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PubMed code 9191956

Compile data set for download or QSAR
Found 51 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50051289
PNG
((R)-Phenyl-[(2-phenyl-quinoline-4-carbonyl)-amino]...)
Show SMILES COC(=O)[C@H](NC(=O)c1cc(nc2ccccc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H20N2O3/c1-30-25(29)23(18-12-6-3-7-13-18)27-24(28)20-16-22(17-10-4-2-5-11-17)26-21-15-9-8-14-19(20)21/h2-16,23H,1H3,(H,27,28)/t23-/m1/s1
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 13n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058261
PNG
(CHEMBL53765 | Phenyl-[(2-thiophen-3-yl-quinoline-4...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1ccsc1)c1ccccc1
Show InChI InChI=1S/C23H18N2O3S/c1-28-23(27)21(15-7-3-2-4-8-15)25-22(26)18-13-20(16-11-12-29-14-16)24-19-10-6-5-9-17(18)19/h2-14,21H,1H3,(H,25,26)
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 26n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50051291
PNG
(CHEMBL429951 | Phenyl-[(2-phenyl-quinoline-4-carbo...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H20N2O3/c1-30-25(29)23(18-12-6-3-7-13-18)27-24(28)20-16-22(17-10-4-2-5-11-17)26-21-15-9-8-14-19(20)21/h2-16,23H,1H3,(H,27,28)
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 31n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058271
PNG
(CHEMBL416309 | Phenyl-{[2-(1H-pyrrol-2-yl)-quinoli...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1ccc[nH]1)c1ccccc1
Show InChI InChI=1S/C23H19N3O3/c1-29-23(28)21(15-8-3-2-4-9-15)26-22(27)17-14-20(19-12-7-13-24-19)25-18-11-6-5-10-16(17)18/h2-14,21,24H,1H3,(H,26,27)
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 49n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058268
PNG
(CHEMBL297736 | [(7-Methoxy-2-phenyl-quinoline-4-ca...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2cc(OC)ccc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H22N2O4/c1-31-19-13-14-20-21(16-22(27-23(20)15-19)17-9-5-3-6-10-17)25(29)28-24(26(30)32-2)18-11-7-4-8-12-18/h3-16,24H,1-2H3,(H,28,29)
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 57n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058276
PNG
(CHEMBL301564 | Phenyl-[(2-thiophen-2-yl-quinoline-...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1cccs1)c1ccccc1
Show InChI InChI=1S/C23H18N2O3S/c1-28-23(27)21(15-8-3-2-4-9-15)25-22(26)17-14-19(20-12-7-13-29-20)24-18-11-6-5-10-16(17)18/h2-14,21H,1H3,(H,25,26)
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 66n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058275
PNG
(CHEMBL50302 | [(2-Furan-2-yl-quinoline-4-carbonyl)...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1ccco1)c1ccccc1
Show InChI InChI=1S/C23H18N2O4/c1-28-23(27)21(15-8-3-2-4-9-15)25-22(26)17-14-19(20-12-7-13-29-20)24-18-11-6-5-10-16(17)18/h2-14,21H,1H3,(H,25,26)
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 77n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058246
PNG
(CHEMBL49999 | {[2-(2-Fluoro-phenyl)-quinoline-4-ca...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1ccccc1F)c1ccccc1
Show InChI InChI=1S/C25H19FN2O3/c1-31-25(30)23(16-9-3-2-4-10-16)28-24(29)19-15-22(18-12-5-7-13-20(18)26)27-21-14-8-6-11-17(19)21/h2-15,23H,1H3,(H,28,29)
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 96n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058263
PNG
(CHEMBL300967 | Phenyl-{[2-(1H-pyrrol-3-yl)-quinoli...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1cc[nH]c1)c1ccccc1
Show InChI InChI=1S/C23H19N3O3/c1-29-23(28)21(15-7-3-2-4-8-15)26-22(27)18-13-20(16-11-12-24-14-16)25-19-10-6-5-9-17(18)19/h2-14,21,24H,1H3,(H,26,27)
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 118n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058257
PNG
(CHEMBL300249 | [(2-Cyclohexyl-quinoline-4-carbonyl...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2ccccc12)C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C25H26N2O3/c1-30-25(29)23(18-12-6-3-7-13-18)27-24(28)20-16-22(17-10-4-2-5-11-17)26-21-15-9-8-14-19(20)21/h3,6-9,12-17,23H,2,4-5,10-11H2,1H3,(H,27,28)
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 132n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058254
PNG
(CHEMBL300180 | Phenyl-[(2-p-tolyl-quinoline-4-carb...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1ccc(C)cc1)c1ccccc1
Show InChI InChI=1S/C26H22N2O3/c1-17-12-14-18(15-13-17)23-16-21(20-10-6-7-11-22(20)27-23)25(29)28-24(26(30)31-2)19-8-4-3-5-9-19/h3-16,24H,1-2H3,(H,28,29)
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 142n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058266
PNG
(CHEMBL50571 | [(6,7-Dihydro-5H-13-aza-benzo[3,4]cy...)
Show SMILES COC(=O)C(NC(=O)c1c2CCCc3ccccc3-c2nc2ccccc12)c1ccccc1
Show InChI InChI=1S/C28H24N2O3/c1-33-28(32)25(19-11-3-2-4-12-19)30-27(31)24-21-15-7-8-17-23(21)29-26-20-14-6-5-10-18(20)13-9-16-22(24)26/h2-8,10-12,14-15,17,25H,9,13,16H2,1H3,(H,30,31)
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 180n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058273
PNG
(CHEMBL51552 | [(2-Phenyl-quinoline-4-carbonyl)-ami...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1ccccc1)c1cccs1
Show InChI InChI=1S/C23H18N2O3S/c1-28-23(27)21(20-12-7-13-29-20)25-22(26)17-14-19(15-8-3-2-4-9-15)24-18-11-6-5-10-16(17)18/h2-14,21H,1H3,(H,25,26)
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 180n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058255
PNG
(CHEMBL301278 | [(5,6-Dihydro-benzo[c]acridine-7-ca...)
Show SMILES COC(=O)C(NC(=O)c1c2CCc3ccccc3-c2nc2ccccc12)c1ccccc1
Show InChI InChI=1S/C27H22N2O3/c1-32-27(31)24(18-10-3-2-4-11-18)29-26(30)23-20-13-7-8-14-22(20)28-25-19-12-6-5-9-17(19)15-16-21(23)25/h2-14,24H,15-16H2,1H3,(H,29,30)
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 234n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058253
PNG
(2-Phenyl-quinoline-4-carboxylic acid benzylamide |...)
Show SMILES O=C(NCc1ccccc1)c1cc(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C23H18N2O/c26-23(24-16-17-9-3-1-4-10-17)20-15-22(18-11-5-2-6-12-18)25-21-14-8-7-13-19(20)21/h1-15H,16H2,(H,24,26)
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 355n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058242
PNG
(CHEMBL53719 | [(2-Benzofuran-2-yl-quinoline-4-carb...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1cc2ccccc2o1)c1ccccc1
Show InChI InChI=1S/C27H20N2O4/c1-32-27(31)25(17-9-3-2-4-10-17)29-26(30)20-16-22(28-21-13-7-6-12-19(20)21)24-15-18-11-5-8-14-23(18)33-24/h2-16,25H,1H3,(H,29,30)
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 377n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058272
PNG
(CHEMBL52496 | {[2-(4-Hydroxy-phenyl)-quinoline-4-c...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1ccc(O)cc1)c1ccccc1
Show InChI InChI=1S/C25H20N2O4/c1-31-25(30)23(17-7-3-2-4-8-17)27-24(29)20-15-22(16-11-13-18(28)14-12-16)26-21-10-6-5-9-19(20)21/h2-15,23,28H,1H3,(H,27,29)
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 493n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058252
PNG
(CHEMBL54205 | {[2-(3-Chloro-phenyl)-quinoline-4-ca...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C25H19ClN2O3/c1-31-25(30)23(16-8-3-2-4-9-16)28-24(29)20-15-22(17-10-7-11-18(26)14-17)27-21-13-6-5-12-19(20)21/h2-15,23H,1H3,(H,28,29)
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 629n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058281
PNG
(CHEMBL298185 | {[2-(2-Hydroxy-phenyl)-quinoline-4-...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1ccccc1O)c1ccccc1
Show InChI InChI=1S/C25H20N2O4/c1-31-25(30)23(16-9-3-2-4-10-16)27-24(29)19-15-21(18-12-6-8-14-22(18)28)26-20-13-7-5-11-17(19)20/h2-15,23,28H,1H3,(H,27,29)
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 653n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058280
PNG
((R)-(4-Methoxy-phenyl)-[(2-phenyl-quinoline-4-carb...)
Show SMILES COC(=O)[C@H](NC(=O)c1cc(nc2ccccc12)-c1ccccc1)c1ccc(OC)cc1
Show InChI InChI=1S/C26H22N2O4/c1-31-19-14-12-18(13-15-19)24(26(30)32-2)28-25(29)21-16-23(17-8-4-3-5-9-17)27-22-11-7-6-10-20(21)22/h3-16,24H,1-2H3,(H,28,29)/t24-/m1/s1
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 666n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058264
PNG
(CHEMBL299973 | {[2-(2-Methoxy-phenyl)-quinoline-4-...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1ccccc1OC)c1ccccc1
Show InChI InChI=1S/C26H22N2O4/c1-31-23-15-9-7-13-19(23)22-16-20(18-12-6-8-14-21(18)27-22)25(29)28-24(26(30)32-2)17-10-4-3-5-11-17/h3-16,24H,1-2H3,(H,28,29)
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 786n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058241
PNG
(CHEMBL53433 | {[2-(4-Chloro-phenyl)-quinoline-4-ca...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1S/C25H19ClN2O3/c1-31-25(30)23(17-7-3-2-4-8-17)28-24(29)20-15-22(16-11-13-18(26)14-12-16)27-21-10-6-5-9-19(20)21/h2-15,23H,1H3,(H,28,29)
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 820n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50051296
PNG
(7-Methoxy-2-phenyl-quinoline-4-carboxylic acid ben...)
Show SMILES COc1ccc2c(cc(nc2c1)-c1ccccc1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C24H20N2O2/c1-28-19-12-13-20-21(24(27)25-16-17-8-4-2-5-9-17)15-22(26-23(20)14-19)18-10-6-3-7-11-18/h2-15H,16H2,1H3,(H,25,27)
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 870n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058278
PNG
(CHEMBL53356 | Phenyl-[(2-phenyl-quinazoline-4-carb...)
Show SMILES COC(=O)C(NC(=O)c1nc(nc2ccccc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H19N3O3/c1-30-24(29)20(16-10-4-2-5-11-16)27-23(28)21-18-14-8-9-15-19(18)25-22(26-21)17-12-6-3-7-13-17/h2-15,20H,1H3,(H,27,28)
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 883n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058279
PNG
(7-Methoxy-2-phenyl-quinoline-4-carboxylic acid phe...)
Show SMILES COc1ccc2c(cc(nc2c1)-c1ccccc1)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C25H22N2O2/c1-29-20-12-13-21-22(25(28)26-15-14-18-8-4-2-5-9-18)17-23(27-24(21)16-20)19-10-6-3-7-11-19/h2-13,16-17H,14-15H2,1H3,(H,26,28)
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 919n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058277
PNG
(CHEMBL51274 | Phenyl-[(2-thiazol-2-yl-quinoline-4-...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1nccs1)c1ccccc1
Show InChI InChI=1S/C22H17N3O3S/c1-28-22(27)19(14-7-3-2-4-8-14)25-20(26)16-13-18(21-23-11-12-29-21)24-17-10-6-5-9-15(16)17/h2-13,19H,1H3,(H,25,26)
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 924n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50051292
PNG
((S)-Phenyl-[(2-phenyl-quinoline-4-carbonyl)-amino]...)
Show SMILES COC(=O)[C@@H](NC(=O)c1cc(nc2ccccc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H20N2O3/c1-30-25(29)23(18-12-6-3-7-13-18)27-24(28)20-16-22(17-10-4-2-5-11-17)26-21-15-9-8-14-19(20)21/h2-16,23H,1H3,(H,27,28)/t23-/m0/s1
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 926n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058256
PNG
(CHEMBL300869 | [Methyl-(2-phenyl-quinoline-4-carbo...)
Show SMILES COC(=O)C(N(C)C(=O)c1cc(nc2ccccc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H22N2O3/c1-28(24(26(30)31-2)19-13-7-4-8-14-19)25(29)21-17-23(18-11-5-3-6-12-18)27-22-16-10-9-15-20(21)22/h3-17,24H,1-2H3
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 1.08E+3n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058259
PNG
(3-Phenyl-2-[(2-phenyl-quinoline-4-carbonyl)-amino]...)
Show SMILES COC(=O)C(Cc1ccccc1)NC(=O)c1cc(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C26H22N2O3/c1-31-26(30)24(16-18-10-4-2-5-11-18)28-25(29)21-17-23(19-12-6-3-7-13-19)27-22-15-9-8-14-20(21)22/h2-15,17,24H,16H2,1H3,(H,28,29)
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 1.15E+3n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058245
PNG
(CHEMBL53884 | Phenyl-[(3-phenyl-naphthalene-1-carb...)
Show SMILES COC(=O)C(NC(=O)c1cc(cc2ccccc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H21NO3/c1-30-26(29)24(19-12-6-3-7-13-19)27-25(28)23-17-21(18-10-4-2-5-11-18)16-20-14-8-9-15-22(20)23/h2-17,24H,1H3,(H,27,28)
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 1.20E+3n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))		BDBM50051289
PNG
((R)-Phenyl-[(2-phenyl-quinoline-4-carbonyl)-amino]...)
Show SMILES COC(=O)[C@H](NC(=O)c1cc(nc2ccccc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H20N2O3/c1-30-25(29)23(18-12-6-3-7-13-18)27-24(28)20-16-22(17-10-4-2-5-11-17)26-21-15-9-8-14-19(20)21/h2-16,23H,1H3,(H,27,28)/t23-/m1/s1
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 1.22E+3n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-Neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058265
PNG
(CHEMBL52537 | Phenyl-[(2-o-tolyl-quinoline-4-carbo...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1ccccc1C)c1ccccc1
Show InChI InChI=1S/C26H22N2O3/c1-17-10-6-7-13-19(17)23-16-21(20-14-8-9-15-22(20)27-23)25(29)28-24(26(30)31-2)18-11-4-3-5-12-18/h3-16,24H,1-2H3,(H,28,29)
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 1.24E+3n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058262
PNG
(7-Methoxy-2-phenyl-quinoline-4-carboxylic acid phe...)
Show SMILES COc1ccc2c(cc(nc2c1)-c1ccccc1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C23H18N2O2/c1-27-18-12-13-19-20(23(26)24-17-10-6-3-7-11-17)15-21(25-22(19)14-18)16-8-4-2-5-9-16/h2-15H,1H3,(H,24,26)
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 1.67E+3n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058260
PNG
(CHEMBL52960 | {[2-(4-Methoxy-phenyl)-quinoline-4-c...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1ccc(OC)cc1)c1ccccc1
Show InChI InChI=1S/C26H22N2O4/c1-31-19-14-12-17(13-15-19)23-16-21(20-10-6-7-11-22(20)27-23)25(29)28-24(26(30)32-2)18-8-4-3-5-9-18/h3-16,24H,1-2H3,(H,28,29)
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 1.85E+3n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058274
PNG
((R)-(4-Hydroxy-phenyl)-[(2-phenyl-quinoline-4-carb...)
Show SMILES COC(=O)[C@H](NC(=O)c1cc(nc2ccccc12)-c1ccccc1)c1ccc(O)cc1
Show InChI InChI=1S/C25H20N2O4/c1-31-25(30)23(17-11-13-18(28)14-12-17)27-24(29)20-15-22(16-7-3-2-4-8-16)26-21-10-6-5-9-19(20)21/h2-15,23,28H,1H3,(H,27,29)/t23-/m1/s1
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 1.93E+3n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058258
PNG
(CHEMBL416487 | Phenyl-[(2-pyridin-4-yl-quinoline-4...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1ccncc1)c1ccccc1
Show InChI InChI=1S/C24H19N3O3/c1-30-24(29)22(17-7-3-2-4-8-17)27-23(28)19-15-21(16-11-13-25-14-12-16)26-20-10-6-5-9-18(19)20/h2-15,22H,1H3,(H,27,28)
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 2.23E+3n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058243
PNG
(CHEMBL299518 | {[2-(2-Chloro-phenyl)-quinoline-4-c...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1ccccc1Cl)c1ccccc1
Show InChI InChI=1S/C25H19ClN2O3/c1-31-25(30)23(16-9-3-2-4-10-16)28-24(29)19-15-22(18-12-5-7-13-20(18)26)27-21-14-8-6-11-17(19)21/h2-15,23H,1H3,(H,28,29)
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 2.58E+3n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))		BDBM50051291
PNG
(CHEMBL429951 | Phenyl-[(2-phenyl-quinoline-4-carbo...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H20N2O3/c1-30-25(29)23(18-12-6-3-7-13-18)27-24(28)20-16-22(17-10-4-2-5-11-17)26-21-15-9-8-14-19(20)21/h2-16,23H,1H3,(H,27,28)
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 2.95E+3n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-Neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058267
PNG
(CHEMBL301603 | [(7-Methoxy-2-phenyl-quinoline-4-ca...)
Show SMILES COc1ccc2c(cc(nc2c1)-c1ccccc1)C(=O)NC(C(O)=O)c1ccccc1
Show InChI InChI=1S/C25H20N2O4/c1-31-18-12-13-19-20(15-21(26-22(19)14-18)16-8-4-2-5-9-16)24(28)27-23(25(29)30)17-10-6-3-7-11-17/h2-15,23H,1H3,(H,27,28)(H,29,30)
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 5.18E+3n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058250
PNG
(Benzyl-(7-methoxy-2-phenyl-quinolin-4-ylmethyl)-am...)
Show SMILES COc1ccc2c(CNCc3ccccc3)cc(nc2c1)-c1ccccc1
Show InChI InChI=1S/C24H22N2O/c1-27-21-12-13-22-20(17-25-16-18-8-4-2-5-9-18)14-23(26-24(22)15-21)19-10-6-3-7-11-19/h2-15,25H,16-17H2,1H3
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 6.20E+3n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058248
PNG
((R)-3-Methyl-2-[(2-phenyl-quinoline-4-carbonyl)-am...)
Show SMILES COC(=O)[C@H](NC(=O)c1cc(nc2ccccc12)-c1ccccc1)C(C)C
Show InChI InChI=1S/C22H22N2O3/c1-14(2)20(22(26)27-3)24-21(25)17-13-19(15-9-5-4-6-10-15)23-18-12-8-7-11-16(17)18/h4-14,20H,1-3H3,(H,24,25)/t20-/m1/s1
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 6.21E+3n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058244
PNG
((7-Methoxy-2-phenyl-quinolin-4-yl)-carbamic acid b...)
Show SMILES COc1ccc2c(NC(=O)OCc3ccccc3)cc(nc2c1)-c1ccccc1
Show InChI InChI=1S/C24H20N2O3/c1-28-19-12-13-20-22(14-19)25-21(18-10-6-3-7-11-18)15-23(20)26-24(27)29-16-17-8-4-2-5-9-17/h2-15H,16H2,1H3,(H,25,26,27)
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 8.13E+3n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))		BDBM50051292
PNG
((S)-Phenyl-[(2-phenyl-quinoline-4-carbonyl)-amino]...)
Show SMILES COC(=O)[C@@H](NC(=O)c1cc(nc2ccccc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H20N2O3/c1-30-25(29)23(18-12-6-3-7-13-18)27-24(28)20-16-22(17-10-4-2-5-11-17)26-21-15-9-8-14-19(20)21/h2-16,23H,1H3,(H,27,28)/t23-/m0/s1
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 8.33E+3n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-Neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058247
PNG
(CHEMBL52907 | Phenyl-[(2-phenyl-pyridine-4-carbony...)
Show SMILES COC(=O)C(NC(=O)c1ccnc(c1)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H18N2O3/c1-26-21(25)19(16-10-6-3-7-11-16)23-20(24)17-12-13-22-18(14-17)15-8-4-2-5-9-15/h2-14,19H,1H3,(H,23,24)
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>1.00E+4n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058249
PNG
(CHEMBL53800 | Phenyl-[(3-phenyl-isoquinoline-1-car...)
Show SMILES COC(=O)C(NC(=O)c1nc(cc2ccccc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H20N2O3/c1-30-25(29)22(18-12-6-3-7-13-18)27-24(28)23-20-15-9-8-14-19(20)16-21(26-23)17-10-4-2-5-11-17/h2-16,22H,1H3,(H,27,28)
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>1.00E+4n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058270
PNG
(Benzyl-(7-methoxy-2-phenyl-quinolin-4-yl)-amine | ...)
Show SMILES COc1ccc2c(NCc3ccccc3)cc(nc2c1)-c1ccccc1
Show InChI InChI=1S/C23H20N2O/c1-26-19-12-13-20-22(24-16-17-8-4-2-5-9-17)15-21(25-23(20)14-19)18-10-6-3-7-11-18/h2-15H,16H2,1H3,(H,24,25)
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 1.03E+4n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058251
PNG
(7-Methoxy-2-methyl-quinoline-4-carboxylic acid ben...)
Show SMILES COc1ccc2c(cc(C)nc2c1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C19H18N2O2/c1-13-10-17(16-9-8-15(23-2)11-18(16)21-13)19(22)20-12-14-6-4-3-5-7-14/h3-11H,12H2,1-2H3,(H,20,22)
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>3.30E+4n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50058269
PNG
(2-Benzyl-7-methoxy-quinoline-4-carboxylic acid ben...)
Show SMILES COc1ccc2c(cc(Cc3ccccc3)nc2c1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C25H22N2O2/c1-29-21-12-13-22-23(25(28)26-17-19-10-6-3-7-11-19)15-20(27-24(22)16-21)14-18-8-4-2-5-9-18/h2-13,15-16H,14,17H2,1H3,(H,26,28)
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>3.30E+4n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes.

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50051289
PNG
((R)-Phenyl-[(2-phenyl-quinoline-4-carbonyl)-amino]...)
Show SMILES COC(=O)[C@H](NC(=O)c1cc(nc2ccccc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H20N2O3/c1-30-25(29)23(18-12-6-3-7-13-18)27-24(28)20-16-22(17-10-4-2-5-11-17)26-21-15-9-8-14-19(20)21/h2-16,23H,1H3,(H,27,28)/t23-/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [3H]-substance P binding in human Tachykinin receptor 1 of chinese hamster ovary (hNK-1-CHO) cell membranes

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50051291
PNG
(CHEMBL429951 | Phenyl-[(2-phenyl-quinoline-4-carbo...)
Show SMILES COC(=O)C(NC(=O)c1cc(nc2ccccc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H20N2O3/c1-30-25(29)23(18-12-6-3-7-13-18)27-24(28)20-16-22(17-10-4-2-5-11-17)26-21-15-9-8-14-19(20)21/h2-16,23H,1H3,(H,27,28)
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>1.00E+5n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [3H]-substance P binding in human Tachykinin receptor 1 of chinese hamster ovary (hNK-1-CHO) cell membranes

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50051292
PNG
((S)-Phenyl-[(2-phenyl-quinoline-4-carbonyl)-amino]...)
Show SMILES COC(=O)[C@@H](NC(=O)c1cc(nc2ccccc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H20N2O3/c1-30-25(29)23(18-12-6-3-7-13-18)27-24(28)20-16-22(17-10-4-2-5-11-17)26-21-15-9-8-14-19(20)21/h2-16,23H,1H3,(H,27,28)/t23-/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



SmithKline Beecham S.p.A. Milano

Curated by ChEMBL


Assay Description
Inhibition of [3H]-substance P binding in human Tachykinin receptor 1 of chinese hamster ovary (hNK-1-CHO) cell membranes

J Med Chem 40: 1794-807 (1997)


Article DOI: 10.1021/jm960818o
BindingDB Entry DOI: 10.7270/Q24T6HHB
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%