-6-16-15(13)5-3-7-17(16)22-11-14(20)12-25/h2-7,14,18,21-22,25H,8-12,20H2,1H3,(H,23,24)/t14-,18+/m1/s1
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n/an/a 2.57E+3n/an/an/an/an/an/a



Centre de Recherches de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into human Ha-Ras by farnesyltransferase

J Med Chem 40: 1763-7 (1997)


Article DOI: 10.1021/jm9701177
BindingDB Entry DOI: 10.7270/Q2J1029S
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50058201
PNG
((S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propio...)
Show SMILES COC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C
Show InChI InChI=1S/C23H36N4O5S2/c1-14(2)19(27-20(28)16(24)13-33)22(30)26-18(12-15-8-6-5-7-9-15)21(29)25-17(10-11-34-4)23(31)32-3/h5-9,14,16-19,33H,10-13,24H2,1-4H3,(H,25,29)(H,26,30)(H,27,28)/t16-,17-,18-,19-/m0/s1
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n/an/a 3.40E+3n/an/an/an/an/an/a



Centre de Recherches de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into human Ha-Ras by farnesyltransferase

J Med Chem 40: 1763-7 (1997)


Article DOI: 10.1021/jm9701177
BindingDB Entry DOI: 10.7270/Q2J1029S
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%